sitagliptin and Hyperglycemia

sitagliptin has been researched along with Hyperglycemia* in 1 studies

Other Studies

1 other study(ies) available for sitagliptin and Hyperglycemia

Article	Year
Design, synthesis and biological evaluation of novel pyrazolo-pyrimidinones as DPP-IV inhibitors in diabetes. Bioorganic & medicinal chemistry letters, 2015, Oct-15, Volume: 25, Issue:20 We report the design, synthesis, biological activity and docking studies of series of novel pyrazolo[3,4-d]pyrimidinones as DPP-IV inhibitors in diabetes. Molecules were synthesized and evaluated for their DPP-IV inhibition activity. Compounds 5e, 5k, 5o and 6a were found to be potent inhibitors of DPP-IV enzyme. Amongst all the synthesized compounds, 6-methyl-5-(4-methylpyridin-2-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (5k) was found to be the most active based on in vitro DPP-IV studies and also exhibited promising in vivo blood glucose lowering activity in male Wistar rats. Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Drug Design; Hyperglycemia; Hypoglycemic Agents; Male; Models, Molecular; Molecular Structure; Pyrazoles; Pyrimidinones; Rats; Rats, Wistar; Structure-Activity Relationship	2015

Article

Year

Design, synthesis and biological evaluation of novel pyrazolo-pyrimidinones as DPP-IV inhibitors in diabetes.

Bioorganic & medicinal chemistry letters, 2015, Oct-15, Volume: 25, Issue:20

We report the design, synthesis, biological activity and docking studies of series of novel pyrazolo[3,4-d]pyrimidinones as DPP-IV inhibitors in diabetes. Molecules were synthesized and evaluated for their DPP-IV inhibition activity. Compounds 5e, 5k, 5o and 6a were found to be potent inhibitors of DPP-IV enzyme. Amongst all the synthesized compounds, 6-methyl-5-(4-methylpyridin-2-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (5k) was found to be the most active based on in vitro DPP-IV studies and also exhibited promising in vivo blood glucose lowering activity in male Wistar rats.

Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Drug Design; Hyperglycemia; Hypoglycemic Agents; Male; Models, Molecular; Molecular Structure; Pyrazoles; Pyrimidinones; Rats; Rats, Wistar; Structure-Activity Relationship

2015