sivelestat has been researched along with Reperfusion Injury in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (29.03) | 18.2507 |
| 2000's | 13 (41.94) | 29.6817 |
| 2010's | 8 (25.81) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Kawamura, T; Sakurai, M; Suzuki, H; Suzuki, T | 1 |
| Fujimura, T; Fushida, S; Hayashi, H; Kitagawa, H; Makino, I; Miyashita, T; Munesue, S; Nakagawara, H; Nakanuma, S; Ohta, T; Saito, H; Sakai, S; Tajima, H; Yamamoto, Y | 1 |
| Fukunaga, K; Kondo, T; Matsuo, R; Murata, S; Nakano, Y; Ohkohchi, N | 1 |
| Busuttil, RW; Freitas, MC; Kupiec-Weglinski, JW; Uchida, Y; Zhao, D | 1 |
| Fukunaga, K; Kondo, T; Murata, S; Nakano, Y; Oda, T; Ohkohchi, N; Pak, S; Sasaki, R | 1 |
| Harada, N; Kawai, M; Okajima, K; Takeyama, H | 1 |
| Dimitriadis, F; Kinoshita, Y; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Shomori, K; Tsounapi, P | 1 |
| Hanazaki, K; Kobayashi, M; Okabayashi, T; Shiga, M; Sugimoto, T; Takezaki, Y; Tsujii, S | 1 |
| Du, W; Fujimura, N; Itano, O; Kawasako, K; Kitagawa, Y; Kitago, M; Maruyama, I; Matsuda, S; Matsumoto, K; Miyasho, T; Obara, H; Ono, S; Sakamoto, M; Shinoda, M; Suda, K; Takeuchi, H; Tanabe, M; Yagi, H; Yamada, S | 1 |
| Abe, C; Binh, NH; Cuong, NT; Hara, A; Morita, H; Ogura, S | 1 |
| Doi, K; Horiuchi, T; Kimura, N; Tabo, T; Tanaka, K; Uchinami, M; Yokomachi, J; Yoshida, M | 1 |
| Ishikawa, N; Kawaguchi, M; Oda, M; Tsunezuka, Y; Watanabe, G | 1 |
| Harada, N; Mori, M; Okajima, K; Uchiba, M | 1 |
| Kotake, Y; Matsumoto, M; Morisaki, H; Takeda, J; Yamamoto, M | 1 |
| Funao, K; Hayama, T; Kawahito, Y; Matsuyama, M; Nakatani, T; Sano, H; Takemoto, Y; Tanaka, T; Tsuchida, K; Yoshimura, R | 1 |
| Kondo, T; Niikawa, H; Oishi, H; Sugawara, T; Suzuki, S; Tabata, T | 1 |
| Date, H; Kotani, K; Mori, H; Nagahiro, I; Nakanishi, H; Osaragi, T; Sano, Y; Shimizu, N | 1 |
| Kono, T; Okada, S; Saito, M | 1 |
| Iwasaki, Y; Kubota, K; Okada, T; Sawada, T; Shimoda, M | 1 |
| Kapoor, S | 1 |
| Akizuki, E; Goto, M; Ichiguchi, O; Miyanari, N; Mori, K; Ogawa, M; Wang, FS; Yamada, S; Yamaguchi, Y | 1 |
| Ichikawa, H; Iino, Y; Kamoshita, N; Kobayashi, J; Morishita, Y; Ohwada, S; Ohya, T; Takahashi, T; Tomizawa, N | 1 |
| Ichikawa, H; Iino, Y; Izumi, M; Kamoshita, N; Kobayashi, J; Morishita, Y; Nakamura, S; Ogawa, T; Ohwada, S; Ohya, T; Takahashi, T; Tomizawa, N | 1 |
| Harada, N; Kushimoto, S; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M | 1 |
| Kawashima, Y; Morishita, Y; Ohwada, S; Ohya, T; Takeyoshi, I; Tomizawa, N | 1 |
| Adachi, M; Kawashima, Y; Morishita, Y; Ogawa, T; Ohwada, S; Ohya, T; Takeyoshi, I; Tomizawa, N | 1 |
| Nishizaki, T; Soejima, Y; Sugimachi, K; Uchiyama, H; Yanaga, K; Yoshizumi, T | 1 |
| Chen, HM; Chen, JC; Chen, MF; Chi, CP; Chi, TY; Fan, LL; Hwang, TL; Shyr, MH | 1 |
| Ooshima, H; Usui, A; Watanabe, T; Yamazaki, T; Yasuura, K | 1 |
| Fukumoto, Y; Moriyama, Y; Nakamura, K; Sakasegawa, K; Sakata, R; Toda, R; Ueno, M; Yamamoto, H; Yotsumoto, G | 1 |
| Ishibashi, M; Ishii, H; Kuraki, T; Nishida, T; Takayama, M; Yoshida, M | 1 |
1 trial(s) available for sivelestat and Reperfusion Injury
| Article | Year |
|---|---|
The effect of the neutrophil elastase inhibitor sivelestat on early injury after liver resection.
