sivelestat has been researched along with Disease Models, Animal in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (11.90) | 18.2507 |
| 2000's | 11 (26.19) | 29.6817 |
| 2010's | 22 (52.38) | 24.3611 |
| 2020's | 4 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Chen, Y; Cui, Y; Deng, Y; Fu, Q; Jiang, P; Li, J; Lin, J; Liu, Y; Meng, Q; Sun, Y; Wang, L; Wang, M; Xu, H; Ye, B; Zhang, M; Zhang, S; Zhang, T; Zhao, X | 1 |
| Kawamura, T; Sakurai, M; Suzuki, H; Suzuki, T | 1 |
| Hayashi, H; Horinokita, I; Mizumura, R; Oteki, R; Takagi, N; Usui, A; Yamaguchi, T; Yuan, B | 1 |
| Bessho, R; Fujii, M | 1 |
| Bali, KK; Kuner, R | 1 |
| Dai, J; Fu, Z; Hu, J; Liu, E; Liu, J; Luo, Z; Niu, C; Tian, D; Wang, T; Xiong, Y; Ying, L; Zhang, M; Zou, L; Zou, W | 1 |
| Ban, E; Bonanomi, D; Choi, H; Han, I; Jo, MJ; Joshi, HP; Kim, A; Kim, KT; Kim, SB; Kumar, H; Lee, SH; Muttigi, M; Sohn, S; Zeng, X | 1 |
| Ageyama, N; Goto, Y; Hiramatsu, Y; Kitazawa, S; Mathis, BJ; Matsubara, M; Sakamoto, H; Sato, S; Sato, Y | 1 |
| Bi, HW; Li, J; Zhang, GR; Zheng, JQ | 1 |
| Cao, J; Liu, Q | 1 |
| Fujimura, T; Fushida, S; Hayashi, H; Kitagawa, H; Makino, I; Miyashita, T; Munesue, S; Nakagawara, H; Nakanuma, S; Ohta, T; Saito, H; Sakai, S; Tajima, H; Yamamoto, Y | 1 |
| Chen, K; Feng, L; Guo, F; Huang, C; Li, Y; Liu, X; Wang, R; Wu, Y; Zhu, W | 1 |
| Katakura, K; Ohira, H; Shioya, Y | 1 |
| Huang, P; Li, QG; Xiao, XG; Zu, HG | 1 |
| Dong, HL; Huo, J; Ma, R; Su, BX; Zhu, XL | 1 |
| Liu, J; Liu, Y; Luo, Y; Ma, X; Shi, J; Wang, L; Xun, Y; Yang, W; Ye, D; Zang, S; Zhao, F; Zhu, G; Zhuang, Z | 1 |
| Guo, Y; Li, T; Ma, L; Sun, R; Zhang, F | 1 |
| Imai, Y; Kawahara, M; Kuba, K; Mizushima, T; Sugizaki, T; Tamura, F; Tanaka, KI | 1 |
| Ando, M; Murai, T; Takahashi, Y | 1 |
| Hagio, T; Hasegawa, N; Hashimoto, S; Ishizaka, A; Kawabata, K; Kishikawa, K; Tasaka, S | 1 |
| Goto, M; Higashi, A; Iguro, Y; Iwamoto, S; Sakata, R; Ueno, T | 1 |
| Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H | 1 |
| Araki, N; Izumikawa, K; Kakeya, H; Kamihira, S; Kohno, S; Morinaga, Y; Seki, M; Yamada, K; Yamada, Y; Yamamoto, Y; Yanagihara, K | 1 |
| Fukatsu, K; Maeshima, Y; Omata, J; Saitoh, D; Tanabe, K; Yasuhara, H | 1 |
| Masaoka, N; Nakajima, Y; Watanabe, M | 1 |
| Chen, HI; Kao, SJ; Lin, CC; Liu, PH | 1 |
| Cai, JH; Chai, JK; Chi, YF; Deng, HP; Feng, R; Hu, QG; Liu, W; Ma, L; Shen, CA; Yin, HN; Zhang, XB; Zou, XF | 1 |
| Chen, L; Tang, AM; Wang, HH; Zhou, MT | 1 |
| Ishii, K; Ito, Y; Kakita, A; Katagiri, H; Majima, M; Matsumoto, Y | 1 |
| Hayashi, N; Kato, S; Kondo, K; Ogawa, M; Tanaka, E; Yamashita, J | 1 |
