sirolimus and Polyneuropathies

Liver transplantation is associated with a number of neurological complications. We herein report a case of chronic inflammatory demyelinating polyneuropathy associated with the use of sirolimus-based immunosuppression. The patient was treated by converting the immunosuppression from sirolimus to cyclosporine and by a short course of oral steroids. Following this, we observed almost complete clinical and electrophysiologic resolution of this syndrome. We believe that this is the first described case of such a complication occurring in association with sirolimus. This immunosuppressive agent can, therefore, lead to neurological complications similar to the ones that have been observed with calcineurin inhibitors.

Topics: alpha 1-Antitrypsin Deficiency; Cyclosporine; Demyelinating Diseases; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Polyneuropathies; Sirolimus