sivelestat has been researched along with Chronic Lung Injury in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akita, K; Inomata, T; Narumi, Y; Okada, Y; Shimbo, T; Takahashi, M; Uesugi, Y; Yoshikawa, N | 1 |
| Asano, M; Mishima, A; Nakayama, T; Nomura, N; Saito, T | 1 |
| Chen, L; Gong, H; Ma, P; Tang, A; Wang, H; Wang, S | 1 |
| Belcastro, R; Jankov, RP; Kantores, C; Li, J; Lopez, L; Masood, A; Tanswell, AK; Yi, M | 1 |
| Imai, Y; Kawahara, M; Kuba, K; Mizushima, T; Sugizaki, T; Tamura, F; Tanaka, KI | 1 |
| Hagiwara, S; Iwasaka, H; Noguchi, T; Togo, K | 1 |
| Abe, T; Akita, T; Oshima, H; Ueda, Y; Usui, A | 1 |
| Koizumi, T; Kubo, K; Tsushima, K; Yoshikawa, S | 1 |
| Cai, JH; Chai, JK; Chi, YF; Deng, HP; Feng, R; Hu, QG; Liu, W; Ma, L; Shen, CA; Yin, HN; Zhang, XB; Zou, XF | 1 |
| Chen, L; Tang, AM; Wang, HH; Zhou, MT | 1 |
| Fujimoto, K; Jian, MY; Koizumi, T; Kubo, K; Tsushima, K | 1 |
| Fujita, K; Hosotsubo, H; Inoue, Y; Ogura, H; Shimazu, T; Sugimoto, H; Tanaka, H; Ukai, I | 1 |
| Akagi, R; Inoue, K; Maeshima, K; Morimatsu, H; Morita, K; Omori, E; Shimizu, H; Takahashi, T; Takeuchi, M; Toda, Y | 1 |
3 trial(s) available for sivelestat and Chronic Lung Injury
| Article | Year |
|---|---|
Sivelestat attenuates lung injury in surgery for congenital heart disease with pulmonary hypertension.
Topics: Blood Pressure; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Glycine; Heart Septal Defects, Ventricular; Humans; Hypertension, Pulmonary; Infant; Infant, Newborn; Intraoperative Period; Lung Injury; Male; Prospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome; Vascular Resistance | 2013 |
A pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery.
Topics: Aged; Atrial Fibrillation; Cardiopulmonary Bypass; Coronary Artery Bypass; Feasibility Studies; Female; Glycine; Humans; Infusions, Intravenous; Length of Stay; Leukocyte Elastase; Lung Compliance; Lung Injury; Male; Middle Aged; Pilot Projects; Pulmonary Circulation; Serine Proteinase Inhibitors; Sulfonamides; Surgical Wound Infection; Time Factors; Treatment Outcome | 2009 |
A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury.
Topics: Adult; Aged; APACHE; C-Reactive Protein; Cell Membrane; Elasticity; Female; Glycine; Humans; Leukocyte Count; Leukocyte Elastase; Leukocytes; Lung; Lung Injury; Male; Microcirculation; Middle Aged; Norepinephrine; Oxygen; Positive-Pressure Respiration; Respiratory Distress Syndrome; Rheology; Sulfonamides; Systemic Inflammatory Response Syndrome; Total Lung Capacity | 2006 |
10 other study(ies) available for sivelestat and Chronic Lung Injury
| Article | Year |
|---|---|
Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase.
Topics: Abnormalities, Radiation-Induced; Animals; Glycine; Humans; Inflammation; Leukocyte Elastase; Lung; Lung Injury; Mice; Radiation-Protective Agents; Sulfonamides | 2013 |
Combined effects of sivelestat and resveratrol on severe acute pancreatitis-associated lung injury in rats.
Topics: Acute Disease; Amylases; Animals; Arterial Pressure; Bronchoalveolar Lavage Fluid; Glycine; Interleukin-6; Leukocyte Elastase; Lung; Lung Injury; Male; Oxygen; Pancreatitis; Peroxidase; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resveratrol; Stilbenes; Sulfonamides | 2014 |
Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats.
Topics: Animals; Animals, Newborn; Cell Movement; Elafin; Elastin; Female; Glycine; Leukocyte Elastase; Lung; Lung Injury; Macrophages; Maternal Exposure; Neutrophils; Oxygen; Peroxynitrous Acid; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-8B; Sulfonamides; Triazoles; Vascular Remodeling | 2015 |
Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models.
Topics: Animals; Cecum; Dexamethasone; Disease Models, Animal; Glycine; Ligation; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred ICR; Multiple Organ Failure; Phosphatidylcholines; Punctures; Reactive Oxygen Species; Respiration, Artificial; Respiratory Distress Syndrome; Sulfonamides; Superoxide Dismutase | 2017 |
A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
Topics: Animals; Glycine; HMGB1 Protein; Interleukin-6; Leukocyte Elastase; Lipopolysaccharides; Lung; Lung Injury; Male; NF-kappa B; Nitrates; Nitrites; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Shock, Septic; Sulfonamides; Tumor Necrosis Factor-alpha | 2008 |
Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats.
Topics: Animals; Bronchoalveolar Lavage Fluid; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Gabexate; Glycine; Hydrochloric Acid; Leukocyte Count; Lung Injury; Male; Neutrophils; Protease Inhibitors; Proteinase Inhibitory Proteins, Secretory; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium; Sulfonamides | 2010 |
Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Topics: Animals; Blast Injuries; Bronchoalveolar Lavage Fluid; Burns; Carbon Dioxide; Disease Models, Animal; Glycine; Interleukin-8; Leukocyte Elastase; Lung Injury; Male; Oxygen; Partial Pressure; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha | 2013 |
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Lung; Lung Injury; Male; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides | 2012 |
Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats.
Topics: Animals; Bronchoalveolar Lavage Fluid; Glycine; Granulocyte Colony-Stimulating Factor; Hydrochloric Acid; Leukocyte Elastase; Lung; Lung Injury; Male; Pneumonia, Aspiration; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors | 2004 |
A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats.
Topics: Animals; DNA; Gene Expression Regulation; Glycine; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lung; Lung Injury; Male; NF-kappa B; Nitric Oxide Synthase Type II; Organ Size; Protein Binding; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Sulfonamides; Tumor Necrosis Factor-alpha | 2007 |