sirolimus and Warts

Topics: Administration, Topical; Adolescent; Anti-Inflammatory Agents; Biopsy; Crohn Disease; Drug Therapy, Combination; Female; Genitalia; Humans; Immunohistochemistry; Immunosuppressive Agents; Injections, Intralesional; Lymphedema; Pain; Pruritus; Sirolimus; Skin; Treatment Outcome; Triamcinolone; Warts

Topics: Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Prognosis; Retrospective Studies; Risk Assessment; Sirolimus; Skin Diseases, Vascular; Treatment Outcome; Vascular Malformations; Veins; Warts

Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cyclophosphamide; Doxorubicin; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Neoplasms, Multiple Primary; Postoperative Complications; Prednisone; Remission Induction; Rituximab; Sirolimus; Skin Diseases; Skin Neoplasms; Vincristine; Warts

Dermatological complications, especially skin infections, are very common following organ transplantation, and result in a lot of distress in the recipient. Herpes zoster, herpes simplex, and human papillomavirus infections are common infections in kidney transplant recipients, and therapeutic management is usually disappointing in immunosuppression state. We report here 2 cases of kidney transplant recipients who developed diffuse human papillomavirus-induced cutaneous warts with no response to conventional treatments. According to similar reports in organ transplant recipients, we modified the immunosuppressive regimen by converting to sirolimus, which led to a rapid relief from cutaneous warts in both patients. This evidence along with other case reports suggest that conversion to sirolimus may be considered as an effective strategy in cases of giant or multiple viral warts in kidney and perhaps other transplant recipients.

Topics: Adolescent; Female; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Transplantation; Male; Postoperative Complications; Sirolimus; Skin Diseases; Warts; Young Adult

Topics: Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Sirolimus; Warts

Dermatological complications following transplantation are very common and the majority of immunosuppressed transplant recipients develop some to many warts due to human papillomavirus (HPV) infection. In the setting of immunosuppression, therapeutic management may be disappointing because of the extent of the lesions in patients unable to develop a sufficient immune response directed against HPV. We report here a case of a young liver transplant recipient who developed diffuse recalcitrant HPV-induced warts leading to an impairment of her quality of life. Taking into account the antiproliferative and cytostatic properties of the target-of-rapamycin (TOR) inhibitors, a new class of immunosuppressive drug, we significantly modified the immunosuppressive regimen. Conversion to sirolimus was followed by a rapid improvement of cutaneous state suggesting that this strategy may be useful for recalcitrant cutaneous viral warts in transplant recipient.

Topics: Adolescent; Female; Humans; Immunosuppressive Agents; Liver Transplantation; Papillomavirus Infections; Sirolimus; Skin Diseases, Viral; Warts