sk&f-38393 has been researched along with Blood Pressure, High in 35 studies
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-three patients with severe systemic hypertension defined as a diastolic blood pressure (DBP) > or = 120 mm Hg were randomized in a single-blind fashion to be treated with either intravenous fenoldopam mesylate (FNP) or sodium nitroprusside (NTP)." | 9.07 | Fenoldopam mesylate versus sodium nitroprusside in the acute management of severe systemic hypertension. ( Elliot, WJ; Green, JA; Murphy, MB; Nara, AR; Panacek, EA; Pilmer, BL; Rutherford, W, 1993) |
| "Fenoldopam mesylate stimulates adenyl cyclase in porcine ocular trabecular meshwork and raises intraocular pressure in humans." | 9.07 | Intraocular pressure increases with fenoldopam, but not nitroprusside, in hypertensive humans. ( Elliott, WJ; Geanon, J; Karnezis, TA; Murphy, MB; Silverman, RA; Tripathi, RC, 1991) |
| "In an open-label study, we compared the efficacy and safety of intravenous infusion of fenoldopam mesylate with that of sodium nitroprusside in patients with severe hypertension or in hypertensive crisis." | 9.06 | Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension. ( Gonzalez, FM; Huth, MM; Nguyen, BP; Reisin, E; Weed, SG, 1990) |
| "To evaluate the acute BP response to iv fenoldopam mesylate (FNP), 14 patients with severe hypertension (diastolic BP 120 to 170 mm Hg) were studied in an open-label trial." | 7.68 | Assessment of intravenous fenoldopam mesylate in the management of severe systemic hypertension. ( Anderson, L; Bednarczyk, EM; Emmanuel, G; Gonzalez, FM; Green, JA; Hakki, AI; Munger, MA; Panacek, EA; Rutherford, WF; Weed, SG, 1990) |
| " Fenoldopam caused an acute fall in blood pressure which lasted approximately 3 h after dosing and was associated with a reflex tachycardia." | 6.67 | A single dose study of the effects of fenoldopam and enalapril in mild hypertension. ( Freestone, S; Jeffrey, RF; Lee, MR; MacDonald, TM, 1991) |
| " Fenoldopam and nitroprusside lowered blood pressure safely to an average pressure of 176/105 mm Hg; highly significant dose-response relations were found for the 13 patients receiving fenoldopam and the 15 receiving nitroprusside." | 5.28 | Renal and hemodynamic effects of intravenous fenoldopam versus nitroprusside in severe hypertension. ( Elliott, WJ; Fumo, MT; Gretler, DD; McCray, GR; Murphy, MB; Nelson, KS; Oliner, CM; Weber, RR, 1990) |
| "Thirty-three patients with severe systemic hypertension defined as a diastolic blood pressure (DBP) > or = 120 mm Hg were randomized in a single-blind fashion to be treated with either intravenous fenoldopam mesylate (FNP) or sodium nitroprusside (NTP)." | 5.07 | Fenoldopam mesylate versus sodium nitroprusside in the acute management of severe systemic hypertension. ( Elliot, WJ; Green, JA; Murphy, MB; Nara, AR; Panacek, EA; Pilmer, BL; Rutherford, W, 1993) |
| "Fenoldopam mesylate stimulates adenyl cyclase in porcine ocular trabecular meshwork and raises intraocular pressure in humans." | 5.07 | Intraocular pressure increases with fenoldopam, but not nitroprusside, in hypertensive humans. ( Elliott, WJ; Geanon, J; Karnezis, TA; Murphy, MB; Silverman, RA; Tripathi, RC, 1991) |
| "In an open-label study, we compared the efficacy and safety of intravenous infusion of fenoldopam mesylate with that of sodium nitroprusside in patients with severe hypertension or in hypertensive crisis." | 5.06 | Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension. ( Gonzalez, FM; Huth, MM; Nguyen, BP; Reisin, E; Weed, SG, 1990) |
| " The novel DA1 receptor agonist fenoldopam is claiming a role in the management of hypertension, heart failure, and the preservation of renal function." | 4.78 | Dopamine and dopamine receptor agonists in cardiovascular therapy. ( Elliott, WJ; Murphy, MB, 1990) |
| "Fenoldopam (FE), a dopamine DA1-receptor agonist, has been introduced for treatment of arterial hypertension and heart failure and for preservation of renal function." | 3.69 | Effects of fenoldopam on intracranial pressure and hemodynamic variables at normal and elevated intracranial pressure in anesthetized pigs. ( Hennes, HJ; Jantzen, JP, 1994) |
| "To evaluate the acute BP response to iv fenoldopam mesylate (FNP), 14 patients with severe hypertension (diastolic BP 120 to 170 mm Hg) were studied in an open-label trial." | 3.68 | Assessment of intravenous fenoldopam mesylate in the management of severe systemic hypertension. ( Anderson, L; Bednarczyk, EM; Emmanuel, G; Gonzalez, FM; Green, JA; Hakki, AI; Munger, MA; Panacek, EA; Rutherford, WF; Weed, SG, 1990) |
| " Fenoldopam caused an acute fall in blood pressure which lasted approximately 3 h after dosing and was associated with a reflex tachycardia." | 2.67 | A single dose study of the effects of fenoldopam and enalapril in mild hypertension. ( Freestone, S; Jeffrey, RF; Lee, MR; MacDonald, TM, 1991) |
