sirolimus and Trauma--Nervous-System

To review the possible mechanisms of the mammalian target of rapamycin (mTOR) in the neuronal restoration process after nervous system injury.. The related literature on mTOR in the restoration of nervous system injury was extensively reviewed and comprehensively analyzed.. mTOR can integrate signals from extracellular stress and then plays a critical role in the regulation of various cell biological processes, thus contributes to the restoration of nervous system injury.. Regulating the activity of mTOR signaling pathway in different aspects can contribute to the restoration of nervous system injury via different mechanisms, especially in the stress-induced brain injury. mTOR may be a potential target for neuronal restoration mechanism after nervous system injury.

Topics: Brain Injuries; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Neovascularization, Physiologic; Nerve Tissue Proteins; Neurons; Oxidative Stress; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Trauma, Nervous System

Activation of mammalian target of rapamycin (mTOR) has been known as one of the contributing factors in nociceptive sensitization after peripheral injury. Its activation followed by the phosphorylation of downstream effectors causes hyperexcitability of primary sensory neurons in the dorsal root ganglion. We investigated whether a single injection of rAAV-shmTOR would effectively downregulate both complexes of mTOR in the long-term and glial activation as well. Male SD rats were categorized into shmTOR (

Topics: Animals; Ganglia, Spinal; Hyperalgesia; Male; Mammals; Neuralgia; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sirolimus; TOR Serine-Threonine Kinases; Trauma, Nervous System