sivelestat has been researched along with Inflammation in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (82.35) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M; Guo, R; Liu, D; Shi, B; Weng, J; Weng, S; Zhou, X | 1 |
| Ahmad, A; Ansari, MM; Jori, C; Khan, R; Kumar, A; Mishra, RK; Nadeem, A; Raza, SS; Siddiqui, N; Vyawahare, A | 1 |
| Colle, I; Debacker, PJ; Devisscher, L; Geerts, A; Lefere, S; Raevens, S; Van Campenhout, S; Van Vlierberghe, H; Verhelst, X | 1 |
| Dai, J; Fu, Z; Hu, J; Liu, E; Liu, J; Luo, Z; Niu, C; Tian, D; Wang, T; Xiong, Y; Ying, L; Zhang, M; Zou, L; Zou, W | 1 |
| Cai, J; Chen, J; Guan, J; Han, X; Hei, Z; Wu, S; Yao, W; Yuan, D | 1 |
| Akita, K; Inomata, T; Narumi, Y; Okada, Y; Shimbo, T; Takahashi, M; Uesugi, Y; Yoshikawa, N | 1 |
| Inoue, N; Itatani, K; Kitamura, T; Miyaji, K; Oka, N; Shibata, K; Tomoyasu, T | 1 |
| Cao, J; Liu, Q | 1 |
| Fujii, M; Hanayama, N; Inoue, N; Itatani, K; Kitamura, T; Kohira, S; Miyaji, K; Oka, N; Oshima, H; Takeda, A; Tojo, K; Yoshitake, S | 1 |
| Horai, T; Inoue, N; Itatani, K; Kitamura, T; Kohira, S; Miyaji, K; Oka, N; Oshima, H; Tojo, K; Yoshitake, S | 1 |
| Carneiro, FS; de Caux, TR; Galvão, I; Lima, GL; Lima, KM; Nunes, FF; Perretti, M; Pinho, V; Ribeiro, AL; Sousa, LP; Sugimoto, MA; Tavares, LP; Teixeira, MM; Vago, JP | 1 |
| Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H | 1 |
| Busuttil, RW; Freitas, MC; Kupiec-Weglinski, JW; Uchida, Y; Zhao, D | 1 |
| Harada, N; Harimoto, N; Kakeji, Y; Koga, T; Maehara, Y; Miyazaki, M; Morita, M; Nagata, S; Oki, E; Saeki, H | 1 |
| Ando, S; Hirasawa, M; Makuuchi, H; Matsuda, M; Nishiyama, J; Suzuki, T | 1 |
| Fukuda, T; Ishii, Y; Takemasa, A | 1 |
| Fuchimoto, Y; Gelfand, EW; Ikeda, G; Kanehiro, A; Kataoka, M; Koga, H; Miyahara, N; Ono, K; Tanimoto, M; Tanimoto, Y; Waseda, K | 1 |
2 trial(s) available for sivelestat and Inflammation
| Article | Year |
|---|---|
Neutrophil elastase inhibitor sivelestat attenuates perioperative inflammatory response in pediatric heart surgery with cardiopulmonary bypass.
Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Double-Blind Method; Female; Glycine; Humans; Infant; Inflammation; Male; Neutrophils; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome | 2013 |
Effect of the neutrophil elastase inhibitor sivelestat on perioperative inflammatory response after pediatric heart surgery with cardiopulmonary bypass: a prospective randomized study.
Topics: Age Factors; Anti-Inflammatory Agents; Blood Coagulation; Blood Loss, Surgical; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Double-Blind Method; Elective Surgical Procedures; Glycine; Humans; Infant; Inflammation; Inflammation Mediators; Infusions, Intravenous; Japan; Leukocyte Count; Leukocyte Elastase; Platelet Count; Prospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome | 2013 |
15 other study(ies) available for sivelestat and Inflammation
| Article | Year |
|---|---|
Sivelestat sodium alleviated lipopolysaccharide-induced acute lung injury by improving endoplasmic reticulum stress.