Topics: Aged; Biomarkers; Drug Administration Schedule; Female; Glycine; Hepatectomy; HMGB1 Protein; Humans; Interleukin-6; Leukocyte Elastase; Liver; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2012 |
30 other study(ies) available for sivelestat and Reperfusion Injury
| Article | Year |
|---|---|
Endoplasmic Reticulum Stress is Involved in the Protective Effect of Sivelestat Sodium Hydrate (ONO-5046) in Spinal Cord Ischemia-Reperfusion Injury.
Topics: Animals; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Ischemia; Male; Rabbits; Reperfusion Injury; Sodium; Spinal Cord; Spinal Cord Ischemia | 2023 |
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Topics: Animals; Cell Adhesion; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Immune System Diseases; Leukocyte Disorders; Liver Diseases; Male; Neutrophils; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome | 2014 |
Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Glycine; Leukocytes; Lipid Peroxidation; Liver; Male; Microcirculation; Models, Animal; Pancreatic Elastase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2009 |
The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.
Topics: Animals; Chemokine CXCL1; DNA Primers; Glycine; Humans; Immunohistochemistry; Inflammation; Interleukin-6; Leukocyte Elastase; Liver; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peroxidase; Polymerase Chain Reaction; Proteinase Inhibitory Proteins, Secretory; Reperfusion Injury; RNA; Sulfonamides; Tumor Necrosis Factor-alpha | 2010 |
Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion.
Topics: Animals; Blood Platelets; Cytokines; Glycine; Liver; Liver Circulation; Liver Diseases; Male; Neutrophils; Platelet Adhesiveness; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2010 |
Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcitonin Gene-Related Peptide; Cephalosporins; Glycine; Hepatic Artery; Iloprost; Indomethacin; Insulin-Like Growth Factor I; Leukocyte Elastase; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Peroxidase; Platelet Aggregation Inhibitors; Portal Vein; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2010 |
Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats.
Topics: Animals; Glycine; HSP70 Heat-Shock Proteins; Male; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfonamides; Testis; Testosterone | 2011 |
Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Constriction; Glycine; Intestines; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate | 2013 |
Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats.
Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Dioxide; Combined Modality Therapy; Crush Syndrome; Drug Evaluation, Preclinical; Fluid Therapy; Glycine; HMGB1 Protein; Liver; Lung; Male; Oxygen; Partial Pressure; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhabdomyolysis; Serine Proteinase Inhibitors; Sulfonamides; Survival Analysis; Treatment Outcome | 2013 |
Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats.
Topics: Animals; Glycine; Liver Circulation; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Reperfusion Injury; Serpins; Sulfonamides | 2002 |
The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury.
Topics: Animals; Cardiac Output; Female; Glycine; Leukocyte Elastase; Lung Diseases; Lung Transplantation; Oxygen; Pulmonary Circulation; Pulmonary Wedge Pressure; Rabbits; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Vascular Resistance | 2003 |
Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Permeability; Cephalosporins; Chemokines, CXC; Cyclooxygenase Inhibitors; Endothelium; Enzyme Inhibitors; Epoprostenol; Glycine; Iloprost; Indomethacin; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Liver; Liver Circulation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides; Transaminases; Vasodilator Agents | 2004 |
Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits.
Topics: Acetylglucosaminidase; Animals; Bronchoalveolar Lavage Fluid; Glycine; Ischemia; L-Lactate Dehydrogenase; Lactates; Leukocyte Elastase; Lipid Peroxides; Liver; Luminescent Measurements; Male; Neutrophils; Rabbits; Reperfusion Injury; Serine Proteinase Inhibitors; Stomach; Sulfonamides; Time Factors; Transaminases | 2005 |
Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Functional Laterality; Glycine; Leukocyte Elastase; Male; Rats; Rats, Inbred Lew; Renal Artery; Renal Circulation; Renal Veins; Reperfusion Injury; Sulfonamides; Survival Analysis | 2006 |
Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation.
Topics: Animals; Cytokines; Endotoxins; Escherichia coli; Glycine; Injections, Intraperitoneal; Interleukin-8; Leukocyte Elastase; Lung; Lung Transplantation; Male; Neutrophils; Pneumonia; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfonamides; Tissue and Organ Harvesting; Tumor Necrosis Factor-alpha | 2007 |
Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation.
