sincalide and Biliary-Dyskinesia

Topics: Biliary Dyskinesia; Gallbladder Emptying; Humans; Lipid Metabolism; Radionuclide Imaging; Reproducibility of Results; Sincalide

Topics: Biliary Dyskinesia; Gastrointestinal Agents; Humans; Infusions, Intravenous; Sincalide

Topics: Biliary Dyskinesia; Child; Cholecystectomy, Laparoscopic; Clofibrate; Gallbladder Diseases; Gastrointestinal Agents; Humans; Sincalide

Topics: Biliary Dyskinesia; Dose-Response Relationship, Drug; Gallbladder; Gallbladder Emptying; Humans; Infusions, Intravenous; Radionuclide Imaging; Research Design; Sincalide

Gallbladder ejection fraction (GBEF) measured with a fatty meal (half-and-half milk) was compared with that measured with 2 equal sequential intravenous infusions of cholecystokinin (CCK-8) in a paired study of healthy subjects.. GBEF was measured by (99m)Tc-hepatic iminodiacetic acid cholescintigraphy in 13 healthy subjects. Each subject received 2 sequential doses of CCK-8 (3 ng/kg/min for 10 min) on day 1, followed by, on day 2, a 240-mL (8 oz) fatty meal (half-and-half milk) per 70 kg of body weight.. The mean +/- SD GBEF of 53.6% +/- 20.2% with fatty meal was significantly lower than the mean of 75.8% +/- 16.3% (P < 0.01) with the first dose of CCK-8 and 71.3% +/- 17.4% (P < 0.05) with the second dose. Fatty meal GBEF varied widely, from 23.5% to 91.8%. Percentile rankings of the fatty meal GBEF were determined as the preferred methodology for reporting results. Latent and ejection periods were significantly longer with fatty meal than with either dose of CCK-8.. GBEF measured with fatty meal can serve as an alternative method to intravenous injection of CCK-8 when the hormone is no longer available for clinical use. The measurement of GBEF with fatty meal requires careful attention to the details of the meal and the measurement time sequence.

Topics: Adult; Biliary Dyskinesia; Fats; Female; Gallbladder Emptying; Humans; Infusions, Intravenous; Liver; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Sincalide; Technetium Tc 99m Lidofenin

The appearance of biliary pain after cholecystectomy in patients with normal ultrasonic and cholangiographic studies has been attributed to functional alterations of the Sphincter of Oddi. We performed dynamic cholescyntigraphic studies of the biliary tract in 32 cholecystectomized patients, at least six months after the operation: 27 were asymptomatic (control group) and 5 had clinical and laboratory findings suggesting temporary functional obstruction of the Sphincter of Oddi. In this group we demonstrated an emptying delay of the biliary tract that was modified by the IV infusion of Cholecystokinin Octapeptide. Biliary Cholescintigraphy appears as a good screening method to evaluate functional alterations of the Sphincter of Oddi.

Topics: Abdominal Pain; Biliary Dyskinesia; Cholecystectomy; Gastric Emptying; Humans; Postoperative Complications; Radionuclide Imaging; Sincalide; Sphincter of Oddi