Topics: Acute Lung Injury; Apoptosis; Endoplasmic Reticulum Stress; Humans; Inflammation; Lipopolysaccharides; Peptide Initiation Factors; Protein Kinases; Sodium | 2023 |
Enzyme targeted delivery of sivelestat loaded nanomicelle inhibits arthritic severity in experimental arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; Inflammation; Peptide Hydrolases; Rats; Rats, Wistar | 2023 |
Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Free Radical Scavengers; Glycine; Inflammation; Male; Mice; Mice, Inbred C57BL; Serine Proteinase Inhibitors; Sulfonamides | 2020 |
Enhanced pause correlates with airway neutrophils and airway-epithelial injury in asthmatic mice treated with dexamethasone.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Eosinophils; Female; Glycine; Inflammation; Lymphocytes; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neutrophils; Ovalbumin; Pyroglyphidae; Respiratory Mucosa; Respiratory System; Sulfonamides | 2019 |
ONO-5046 suppresses reactive oxidative species-associated formation of neutrophil extracellular traps.
Topics: Adult; Cells, Cultured; Extracellular Traps; Glycine; Humans; Inflammation; Lipopolysaccharides; Neutrophils; Oxidative Stress; Reactive Oxygen Species; Serine Proteinase Inhibitors; Sulfonamides | 2018 |
Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase.
Topics: Abnormalities, Radiation-Induced; Animals; Glycine; Humans; Inflammation; Leukocyte Elastase; Lung; Lung Injury; Mice; Radiation-Protective Agents; Sulfonamides | 2013 |
Protective effects of sivelestat in a caerulein-induced rat acute pancreatitis model.
Topics: Amylases; Animals; Antioxidants; Ceruletide; Corticosterone; Disease Models, Animal; Glycine; Inflammation; Interleukin-1beta; Interleukin-4; Lipase; Male; Oxidative Stress; Pancreas; Pancreatitis, Acute Necrotizing; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Survival; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2013 |
Effect of additional preoperative administration of the neutrophil elastase inhibitor sivelestat on perioperative inflammatory response after pediatric heart surgery with cardiopulmonary bypass.
Topics: C-Reactive Protein; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Glycine; Heart Septal Defects, Ventricular; Humans; Infant; Inflammation; Leukocyte Count; Male; Neutrophils; Pancreatic Elastase; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2014 |
Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1.
Topics: Animals; Annexin A1; Apoptosis; Blotting, Western; Flow Cytometry; Glycine; Humans; Inflammation; Leukocyte Elastase; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Neutrophils; Protease Inhibitors; Secretory Leukocyte Peptidase Inhibitor; Sulfonamides | 2016 |
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Glycine; HMGB1 Protein; Inflammation; Interleukin-8; Ligation; Lung; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides; Survival Analysis | 2010 |
The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.
Topics: Animals; Chemokine CXCL1; DNA Primers; Glycine; Humans; Immunohistochemistry; Inflammation; Interleukin-6; Leukocyte Elastase; Liver; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peroxidase; Polymerase Chain Reaction; Proteinase Inhibitory Proteins, Secretory; Reperfusion Injury; RNA; Sulfonamides; Tumor Necrosis Factor-alpha | 2010 |
A survey of the effects of sivelestat sodium administration on patients with postoperative respiratory dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Female; Glycine; Health Status; Health Surveys; Humans; Inflammation; Japan; Lung Diseases; Male; Middle Aged; Postoperative Complications; Risk Factors; Serine Proteinase Inhibitors; Stress, Psychological; Sulfonamides; Systemic Inflammatory Response Syndrome | 2010 |
The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer.
Topics: Acute Lung Injury; Aged; C-Reactive Protein; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Inflammation; Length of Stay; Male; Middle Aged; Oxygen; Perioperative Period; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Retrospective Studies; Sulfonamides; Survival Rate | 2012 |
A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage; Collagen; Fibrosis; Glycine; Inflammation; Leukocyte Elastase; Lung; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Pulmonary Fibrosis; Serine Proteinase Inhibitors; Smad2 Protein; Sulfonamides; Time Factors; Transforming Growth Factor beta1 | 2012 |
Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses.
Topics: Allergens; Animals; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokines; Cytokines; Female; Flow Cytometry; Glycine; Immunohistochemistry; Inflammation; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Ovalbumin; Proteinase Inhibitory Proteins, Secretory; Receptor, PAR-2; Respiratory Hypersensitivity; Sulfonamides | 2013 |