Compounds > sk&f-38393
Page last updated: 2024-10-21

sk&f-38393 and Drug Withdrawal Symptoms

sk&f-38393 has been researched along with Drug Withdrawal Symptoms in 17 studies

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393

Research Excerpts

ExcerptRelevanceReference
"The effects of chronic oral fenoldopam in the treatment of NYHA grade II-III heart failure secondary to ischaemic heart disease, were studied in a placebo controlled, double blind, randomised, parallel group fashion in 20 patients."5.06A preliminary study of the dopamine DA1 agonist fenoldopam in the treatment of chronic left ventricular failure due to ischaemic heart disease. ( Jeffrey, RF; Lee, MR; MacDonald, TM; Muir, AL, 1990)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.76)18.7374
1990's9 (52.94)18.2507
2000's2 (11.76)29.6817
2010's3 (17.65)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Liu, Q1
Du, G1
Xiao, R1
Liu, Y1
Cao, K1
Du, X1
Tang, S1
Huang, W1
Wang, X1
Cannella, N1
Oliveira, AMM1
Hemstedt, T1
Lissek, T1
Buechler, E1
Bading, H1
Spanagel, R1
Fu, R1
Zuo, W1
Shiwalkar, N1
Mei, Q1
Fan, Q1
Chen, X1
Li, J1
Bekker, A1
Ye, JH1
Kang, S1
Paul, K1
Hankosky, ER1
Cox, CL1
Gulley, JM1
Dizgah, IM1
Karimian, SM1
Zarrindast, MR1
Sohanaki, H1
Fletcher, PJ1
Tenn, CC1
Sinyard, J1
Rizos, Z1
Kapur, S1
Pierce, RC1
Kalivas, PW1
Neisewander, JL1
Lucki, I1
McGonigle, P1
Zhang, XF1
Hu, XT1
White, FJ1
Samochowiec, J1
Kleinrok, Z1
Jagiełło-Wójtowicz, E1
Horodnicki, J1
Rommelspacher, H1
Schmidt, LG1
Tidey, JW1
Miczek, KA1
Lublin, H1
Gerlach, J1
Peacock, L1
Van Vliet, BJ1
De Vries, TJ1
Wardeh, G1
Mulder, AH1
Schoffelmeer, AN1
MacDonald, TM1
Jeffrey, RF1
Muir, AL1
Lee, MR1
Bhargava, HN1
Gulati, A1
Trzaskowska, E1
Krzaścik, P1
Staniszewska, A1
Puciłowski, O1
Kostowski, W1
Dall'Olio, R1
Gandolfi, O1
Vaccheri, A1
Roncada, P1
Montanaro, N1

Trials

1 trial available for sk&f-38393 and Drug Withdrawal Symptoms

ArticleYear
A preliminary study of the dopamine DA1 agonist fenoldopam in the treatment of chronic left ventricular failure due to ischaemic heart disease.
    European journal of clinical pharmacology, 1990, Volume: 38, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aged; Body Weight; Coronary Disease; Dop

1990

Other Studies

16 other studies available for sk&f-38393 and Drug Withdrawal Symptoms

ArticleYear
Injection of D1 receptor antagonist SCH23390 into the periaqueductal gray attenuates morphine withdrawal symptoms in rats.
    Neuroscience letters, 2020, 01-01, Volume: 714

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Calcium-Calmoduli

2020
Dnmt3a2 in the Nucleus Accumbens Shell Is Required for Reinstatement of Cocaine Seeking.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 08-22, Volume: 38, Issue:34

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cocaine; Cocaine-

2018
Alcohol withdrawal drives depressive behaviors by activating neurons in the rostromedial tegmental nucleus.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019, Volume: 44, Issue:8

    Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Be

2019
D1 receptor-mediated inhibition of medial prefrontal cortex neurons is disrupted in adult rats exposed to amphetamine in adolescence.
    Neuroscience, 2016, Jun-02, Volume: 324

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Amphetamine-Related Disorde

2016
Attenuation of morphine withdrawal signs by a D1 receptor agonist in the locus coeruleus of rats.
    Neuroreport, 2005, Oct-17, Volume: 16, Issue:15

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Benzazepines;

2005
A sensitizing regimen of amphetamine impairs visual attention in the 5-choice serial reaction time test: reversal by a D1 receptor agonist injected into the medial prefrontal cortex.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:5

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Attention; Cogniti

2007
Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Behavior, Animal;

1995
Changes in behavioral sensitivity to SKF-38393 and quinpirole following withdrawal from continuous cocaine administration in rats.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Cocaine; Dopa

1996
Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jan-01, Volume: 18, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Bromo Cyclic Adenosine Monophosphate;

1998
Effects of dopaminergic agonists and antagonists on the serum prolactin levels in alcoholized rats.
    Polish journal of pharmacology, 1997, Volume: 49, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Central Nervous S

1997
Morphine withdrawal aggression: modification with D1 and D2 receptor agonists.
    Psychopharmacology, 1992, Volume: 108, Issue:1-2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aggression; Animals; Body Temperature; D

1992
Effect of D1 and D2 agonists in primates withdrawn from long-term treatment with haloperidol: the potential role of dopamine D1 receptors in dyskinesia.
    Clinical neuropharmacology, 1992, Volume: 15, Issue:6

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal;

1992
mu-Opioid receptor-regulated adenylate cyclase activity in primary cultures of rat striatal neurons upon chronic morphine exposure.
    European journal of pharmacology, 1991, Oct-14, Volume: 208, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Cells, Cultu

1991
Modification of brain and spinal cord dopamine D1 receptors labeled with [3H]SCH 23390 after morphine withdrawal from tolerant and physically dependent rats.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Brain; Dopamine A

1990
On the relative importance of D-1 vs. D-2 dopaminergic receptors in the control of audiogenic seizures in ethanol withdrawn rats.
    Drug and alcohol dependence, 1989, Volume: 24, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acoustic Stimulation; Animals; Benzazepi

1989
Changes in behavioural responses to the combined administration of D1 and D2 dopamine agonists in normosensitive and D1 supersensitive rats.
    Psychopharmacology, 1988, Volume: 95, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Appetite

1988