sitosterol--(3beta)-isomer and Body-Weight

sitosterol--(3beta)-isomer has been researched along with Body-Weight* in 2 studies

Other Studies

2 other study(ies) available for sitosterol--(3beta)-isomer and Body-Weight

Article	Year
Effect of Sobatum on radiation-induced toxicity in mice. Cancer letters, 1998, Jan-30, Volume: 123, Issue:2 Sobatum, the active fraction of the plant Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. Sobatum was proven to be an anticancer agent by in vitro and in vivo methods. The aim of this study is to evaluate the effect of Sobatum on radiation-induced toxicity in mice. In this assay there are three groups. Group I, the control group, received radiation alone, while groups II and III received Sobatum (100 and 200 mg/kg body weight, respectively) with radiation. Sobatum was administered 24 h before radiation and was continued for 4 alternate days. Body weight, food intake and blood parameters were determined before radiation and every 3 days after radiation for 17 days. The results indicated that there was significantly less body weight gain and food intake in the radiation alone-treated group compared to the Sobatum-treated group. The average leukocyte count and haemoglobin level of the Sobatum-treated group was considerably improved at the end of the experimental period. Hence, it can be concluded that Sobatum reduced the side-effects of radiation-induced toxicity and suggested that it could be used along with radiation therapy. Topics: Animals; Anticarcinogenic Agents; Body Weight; Eating; Evaluation Studies as Topic; Hemoglobins; Leukocyte Count; Male; Mice; Plant Extracts; Radiation Injuries, Experimental; Survival Rate	1998
Chemoprotective effect of Sobatum against cyclophosphamide toxicity in mice. Journal of experimental & clinical cancer research : CR, 1998, Volume: 17, Issue:2 The partially purified component of Solanum trilobatum named as Sobatum was found to be cytotoxic in Dalton's lymphoma ascites (DLA), Ehrlich ascites (EA) and tissue cultured cells. It significantly inhibited the peritoneal and solid tumours induced by DLA and EA tomour cells along with the chemically induced skin carcinogenesis. Sobatum did not produce any chromosomal anomalies in the bone marrow cells of Swiss mice. In the present study, we have evaluated the chemoprotective effect of Sobatum on cyclophosphamide induced toxicity in mice. The results showed that the co-administration of Sobatum increase the total leucocyte count, haemoglobin level, average life span of animals; we concluded that Sobatum has chemoprotective action on cyclophosphamide induced toxicity. Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Alkylating; Body Weight; Cyclophosphamide; Drug Interactions; Hemoglobins; Leukocyte Count; Mice; Plant Extracts	1998

Article

Year

Effect of Sobatum on radiation-induced toxicity in mice.

Cancer letters, 1998, Jan-30, Volume: 123, Issue:2

Sobatum, the active fraction of the plant Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. Sobatum was proven to be an anticancer agent by in vitro and in vivo methods. The aim of this study is to evaluate the effect of Sobatum on radiation-induced toxicity in mice. In this assay there are three groups. Group I, the control group, received radiation alone, while groups II and III received Sobatum (100 and 200 mg/kg body weight, respectively) with radiation. Sobatum was administered 24 h before radiation and was continued for 4 alternate days. Body weight, food intake and blood parameters were determined before radiation and every 3 days after radiation for 17 days. The results indicated that there was significantly less body weight gain and food intake in the radiation alone-treated group compared to the Sobatum-treated group. The average leukocyte count and haemoglobin level of the Sobatum-treated group was considerably improved at the end of the experimental period. Hence, it can be concluded that Sobatum reduced the side-effects of radiation-induced toxicity and suggested that it could be used along with radiation therapy.

Topics: Animals; Anticarcinogenic Agents; Body Weight; Eating; Evaluation Studies as Topic; Hemoglobins; Leukocyte Count; Male; Mice; Plant Extracts; Radiation Injuries, Experimental; Survival Rate

1998

Chemoprotective effect of Sobatum against cyclophosphamide toxicity in mice.

Journal of experimental & clinical cancer research : CR, 1998, Volume: 17, Issue:2

The partially purified component of Solanum trilobatum named as Sobatum was found to be cytotoxic in Dalton's lymphoma ascites (DLA), Ehrlich ascites (EA) and tissue cultured cells. It significantly inhibited the peritoneal and solid tumours induced by DLA and EA tomour cells along with the chemically induced skin carcinogenesis. Sobatum did not produce any chromosomal anomalies in the bone marrow cells of Swiss mice. In the present study, we have evaluated the chemoprotective effect of Sobatum on cyclophosphamide induced toxicity in mice. The results showed that the co-administration of Sobatum increase the total leucocyte count, haemoglobin level, average life span of animals; we concluded that Sobatum has chemoprotective action on cyclophosphamide induced toxicity.

Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Alkylating; Body Weight; Cyclophosphamide; Drug Interactions; Hemoglobins; Leukocyte Count; Mice; Plant Extracts

1998