sitafloxacin and Drug-Hypersensitivity

Eradication of H. pylori in patients allergic to penicillin should be performed using regimens without penicillin derivatives. We treated a total of 28 patients allergic to penicillin with a proton pump inhibitor (PPI), metronidazole (250 mg bid) and sitafloxacin (100 mg bid) for one to two weeks. At four to eight weeks after the treatment, the patients underwent the [(13)C]-urea breath test. The overall eradication rate was 100.0%. Mild adverse events were observed. Triple therapy with a PPI, metronidazole and sitafloxacin is well tolerated and effective for the eradication of H. pylori in patients allergic to penicillin.

Topics: Anti-Bacterial Agents; Breath Tests; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Hypersensitivity; Drug Therapy, Combination; Female; Fluoroquinolones; Genotype; Helicobacter Infections; Helicobacter pylori; Humans; Japan; Metronidazole; Middle Aged; Penicillins; Proton Pump Inhibitors; Retrospective Studies; Treatment Outcome