Page last updated: 2024-08-26

sivelestat and Lung Injury, Acute

sivelestat has been researched along with Lung Injury, Acute in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (4.88)	29.6817
2010's	33 (80.49)	24.3611
2020's	6 (14.63)	2.80

Authors

Authors	Studies
Hsieh, PW; Hwang, TL; Wang, TY; Wang, WH; Yu, HP	1
Chen, Y; Cui, Y; Deng, Y; Fu, Q; Jiang, P; Li, J; Lin, J; Liu, Y; Meng, Q; Sun, Y; Wang, L; Wang, M; Xu, H; Ye, B; Zhang, M; Zhang, S; Zhang, T; Zhao, X	1
Dong, T; Tian, W	1
Chen, M; Dong, H; Duan, H; Gong, H; Haung, L; Li, J; Li, Q; Liu, S; Luo, S; Lv, C; Xu, Y; Zeng, J; Zhang, H	1
Chen, W; Chen, X; Cheng, YQ; Ge, M; Jiang, CY; Jiang, XY; Li, ZS; Lu, LC; Pan, T; Tuoerxun, T; Wang, DJ; Wang, YP; Yang, CJ; Zhang, H; Zhang, HT; Zhou, Q; Zhu, YF	1
Chen, M; Guo, R; Liu, D; Shi, B; Weng, J; Weng, S; Zhou, X	1
Avan, R; Bagheri, M; Habtemariam, S; Khataminia, M; Rezai Ghaleno, H; Sadremomtaz, A; Safdari, M; Saghafi, F; Sahebnasagh, A; Talaei, Z	1
Baba, H; Baba, Y; Hirashima, K; Iwatsuki, M; Karashima, R; Kinoshita, K; Kurashige, J; Nagai, Y; Watanabe, M	1
Hwang, JJ; Kim, DH; Kim, KD; Lee, SK; Son, BS	1
Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T	1
Eguchi, T; Hamanaka, K; Hasegawa, J; Koizumi, T; Komatsu, Y; Kondo, R; Kubo, K; Shiina, T; Yamamoto, H; Yoshida, K	1
Choi, SY; Kim, H; Park, JS; Park, KH	1
Fang, QH; Jiang, YW; Yuan, Q	1
Hou, Y; Hu, Q; Liu, L; Luo, H; Wang, Y; Yang, H	1
Cai, J; Chen, LQ; Niu, ZX; Wang, WP; Wang, ZQ; Yang, YS; Yuan, Y	1
Huang, P; Li, QG; Xiao, XG; Zu, HG	1
Shang, Y; Sun, Z; Xia, H; Yang, Y; Yao, S	1
Guo, Y; Li, T; Ma, L; Sun, R; Zhang, F	1
Asakawa, T; Fujino, Y; Kido, T; Kubo, T; Matsuda, S; Mayumi, T; Mukae, H; Muramatsu, K; Otsubo, H; Yatera, K	1
Kim, IK; Kim, JW; Lee, DG; Lee, HY; Lee, JM; Lee, SH; Rhee, CK; Yeo, CD	1
Hagio, T; Hasegawa, N; Hashimoto, S; Ishizaka, A; Kawabata, K; Kishikawa, K; Tasaka, S	1
Izumikawa, K; Kakeya, H; Kohno, S; Mukae, H; Nakamura, S; Seki, M; Tashiro, T; Yamamoto, Y; Yanagihara, K	1
Fujimura, T; Funaki, H; Fushida, S; Inaba, H; Kawahara, Y; Kayahara, M; Nakagawara, H; Ninomiya, I; Oyama, K; Tajima, H; Takamura, H	1
Goto, K; Hagiwara, S; Hidaka, S; Iwasaka, H; Koga, H; Matsumoto, S; Noguchi, T; Shingu, C; Yokoi, I	1
Kobayashi, N; Koizumi, T; Kubo, K; Tsushima, K; Urushihata, K; Ushiki, A; Yokoyama, T	1
Bessho, R; Fujii, M; Miyagi, Y; Nitta, T; Ochi, M; Shimizu, K	1
Kaido, T; Uemoto, S	1
Dohi, M; Doi, K; Fujita, T; Imamura, M; Ishii, T; Noiri, E; Okamoto, K; Yamamoto, K	1
Endo, S; Inada, K; Shibata, S; Shioya, N; Takahashi, G	1
Doi, A; Gremillion, DH; Igarashi, W; Iwata, K; Oba, Y; Ohji, G; Oka, H; Shimada, T; Takimoto, K	1
Aikawa, N; Endo, S; Hirasawa, H; Ikeda, T; Ishizaka, A; Kawasaki, Y; Shimazaki, S; Shinozaki, M; Sugimoto, H; Taenaka, N; Yamamoto, Y	1
Inada, E; Iwanuma, Y; Kajiyama, Y; Kugimiya, T; Kumakura, S; Nagaoka, I; Sugasawa, Y; Takeuchi, K; Tsurumaru, M; Yamaguchi, K	1
Fujishima, S; Hayashida, K; Hori, S; Kitano, M; Orita, T; Sasao, K; Toyoda, Y	1
Churg, A; Ekholm, K; Falk-Håkansson, H; Gränse, M; Jungar, C; Kozma, V; Lal, H; Lindahl, M; Ottosson, T; Sanfridson, A; Stevens, T; Wright, JL	1
Fujino, N; He, M; Kubo, H; Ota, C; Suzuki, T; Takahashi, T; Yamada, M; Yamaya, M	1
Ando, S; Hirasawa, M; Makuuchi, H; Matsuda, M; Nishiyama, J; Suzuki, T	1
Miao, QB; Shu, YS; Tao, W; Zhu, YB	1
Chen, HI; Kao, SJ; Lin, CC; Liu, PH	1
Bao, R; Chen, H; Deng, X; Hou, J; Li, J; Liu, Y; Sun, L; Wang, J; Yang, T; Zhang, J; Zhu, X	1
Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E	1
Abe, C; Binh, NH; Cuong, NT; Hara, A; Morita, H; Ogura, S	1

