sincalide and Common-Bile-Duct-Neoplasms

Palliative operation plays an important part in the treatment of periampullary carcinoma. However, gastric bypass such as the widely practiced side-to-side gastrojejunostomy frequently fails to provide adequate drainage. Here we attempted to fashion an end-to-end duodenojejunostomy in the hope of establishing physiological continuity of the stomach and duodenum. Biliary bypass with side-to-side choledochojejunostomy is performed simultaneously. Eight patients underwent this surgery. In seven of these, radical resection proved to be impossible, and in one the duodeno-biliary decompression was attempted before the radical operation. Early results were satisfactory in all patients. They began to eat liquid meals within a week, and were discharged uneventfully within the third postoperative week, when they were able to eat a regular diet. No ulcer developed in any of the patients. Plasma gastrin levels following a test meal was significantly lower after the operation, but plasma CCK-N and GIP levels showed no statistical difference prior to and after surgery. This duodenojejunal bypass is recommended as a means of improving the quality of the remaining life of the patients.

Topics: Aged; Ampulla of Vater; Biliopancreatic Diversion; Choledochostomy; Common Bile Duct Neoplasms; Duodenostomy; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrins; Gastrointestinal Transit; Humans; Jejunostomy; Male; Middle Aged; Palliative Care; Pancreatic Neoplasms; Postoperative Care; Sincalide; Survival Rate