sirolimus and Neoplasms--Germ-Cell-and-Embryonal

sirolimus has been researched along with Neoplasms--Germ-Cell-and-Embryonal* in 1 studies

Other Studies

1 other study(ies) available for sirolimus and Neoplasms--Germ-Cell-and-Embryonal

ArticleYear
EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors.
    Molecular cancer therapeutics, 2018, Volume: 17, Issue:5

    Germ cell tumors (GCT) are malignant tumors that arise from pluripotent embryonic germ cells and occur in children and young adults. GCTs are treated with cisplatin-based regimens which, while overall effective, fail to cure all patients and cause significant adverse late effects. The seminoma and nonseminoma forms of GCT exhibit distinct differentiation states, clinical behavior, and response to treatment; however, the molecular mechanisms of GCT differentiation are not fully understood. We tested whether the activity of the mTORC1 and MAPK pathways were differentially active in the two classes of GCT. Here we show that nonseminomatous germ cell tumors (NSGCT, including embryonal carcinoma, yolk sac tumor, and choriocarcinoma) from both children and adults display activation of the mTORC1 pathway, while seminomas do not. In seminomas, high levels of REDD1 may negatively regulate mTORC1 activity. In NSGCTs, on the other hand, EGF and FGF2 ligands can stimulate mTORC1 and MAPK signaling, and members of the EGF and FGF receptor families are more highly expressed. Finally, proliferation of NSGCT cells

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; ErbB Receptors; Erlotinib Hydrochloride; Humans; Interleukin Receptor Common gamma Subunit; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Neoplasms, Germ Cell and Embryonal; Sirolimus; Testicular Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays

2018