Reviews

4 review(s) available for sivelestat and Lung Injury, Acute

Article	Year
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. Journal of clinical pharmacy and therapeutics, 2020, Volume: 45, Issue:6 Topics: Acute Lung Injury; COVID-19; COVID-19 Drug Treatment; Disseminated Intravascular Coagulation; Glycine; Humans; Proteinase Inhibitory Proteins, Secretory; Respiratory Distress Syndrome; Sulfonamides; Treatment Outcome	2020
Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: a systematic review and meta-analysis. World journal of gastroenterology, 2015, Mar-28, Volume: 21, Issue:12 Topics: Acute Lung Injury; Aged; Esophagectomy; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Odds Ratio; Respiration, Artificial; Risk Factors; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome	2015
[Effect of sivelestat sodium on the prognosis of patients with acute lung injury and acute respiratory distress syndrome: a meta-analysis]. Zhonghua wei zhong bing ji jiu yi xue, 2015, Volume: 27, Issue:10 Topics: Acute Lung Injury; China; Glycine; Humans; Intensive Care Units; Length of Stay; Prognosis; Randomized Controlled Trials as Topic; Respiration, Artificial; Respiratory Distress Syndrome; Sulfonamides	2015
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis. Internal medicine (Tokyo, Japan), 2010, Volume: 49, Issue:22 Topics: Acute Lung Injury; Glycine; Humans; Proteinase Inhibitory Proteins, Secretory; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sulfonamides	2010

