sirolimus has been researched along with Azoospermia* in 2 studies
2 other study(ies) available for sirolimus and Azoospermia
| Article | Year |
|---|---|
[Everolimus and azoospermia, a causal relationship? About one case in a renal transplant patient].
Adverse effects of mTOR inhibitors on spermatogenesis are poorly evaluated but hypogonadism is described under sirolimus. We report the case of a renal transplant 30 years old patient in whom azoospermia was discovered while he was being treated by everolimus. Topics: Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Azoospermia; Basiliximab; Causality; Cyclosporine; Drug Substitution; Everolimus; Graft Rejection; Humans; Immunosuppressive Agents; Infertility, Male; Kidney Transplantation; Male; Mycophenolic Acid; Recombinant Fusion Proteins; Sirolimus; Spermatogenesis; TOR Serine-Threonine Kinases | 2014 |
Azoospermia in a renal transplant recipient during sirolimus (rapamycin) treatment.
Sirolimus is used as a powerful immunosuppressant drug in patients after organ transplantation. It was shown to block spermatogenesis by interrupting the stem cell factor/c-kit system. Oligozoospermia was shown in single patients. In addition, a decrease of testosterone and an increase of gonadotropin levels were observed. We report on a young patient who showed azoospermia during the treatment with sirolimus after renal transplantation. After changing the immunosuppression to tacrolimus, spermatogenesis of the patient recovered. Five months after cessation of the treatment with sirolimus, a sperm concentration of 8 x 10(6) ml(-1) was found. Depression of spermatogenesis is an important side effect in younger men who aspire paternity, so that waiving of sirolimus is advisable in these patients. Topics: Adult; Azoospermia; Humans; Immunosuppressive Agents; Infertility, Male; Kidney Transplantation; Male; Sirolimus; Spermatogenesis | 2007 |