sirolimus and Laryngeal-Diseases

sirolimus has been researched along with Laryngeal-Diseases* in 1 studies

Other Studies

1 other study(ies) available for sirolimus and Laryngeal-Diseases

ArticleYear
Treatment-recalcitrant laryngeal sarcoidosis responsive to sirolimus.
    BMJ case reports, 2020, Aug-26, Volume: 13, Issue:8

    A 15-year-old girl presented with gradual-onset dysphonia and dysphagia. Laryngoscopy revealed significant supraglottic airway obstruction with swelling of both the epiglottis and arytenoids. After emergency tracheostomy, biopsy of the epiglottis revealed lymphoid hyperplasia with focal non-necrotising granulomata, leading to a presumed diagnosis of laryngeal sarcoidosis. Treatment with prednisolone and methotrexate produced minimal clinical improvement. A switch to sirolimus was followed by significant reduction in the laryngeal swelling, allowing decannulation of the tracheostomy. Treatment with sirolimus should be considered as a steroid sparing agent in laryngeal sarcoidosis, particularly in the presence of lymphoid hyperplasia on biopsy.

    Topics: Adolescent; Female; Humans; Laryngeal Diseases; Sarcoidosis; Sirolimus

2020