sitagliptin-phosphate and Seizures

sitagliptin-phosphate has been researched along with Seizures* in 2 studies

Other Studies

2 other study(ies) available for sitagliptin-phosphate and Seizures

ArticleYear
Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats.
    Chemico-biological interactions, 2020, Sep-01, Volume: 328

    Topics: Amyloid; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Biomarkers; Brain-Derived Neurotrophic Factor; Cognition Disorders; Glucagon-Like Peptide 1; Glycogen Synthase Kinase 3 beta; Hippocampus; Insulin-Like Growth Factor I; Kindling, Neurologic; Male; Matrix Metalloproteinase 9; Neural Inhibition; Neurons; Neurotransmitter Agents; Pentylenetetrazole; Rats, Wistar; Receptor for Advanced Glycation End Products; Seizures; Signal Transduction; Sitagliptin Phosphate; Spatial Memory; tau Proteins

2020
Anticonvulsant agent DPP4 inhibitor sitagliptin downregulates CXCR3/RAGE pathway on seizure models.
    Experimental neurology, 2018, Volume: 307

    Epilepsy is a common neurological disorder with a complex etiology. Our previous study demonstrated that dipeptidyl peptidase IV (DPP4) may be associated with the pathogenesis of epilepsy. However, whether the DPP4 inhibitor sitagliptin has an anticonvulsant effect and the underlying mechanism remain to be elucidated. In this study, we determined that sitagliptin remarkably attenuated the severity of seizures in a pentylenetetrazole (PTZ)-induced rat model. In addition, sitagliptin decreased epileptiform activity measured by electroencephalography (EEG) recordings and patch-clamp methods. Interestingly, sitagliptin pretreatment downregulated the RAGE-JAK2/STAT3 pathway and decreased the expression of CXCL4 and CXCR3. Moreover, CXCR3 knockdown decreased the expression of RAGE, JAK2 and STAT3 in cultured neurons, which suggests that CXCR3 is upstream of the RAGE-JAK2/STAT3 pathway. Altogether, our present data suggest that sitagliptin has an anticonvulsant effect, which might act via downregulation of the CXCL4/CXCR3 axis, followed by a decrease in RAGE and JAK2/STAT3 expression. Considering these effects, sitagliptin could be considered as a novel potential anticonvulsant drug.

    Topics: Animals; Anticonvulsants; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Down-Regulation; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, CXCR3; Seizures; Signal Transduction; Sitagliptin Phosphate

2018