Trials

6 trial(s) available for sivelestat and Lung Injury, Acute

Article	Year
Sivelestat prevents cytoskeletal rearrangements in neutrophils resulting from lung re-expansion following one-lung ventilation during thoracic surgery. Inflammation, 2013, Volume: 36, Issue:6 Topics: Actin Cytoskeleton; Actins; Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Interleukin-8; Lung; Male; Malondialdehyde; Middle Aged; Neutrophils; One-Lung Ventilation; Oxygen; Serine Proteinase Inhibitors; Sulfonamides; Thoracic Surgical Procedures	2013
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2010, Volume: 23, Issue:4 Topics: Acute Lung Injury; Aged; Double-Blind Method; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Male; Middle Aged; Perioperative Care; Postoperative Complications; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Serine Proteinase Inhibitors; Sulfonamides; Thoracic Surgery, Video-Assisted	2010
Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass. Interactive cardiovascular and thoracic surgery, 2010, Volume: 10, Issue:6 Topics: Acute Lung Injury; Aged; Anti-Inflammatory Agents; Aortic Valve; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cardiopulmonary Bypass; Female; Glycine; Heart Valve Prosthesis Implantation; Humans; Inflammation Mediators; Infusions, Intravenous; Interleukin-6; Interleukin-8; Leukocyte Elastase; Lung; Male; Middle Aged; Proteinase Inhibitory Proteins, Secretory; Pulmonary Gas Exchange; Sulfonamides; Time Factors; Treatment Outcome	2010
Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation. Transplantation, 2010, Aug-15, Volume: 90, Issue:3 Topics: Acute Lung Injury; Glycine; Humans; Infusions, Intravenous; Leukocyte Elastase; Liver Transplantation; Pilot Projects; Prospective Studies; Protease Inhibitors; Sulfonamides; Time Factors; Treatment Outcome	2010
Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study. Pulmonary pharmacology & therapeutics, 2011, Volume: 24, Issue:5 Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Infusions, Intravenous; Male; Middle Aged; Proteinase Inhibitory Proteins, Secretory; Respiration, Artificial; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate; Systemic Inflammatory Response Syndrome; Ventilator Weaning	2011
Effects of sivelestat on bronchial inflammatory responses after esophagectomy. International journal of molecular medicine, 2011, Volume: 28, Issue:2 Topics: Acute Lung Injury; Aged; Bronchitis; Esophagectomy; Female; Glycine; Humans; Interleukin-6; Interleukin-8; Leukocyte Elastase; Male; Middle Aged; Postoperative Complications; Premedication; Respiratory Distress Syndrome; Respiratory Function Tests; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome	2011