Topics: Animals; Glycine; Leukocyte Elastase; Lung; Lung Transplantation; Male; Models, Animal; Organ Preservation; Organ Preservation Solutions; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2007 |
Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.
Topics: Animals; Glycine; Leukocyte Elastase; Male; Malondialdehyde; Nitrates; Nitrites; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Sulfonamides; Urinary Bladder | 2008 |
Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method.
Topics: Animals; Aspartate Aminotransferases; Blood Pressure; Cell Line; Enzyme Inhibitors; Glycine; Heart Rate; Hepatectomy; Hepatocytes; In Situ Nick-End Labeling; In Vitro Techniques; Leukocyte Elastase; Lipopolysaccharides; Liver Diseases; Nitric Oxide Synthase Type II; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Serine Proteinase Inhibitors; Sulfonamides; Swine; Tumor Necrosis Factor-alpha | 2008 |
Sivelestat and its role in tissue reperfusion injury.
Topics: Glycine; Humans; Leukocyte Elastase; Lung; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2008 |
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
Topics: Animals; Chemokines, CXC; Chemotactic Factors; Duodenum; Glycine; Growth Substances; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Male; Pancreas Transplantation; Pancreatic Elastase; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 1996 |
Effects of neutrophil elastase inhibitor on reperfusion injury in the canine liver.
Topics: Alanine Transaminase; Animals; Biomarkers; Dogs; Glycine; Hyaluronic Acid; Ischemia; L-Lactate Dehydrogenase; Leukocyte Elastase; Liver; Pancreatic Elastase; Purine-Nucleoside Phosphorylase; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 1996 |
Effects of a specific neutrophil elastase inhibitor (ONO-5046 Na) and neutrophil depletion using a G-1 column on lung reperfusion injury in dogs.
Topics: Animals; Chromatography; Dogs; Glycine; Graft Survival; Ischemia; Leukapheresis; Leukocyte Count; Leukocyte Elastase; Lung; Lung Transplantation; Neutrophils; Pancreatic Elastase; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 1996 |
Role of granulocyte elastase in ischemia/reperfusion injury of rat liver.
Topics: Animals; Bile; Coloring Agents; Glycine; Indocyanine Green; Leukocyte Elastase; Liver; Male; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Transaminases | 1996 |
The effect of neutrophil elastase inhibitor in hepatectomy with ischemia in dogs.
Topics: Alanine Transaminase; Animals; Biomarkers; Dogs; Endothelium, Vascular; Glycine; Hemorrhage; Hepatectomy; Hyaluronic Acid; Ischemia; L-Lactate Dehydrogenase; Leukocyte Elastase; Liver; Liver Circulation; Portal System; Purine-Nucleoside Phosphorylase; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 1999 |
The effects of a neutrophil elastase inhibitor (ONO-5046.Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs.
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Glycine; Hemodynamics; Leukapheresis; Leukocyte Elastase; Lung; Neutrophils; Organ Size; Random Allocation; Recombinant Proteins; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 1999 |
Effect of specific neutrophil elastase inhibitor on ischemia/reperfusion injury in rat liver transplantation.
Topics: Adenine Nucleotides; Animals; Bile; Glycine; Hyaluronic Acid; Ischemia; Leukocyte Elastase; Liver; Liver Circulation; Liver Transplantation; Male; Rats; Rats, Inbred Lew; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 1999 |
Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats.
Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Glycine; Hemodynamics; Ischemia; Laser-Doppler Flowmetry; Leukocyte Elastase; Lipid Peroxidation; Liver; Male; Malondialdehyde; Microcirculation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Ultrasonography | 1999 |
Protective effects of ONO-5046*Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury.
Topics: Animals; Cardiopulmonary Bypass; Dogs; Extravascular Lung Water; Glycine; Hemodynamics; Interleukin-6; Interleukin-8; Leukocyte Count; Leukocyte Elastase; Lung; Oxygen; Protective Agents; Pulmonary Circulation; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Vascular Resistance | 1999 |
Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model.
Topics: Animals; Cytokines; Dogs; Glycine; Heart Transplantation; Inflammation Mediators; Leukocyte Elastase; Neutrophil Activation; Reperfusion Injury; Serine Proteinase Inhibitors; Stroke Volume; Sulfonamides; Transplantation, Heterotopic | 2001 |
Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion.
Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotactic Factors; Extravascular Lung Water; Glycine; Growth Substances; Hydrogen Peroxide; Intercellular Signaling Peptides and Proteins; Intestines; Leukocyte Count; Leukocyte Elastase; Lung; Male; Microcirculation; Neutrophil Infiltration; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2001 |