sinomenine and Erythema

Sinomenine transdermal patch was prepared and its properties were studied. The patches were produced by salivation method. The releasing rate in vitro of the patch was determined by HPLC. Peel test was used to evaluate the adhesion. Acute skin irritation test was performed in comparison with formalin (0.8%) by using mouse model. The Sinomenine TDDS Patch was prepared. The releasing rate in vitro followed the Higuchi equation (r>0.99), the releasing amount was beyond 90% in 24h. The peel adhesion to steel (N/25 mm) is 10 or above. The skin irritation tests showed negligible erythema and edema. The Sinomenine transdermal patch was prepared successfully and it may be beneficial for topical use.

Topics: Adhesiveness; Administration, Cutaneous; Animals; Antirheumatic Agents; Chemistry, Pharmaceutical; Dosage Forms; Edema; Erythema; Excipients; Kinetics; Male; Mice; Morphinans; Permeability; Skin; Skin Absorption; Skin Irritancy Tests; Solubility; Tissue Adhesives

We report a case of drug eruption caused by the crude drug Boi. A 41-year-old female patient had been diagnosed with chronic rheumatoid arthritis in the department of internal medicine. After ingestion of a decoction of the crude drug Boi for the alleviation of arthralgia, a slight fever developed, which was followed by systemic edematous erythema with itching. HPLC showed that the main components of the crude drug Boi are sinomenine and magnoflorine. The results of patch tests were negative for all oral drugs that the patient had been taking. Oral ingestion tests showed that the patient showed positive reactions to the as-is Boi boiling-water decoction and 1/10-volume sinomenine. Based on this, the drug eruption was judged to be caused by sinomenine. It is considered the first time that the causative component of a drug eruption was confirmed by oral ingestion tests with components of a crude drug of Kampo medicine (Sino-Japanese traditional medicine).

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aporphines; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Drug Eruptions; Drugs, Chinese Herbal; Erythema; Female; Humans; Morphinans; Plant Roots; Plant Shoots; Pruritus