sk&f-38393 has been researched along with Aging in 48 studies
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Excerpt | Relevance | Reference |
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" Old (23 mo) rats were subjected to rest (sedentary) or to treadmill exercise followed by measurement of oxidative stress [malondialdehyde (MDA)], inflammation [C-reactive protein (CRP)], anti-inflammation (IL-10), antioxidant enzyme [superoxide dismutase (SOD)], and natriuretic response to SKF 38393." | 3.74 | Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats. ( Asghar, M; George, L; Lokhandwala, MF, 2007) |
"Hyperactivity and hypertension are both expressed in the SHR." | 1.29 | Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity. ( Felder, RA; Hendley, ED; Ohbu, K; Yamaguchi, I, 1993) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (8.33) | 18.7374 |
1990's | 23 (47.92) | 18.2507 |
2000's | 13 (27.08) | 29.6817 |
2010's | 5 (10.42) | 24.3611 |
2020's | 3 (6.25) | 2.80 |
Authors | Studies |
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Cleal, M | 1 |
Fontana, BD | 1 |
Double, M | 1 |
Mezabrovschi, R | 1 |
Parcell, L | 1 |
Redhead, E | 1 |
Parker, MO | 1 |
Elgueta-Reyes, M | 1 |
Martínez-Pinto, J | 1 |
Renard, GM | 1 |
Sotomayor-Zárate, R | 1 |
Huang, H | 1 |
Zhang, B | 1 |
Zheng, S | 1 |
Li, C | 2 |
Zhu, X | 1 |
Wang, J | 1 |
Asghar, M | 8 |
Chillar, A | 1 |
Lokhandwala, MF | 9 |
George, L | 2 |
Hostetler, CM | 1 |
Harkey, SL | 1 |
Bales, KL | 1 |
Chugh, G | 2 |
Lorelli, CJ | 1 |
Wreschnig, D | 1 |
Davis, FC | 2 |
Huppé-Gourgues, F | 1 |
O'Donnell, P | 1 |
Hussain, T | 4 |
Alonso, G | 1 |
Runquist, M | 1 |
Hussy, N | 1 |
Duvoid, A | 1 |
Moos, F | 1 |
Brus, R | 2 |
Kostrzewa, RM | 5 |
Nowak, P | 1 |
Perry, KW | 2 |
Kostrzewa, JP | 1 |
Fardoun, RZ | 1 |
Lokhandwala, M | 1 |
Lee, Y | 1 |
Paik, D | 1 |
Bang, S | 1 |
Kang, J | 1 |
Chun, B | 1 |
Lee, S | 1 |
Bae, E | 1 |
Chung, J | 1 |
Kim, J | 1 |
Dose, JM | 1 |
Zolman, JF | 1 |
Arnsten, AF | 1 |
Cai, JX | 1 |
Murphy, BL | 1 |
Goldman-Rakic, PS | 1 |
Guo, J | 1 |
Kostrzewa, FP | 1 |
Byrnes, EM | 2 |
Abrams, D | 1 |
Bruno, JP | 2 |
Gong, L | 1 |
Ohbu, K | 2 |
Hendley, ED | 1 |
Yamaguchi, I | 1 |
Felder, RA | 2 |
Fuller, RW | 1 |
Undie, AS | 1 |
Friedman, E | 1 |
Hersi, AI | 1 |
Rowe, W | 1 |
Gaudreau, P | 1 |
Quirion, R | 1 |
Drago, F | 1 |
Nardo, L | 1 |
Rampello, L | 1 |
Raffaele, R | 1 |
Kansra, V | 2 |
Sajnani, GG | 1 |
Abreu, P | 1 |
Castro, R | 1 |
Levine, MS | 1 |
Cepeda, C | 1 |
Grosse, J | 1 |
Vieira-Coelho, MA | 1 |
Soares-da-Silva, P | 1 |
Rehders, JH | 1 |
Löscher, W | 1 |
Richter, A | 1 |
Beheray, S | 1 |
Andersen, SL | 1 |
Moody, CA | 2 |
Spear, LP | 2 |
Neal, BS | 1 |
Joyce, JN | 1 |
Hamdi, A | 1 |
Amenta, F | 1 |
Cavallotti, C | 1 |
Collier, WL | 1 |
De Michele, M | 1 |
Ricci, A | 1 |
Kinoshita, S | 1 |
Sidhu, A | 1 |
Kaskel, FJ | 1 |
Parfitt, KD | 1 |
Gratton, A | 1 |
Bickford-Wimer, PC | 1 |
McDougall, SA | 1 |
Arnold, TF | 1 |
Nonneman, AJ | 1 |
Freeman, AS | 1 |
Kelland, MD | 1 |
Rouillard, C | 1 |
Chiodo, LA | 1 |
Sivam, SP | 1 |
Breese, GR | 1 |
Krause, JE | 1 |
Napier, TC | 1 |
Mueller, RA | 1 |
Hong, JS | 1 |
Molloy, AG | 1 |
Waddington, JL | 1 |
Burchill, SA | 1 |
Thody, AJ | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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A D1 Agonist For Working Memory Enhancement In The Schizophrenia Spectrum[NCT02507206] | Phase 2 | 120 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
48 other studies available for sk&f-38393 and Aging
Article | Year |
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Dopaminergic modulation of working memory and cognitive flexibility in a zebrafish model of aging-related cognitive decline.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adolescent; Adult; Aged; Aged, 80 and ov | 2021 |
Neonatal programming with sex hormones: Effect on expression of dopamine D
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Dopami | 2021 |
The effects of aging and dopaminergic inhibition on large scale maze learning in rhesus monkeys.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Administration, Intravenous; Aging; Anim | 2021 |
Renal proximal tubules from old Fischer 344 rats grow into epithelial cells in cultures and exhibit increased oxidative stress and reduced D1 receptor function.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Aging; Animals; Cells, Cult | 2008 |
Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Dopamine Agonists; GTP-B | 2009 |
D2 antagonist during development decreases anxiety and infanticidal behavior in adult female prairie voles (Microtus ochrogaster).