| "Hyperinsulinemia is reported to play a role in hypertension, as abnormalities in blood pressure regulation and sodium handling exist in diabetes mellitus." | 1.33 | Defective renal dopamine D1 receptor function contributes to hyperinsulinemia-mediated hypertension. ( Ahmad Banday, A; Lokhandwala, MF, 2006) |
| "Hyperactivity and hypertension are both expressed in the SHR." | 1.29 | Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity. ( Felder, RA; Hendley, ED; Ohbu, K; Yamaguchi, I, 1993) |
| " Fenoldopam and nitroprusside lowered blood pressure safely to an average pressure of 176/105 mm Hg; highly significant dose-response relations were found for the 13 patients receiving fenoldopam and the 15 receiving nitroprusside." | 1.28 | Renal and hemodynamic effects of intravenous fenoldopam versus nitroprusside in severe hypertension. ( Elliott, WJ; Fumo, MT; Gretler, DD; McCray, GR; Murphy, MB; Nelson, KS; Oliner, CM; Weber, RR, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.57) | 18.7374 |
| 1990's | 25 (71.43) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chugh, G | 1 |
| Lokhandwala, MF | 5 |
| Asghar, M | 1 |
| Pedrosa, R | 2 |
| Jose, PA | 5 |
| Soares-da-Silva, P | 3 |
| Gomes, P | 1 |
| Zeng, C | 1 |
| Hopfer, U | 1 |
| Ahmad Banday, A | 1 |
| Banday, AA | 2 |
| Fazili, FR | 1 |
| Lau, YS | 1 |
| Chatziantoniou, C | 1 |
| Ruan, X | 1 |
| Arendshorst, WJ | 1 |
| Bodmann, KF | 1 |
| Tröster, S | 1 |
| Clemens, R | 1 |
| Schuster, HP | 1 |
| Hennes, HJ | 1 |
| Jantzen, JP | 1 |
| Ohbu, K | 2 |
| Hendley, ED | 1 |
| Yamaguchi, I | 1 |
| Felder, RA | 6 |
| Hill, AJ | 1 |
| Feneck, RO | 1 |
| Walesby, RK | 1 |
| Shusterman, NH | 1 |
| Elliott, WJ | 5 |
| White, WB | 1 |
| Pilmer, BL | 1 |
| Green, JA | 2 |
| Panacek, EA | 2 |
| Elliot, WJ | 1 |
| Murphy, MB | 5 |
| Rutherford, W | 1 |
| Nara, AR | 1 |
| Uh, M | 1 |
| White, BH | 1 |
| Sidhu, A | 3 |
| Yao, LP | 1 |
| Li, XX | 1 |
| Yu, PY | 1 |
| Xu, J | 1 |
| Asico, LD | 1 |
| Lucas-Teixeira, VA | 1 |
| Vieira-Coelho, MA | 1 |
| Serrão, P | 1 |
| Pestana, M | 1 |
| Hackman, BB | 1 |
| Griffin, B | 1 |
| Mills, M | 1 |
| Ramanathan, KB | 1 |
| Chen, CJ | 1 |
| Gretler, DD | 2 |
| Moscucci, M | 1 |
| Childers, RW | 1 |
| Karnezis, TA | 1 |
| Silverman, RA | 1 |
| Geanon, J | 1 |
| Tripathi, RC | 1 |
| MacDonald, TM | 1 |
| Jeffrey, RF | 1 |
| Freestone, S | 1 |
| Lee, MR | 1 |
| Girbes, AR | 1 |
| van Veldhuisen, DJ | 1 |
| Smit, AJ | 1 |
| Reisin, E | 1 |
| Huth, MM | 1 |
| Nguyen, BP | 1 |
| Weed, SG | 2 |
| Gonzalez, FM | 2 |
| Weber, RR | 1 |
| Nelson, KS | 1 |
| Oliner, CM | 1 |
| Fumo, MT | 1 |
| McCray, GR | 1 |
| Munger, MA | 1 |
| Rutherford, WF | 1 |
| Anderson, L | 1 |
| Hakki, AI | 1 |
| Bednarczyk, EM | 1 |
| Emmanuel, G | 1 |
| Seikaly, MG | 2 |
| Cody, P | 1 |
| Eisner, GM | 2 |
| Horton, R | 2 |
| Bughi, S | 2 |
| Jost-Vu, E | 1 |
| Antonipillai, I | 2 |
| Nadler, J | 2 |
| Holcslaw, TL | 1 |
| Beck, TR | 1 |
| Kinoshita, S | 2 |
| Kaskel, FJ | 1 |
| VanCampen, M | 1 |
| Manoogian, C | 1 |
| Ehrlich, L | 1 |
2 reviews available for sk&f-38393 and Blood Pressure, High
| Article | Year |
|---|---|
Dopamine and dopamine receptor agonists in cardiovascular therapy.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Biological Availability; Blood Pressure; | 1990 |
Clinical experience with intravenous fenoldopam.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Cardiovascular System; Chemical Phenomen | 1990 |
10 trials available for sk&f-38393 and Blood Pressure, High
| Article | Year |
|---|---|
Hemodynamic profile of intravenous fenoldopam in patients with hypertensive crisis.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acute Disease; Aged; Aged, 80 and over; | 1993 |
A comparison of fenoldopam and nitroprusside in the control of hypertension following coronary artery surgery.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Aged; Atrial Function, Right; Blo | 1993 |
Fenoldopam, but not nitroprusside, improves renal function in severely hypertensive patients with impaired renal function.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Creatinine; Female; Fenoldopam; H | 1993 |
Fenoldopam mesylate versus sodium nitroprusside in the acute management of severe systemic hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Aged; Blood Pressure; Female; Fen | 1993 |
Comparative effects of fenoldopam mesylate and nitroprusside on left ventricular performance in severe systemic hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Analysis of Variance; Blood Press | 1992 |
Effects of intravenous fenoldopam (SK&F 82526-J) on blood pressure in severe hypertension. SK&F Fenoldopam Working Group.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Blood Pressure; Fenoldopam; Heart Rate; | 1992 |
