Page last updated: 2024-10-21

sk&f-38393 and Aging

sk&f-38393 has been researched along with Aging in 48 studies

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

Excerpt	Relevance	Reference
" Old (23 mo) rats were subjected to rest (sedentary) or to treadmill exercise followed by measurement of oxidative stress [malondialdehyde (MDA)], inflammation [C-reactive protein (CRP)], anti-inflammation (IL-10), antioxidant enzyme [superoxide dismutase (SOD)], and natriuretic response to SKF 38393."	3.74	Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats. ( Asghar, M; George, L; Lokhandwala, MF, 2007)
"Hyperactivity and hypertension are both expressed in the SHR."	1.29	Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity. ( Felder, RA; Hendley, ED; Ohbu, K; Yamaguchi, I, 1993)

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (8.33)	18.7374
1990's	23 (47.92)	18.2507
2000's	13 (27.08)	29.6817
2010's	5 (10.42)	24.3611
2020's	3 (6.25)	2.80

Authors

Authors	Studies
Cleal, M	1
Fontana, BD	1
Double, M	1
Mezabrovschi, R	1
Parcell, L	1
Redhead, E	1
Parker, MO	1
Elgueta-Reyes, M	1
Martínez-Pinto, J	1
Renard, GM	1
Sotomayor-Zárate, R	1
Huang, H	1
Zhang, B	1
Zheng, S	1
Li, C	2
Zhu, X	1
Wang, J	1
Asghar, M	8
Chillar, A	1
Lokhandwala, MF	9
George, L	2
Hostetler, CM	1
Harkey, SL	1
Bales, KL	1
Chugh, G	2
Lorelli, CJ	1
Wreschnig, D	1
Davis, FC	2
Huppé-Gourgues, F	1
O'Donnell, P	1
Hussain, T	4
Alonso, G	1
Runquist, M	1
Hussy, N	1
Duvoid, A	1
Moos, F	1
Brus, R	2
Kostrzewa, RM	5
Nowak, P	1
Perry, KW	2
Kostrzewa, JP	1
Fardoun, RZ	1
Lokhandwala, M	1
Lee, Y	1
Paik, D	1
Bang, S	1
Kang, J	1
Chun, B	1
Lee, S	1
Bae, E	1
Chung, J	1
Kim, J	1
Dose, JM	1
Zolman, JF	1
Arnsten, AF	1
Cai, JX	1
Murphy, BL	1
Goldman-Rakic, PS	1
Guo, J	1
Kostrzewa, FP	1
Byrnes, EM	2
Abrams, D	1
Bruno, JP	2
Gong, L	1
Ohbu, K	2
Hendley, ED	1
Yamaguchi, I	1
Felder, RA	2
Fuller, RW	1
Undie, AS	1
Friedman, E	1
Hersi, AI	1
Rowe, W	1
Gaudreau, P	1
Quirion, R	1
Drago, F	1
Nardo, L	1
Rampello, L	1
Raffaele, R	1
Kansra, V	2
Sajnani, GG	1
Abreu, P	1
Castro, R	1
Levine, MS	1
Cepeda, C	1
Grosse, J	1
Vieira-Coelho, MA	1
Soares-da-Silva, P	1
Rehders, JH	1
Löscher, W	1
Richter, A	1
Beheray, S	1
Andersen, SL	1
Moody, CA	2
Spear, LP	2
Neal, BS	1
Joyce, JN	1
Hamdi, A	1
Amenta, F	1
Cavallotti, C	1
Collier, WL	1
De Michele, M	1
Ricci, A	1
Kinoshita, S	1
Sidhu, A	1
Kaskel, FJ	1
Parfitt, KD	1
Gratton, A	1
Bickford-Wimer, PC	1
McDougall, SA	1
Arnold, TF	1
Nonneman, AJ	1
Freeman, AS	1
Kelland, MD	1
Rouillard, C	1
Chiodo, LA	1
Sivam, SP	1
Breese, GR	1
Krause, JE	1
Napier, TC	1
Mueller, RA	1
Hong, JS	1
Molloy, AG	1
Waddington, JL	1
Burchill, SA	1
Thody, AJ	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
A D1 Agonist For Working Memory Enhancement In The Schizophrenia Spectrum[NCT02507206]			Phase 2	120 participants (Actual)	Interventional	2013-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