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Anxiety; Arvicolinae; Be | 2010 |
Oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Antioxidants; Benzimidaz | 2011 |
Resilience of circadian pacemaker development in hamsters.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Chronobiology Disorders; | 2011 |
D₁-NMDA receptor interactions in the rat nucleus accumbens change during adolescence.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Corpus Striatum; Dopamin | 2012 |
Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Binding Sites; Cyclic N- | 2012 |
Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Aging; Animals; Benzazepine | 2002 |
Overexpression of PKC-betaI and -delta contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Dopamine Agonists; Kidne | 2003 |
Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Afferent Pathways; Aging; Animals; Astro | 2003 |
Ontogenetic quinpirole treatments fail to prime for D2 agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Biogenic Monoamines; Den | 2003 |
Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Antioxidants; beta-Adren | 2006 |
Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Genetically Mod | 2008 |
Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; C-Reactive Protein; Infl | 2007 |
Separate and combined effects of dopamine D1 and D2 receptor agonists on key pecking in the developing chick.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Chickens; Conditioning, | 1994 |
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Behavior, Animal; Benzaz | 1994 |
Ontogenetic quinpirole treatment induces vertical jumping activity in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Behavior, Animal; Benzaz | 1993 |
Co-activation of D1- and D2-like receptors is unnecessary for stimulated motor behavior in rats depleted of dopamine during development.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Brain; Dopamine; Dopamin | 1994 |
Neonatal 6-hydroxydopamine and adult SKF 38393 treatments alter dopamine D1 receptor mRNA levels: absence of other neurochemical associations with the enhanced behavioral responses of lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Anima | 1994 |
Development of uncoupling between D1- and D2-mediated motor behavior in rats depleted of dopamine as neonates.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Benzam | 1994 |
Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Benza | 1993 |
Age-dependence of a 6-hydroxydopamine lesion on SKF 38393- and m-chlorophenylpiperazine-induced oral activity responses of rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Biogenic Monoamines; Cor | 1993 |
Diet restriction prevents aging-induced deficits in brain phosphoinositide metabolism.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Atropine; Brain; Carbach | 1993 |
Dopamine D1 receptor ligands modulate cognitive performance and hippocampal acetylcholine release in memory-impaired aged rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Age Factors; Aging; Anima | 1995 |
Vestibular compensation in aged rats with unilateral labyrinthectomy treated with dopaminergic drugs.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Analysis of Variance; Animals; Be | 1996 |
Alterations in dopamine DA1 receptor and G proteins in renal proximal tubules of old rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Blood Pres | 1997 |
Pre/postnatal dopamine D1 receptor stimulation induces a differential reduction of serotonin levels in hippocampus and superior colliculus of puber rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Aging; A | 1997 |
Dopamine modulation of responses mediated by excitatory amino acids in the neostriatum.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Brain; Dopamine; Dopamin | 1998 |
Transient entrainment of a circadian pacemaker during development by dopaminergic activation in Syrian hamsters.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Circadian Rhythm; Cricet | 1999 |
Ontogenic aspects of D1 receptor coupling to G proteins and regulation of rat jejunal Na+, K+ ATPase activity and electrolyte transport.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Biological | 2000 |
Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Amphetamine; Animals; Benzazepine | 2000 |
Diminished natriuretic response to dopamine in old rats is due to an impaired D1-like receptor-signaling pathway.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Age Factors; Aging; A | 2000 |
Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD).
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Attention Deficit Disord | 2002 |
Ontogenetic differences in the psychopharmacological responses to separate and combined stimulation of D1 and D2 dopamine receptors during the neonatal to weanling age period.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Behavi | 1992 |
Effects of acute dopamine depletion on responsiveness to D1 and D2 receptor agonists in infant and weanling rat pups.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; alpha-Methyltyrosine; Analysis of | 1992 |
Dopamine D1 receptor behavioral responsitivity following selective lesions of the striatal patch compartment during development.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Analysis of Variance; Animals; An | 1991 |
Ontogenic homologous supersensitization of dopamine D1 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Corpus | 1991 |
Age-related changes of dopamine sensitive cyclic AMP generation in the rat frontal cortex.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Apomorphine; Benzazepine | 1990 |
A renal dopamine-1 receptor defect in two genetic models of hypertension.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Dopam | 1990 |
Electrophysiological effects of selective D1 and D2 dopamine receptor agonists in the medial prefrontal cortex of young and aged Fischer 344 rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzamides; Benzazepines | 1990 |
Ontogeny of locomotor activity and grooming in the young rat: role of dopamine D1 and D2 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Dopamine A | 1990 |
Electrophysiological characteristics and pharmacological responsiveness of midbrain dopaminergic neurons of the aged rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Apomorphine; Benzazepine | 1989 |
Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Benzaz | 1987 |
Behavioural responses to the selective D1-dopamine receptor agonist R-SK&F 38393 and the selective D2-agonist RU 24213 in young compared with aged rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Apomorphine; Appetite De | 1988 |
Dopaminergic inhibition of tyrosinase activity in hair follicular melanocytes of the mouse.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Bromocript | 1986 |