sk&f-38393 has been researched along with Idiopathic Parkinson Disease in 28 studies
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393
| Excerpt | Relevance | Reference |
|---|---|---|
| " All rats separately underwent dose-response behavior testing for SKF38393 (0, 0." | 1.62 | Effects of intrastriatal injection of the dopamine receptor agonist SKF38393 and quinpirole on locomotor behavior in hemiparkinsonism rats. ( Chen, D; Guo, M; He, F; Jia, Q; Li, M; Li, Y; Sun, S; Sun, Y; Wang, M; Wang, X; Xiang, T; Yao, X; Zhang, X, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.00) | 18.7374 |
| 1990's | 9 (32.14) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, M | 1 |
| Xiang, T | 1 |
| Li, M | 1 |
| Sun, Y | 1 |
| Sun, S | 1 |
| Chen, D | 1 |
| Jia, Q | 1 |
| Li, Y | 1 |
| Yao, X | 1 |
| Wang, X | 1 |
| Zhang, X | 1 |
| He, F | 1 |
| Wang, M | 1 |
| Frau, L | 1 |
| Morelli, M | 2 |
| Simola, N | 1 |
| Fisone, G | 1 |
| Vorobyov, VV | 1 |
| Schibaev, NV | 1 |
| Carta, AR | 1 |
| Yoshimura, N | 1 |
| Kuno, S | 1 |
| Chancellor, MB | 1 |
| De Groat, WC | 1 |
| Seki, S | 1 |
| Kovoor, A | 1 |
| Seyffarth, P | 1 |
| Ebert, J | 1 |
| Barghshoon, S | 1 |
| Chen, CK | 1 |
| Schwarz, S | 1 |
| Axelrod, JD | 1 |
| Cheyette, BN | 1 |
| Simon, MI | 1 |
| Lester, HA | 1 |
| Schwarz, J | 1 |
| Kachroo, A | 1 |
| Orlando, LR | 1 |
| Grandy, DK | 1 |
| Chen, JF | 1 |
| Young, AB | 1 |
| Schwarzschild, MA | 1 |
| Zhang, H | 1 |
| Ma, L | 1 |
| Wang, F | 1 |
| Chen, J | 1 |
| Zhen, X | 1 |
| Gershanik, O | 1 |
| Heikkila, RE | 2 |
| Duvoisin, RC | 1 |
| Fornaguera, J | 1 |
| Huston, JP | 1 |
| Carey, RJ | 1 |
| Schwarting, RK | 1 |
| Olsson, M | 1 |
| Nikkhah, G | 2 |
| Bentlage, C | 2 |
| Björklund, A | 2 |
| Silverman, PB | 1 |
| Watts, VJ | 1 |
| Lawler, CP | 1 |
| Gilmore, JH | 1 |
| Southerland, SB | 1 |
| Nichols, DE | 1 |
| Mailman, RB | 1 |
| Boldry, RC | 1 |
| Chase, TN | 5 |
| Engber, TM | 1 |
| Cunningham, MG | 1 |
| Brooks, S | 1 |
| Kaur, S | 1 |
| Starr, BS | 1 |
| Starr, MS | 1 |
| Rodríguez-Puertas, R | 1 |
| Herrera-Marschitz, M | 1 |
| Koistinaho, J | 1 |
| Hökfelt, T | 1 |
| Popoli, P | 1 |
| Reggio, R | 1 |
| Pèzzola, A | 1 |
| Hayakawa, T | 1 |
| Chang, MC | 1 |
| Rapoport, SI | 1 |
| Appel, NM | 1 |
| Zhao, Y | 1 |
| Kerscher, N | 1 |
| Eysel, U | 1 |
| Funke, K | 1 |
| Pendleton, RG | 1 |
| Parvez, F | 1 |
| Sayed, M | 1 |
| Hillman, R | 1 |
| Paul, ML | 1 |
| Graybiel, AM | 1 |
| David, JC | 1 |
| Robertson, HA | 1 |
| Braun, A | 2 |
| Fabbrini, G | 2 |
| Mouradian, MM | 2 |
| Serrati, C | 1 |
| Barone, P | 3 |
| Braun, AR | 1 |
| Tamminga, CA | 1 |
| Sonsalla, PK | 1 |
| Manzino, L | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
| Bankiewicz, KS | 1 |
| Corsini, GU | 1 |
| Kopin, IJ | 1 |
1 review available for sk&f-38393 and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzaze | 1986 |
1 trial available for sk&f-38393 and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Selective D-1 dopamine receptor agonist treatment of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aged; Benzazepines; Double-Blind Method; | 1987 |
26 other studies available for sk&f-38393 and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Effects of intrastriatal injection of the dopamine receptor agonist SKF38393 and quinpirole on locomotor behavior in hemiparkinsonism rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Corpus Striatum; Disease Models | 2021 |
Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Analysis of Variance; | 2013 |
Monitoring dyskinesia with Zif.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Biomarker | 2010 |
