sirolimus and Neuronal-Ceroid-Lipofuscinoses

The neuronal ceroid lipofuscinoses comprise a group of neurodegenerative disorders with similar clinical manifestations whose precise mechanisms of disease are presently unknown. We created multiple cell lines each with different levels of reduction of expression of the gene coding for the type 2 variant of the disease, Tripeptidyl peptidase (Tpp1), in the cellular slime mould

Topics: Aminopeptidases; Cell Line; Cell Proliferation; Dictyostelium; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; DNA, Antisense; DNA, Protozoan; Gene Expression; Gene Knockdown Techniques; Lysosomes; Mutation; Neuronal Ceroid-Lipofuscinoses; Optical Imaging; Phagocytosis; Phenotype; Phototaxis; Ras Homolog Enriched in Brain Protein; RNA, Messenger; Serine Proteases; Sirolimus; TOR Serine-Threonine Kinases; Tripeptidyl-Peptidase 1