sirolimus and Gastritis

Radiation-induced gastritis is an infrequent cause of gastrointestinal bleeding. It is a serious complication arising from radiation therapy, and the standard treatment method has not been established. The initial injury is characteristically acute inflammation of gastric mucosa. We presented a 46-year-old male patient with hemorrhagic gastritis induced by external radiotherapy for metastatic retroperitoneal lymph node of hepatocellular carcinoma. The endoscopic examination showed diffuse edematous hyperemicmucosa with telangiectasias in the whole muscosa of the stomach and duodenal bulb. Multiple hemorrhagic patches with active oozing were found over the antrum. Anti-secretary therapy was initiated for hemostasis, but melena still occurred off and on. Finally, he was successfully treated by prednisolone therapy. We therefore strongly argue in favor of perdnisolone therapy to effectively treat patients with radiation-induced hemorrhagic gastritis.

Topics: Carcinoma, Hepatocellular; Endoscopy; Gastritis; Gastrointestinal Hemorrhage; Hemostasis; Humans; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Neoplasm Metastasis; Prednisolone; Radiation Injuries; Sirolimus

Topics: Animals; Cyclosporine; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Duodenitis; Female; Gastritis; Graft Survival; Kidney Transplantation; Male; Pancreatitis; Polyenes; Sirolimus; Time Factors; Transplantation, Homologous