sivelestat has been researched along with Sepsis in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, Y; Ding, X; Li, H; Liang, H; Liu, S; Sun, T; Sun, Y; Wang, D; Wang, H; Zhang, X | 1 |
| Dilireba, T; Ding, Q; Li, X; Wang, Y; Yang, C; Yu, X | 1 |
| Gao, Z; Li, C; Liu, L; Ma, S; Qiu, H; Xie, J; Yang, Y | 1 |
| Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T | 1 |
| Fang, QH; Jiang, YW; Yuan, Q | 1 |
| Gong, X; Ji, K; Jia, J; Li, G; Wang, H; Wang, R; Zang, B; Zhang, X | 1 |
| Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T | 1 |
| Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H | 1 |
| Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E | 1 |
| Bellomo, R; Naka, T; Uchino, S; Wan, L | 1 |
1 trial(s) available for sivelestat and Sepsis
| Article | Year |
|---|---|
Effects of intravenous sivelestat sodium on prevention of acute respiratory distress syndrome in patients with sepsis: study protocol for a double-blind multicentre randomised controlled trial.
Topics: Double-Blind Method; Humans; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sepsis; Sodium | 2023 |
9 other study(ies) available for sivelestat and Sepsis
| Article | Year |
|---|---|
Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.
Topics: Animals; Gastrointestinal Microbiome; Glycine; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides | 2022 |
[Sivelestat protects acute kidney injury by inhibiting the PI3K/AKT pathway in septic rats].
Topics: Acute Kidney Injury; Animals; Interleukin-6; Male; NF-kappa B; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Sepsis; Tumor Necrosis Factor-alpha | 2023 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; Middle Aged; Oxygen; Protein Precursors; Proteinase Inhibitory Proteins, Secretory; Retrospective Studies; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate | 2013 |
Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats.
Topics: Acute Lung Injury; Animals; Endothelial Cells; Glycine; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Neutrophil Infiltration; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Pulmonary Edema; Rats; Rats, Wistar; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Transcription Factor RelA | 2014 |
The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Glomerular Filtration Rate; Glycine; HMGB1 Protein; Injections, Intraperitoneal; Interleukin-1beta; Kaplan-Meier Estimate; Kidney; Leukocyte Elastase; Lipocalin-2; Male; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha | 2016 |
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients.
Topics: Adult; Aged; Disseminated Intravascular Coagulation; Female; Glycine; Humans; Male; Middle Aged; Respiratory Distress Syndrome; Retrospective Studies; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2010 |
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Glycine; HMGB1 Protein; Inflammation; Interleukin-8; Ligation; Lung; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides; Survival Analysis | 2010 |
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.
Topics: Abdomen; Acute Lung Injury; Aged; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Respiratory Distress Syndrome; Sepsis; Sulfonamides; Ventilator Weaning | 2012 |
Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals.
Topics: Anti-Inflammatory Agents; Communication Barriers; Double-Blind Method; Evidence-Based Medicine; Glycine; Humans; Japan; Methylprednisolone; Multicenter Studies as Topic; Periodicals as Topic; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome | 2004 |