| Hagio, T; Kawabata, K; Matsuoka, S | 1 |
| Chinen, H; Hibi, T; Hisamatsu, T; Inoue, N; Iwao, Y; Kamada, N; Matsuoka, K; Morohoshi, Y; Ogata, H; Okamoto, S; Sato, T; Takaishi, H | 1 |
| Funao, K; Hayama, T; Kawahito, Y; Matsuyama, M; Nakatani, T; Sano, H; Takemoto, Y; Tanaka, T; Tsuchida, K; Yoshimura, R | 1 |
| Fukuda, Y; Hirakata, Y; Izumikawa, K; Kamhira, S; Kohno, S; Miyazaki, Y; Seki, M; Tsukamoto, K; Yamada, Y; Yanagihara, K | 1 |
| Fujita, T; Kumasaka, R; Murakami, R; Nakamura, N; Okumura, K; Osawa, H; Shimada, M; Yamabe, H | 1 |
| Guo, L; Ikei, S; Ogawa, M; Sugita, H; Yamaguchi, Y | 1 |
| Inoue, T; Kyi, M; Miyake, S; Miyazaki, Y; Sawada, M; Yoshizawa, Y | 1 |
| Arakawa, M; Gejyo, F; Imai, N; Kazama, JJ; Kimura, H; Kuroda, T; Suzuki, S | 1 |
| Harada, N; Irie, T; Isobe, H; Liu, W; Murakami, K; Okajima, K | 1 |
| Imamura, M; Mikami, Y; Takahashi, H; Yamauchi, H | 1 |
| Fujimoto, J; Fukushima, J; Kudoh, I; Miyazaki, H; Ohara, M; Okumura, F; Tazawa, T; Yamada, H | 1 |
1 review(s) available for sivelestat and Disease Models, Animal
| Article | Year |
|---|---|
[Pharmacological profile of a specific neutrophil elastase inhibitor, Sivelestat sodium hydrate].
Topics: Animals; Clinical Trials, Phase III as Topic; Disease Models, Animal; Glycine; Humans; Leukocyte Elastase; Serpins; Sulfonamides; Systemic Inflammatory Response Syndrome | 2003 |
41 other study(ies) available for sivelestat and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Bleomycin; Cell Line; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Humans; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Peptides, Cyclic; Respiratory Distress Syndrome; Serine Proteinase Inhibitors | 2022 |
Endoplasmic Reticulum Stress is Involved in the Protective Effect of Sivelestat Sodium Hydrate (ONO-5046) in Spinal Cord Ischemia-Reperfusion Injury.
Topics: Animals; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Ischemia; Male; Rabbits; Reperfusion Injury; Sodium; Spinal Cord; Spinal Cord Ischemia | 2023 |
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cytokines; Disease Models, Animal; Glycine; Granulins; Leukocyte Elastase; Male; Microglia; Progranulins; Rats; Sulfonamides; Up-Regulation | 2019 |
Neutrophil Elastase Inhibitor Sivelestat Attenuates Myocardial Injury after Cardioplegic Arrest in Rat Hearts.
Topics: Animals; Disease Models, Animal; Glycine; Heart Arrest, Induced; Isolated Heart Preparation; Leukocyte Elastase; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Troponin T; Ventricular Function, Left; Ventricular Pressure | 2020 |
Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.
