sirolimus has been researched along with Histiocytosis--Sinus* in 3 studies
3 other study(ies) available for sirolimus and Histiocytosis--Sinus
| Article | Year |
|---|---|
Treatment of purely cutaneous ​Rosai-Dorfman disease with topical rapamycin.
Topics: Histiocytosis, Sinus; Humans; Immunosuppressive Agents; Sirolimus; Skin Diseases | 2023 |
Sirolimus-A targeted therapy for Rosai-Dorfman disease.
Topics: Antibiotics, Antineoplastic; Child; Child, Preschool; Female; Histiocytosis, Sinus; Humans; Male; Prognosis; Sirolimus | 2019 |
Successful Treatment of Recurrent Autoimmune Cytopenias in the Context of Sinus Histiocytosis With Massive Lymphadenopathy Using Sirolimus.
Sinus histiocytosis with massive lymphadenopathy (SHML), or Rosai-Dorfman disease (RDD), is a non-neoplastic, lymphoproliferative disorder that usually resolves spontaneously or with minimal conventional chemotherapy. Rarely, SHML can be associated with autoimmune findings. Such cases are often treatment resistant and have high rates of morbidity and mortality. We present a case of a patient with long-standing autoimmunity in the context of SHML, dependent on standard-treatment until he was transitioned to novel monotherapy with sirolimus. Sirolimus treatment resulted in a complete remission, now sustained after discontinuation of all treatments for over 23 months, with no observable long-term sequelae. Topics: Autoimmune Diseases; Child, Preschool; Histiocytosis, Sinus; Humans; Immunosuppressive Agents; Male; Sirolimus | 2016 |