sitosterol--(3beta)-isomer and Ovarian-Neoplasms

sitosterol--(3beta)-isomer has been researched along with Ovarian-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for sitosterol--(3beta)-isomer and Ovarian-Neoplasms

Article	Year
Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii. Journal of natural products, 2003, Volume: 66, Issue:11 Twenty-one compounds, including five new agarofuran sesquiterpenes, reissantins A-E (1-5), were isolated from Reissantia buchananii by means of bioassay-directed fractionation and their structures identified from spectral data. Reissantins A-C are the first reported simple agarofuran sesquiterpenes to contain a 5-carboxy-N-methyl-2-pyridone (CNMP) substituent, which has previously been found only in macroring agarofuran pyridine alkaloids. The major terpenoid components, celastrol (6) and its methyl ester derivative, pristimerin (7), were significantly active against nine cancer cell lines, including A549, MCF-7, HCT-8, KB, KB-VIN, U-87-MG, PC-3, 1A9, and PTX10 cell lines, with ED(50) values ranging from 0.076 to 0.34 microg/mL. Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Celastraceae; Drug Screening Assays, Antitumor; Female; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plants, Medicinal; Sesquiterpenes; Tanzania; Tumor Cells, Cultured	2003

Article

Year

Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.

Journal of natural products, 2003, Volume: 66, Issue:11

Twenty-one compounds, including five new agarofuran sesquiterpenes, reissantins A-E (1-5), were isolated from Reissantia buchananii by means of bioassay-directed fractionation and their structures identified from spectral data. Reissantins A-C are the first reported simple agarofuran sesquiterpenes to contain a 5-carboxy-N-methyl-2-pyridone (CNMP) substituent, which has previously been found only in macroring agarofuran pyridine alkaloids. The major terpenoid components, celastrol (6) and its methyl ester derivative, pristimerin (7), were significantly active against nine cancer cell lines, including A549, MCF-7, HCT-8, KB, KB-VIN, U-87-MG, PC-3, 1A9, and PTX10 cell lines, with ED(50) values ranging from 0.076 to 0.34 microg/mL.

Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Celastraceae; Drug Screening Assays, Antitumor; Female; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plants, Medicinal; Sesquiterpenes; Tanzania; Tumor Cells, Cultured

2003