EEG modifications in the cortex and striatum after dopaminergic priming in the 6-hydroxydopamine rat model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Animals; Apomorphine; | 2003 |
Dopaminergic mechanisms underlying bladder hyperactivity in rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzopyrans; Disease Models, An | 2003 |
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Antipsych | 2005 |
Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Animals, | 2005 |
Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Disease M | 2007 |
Behavioral correlations of dopamine receptor activation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Disease Models, A | 1983 |
Stimulation of D1- or D2-receptors in drug-naive rats with different degrees of unilateral nigro-striatal dopamine lesions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Dopamine; Erg | 1995 |
Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Apomorphi | 1995 |
On-off effects of dopamine receptor agonists in the hemi-parkinsonian rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Bromocriptine; Cocaine; Dopamin | 1993 |
Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Dopamine Age | 1993 |
Influence of previous exposure to levodopa on the interaction between dizocilpine and dopamine D1 and D2 agonists in rats with 6-hydroxydopamine-induced lesions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Brain Disease | 1993 |
Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Behavior, Animal; | 1994 |
Motor actions of eliprodil in the normal and monoamine-depleted mouse: a role in the treatment of Parkinson's disease?
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Biogenic Mono | 1996 |
Dopamine D1 receptor modulation of glutamate receptor messenger RNA levels in the neocortex and neostriatum of unilaterally 6-hydroxydopamine-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Corpus Striatum; Dopamine; Dopa | 1999 |
Effects of SCH 58261, an adenosine A(2A) receptor antagonist, on quinpirole-induced turning in 6-hydroxydopamine-lesioned rats. Lack of tolerance after chronic caffeine intake.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Caffeine; Cen | 2000 |
Selective dopamine receptor stimulation differentially affects [3H]arachidonic acid incorporation, a surrogate marker for phospholipase A2-mediated neurotransmitter signal transduction, in a rodent model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Arachidonic Acid; Biomarkers; D | 2001 |
Changes of contrast gain in cat dorsal lateral geniculate nucleus by dopamine receptor agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Cats; Contra | 2001 |
Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Methyltyrosine; alpha-Synuclein; A | 2002 |
D1-like and D2-like dopamine receptors synergistically activate rotation and c-fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amino Acid Sequence; Animals; Behavior, | 1992 |
D-1/D-2 dopamine receptor interactions in the regulation of extrapyramidal motor function: studies in animal models and parkinsonian patients.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Ergolines; Humans | 1986 |
Dopamine D-1 receptor agonist stimulation of prolactin secretion in man.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Benzazepines; Dyskinesia, Drug-Induced; | 1988 |
Interactions of D1 and D2 dopamine receptors on the ipsilateral vs. contralateral side in rats with unilateral lesions of the dopaminergic nigrostriatal pathway.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Basal Ganglia; Benzazepines; Co | 1988 |
Dopaminergic mechanisms in hemiparkinsonian monkeys.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Biomechanical Phe | 1987 |