Topics: Analgesics; Animals; Cancer Pain; Chronic Pain; Cyclic S-Oxides; Disease Models, Animal; Female; Glycine; Hyperalgesia; Leukocyte Elastase; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity; Neuralgia; Pain Measurement; Pain Threshold; Pregabalin; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles | 2017 |
Enhanced pause correlates with airway neutrophils and airway-epithelial injury in asthmatic mice treated with dexamethasone.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Eosinophils; Female; Glycine; Inflammation; Lymphocytes; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neutrophils; Ovalbumin; Pyroglyphidae; Respiratory Mucosa; Respiratory System; Sulfonamides | 2019 |
Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Cicatrix; Cytokines; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation; Glycine; Humans; Laminin; Leukocyte Elastase; Nerve Tissue Proteins; Nociceptin; Occludin; Opioid Peptides; Rats; Rats, Sprague-Dawley; Recovery of Function; Serine Proteinase Inhibitors; Spinal Cord Injuries; Sulfonamides; Transforming Growth Factor beta1; Zonula Occludens-1 Protein | 2018 |
Rolipram plus Sivelestat inhibits bone marrow-derived leukocytic lung recruitment after cardiopulmonary bypass in a primate model.
Topics: Animals; Bone Marrow Cells; Cardiopulmonary Bypass; Chemotaxis, Leukocyte; Disease Models, Animal; Glycine; Lung; Macaca fascicularis; Male; Neutrophils; Phosphodiesterase 4 Inhibitors; Rolipram; Serine Proteinase Inhibitors; Sulfonamides | 2019 |
Neutrophil elastase inhibitor suppresses oxidative stress in obese asthmatic rats by activating Keap1/Nrf2 signaling pathway.
Topics: Animals; Antioxidants; Asthma; Disease Models, Animal; Glycine; Humans; Kelch-Like ECH-Associated Protein 1; Leukocyte Elastase; Male; NF-E2-Related Factor 2; Obesity; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serine Proteinase Inhibitors; Signal Transduction; Sulfonamides | 2019 |
Protective effects of sivelestat in a caerulein-induced rat acute pancreatitis model.
Topics: Amylases; Animals; Antioxidants; Ceruletide; Corticosterone; Disease Models, Animal; Glycine; Inflammation; Interleukin-1beta; Interleukin-4; Lipase; Male; Oxidative Stress; Pancreas; Pancreatitis, Acute Necrotizing; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Survival; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2013 |
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Topics: Animals; Cell Adhesion; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Immune System Diseases; Leukocyte Disorders; Liver Diseases; Male; Neutrophils; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome | 2014 |
Inhibition of human neutrophil elastase by pentacyclic triterpenes.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Glycine; Humans; Kinetics; Leukocyte Elastase; Mice, Inbred BALB C; Molecular Docking Simulation; Pentacyclic Triterpenes; Pneumonia; Proton Magnetic Resonance Spectroscopy; Saponins; Smoking; Sulfonamides; Triterpenes; Ursolic Acid | 2013 |
Neutrophil elastase inhibitor suppresses IL-17 based inflammation of murine experimental colitis.
Topics: Animals; Chemokines; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Glycine; Interleukin-17; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Peroxidase; Proteinase Inhibitory Proteins, Secretory; RNA, Messenger; Sulfonamides | 2014 |
Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Disease Models, Animal; Glycine; Inflammation Mediators; Interleukin-8; Leukocyte Elastase; Lung; Rats; Rats, Sprague-Dawley; Sulfonamides; Systemic Inflammatory Response Syndrome | 2016 |
GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Disease Models, Animal; Drug Evaluation, Preclinical; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycine; Interleukin-1beta; Male; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Nuclear Proteins; Random Allocation; Rats, Sprague-Dawley; Recovery of Function; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Sulfonamides; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases | 2016 |
Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice.
Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apolipoproteins E; Chemokine CCL2; Diet, High-Fat; Disease Models, Animal; Glycine; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Kupffer Cells; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Non-alcoholic Fatty Liver Disease; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha | 2015 |
Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glycine; Inflammation Mediators; Interleukin-6; Leukocyte Count; Leukocyte Elastase; Lipopolysaccharides; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Neutrophils; Sulfonamides; Survival Analysis; Tetracyclines; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factors | 2016 |
Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models.
Topics: Animals; Cecum; Dexamethasone; Disease Models, Animal; Glycine; Ligation; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred ICR; Multiple Organ Failure; Phosphatidylcholines; Punctures; Reactive Oxygen Species; Respiration, Artificial; Respiratory Distress Syndrome; Sulfonamides; Superoxide Dismutase | 2017 |
The effect of sivelestat sodium on post-cardiopulmonary bypass acute lung injury in a neonatal piglet model.
Topics: Animals; Animals, Newborn; Cardiopulmonary Bypass; Disease Models, Animal; Drug Administration Schedule; Glycine; Leukocyte Elastase; Lung; Lung Diseases; Neutrophil Activation; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides; Swine; Time Factors | 2008 |
Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Colony Count, Microbial; Cricetinae; Disease Models, Animal; Glycine; Leukocyte Elastase; Mesocricetus; Pneumonia, Pneumococcal; Proteinase Inhibitory Proteins, Secretory; Pulmonary Surfactant-Associated Protein D; Streptococcus pneumoniae; Sulfonamides; Time Factors | 2008 |
Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury.
Topics: Animals; Apoptosis; Disease Models, Animal; Glycine; Infusions, Intra-Arterial; Leukocyte Elastase; Motor Activity; Motor Neurons; Neuroprotective Agents; Paraplegia; Rabbits; Serine Proteinase Inhibitors; Spinal Cord Injuries; Spinal Cord Ischemia; Sulfonamides | 2009 |
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Glycine; HMGB1 Protein; Inflammation; Interleukin-8; Ligation; Lung; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides; Survival Analysis | 2010 |
In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Therapy, Combination; Fluoroquinolones; Glycine; Legionella pneumophila; Legionnaires' Disease; Leukocyte Elastase; Longevity; Lung; Male; Mice; Mice, Inbred Strains; Oxazines; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2010 |
Neutrophil elastase inhibitor restores gut ischemia reperfusion-induced impairment of gut immunity with reduced plasma interleukin-6 concentrations in mice.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Flow Cytometry; Gastrointestinal Tract; Glycine; Interleukin-6; Intestinal Mucosa; Ischemia; Leukocyte Elastase; Lymphocyte Count; Lymphocyte Subsets; Male; Mice; Mice, Inbred ICR; Reperfusion; Sulfonamides; Survival Analysis | 2010 |
The effects of sivelestat sodium hydrate on uterine contraction and the concentration of maternal and fetal blood cytokines in a sheep model of intra-amniotic infection induced by lipopolysaccharide.
Topics: Animals; Chorioamnionitis; Cytokines; Dinoprostone; Disease Models, Animal; Female; Fetal Blood; Glycine; Lipopolysaccharides; Obstetric Labor, Premature; Pregnancy; Random Allocation; Serine Proteinase Inhibitors; Sheep; Sulfonamides; Uterine Contraction | 2011 |
Effects of phorbol myristate acetate and sivelestat on the lung injury caused by fat embolism in isolated lungs.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Embolism, Fat; Glycine; In Vitro Techniques; Inflammation Mediators; Leukocyte Elastase; Lung; Male; Neutrophil Activation; Neutrophils; Pulmonary Embolism; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate | 2012 |
Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Topics: Animals; Blast Injuries; Bronchoalveolar Lavage Fluid; Burns; Carbon Dioxide; Disease Models, Animal; Glycine; Interleukin-8; Leukocyte Elastase; Lung Injury; Male; Oxygen; Partial Pressure; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha | 2013 |
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Lung; Lung Injury; Male; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides | 2012 |
Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice.
