sitafloxacin and Sepsis

sitafloxacin has been researched along with Sepsis* in 1 studies

Other Studies

1 other study(ies) available for sitafloxacin and Sepsis

Article	Year
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds. Bioorganic & medicinal chemistry letters, 2003, Dec-01, Volume: 13, Issue:23 Problems of low solubility, high serum protein binding, and lack of efficacy in vivo in first generation MexAB-OprM specific efflux pump inhibitors were addressed. Through the use of pharmacophore modelling, the key structural elements for pump inhibition were defined. Use of alternative scaffolds upon which the key elements were arrayed gave second generation leads with greatly improved physical properties and activity in the potentiation of antibacterial quinolones (levofloxacin and sitafloxacin) versus Pseudomonas aeruginosa in vivo. Topics: Animals; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Biological Transport, Active; Carrier Proteins; Drug Resistance, Microbial; Fluoroquinolones; Gene Expression Regulation, Bacterial; Lactams; Levofloxacin; Membrane Transport Proteins; Mice; Microbial Sensitivity Tests; Neutropenia; Ofloxacin; Protein Binding; Pseudomonas aeruginosa; Rats; Sepsis; Serum Albumin; Structure-Activity Relationship	2003

Article

Year

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds.

Bioorganic & medicinal chemistry letters, 2003, Dec-01, Volume: 13, Issue:23

Problems of low solubility, high serum protein binding, and lack of efficacy in vivo in first generation MexAB-OprM specific efflux pump inhibitors were addressed. Through the use of pharmacophore modelling, the key structural elements for pump inhibition were defined. Use of alternative scaffolds upon which the key elements were arrayed gave second generation leads with greatly improved physical properties and activity in the potentiation of antibacterial quinolones (levofloxacin and sitafloxacin) versus Pseudomonas aeruginosa in vivo.

Topics: Animals; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Biological Transport, Active; Carrier Proteins; Drug Resistance, Microbial; Fluoroquinolones; Gene Expression Regulation, Bacterial; Lactams; Levofloxacin; Membrane Transport Proteins; Mice; Microbial Sensitivity Tests; Neutropenia; Ofloxacin; Protein Binding; Pseudomonas aeruginosa; Rats; Sepsis; Serum Albumin; Structure-Activity Relationship

2003