sitafloxacin and Seizures

We studied the convulsant activity of sitafloxacin, a newly developed quinolone, and its interaction with anti-inflammatory drugs in mice. Intraventricular injections of sitafloxacin and levofloxacin induced convulsions dose-dependently in the mice. The value of the effective dose for producing convulsions in 50% of the mice (ED(50)) of sitafloxacin was 50.6 nmol/head, whereas that of levofloxacin was 76.7 nmol/head. The convulsant activity of these quinolones was not affected by concurrent administration with anti-inflammatory drugs. From these results obtained in a mouse model, it is suggested that sitafloxacin has weak convulsant activity and that the convulsant activity of sitafloxacin is not enhanced when it is administered with anti-inflammatory drugs.

Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Interactions; Fluoroquinolones; Injections, Intraventricular; Levofloxacin; Mice; Ofloxacin; Seizures