sk&f-38393 has been researched along with Hypertension in 35 studies
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-three patients with severe systemic hypertension defined as a diastolic blood pressure (DBP) > or = 120 mm Hg were randomized in a single-blind fashion to be treated with either intravenous fenoldopam mesylate (FNP) or sodium nitroprusside (NTP)." | 9.07 | Fenoldopam mesylate versus sodium nitroprusside in the acute management of severe systemic hypertension. ( Elliot, WJ; Green, JA; Murphy, MB; Nara, AR; Panacek, EA; Pilmer, BL; Rutherford, W, 1993) |
| "Fenoldopam mesylate stimulates adenyl cyclase in porcine ocular trabecular meshwork and raises intraocular pressure in humans." | 9.07 | Intraocular pressure increases with fenoldopam, but not nitroprusside, in hypertensive humans. ( Elliott, WJ; Geanon, J; Karnezis, TA; Murphy, MB; Silverman, RA; Tripathi, RC, 1991) |
| "In an open-label study, we compared the efficacy and safety of intravenous infusion of fenoldopam mesylate with that of sodium nitroprusside in patients with severe hypertension or in hypertensive crisis." | 9.06 | Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension. ( Gonzalez, FM; Huth, MM; Nguyen, BP; Reisin, E; Weed, SG, 1990) |
| "To evaluate the acute BP response to iv fenoldopam mesylate (FNP), 14 patients with severe hypertension (diastolic BP 120 to 170 mm Hg) were studied in an open-label trial." | 7.68 | Assessment of intravenous fenoldopam mesylate in the management of severe systemic hypertension. ( Anderson, L; Bednarczyk, EM; Emmanuel, G; Gonzalez, FM; Green, JA; Hakki, AI; Munger, MA; Panacek, EA; Rutherford, WF; Weed, SG, 1990) |
| " Fenoldopam caused an acute fall in blood pressure which lasted approximately 3 h after dosing and was associated with a reflex tachycardia." | 6.67 | A single dose study of the effects of fenoldopam and enalapril in mild hypertension. ( Freestone, S; Jeffrey, RF; Lee, MR; MacDonald, TM, 1991) |
| " Fenoldopam and nitroprusside lowered blood pressure safely to an average pressure of 176/105 mm Hg; highly significant dose-response relations were found for the 13 patients receiving fenoldopam and the 15 receiving nitroprusside." | 5.28 | Renal and hemodynamic effects of intravenous fenoldopam versus nitroprusside in severe hypertension. ( Elliott, WJ; Fumo, MT; Gretler, DD; McCray, GR; Murphy, MB; Nelson, KS; Oliner, CM; Weber, RR, 1990) |
| "Thirty-three patients with severe systemic hypertension defined as a diastolic blood pressure (DBP) > or = 120 mm Hg were randomized in a single-blind fashion to be treated with either intravenous fenoldopam mesylate (FNP) or sodium nitroprusside (NTP)." | 5.07 | Fenoldopam mesylate versus sodium nitroprusside in the acute management of severe systemic hypertension. ( Elliot, WJ; Green, JA; Murphy, MB; Nara, AR; Panacek, EA; Pilmer, BL; Rutherford, W, 1993) |
| "Fenoldopam mesylate stimulates adenyl cyclase in porcine ocular trabecular meshwork and raises intraocular pressure in humans." | 5.07 | Intraocular pressure increases with fenoldopam, but not nitroprusside, in hypertensive humans. ( Elliott, WJ; Geanon, J; Karnezis, TA; Murphy, MB; Silverman, RA; Tripathi, RC, 1991) |
| "In an open-label study, we compared the efficacy and safety of intravenous infusion of fenoldopam mesylate with that of sodium nitroprusside in patients with severe hypertension or in hypertensive crisis." | 5.06 | Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension. ( Gonzalez, FM; Huth, MM; Nguyen, BP; Reisin, E; Weed, SG, 1990) |
| " The novel DA1 receptor agonist fenoldopam is claiming a role in the management of hypertension, heart failure, and the preservation of renal function." | 4.78 | Dopamine and dopamine receptor agonists in cardiovascular therapy. ( Elliott, WJ; Murphy, MB, 1990) |
| "Fenoldopam (FE), a dopamine DA1-receptor agonist, has been introduced for treatment of arterial hypertension and heart failure and for preservation of renal function." | 3.69 | Effects of fenoldopam on intracranial pressure and hemodynamic variables at normal and elevated intracranial pressure in anesthetized pigs. ( Hennes, HJ; Jantzen, JP, 1994) |
| "To evaluate the acute BP response to iv fenoldopam mesylate (FNP), 14 patients with severe hypertension (diastolic BP 120 to 170 mm Hg) were studied in an open-label trial." | 3.68 | Assessment of intravenous fenoldopam mesylate in the management of severe systemic hypertension. ( Anderson, L; Bednarczyk, EM; Emmanuel, G; Gonzalez, FM; Green, JA; Hakki, AI; Munger, MA; Panacek, EA; Rutherford, WF; Weed, SG, 1990) |
| " Fenoldopam caused an acute fall in blood pressure which lasted approximately 3 h after dosing and was associated with a reflex tachycardia." | 2.67 | A single dose study of the effects of fenoldopam and enalapril in mild hypertension. ( Freestone, S; Jeffrey, RF; Lee, MR; MacDonald, TM, 1991) |
