sk&f-38393 has been researched along with Depression in 11 studies
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "HCl), and that of imipramine in the behavioural despair model of depression." | 3.69 | Antidepressant-like effect of selective dopamine D1 receptor agonists in the behavioural despair animal model of depression. ( Collu, M; D'Aquila, PS; Gessa, GL; Pani, L; Serra, G, 1994) |
| " Moreover, long term administration of both imipramine or SKF 38393 down regulated D1 dopamine receptor number in the prefrontal cortex, while the association of the two drugs resulted in a receptor density similar to that of control rats." | 1.29 | Desensitization of the D1 dopamine receptors in rats reproduces a model of escape deficit reverted by imipramine, fluoxetine and clomipramine. ( Gambarana, C; Ghiglieri, O; Graziella de Montis, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Hasbi, A | 1 |
| Nguyen, T | 1 |
| Rahal, H | 1 |
| Manduca, JD | 1 |
| Miksys, S | 1 |
| Tyndale, RF | 1 |
| Madras, BK | 1 |
| Perreault, ML | 1 |
| George, SR | 1 |
| Fang, X | 1 |
| Guo, L | 1 |
| Jia, J | 1 |
| Jin, GZ | 1 |
| Zhao, B | 1 |
| Zheng, YY | 1 |
| Li, JQ | 1 |
| Zhang, A | 1 |
| Zhen, XC | 1 |
| Jiang, B | 1 |
| Wang, F | 1 |
| Yang, S | 1 |
| Fang, P | 1 |
| Deng, ZF | 1 |
| Xiao, JL | 1 |
| Hu, ZL | 1 |
| Chen, JG | 1 |
| Dubrovina, NI | 2 |
| Zinov'eva, DV | 2 |
| Fedotova, J | 1 |
| Ordyan, N | 1 |
| Yuan, TT | 1 |
| Qiao, H | 1 |
| Dong, SP | 1 |
| An, SC | 1 |
| D'Aquila, PS | 1 |
| Collu, M | 2 |
| Pani, L | 2 |
| Gessa, GL | 2 |
| Serra, G | 2 |
| Gambarana, C | 1 |
| Ghiglieri, O | 1 |
| Graziella de Montis, M | 1 |
| Nikulina, EM | 1 |
| Skrinskaya, JA | 1 |
| Popova, NK | 1 |
| D'Aquila, P | 1 |
11 other studies available for sk&f-38393 and Depression
| Article | Year |
|---|---|
Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anxiety; Behavior, Animal; beta | 2020 |
SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antidepressive Agents; CHO Cell | 2013 |
SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antidepressive Agents; Behavior | 2014 |
Effects of activation and blockade of dopamine receptors on the extinction of a passive avoidance reaction in mice with a depressive-like state.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Avoidance Learning; Benzazepine | 2010 |
Involvement of D1 receptors in depression-like behavior of ovariectomized rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Benzazepines; | 2011 |
[Activation of hippocampal D1 dopamine receptor inhibits glutamate-mediated depression induced by chronic unpredictable mild stress in rats].
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Depression; Dizocilpine Maleate | 2011 |
[Interaction of N-methyl-D-aspartate and Dopamine D1 receptors in modulation of passive avoidance extinction at mice with depressive-like state].
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Avoidance Learning; Cycloserine | 2011 |
Antidepressant-like effect of selective dopamine D1 receptor agonists in the behavioural despair animal model of depression.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Antidepre | 1994 |
Desensitization of the D1 dopamine receptors in rats reproduces a model of escape deficit reverted by imipramine, fluoxetine and clomipramine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clomipramine; Depression; Disea | 1995 |
Role of genotype and dopamine receptors in behaviour of inbred mice in a forced swimming test.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Behavior, | 1991 |
Are D1 dopamine receptor agonists potential antidepressants?
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Benzazepines; | 1988 |