Page last updated: 2024-08-26

sivelestat and Sepsis

sivelestat has been researched along with Sepsis in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's6 (60.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Cui, Y; Ding, X; Li, H; Liang, H; Liu, S; Sun, T; Sun, Y; Wang, D; Wang, H; Zhang, X1
Dilireba, T; Ding, Q; Li, X; Wang, Y; Yang, C; Yu, X1
Gao, Z; Li, C; Liu, L; Ma, S; Qiu, H; Xie, J; Yang, Y1
Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T1
Fang, QH; Jiang, YW; Yuan, Q1
Gong, X; Ji, K; Jia, J; Li, G; Wang, H; Wang, R; Zang, B; Zhang, X1
Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T1
Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H1
Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E1
Bellomo, R; Naka, T; Uchino, S; Wan, L1

Trials

1 trial(s) available for sivelestat and Sepsis

ArticleYear
Effects of intravenous sivelestat sodium on prevention of acute respiratory distress syndrome in patients with sepsis: study protocol for a double-blind multicentre randomised controlled trial.
    BMJ open, 2023, 09-13, Volume: 13, Issue:9

    Topics: Double-Blind Method; Humans; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sepsis; Sodium

2023

Other Studies

9 other study(ies) available for sivelestat and Sepsis

ArticleYear
Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.
    Frontiers in cellular and infection microbiology, 2022, Volume: 12

    Topics: Animals; Gastrointestinal Microbiome; Glycine; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides

2022
[Sivelestat protects acute kidney injury by inhibiting the PI3K/AKT pathway in septic rats].
    Zhonghua wei zhong bing ji jiu yi xue, 2023, Volume: 35, Issue:3

    Topics: Acute Kidney Injury; Animals; Interleukin-6; Male; NF-kappa B; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Sepsis; Tumor Necrosis Factor-alpha

2023
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; Middle Aged; Oxygen; Protein Precursors; Proteinase Inhibitory Proteins, Secretory; Retrospective Studies; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate

2013
Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2014, Volume: 122, Issue:9

    Topics: Acute Lung Injury; Animals; Endothelial Cells; Glycine; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Neutrophil Infiltration; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Pulmonary Edema; Rats; Rats, Wistar; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Transcription Factor RelA

2014
The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.
    International journal of molecular medicine, 2016, Volume: 38, Issue:3

    Topics: Acute Kidney Injury; Animals; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Glomerular Filtration Rate; Glycine; HMGB1 Protein; Injections, Intraperitoneal; Interleukin-1beta; Kaplan-Meier Estimate; Kidney; Leukocyte Elastase; Lipocalin-2; Male; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha

2016
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients.
    Shock (Augusta, Ga.), 2010, Volume: 33, Issue:1

    Topics: Adult; Aged; Disseminated Intravascular Coagulation; Female; Glycine; Humans; Male; Middle Aged; Respiratory Distress Syndrome; Retrospective Studies; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2010
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
    Shock (Augusta, Ga.), 2010, Volume: 33, Issue:5

    Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Glycine; HMGB1 Protein; Inflammation; Interleukin-8; Ligation; Lung; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides; Survival Analysis

2010
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.
    Drug design, development and therapy, 2012, Volume: 6

    Topics: Abdomen; Acute Lung Injury; Aged; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Respiratory Distress Syndrome; Sepsis; Sulfonamides; Ventilator Weaning

2012
Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals.
    Intensive care medicine, 2004, Volume: 30, Issue:5

    Topics: Anti-Inflammatory Agents; Communication Barriers; Double-Blind Method; Evidence-Based Medicine; Glycine; Humans; Japan; Methylprednisolone; Multicenter Studies as Topic; Periodicals as Topic; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome

2004