sitagliptin-phosphate and Acidosis--Lactic

Metformin and Sitagliptin are often used in combination in the management of non-insulin dependent diabetes mellitus. Though toxicity is rare, but occurs more frequently in cases of intentional or unintentional overdose of these drugs. Here, we present a case of an intentional overdose of a metformin- sitagliptin combination (70g metformin and 3500mg sitagliptin) in a suicide attempt by a young non-diabetic female who presented with severe lactic acidosis and was successfully treated with prompt hemodialysis and bicarbonate therapy.

Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Humans; Metformin; Sitagliptin Phosphate; Suicide, Attempted