| "Hyperinsulinemia is reported to play a role in hypertension, as abnormalities in blood pressure regulation and sodium handling exist in diabetes mellitus." | 1.33 | Defective renal dopamine D1 receptor function contributes to hyperinsulinemia-mediated hypertension. ( Ahmad Banday, A; Lokhandwala, MF, 2006) |
| "Hyperactivity and hypertension are both expressed in the SHR." | 1.29 | Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity. ( Felder, RA; Hendley, ED; Ohbu, K; Yamaguchi, I, 1993) |
| " Fenoldopam and nitroprusside lowered blood pressure safely to an average pressure of 176/105 mm Hg; highly significant dose-response relations were found for the 13 patients receiving fenoldopam and the 15 receiving nitroprusside." | 1.28 | Renal and hemodynamic effects of intravenous fenoldopam versus nitroprusside in severe hypertension. ( Elliott, WJ; Fumo, MT; Gretler, DD; McCray, GR; Murphy, MB; Nelson, KS; Oliner, CM; Weber, RR, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.57) | 18.7374 |
| 1990's | 25 (71.43) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chugh, G | 1 |
| Lokhandwala, MF | 5 |
| Asghar, M | 1 |
| Pedrosa, R | 2 |
| Jose, PA | 5 |
| Soares-da-Silva, P | 3 |
| Gomes, P | 1 |
| Zeng, C | 1 |
| Hopfer, U | 1 |
| Ahmad Banday, A | 1 |
| Banday, AA | 2 |
| Fazili, FR | 1 |
| Lau, YS | 1 |
| Chatziantoniou, C | 1 |
| Ruan, X | 1 |
| Arendshorst, WJ | 1 |
| Bodmann, KF | 1 |
| Tröster, S | 1 |
| Clemens, R | 1 |
| Schuster, HP | 1 |
| Hennes, HJ | 1 |
| Jantzen, JP | 1 |
| Ohbu, K | 2 |
| Hendley, ED | 1 |
| Yamaguchi, I | 1 |
| Felder, RA | 6 |
| Hill, AJ | 1 |
| Feneck, RO | 1 |
| Walesby, RK | 1 |
| Shusterman, NH | 1 |
| Elliott, WJ | 5 |
| White, WB | 1 |
| Pilmer, BL | 1 |
| Green, JA | 2 |
| Panacek, EA | 2 |
| Elliot, WJ | 1 |
| Murphy, MB | 5 |
| Rutherford, W | 1 |
| Nara, AR | 1 |
| Uh, M | 1 |
| White, BH | 1 |
| Sidhu, A | 3 |
| Yao, LP | 1 |
| Li, XX | 1 |
| Yu, PY | 1 |
| Xu, J | 1 |
| Asico, LD | 1 |
| Lucas-Teixeira, VA | 1 |
| Vieira-Coelho, MA | 1 |
| Serrão, P | 1 |
| Pestana, M | 1 |
| Hackman, BB | 1 |
| Griffin, B | 1 |
| Mills, M | 1 |
| Ramanathan, KB | 1 |
| Chen, CJ | 1 |
| Gretler, DD | 2 |
| Moscucci, M | 1 |
| Childers, RW | 1 |
| Karnezis, TA | 1 |
| Silverman, RA | 1 |
| Geanon, J | 1 |
| Tripathi, RC | 1 |
| MacDonald, TM | 1 |
| Jeffrey, RF | 1 |
| Freestone, S | 1 |
| Lee, MR | 1 |
| Girbes, AR | 1 |
| van Veldhuisen, DJ | 1 |
| Smit, AJ | 1 |
| Reisin, E | 1 |
| Huth, MM | 1 |
| Nguyen, BP | 1 |
| Weed, SG | 2 |
| Gonzalez, FM | 2 |
| Weber, RR | 1 |
| Nelson, KS | 1 |
| Oliner, CM | 1 |
| Fumo, MT | 1 |
| McCray, GR | 1 |
| Munger, MA | 1 |
| Rutherford, WF | 1 |
| Anderson, L | 1 |
| Hakki, AI | 1 |
| Bednarczyk, EM | 1 |
| Emmanuel, G | 1 |
| Seikaly, MG | 2 |
| Cody, P | 1 |
| Eisner, GM | 2 |
| Horton, R | 2 |
| Bughi, S | 2 |
| Jost-Vu, E | 1 |
| Antonipillai, I | 2 |
| Nadler, J | 2 |
| Holcslaw, TL | 1 |
| Beck, TR | 1 |
| Kinoshita, S | 2 |
| Kaskel, FJ | 1 |
| VanCampen, M | 1 |
| Manoogian, C | 1 |
| Ehrlich, L | 1 |
2 reviews available for sk&f-38393 and Hypertension
| Article | Year |
|---|---|
Dopamine and dopamine receptor agonists in cardiovascular therapy.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Biological Availability; Blood Pressure; | 1990 |
Clinical experience with intravenous fenoldopam.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Cardiovascular System; Chemical Phenomen | 1990 |
10 trials available for sk&f-38393 and Hypertension
| Article | Year |
|---|---|
Hemodynamic profile of intravenous fenoldopam in patients with hypertensive crisis.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acute Disease; Aged; Aged, 80 and over; | 1993 |
A comparison of fenoldopam and nitroprusside in the control of hypertension following coronary artery surgery.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Aged; Atrial Function, Right; Blo | 1993 |
Fenoldopam, but not nitroprusside, improves renal function in severely hypertensive patients with impaired renal function.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Creatinine; Female; Fenoldopam; H | 1993 |
Fenoldopam mesylate versus sodium nitroprusside in the acute management of severe systemic hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Aged; Blood Pressure; Female; Fen | 1993 |
Comparative effects of fenoldopam mesylate and nitroprusside on left ventricular performance in severe systemic hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Analysis of Variance; Blood Press | 1992 |
Effects of intravenous fenoldopam (SK&F 82526-J) on blood pressure in severe hypertension. SK&F Fenoldopam Working Group.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Blood Pressure; Fenoldopam; Heart Rate; | 1992 |