48 other studies available for sk&f-38393 and Aging

Article	Year
Dopaminergic modulation of working memory and cognitive flexibility in a zebrafish model of aging-related cognitive decline. Neurobiology of aging, 2021, Volume: 102 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adolescent; Adult; Aged; Aged, 80 and ov	2021
Neonatal programming with sex hormones: Effect on expression of dopamine D European journal of pharmacology, 2021, Jul-05, Volume: 902 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Dopami	2021
The effects of aging and dopaminergic inhibition on large scale maze learning in rhesus monkeys. Brain research bulletin, 2021, Volume: 175 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Administration, Intravenous; Aging; Anim	2021
Renal proximal tubules from old Fischer 344 rats grow into epithelial cells in cultures and exhibit increased oxidative stress and reduced D1 receptor function. American journal of physiology. Cell physiology, 2008, Volume: 295, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Aging; Animals; Cells, Cult	2008
Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats. American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Dopamine Agonists; GTP-B	2009
D2 antagonist during development decreases anxiety and infanticidal behavior in adult female prairie voles (Microtus ochrogaster). Behavioural brain research, 2010, Jun-26, Volume: 210, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Anxiety; Arvicolinae; Be	2010
Oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old rats. American journal of physiology. Renal physiology, 2011, Volume: 300, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Antioxidants; Benzimidaz	2011
Resilience of circadian pacemaker development in hamsters. Journal of biological rhythms, 2011, Volume: 26, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Chronobiology Disorders;	2011
D₁-NMDA receptor interactions in the rat nucleus accumbens change during adolescence. Synapse (New York, N.Y.), 2012, Volume: 66, Issue:7 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Corpus Striatum; Dopamin	2012
Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Binding Sites; Cyclic N-	2012
Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats. American journal of physiology. Renal physiology, 2002, Volume: 283, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Aging; Animals; Benzazepine	2002
Overexpression of PKC-betaI and -delta contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats. American journal of physiology. Renal physiology, 2003, Volume: 285, Issue:6 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Dopamine Agonists; Kidne	2003
Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe. The European journal of neuroscience, 2003, Volume: 18, Issue:7 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Afferent Pathways; Aging; Animals; Astro	2003
Ontogenetic quinpirole treatments fail to prime for D2 agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned rats. Neurotoxicity research, 2003, Volume: 5, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Biogenic Monoamines; Den	2003
Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats. American journal of physiology. Renal physiology, 2006, Volume: 291, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Antioxidants; beta-Adren	2006
Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila. Neurobiology of aging, 2008, Volume: 29, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Genetically Mod	2008
Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats. American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; C-Reactive Protein; Infl	2007
Separate and combined effects of dopamine D1 and D2 receptor agonists on key pecking in the developing chick. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Chickens; Conditioning,	1994
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys. Psychopharmacology, 1994, Volume: 116, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Behavior, Animal; Benzaz	1994
Ontogenetic quinpirole treatment induces vertical jumping activity in rats. European journal of pharmacology, 1993, Aug-03, Volume: 239, Issue:1-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Behavior, Animal; Benzaz	1993
Co-activation of D1- and D2-like receptors is unnecessary for stimulated motor behavior in rats depleted of dopamine during development. Behavioural brain research, 1994, Apr-18, Volume: 61, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Brain; Dopamine; Dopamin	1994
Neonatal 6-hydroxydopamine and adult SKF 38393 treatments alter dopamine D1 receptor mRNA levels: absence of other neurochemical associations with the enhanced behavioral responses of lesioned rats. Journal of neurochemistry, 1994, Volume: 63, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Anima	1994
Development of uncoupling between D1- and D2-mediated motor behavior in rats depleted of dopamine as neonates. Developmental psychobiology, 1994, Volume: 27, Issue:6 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Benzam	1994
Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity. Hypertension (Dallas, Tex. : 1979), 1993, Volume: 21, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Benza	1993