Electrocardiographic changes during acute treatment of hypertensive emergencies with sodium nitroprusside or fenoldopam.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acute Disease; Adult; Dopamine Agents; E | 1992 |
Intraocular pressure increases with fenoldopam, but not nitroprusside, in hypertensive humans.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Blood Pressure; Dose-Response Rel | 1991 |
A single dose study of the effects of fenoldopam and enalapril in mild hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Blood Pressure; Creatinine; Dopam | 1991 |
Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Blood Pressure; Blood Urea Nitrog | 1990 |
23 other studies available for sk&f-38393 and Blood Pressure, High
| Article | Year |
|---|---|
Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Binding Sites; Cyclic N- | 2012 |
Defective D1-like receptor-mediated inhibition of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiporters; Bucladesine; Chlor | 2004 |
Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blood Pressure; Cell Line, Tran | 2004 |
Defective renal dopamine D1 receptor function contributes to hyperinsulinemia-mediated hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blood Glucose; Dopamine Agonist | 2006 |
Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-kappaB and protein kinase C.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; beta-Adrener | 2007 |
Oxidative stress causes renal dopamine D1 receptor dysfunction and salt-sensitive hypertension in Sprague-Dawley rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Antioxidants | 2008 |
Interactions of cAMP-mediated vasodilators with angiotensin II in rat kidney during hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Angiotensin II; Animals; | 1993 |
Effects of fenoldopam on intracranial pressure and hemodynamic variables at normal and elevated intracranial pressure in anesthetized pigs.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Anesthesia, General; Angiotensin II; Ani | 1994 |
Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Benza | 1993 |
Alteration of association of agonist-activated renal D1(A) dopamine receptors with G proteins in proximal tubules of the spontaneously hypertensive rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine Agonists; GTP-Binding | 1998 |
Dopamine D1 receptor and protein kinase C isoforms in spontaneously hypertensive rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Angiotensin II; Animals; Biological Tran | 1998 |
Salt intake and sensitivity of intestinal and renal Na+-K+ atpase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Diet, Sodium-Restricted; Dopami | 2000 |
An impairment of renal tubular DA-1 receptor function as the causative factor for diminished natriuresis to volume expansion in spontaneously hypertensive rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Diuresis; Dopamin | 1992 |
Dopamine agonists, a new perspective in cardiovascular therapy?
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Deoxyepinephrine; Dopamine Agents; Fenol | 1991 |
Renal and hemodynamic effects of intravenous fenoldopam versus nitroprusside in severe hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Dopamine Agents; Dose-Response Relations | 1990 |
Assessment of intravenous fenoldopam mesylate in the management of severe systemic hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Aged; Blood Pressure; Female; Fen | 1990 |
Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzamides; Benzazepines; Dopam | 1990 |
Effect of dopamine on renal blood flow, prostaglandins, renin and electrolyte excretion in normal and hypertensive humans.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine; Dopamine Agents; Dose | 1990 |
A renal dopamine-1 receptor defect in two genetic models of hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Dopam | 1990 |
Differential modulation of the renal proximal tubular DA-1 receptor by Gpp(NH)p and sodium in the spontaneously hypertensive rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine Agents; Fenoldopam; Gu | 1990 |
Comparison of dopamine and fenoldopam effects on renal blood flow and prostacyclin excretion in normal and essential hypertensive subjects.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adult; Aged; Aldosterone; Blood Pressure | 1989 |
Defective dopamine-1 receptor adenylate cyclase coupling in the proximal convoluted tubule from the spontaneously hypertensive rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Affinity Labels; Anim | 1989 |
Renal dopamine-1 defect in spontaneous hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Dopamine; Hyperte | 1988 |