Topics: Analysis of Variance; Animals; Benzoates; Cytokines; Disease Models, Animal; Drug Interactions; Glycine; Injections, Intravenous; Interleukin-1; Lipopolysaccharides; Liver Circulation; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Microcirculation; Microscopy; Probability; Pyrrolidines; Random Allocation; Reference Values; Sensitivity and Specificity; Sulfonamides; Treatment Outcome; Tumor Necrosis Factor-alpha | 2002 |
A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Female; Glycine; Immunohistochemistry; Leukocyte Elastase; Lung Neoplasms; Mice; Mice, SCID; Sulfonamides; Tumor Cells, Cultured | 2003 |
Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.
Topics: Adult; Animals; Biomarkers; Cells, Cultured; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Glycine; Humans; Intestinal Mucosa; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Serine Proteinase Inhibitors; Sulfonamides | 2006 |
Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Functional Laterality; Glycine; Leukocyte Elastase; Male; Rats; Rats, Inbred Lew; Renal Artery; Renal Circulation; Renal Veins; Reperfusion Injury; Sulfonamides; Survival Analysis | 2006 |
Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.
Topics: Animals; Blood; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Female; Glycine; Leukocyte Elastase; Lung; Mice; Mice, Inbred CBA; Pneumonia, Pneumococcal; Serine Proteinase Inhibitors; Streptococcus pneumoniae; Sulfonamides; Survival Rate | 2007 |
Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Topics: Animals; Disease Models, Animal; Glycine; Kidney Glomerulus; Male; Microscopy, Electron; Microscopy, Fluorescence; Nephritis; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Thy-1 Antigens; Treatment Outcome | 2008 |
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis.
Topics: Animals; Ceruletide; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Hemorrhage; Leukocyte Elastase; Lipopolysaccharides; Lung Diseases; Macrophages, Peritoneal; Male; Organ Size; Pancreas; Pancreatic Elastase; Pancreatitis; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 1995 |
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Topics: Animals; Capillary Permeability; Carcinogens; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Infusions, Intravenous; Leukocyte Elastase; Neutrophil Activation; Pulmonary Wedge Pressure; Rabbits; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
Topics: Animals; Antibodies, Heterophile; Basement Membrane; Disease Models, Animal; Glycine; Hematuria; Humans; Kidney Glomerulus; Leukocyte Elastase; Macrophages; Male; Monocytes; Nephritis; Proteinuria; Rats; Rats, Inbred WKY; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
Role of neutrophil elastase in stress-induced gastric mucosal injury in rats.
Topics: Animals; Capillary Permeability; Cephalosporins; Disease Models, Animal; Gastric Mucosa; Glycine; Leukocyte Elastase; Leukopenia; Male; Mechlorethamine; Neutrophils; Peptic Ulcer; Peroxidase; Rats; Rats, Wistar; Restraint, Physical; Serine Proteinase Inhibitors; Specific Pathogen-Free Organisms; Stress, Physiological; Sulfonamides | 1998 |
Effect of a specific synthetic inhibitor of neutrophil elastase (ONO-5046) on the course of acute hemorrhagic pancreatitis in dogs.
Topics: alpha-Macroglobulins; Amylases; Animals; Blood Pressure; Calcium; Disease Models, Animal; Dogs; Glycine; Hematocrit; Hemorrhage; Leukocyte Count; Lipopolysaccharides; Multiple Organ Failure; Organ Size; Pancreatitis; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
[Pretreatment of acid-induced lung injury with specific neutrophil elastase inhibitor ONO-5046 did not exasperate the subsequent bacterial lung infection by Pseudomonas aeruginosa].
Topics: Animals; Disease Models, Animal; Glycine; Hydrochloric Acid; Leukocyte Elastase; Male; Pneumonia, Aspiration; Pneumonia, Bacterial; Pseudomonas Infections; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides | 2000 |