Other Studies

31 other study(ies) available for sivelestat and Lung Injury, Acute

Article	Year
Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3. Bioorganic & medicinal chemistry, 2015, Mar-01, Volume: 23, Issue:5 Topics: Acute Lung Injury; Animals; Benzaldehydes; Edema; Enzyme Inhibitors; Humans; Leukocyte Elastase; Lipopolysaccharides; Lung; Mice; Myeloblastin; Neutrophils; Oximes; Peroxidase; Structure-Activity Relationship; Superoxides	2015
Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury. Journal of medicinal chemistry, 2022, 02-24, Volume: 65, Issue:4 Topics: Acute Lung Injury; Animals; Bleomycin; Cell Line; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Humans; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Peptides, Cyclic; Respiratory Distress Syndrome; Serine Proteinase Inhibitors	2022
[Comparative study of the protective effect of Xuebijing injection and Sivelestat sodium on acute lung injury/acute respiratory distress syndrome rats]. Zhonghua wei zhong bing ji jiu yi xue, 2022, Volume: 34, Issue:8 Topics: Acute Lung Injury; Animals; Drugs, Chinese Herbal; Glycine; Interleukin-6; Lipopolysaccharides; Lung; Male; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sulfonamides	2022
Sivelestat sodium attenuates acute lung injury by inhibiting JNK/NF-κB and activating Nrf2/HO-1 signaling pathways. Biomolecules & biomedicine, 2023, May-01, Volume: 23, Issue:3 Topics: Acute Lung Injury; Animals; Endothelial Cells; Heme Oxygenase-1; Humans; Male; MAP Kinase Kinase 4; NF-E2-Related Factor 2; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium	2023
The neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury in patients with cardiopulmonary bypass. Frontiers in immunology, 2023, Volume: 14 Topics: Acute Lung Injury; Cardiopulmonary Bypass; Case-Control Studies; Humans; Proteinase Inhibitory Proteins, Secretory	2023
Sivelestat sodium alleviated lipopolysaccharide-induced acute lung injury by improving endoplasmic reticulum stress. Gene, 2023, Oct-30, Volume: 884 Topics: Acute Lung Injury; Apoptosis; Endoplasmic Reticulum Stress; Humans; Inflammation; Lipopolysaccharides; Peptide Initiation Factors; Protein Kinases; Sodium	2023
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy. Surgery today, 2013, Volume: 43, Issue:4 Topics: Acute Lung Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Drug Administration Schedule; Drug Therapy, Combination; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Intraoperative Care; Male; Methylprednisolone; Middle Aged; Postoperative Care; Postoperative Complications; Respiratory Distress Syndrome; Respiratory Function Tests; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome	2013
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy. Journal of cardiothoracic surgery, 2013, Apr-08, Volume: 8 Topics: Acute Lung Injury; Adult; Aged; Combined Modality Therapy; Drug Administration Schedule; Glycine; Humans; Infusions, Intravenous; Male; Middle Aged; Pneumonectomy; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Respiration, Artificial; Respiratory Distress Syndrome; Retrospective Studies; Sulfonamides; Treatment Outcome	2013
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis. Drug design, development and therapy, 2013, Volume: 7 Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; Middle Aged; Oxygen; Protein Precursors; Proteinase Inhibitory Proteins, Secretory; Retrospective Studies; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate	2013
Effects of sivelestat treatment on acute lung injury in paraquat-intoxicated rats. Drug and chemical toxicology, 2014, Volume: 37, Issue:1 Topics: Acute Lung Injury; Animals; Glycine; Histological Techniques; Injections, Intraperitoneal; Interleukin-6; Lung; Male; Neutrophil Activation; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Sulfonamides; Tumor Necrosis Factor-alpha	2014
Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2014, Volume: 122, Issue:9 Topics: Acute Lung Injury; Animals; Endothelial Cells; Glycine; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Neutrophil Infiltration; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Pulmonary Edema; Rats; Rats, Wistar; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Transcription Factor RelA	2014
[Effects of sivelestat on acute lung injury in dogs with severe burn-blast combined injury]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 2014, Volume: 30, Issue:2 Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Capillary Permeability; Dogs; Extravascular Lung Water; Glycine; Infusions, Intravenous; Interleukin-8; Male; Pulmonary Edema; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha	2014
Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns. European review for medical and pharmacological sciences, 2016, Volume: 20, Issue:3 Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Disease Models, Animal; Glycine; Inflammation Mediators; Interleukin-8; Leukocyte Elastase; Lung; Rats; Rats, Sprague-Dawley; Sulfonamides; Systemic Inflammatory Response Syndrome	2016
Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1. Acta cirurgica brasileira, 2016, Volume: 31, Issue:6 Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glycine; Inflammation Mediators; Interleukin-6; Leukocyte Count; Leukocyte Elastase; Lipopolysaccharides; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Neutrophils; Sulfonamides; Survival Analysis; Tetracyclines; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factors	2016
Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome. Respirology (Carlton, Vic.), 2017, Volume: 22, Issue:4 Topics: Acute Lung Injury; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glycine; Humans; Male; Prognosis; Respiratory Distress Syndrome; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome	2017
Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice. Journal of anesthesia, 2017, Volume: 31, Issue:3 Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Female; Glycine; Intercellular Adhesion Molecule-1; Interleukin-6; Leukocyte Elastase; Lipopolysaccharides; Lung; Mice; Mice, Inbred ICR; Neutropenia; Neutrophils; Pulmonary Edema; Sulfonamides; Transcription Factor RelA; Tumor Necrosis Factor-alpha	2017
Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters. Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:6 Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Colony Count, Microbial; Cricetinae; Disease Models, Animal; Glycine; Leukocyte Elastase; Mesocricetus; Pneumonia, Pneumococcal; Proteinase Inhibitory Proteins, Secretory; Pulmonary Surfactant-Associated Protein D; Streptococcus pneumoniae; Sulfonamides; Time Factors	2008
[Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2008, Volume: 46, Issue:10 Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Leukocyte Elastase; Male; Pneumonia, Bacterial; Retrospective Studies; Serine Proteinase Inhibitors; Severity of Illness Index; Sulfonamides; Systemic Inflammatory Response Syndrome	2008
The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study. The Journal of trauma, 2010, Volume: 68, Issue:4 Topics: Acute Lung Injury; Adult; Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Dehydroascorbic Acid; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Female; Glycine; Humans; Male; Middle Aged; Oxidative Stress; Point-of-Care Systems; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome	2010
Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus. Internal medicine (Tokyo, Japan), 2010, Volume: 49, Issue:5 Topics: Acute Lung Injury; Adult; Antiviral Agents; Female; Glycine; Hemorrhage; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lung Diseases; Oseltamivir; Sulfonamides; Treatment Outcome	2010
Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy. The American journal of pathology, 2010, Volume: 177, Issue:4 Topics: Acute Lung Injury; Animals; Blotting, Western; Chemokines; Glycine; Interleukin-6; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Nephrectomy; Neutrophil Activation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate; Tumor Necrosis Factor-alpha	2010
Suppressive effects of sivelestat on interleukin 8 and TNF-α production from LPS-stimulated granulocytes in whole blood culture. Journal of anesthesia, 2010, Volume: 24, Issue:6 Topics: Acute Lung Injury; Flow Cytometry; Glycine; Granulocytes; Humans; In Vitro Techniques; Interleukin-8; Lipopolysaccharides; Monocytes; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Tumor Necrosis Factor-alpha	2010
Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration. Shock (Augusta, Ga.), 2011, Volume: 36, Issue:3 Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Laryngopharyngeal Reflux; Male; Middle Aged; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Time Factors; Treatment Outcome	2011
AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:1 Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Dogs; Dose-Response Relationship, Drug; Emphysema; Female; Glycine; Guinea Pigs; Humans; Kinetics; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Oxadiazoles; Pneumonia; Protein Binding; Pyridones; Pyrimidinones; Rats; Serine Proteinase Inhibitors; Species Specificity; Substrate Specificity; Sulfonamides; Sulfones; Swine; Tobacco Smoke Pollution	2011
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice. Experimental lung research, 2012, Volume: 38, Issue:1 Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Collagen; Glycine; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Smad2 Protein; Smad3 Protein; Sulfonamides; Transforming Growth Factor beta1	2012
The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer. Surgery today, 2012, Volume: 42, Issue:7 Topics: Acute Lung Injury; Aged; C-Reactive Protein; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Inflammation; Length of Stay; Male; Middle Aged; Oxygen; Perioperative Period; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Retrospective Studies; Sulfonamides; Survival Rate	2012
Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats. Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:1 Topics: Acute Lung Injury; Administration, Inhalation; Albumins; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Cell Count; Extravascular Lung Water; Female; Glycine; Injections, Intravenous; Leukocyte Count; Leukocyte Elastase; Oleic Acid; Ovalbumin; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sulfonamides; Survival Analysis	2012
Effects of phorbol myristate acetate and sivelestat on the lung injury caused by fat embolism in isolated lungs. Journal of biomedical science, 2012, Jan-05, Volume: 19 Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Embolism, Fat; Glycine; In Vitro Techniques; Inflammation Mediators; Leukocyte Elastase; Lung; Male; Neutrophil Activation; Neutrophils; Pulmonary Embolism; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate	2012
Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012, Volume: 61, Issue:6 Topics: Acute Lung Injury; Animals; Antipyrine; Drug Combinations; Edaravone; Free Radical Scavengers; Glycine; Interleukin-6; Lipopolysaccharides; Male; Malondialdehyde; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sulfonamides; Tumor Necrosis Factor-alpha	2012
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. Drug design, development and therapy, 2012, Volume: 6 Topics: Abdomen; Acute Lung Injury; Aged; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Respiratory Distress Syndrome; Sepsis; Sulfonamides; Ventilator Weaning	2012
Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats. Shock (Augusta, Ga.), 2013, Volume: 39, Issue:1 Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Dioxide; Combined Modality Therapy; Crush Syndrome; Drug Evaluation, Preclinical; Fluid Therapy; Glycine; HMGB1 Protein; Liver; Lung; Male; Oxygen; Partial Pressure; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhabdomyolysis; Serine Proteinase Inhibitors; Sulfonamides; Survival Analysis; Treatment Outcome	2013