Electrocardiographic changes during acute treatment of hypertensive emergencies with sodium nitroprusside or fenoldopam.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acute Disease; Adult; Dopamine Agents; E | 1992 |
Intraocular pressure increases with fenoldopam, but not nitroprusside, in hypertensive humans.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Blood Pressure; Dose-Response Rel | 1991 |
A single dose study of the effects of fenoldopam and enalapril in mild hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Blood Pressure; Creatinine; Dopam | 1991 |
Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Blood Pressure; Blood Urea Nitrog | 1990 |
23 other studies available for sk&f-38393 and Hypertension
| Article | Year |
|---|---|
Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Binding Sites; Cyclic N- | 2012 |
Defective D1-like receptor-mediated inhibition of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiporters; Bucladesine; Chlor | 2004 |
Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blood Pressure; Cell Line, Tran | 2004 |
Defective renal dopamine D1 receptor function contributes to hyperinsulinemia-mediated hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blood Glucose; Dopamine Agonist | 2006 |
Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-kappaB and protein kinase C.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; beta-Adrener | 2007 |
Oxidative stress causes renal dopamine D1 receptor dysfunction and salt-sensitive hypertension in Sprague-Dawley rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Antioxidants | 2008 |
Interactions of cAMP-mediated vasodilators with angiotensin II in rat kidney during hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Angiotensin II; Animals; | 1993 |
Effects of fenoldopam on intracranial pressure and hemodynamic variables at normal and elevated intracranial pressure in anesthetized pigs.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Anesthesia, General; Angiotensin II; Ani | 1994 |
Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Benza | 1993 |
Alteration of association of agonist-activated renal D1(A) dopamine receptors with G proteins in proximal tubules of the spontaneously hypertensive rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine Agonists; GTP-Binding | 1998 |
Dopamine D1 receptor and protein kinase C isoforms in spontaneously hypertensive rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Angiotensin II; Animals; Biological Tran | 1998 |
Salt intake and sensitivity of intestinal and renal Na+-K+ atpase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Diet, Sodium-Restricted; Dopami | 2000 |
An impairment of renal tubular DA-1 receptor function as the causative factor for diminished natriuresis to volume expansion in spontaneously hypertensive rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Diuresis; Dopamin | 1992 |
Dopamine agonists, a new perspective in cardiovascular therapy?
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Deoxyepinephrine; Dopamine Agents; Fenol | 1991 |
Renal and hemodynamic effects of intravenous fenoldopam versus nitroprusside in severe hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Dopamine Agents; Dose-Response Relations | 1990 |
Assessment of intravenous fenoldopam mesylate in the management of severe systemic hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Aged; Blood Pressure; Female; Fen | 1990 |
Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzamides; Benzazepines; Dopam | 1990 |
Effect of dopamine on renal blood flow, prostaglandins, renin and electrolyte excretion in normal and hypertensive humans.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine; Dopamine Agents; Dose | 1990 |
A renal dopamine-1 receptor defect in two genetic models of hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Dopam | 1990 |
Differential modulation of the renal proximal tubular DA-1 receptor by Gpp(NH)p and sodium in the spontaneously hypertensive rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine Agents; Fenoldopam; Gu | 1990 |
Comparison of dopamine and fenoldopam effects on renal blood flow and prostacyclin excretion in normal and essential hypertensive subjects.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Aged; Aldosterone; Blood Pressure | 1989 |
Defective dopamine-1 receptor adenylate cyclase coupling in the proximal convoluted tubule from the spontaneously hypertensive rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Affinity Labels; Anim | 1989 |
Renal dopamine-1 defect in spontaneous hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Dopamine; Hyperte | 1988 |