sirolimus and Bronchiolitis

sirolimus has been researched along with Bronchiolitis* in 2 studies

Other Studies

2 other study(ies) available for sirolimus and Bronchiolitis

ArticleYear
Radical reduction of smooth muscle cells in explanted lung of a LAM patient treated with sirolimus: first case report.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2012, Volume: 31, Issue:4

    Topics: Biopsy; Bronchiolitis; Cell Count; Cell Proliferation; Female; Humans; Immunosuppressive Agents; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lung Transplantation; Lymphangioleiomyomatosis; Middle Aged; Myocytes, Smooth Muscle; Sirolimus; Treatment Outcome

2012
Immune cells and immunosuppression in a porcine bronchial model of obliterative bronchiolitis.
    Transplantation, 2001, Sep-27, Volume: 72, Issue:6

    To study obliterative bronchiolitis (OB), we have developed a porcine heterotopic bronchial model. Allografts obliterate within 3 weeks, the immunosuppression cyclosporine (CsA)-azathioprine (AZA)-methylprednisolone (MP) delays OB, but OB is prevented when AZA is switched to 40-0-(2-hydroxyethyl)-rapamycin (RAD). To characterize our model, we studied immune cells under various immunosuppressive conditions.. The groups studied were autografts (U), allografts (A), and allografts given either CsA-RAD-MP (R), or CsA-AZA-MP (C). The implants were harvested at 3, 7, 10, 14, 21, 30, 60, and 90 days after transplantation. Epithelial damage and obliteration were graded histologically, and the number of CD4, CD8, MHC class II expressing cells, macrophages, and B lymphocytes were counted (mean+SEM)/high-power visual field.. In group U, normal epithelium was regained with no obliteration and only few immune cells. In group A, consistent with initially acute ejection, an influx of CD4 (105+23), CD8 (166+23), and class II (92+20) cells was seen up to day 21, when total obliteration preceded by epithelial destruction had already developed. Some macrophages were seen and B cells were scarce. In group R, epithelial damage and obliteration were insignificant, but moderate numbers of CD4, CD8, and class II cells were seen. In group C, epithelial damage and obliteration were only delayed, but the immune cell response was clearly blunted.. In our model, rejection with significant immune cell influx was still active when obliteration was total in nontreated allografts. In immunosuppressed allografts, decrease in the number of immune cells alone did prevent OB. These results support OB being T-cell mediated. RAD may have additional important effects on growth factors and proliferation in prevention of OB.

    Topics: Animals; Azathioprine; Bronchi; Bronchiolitis; Cyclosporine; Drug Therapy, Combination; Everolimus; Glucocorticoids; Graft Rejection; Immune System; Immunohistochemistry; Immunosuppression Therapy; Immunosuppressive Agents; Methylprednisolone; Sirolimus; Swine; Time Factors; Transplantation Immunology; Transplantation, Autologous; Transplantation, Homologous

2001