Age-dependence of a 6-hydroxydopamine lesion on SKF 38393- and m-chlorophenylpiperazine-induced oral activity responses of rats. Brain research. Developmental brain research, 1993, Nov-19, Volume: 76, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Biogenic Monoamines; Cor	1993
Diet restriction prevents aging-induced deficits in brain phosphoinositide metabolism. Journal of gerontology, 1993, Volume: 48, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Atropine; Brain; Carbach	1993
Dopamine D1 receptor ligands modulate cognitive performance and hippocampal acetylcholine release in memory-impaired aged rats. Neuroscience, 1995, Volume: 69, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Age Factors; Aging; Anima	1995
Vestibular compensation in aged rats with unilateral labyrinthectomy treated with dopaminergic drugs. Pharmacological research, 1996, Volume: 33, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Analysis of Variance; Animals; Be	1996
Alterations in dopamine DA1 receptor and G proteins in renal proximal tubules of old rats. The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Blood Pres	1997
Pre/postnatal dopamine D1 receptor stimulation induces a differential reduction of serotonin levels in hippocampus and superior colliculus of puber rats. Neuroscience letters, 1997, Jul-18, Volume: 230, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Aging; A	1997
Dopamine modulation of responses mediated by excitatory amino acids in the neostriatum. Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Brain; Dopamine; Dopamin	1998
Transient entrainment of a circadian pacemaker during development by dopaminergic activation in Syrian hamsters. Brain research bulletin, 1999, Jan-15, Volume: 48, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Circadian Rhythm; Cricet	1999
Ontogenic aspects of D1 receptor coupling to G proteins and regulation of rat jejunal Na+, K+ ATPase activity and electrolyte transport. British journal of pharmacology, 2000, Volume: 129, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Biological	2000
Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model. Neuroscience, 2000, Volume: 97, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Amphetamine; Animals; Benzazepine	2000
Diminished natriuretic response to dopamine in old rats is due to an impaired D1-like receptor-signaling pathway. Kidney international, 2000, Volume: 58, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Age Factors; Aging; A	2000
Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD). Behavioural brain research, 2002, Mar-10, Volume: 130, Issue:1-2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Attention Deficit Disord	2002
Ontogenetic differences in the psychopharmacological responses to separate and combined stimulation of D1 and D2 dopamine receptors during the neonatal to weanling age period. Psychopharmacology, 1992, Volume: 106, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Behavi	1992
Effects of acute dopamine depletion on responsiveness to D1 and D2 receptor agonists in infant and weanling rat pups. Psychopharmacology, 1992, Volume: 107, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; alpha-Methyltyrosine; Analysis of	1992
Dopamine D1 receptor behavioral responsitivity following selective lesions of the striatal patch compartment during development. Brain research. Developmental brain research, 1991, Jun-21, Volume: 60, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Analysis of Variance; Animals; An	1991
Ontogenic homologous supersensitization of dopamine D1 receptors. European journal of pharmacology, 1991, Oct-02, Volume: 203, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Corpus	1991
Age-related changes of dopamine sensitive cyclic AMP generation in the rat frontal cortex. Mechanisms of ageing and development, 1990, May-15, Volume: 54, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Apomorphine; Benzazepine	1990
A renal dopamine-1 receptor defect in two genetic models of hypertension. American journal of hypertension, 1990, Volume: 3, Issue:6 Pt 2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Dopam	1990
Electrophysiological effects of selective D1 and D2 dopamine receptor agonists in the medial prefrontal cortex of young and aged Fischer 344 rats. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzamides; Benzazepines	1990
Ontogeny of locomotor activity and grooming in the young rat: role of dopamine D1 and D2 receptors. European journal of pharmacology, 1990, Sep-21, Volume: 186, Issue:2-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Dopamine A	1990
Electrophysiological characteristics and pharmacological responsiveness of midbrain dopaminergic neurons of the aged rat. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Apomorphine; Benzazepine	1989
Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression. Journal of neurochemistry, 1987, Volume: 49, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Benzaz	1987
Behavioural responses to the selective D1-dopamine receptor agonist R-SK&F 38393 and the selective D2-agonist RU 24213 in young compared with aged rats. British journal of pharmacology, 1988, Volume: 95, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Apomorphine; Appetite De	1988
Dopaminergic inhibition of tyrosinase activity in hair follicular melanocytes of the mouse. The Journal of endocrinology, 1986, Volume: 111, Issue:2 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Bromocript	1986

chemdatabank.com