Compounds > simvastatin
Page last updated: 2024-08-23

simvastatin and Reperfusion Injury

simvastatin has been researched along with Reperfusion Injury in 56 studies

Research

Studies (56)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's20 (35.71)29.6817
2010's34 (60.71)24.3611
2020's2 (3.57)2.80

Authors

AuthorsStudies
Breithaupt-Faloppa, AC; Davel, AP; Nunes-Souza, V; Peres, EC; Rabelo, LA; Rossoni, LV; Tavares-de-Lima, W; Victorio, JA1
Fan, X; Huang, X; Lai, CH; Liu, Z; Luo, J; Mao, X; Wang, W; Wang, Y; Xia, Z; Xiao, Q; Xiong, Y; Ye, Q; Ye, S; Zeng, C; Zhang, X; Zhong, Z1
Han, SH; Hwang, JY; Kim, JH; Park, JW; Park, SJ; Ryu, JH; Sohn, HM1
Bao, B; Chen, Z; Nie, H; Wu, X; Xia, Z; Xiang, Y; You, J1
Huang, X; Lai, CH; Li, L; Liu, Z; Luo, J; Qi, X; Senninger, N; Wang, W; Wang, Y; Xiaoli, F; Xiong, Y; Ye, Q; Ye, S; Zhang, X; Zhong, Z1
Bonsignore, P; Calamia, S; Cintorino, D; Costanzo, F; di Francesco, F; Gruttadauria, S; Khouzam, S; Li Petri, S; Luca, A; Oliva, E; Pagano, D; Ricotta, C; Tropea, A; Tuzzolino, F1
Bosch, J; Cogger, VC; Fernández-Iglesias, A; Gracia-Sancho, J; Hide, D; Le Couteur, DG; Maeso-Díaz, R; Peralta, C; Warren, A1
Cao, K; Chen, H; Chen, S; Cheng, T; Dong, C; Han, J; Hong, G; Li, S; Lv, X; Ma, H; Ma, J; Shen, J; Shen, L; Tong, F; Wang, X; Wang, Y; Wang, Z; Wu, M; Xing, C; Yan, Y; Zhu, Y1
Dhaygude, K; Helanterä, I; Holmström, EJ; Jokinen, JJ; Kankainen, M; Krebs, R; Lemström, KB; Lommi, J; Nykänen, AI; Räisänen-Sokolowski, A; Syrjälä, SO; Tuuminen, R1
Arnaudova, R; Krebs, R; Lemström, KB; Nykänen, AI; Rouvinen, E; Syrjälä, S; Tuuminen, R1
Arnaudova, R; Gautam, P; Helin, H; Keränen, MA; Krebs, R; Lemström, KB; Nykänen, AI; Rilla, K; Rouvinen, E; Saharinen, P; Tammi, R; Tuuminen, R1
Andres, AM; Damasco, MV; Gottlieb, RA; Hernandez, G; Huang, C; Lee, P; Ratliff, EP; Sin, J; Thornton, CA1
Gokcinar, D; Guler, A; Guler, L; Kirkluoglu, M; Yesil, FG; Zorlu, E1
Han, JI; Hwang, J1
Chen, B; Ding, W; Feng, Q; Huang, Z; Jiang, L; Li, W; Luo, Q; Luo, W; Pan, H; Wei, W; Wu, B; Xu, G; Zhao, Y1
Yan, H; Zhang, Y1
Yan, H; Zhang, Y; Zhang, Z1
Koskinen, PK; Palin, NK; Rintala, JM; Savikko, J1
Ahmad, A; Khan, MU; Khanam, R; Rohilla, A1
Ekici, MF; Genc, O; Kocak, A; Kocak, C; Kocak, FE; Kucuk, A; Ozyigit, F; Tosun, M; Yaylak, F1
Kim, EJ; Kim, SH; Kong, HS; Lee, J; Lee, JR; Suh, CS; Youm, HW1
Bradamante, V; Kelava, M; Konjevoda, P; Lovrić, J; Macan, M; Štambuk, N; Vrkić, N; Vukšić, A; Žunec, S1
Bosch, J; Garcia-Pagan, JC; Gracia-Sancho, J; Hide, D; Ortega-Ribera, M; Peralta, C1
Holmström, E; Krebs, R; Lemström, KB; Raissadati, A; Rouvinen, E; Saharinen, P; Tuuminen, R1
Han, SH; Hwang, JY; Kim, J; Park, JW; Park, S; Ryu, JH; Sohn, HM1
Abolhassani, F; Akbari, M; Amoli, FA; Dehpoor, AR; Dehpour, AR; Eshraghian, MR; Gholami, MR; Kamalian, N; Pasbakhsh, P; Sobhani, A; Sohrabi, D1
Basta-Jovanović, G; Chatterjee, PK; Nesic, Z; Prostran, M; Radojevic-Skodrić, S; Stojanović, R; Thiemermann, C; Todorovic, Z; Velicković, R2
Kaminska, B; Kaplán, P; Lehotský, J; Pavlíková, M; Sivonová, M; Tatarková, Z; Urban, P1
Dibazar, F; Ghandiha, A; Hajipour, B; Hemmati, MR; Hosseinian, MM1
Asl, NA; Hajipour, B; Hemmati, MR; Moein, A; Nasirizade, MR; Nourazar, AR; Saberifar, F; Somi, MH; Vatankhah, AM1
Bashenko, Y; Chemodanov, E; Coran, AG; Mogilner, J; Shaoul, R; Slijper, N; Sukhotnik, I1
Nissen, SE; Taylor, AJ1
Isenmann, S; Krempler, K; Löwel, S; Schmeer, CW; Witte, OW1
Hayashi, J; Kohno, T; Saito, T; Tsuchida, M; Umehara, S; Yamamoto, H1
Sun, XF; Wang, JK; Yang, J; Zhao, H1
Chen, CF; Ko, ML; Peng, PH; Peng, YH1
Abo-Ramadan, U; Keränen, MA; Koli, K; Krebs, R; Lemström, KB; Neuvonen, PJ; Nykänen, AI; Syrjälä, S; Tikkanen, JM; Tuuminen, R1
Chen, CF; Chen, SC; Chuang, SJ; Hour, TC; Liu, YH; Tu, YP1
Bosch, J; García-Calderó, H; García-Cardeña, G; García-Pagán, JC; Gracia-Sancho, J; Marrone, G; Russo, L1
Han, JI; Han, S; Hwang, J1
Fan, X; Feng, D; Jiang, F; Lv, J; Wu, Y; Xu, L; Yin, R; Zhang, Z1
Adameová, A; Čarnická, S; Máťuš, M; Mesárošová, L; Rajtík, T; Ravingerová, T; Švec, P; Szobi, A1
Farivar, AS; Fraga, C; Mulligan, MS; Naidu, BV; Thomas, R; Woolley, SM1
Davis, NA; Inman, SR; Lukaszek, VA; Olson, KM1
Davis, NA; Inman, SR; Lukaszek, VA; Mazzone, ME; Olson, KM; Yoder, KN1
Aldemir, D; Arslan, G; Candan, S; Ozen, O; Pirat, A; Yücel, M; Zeyneloglu, P1
Adameová, A; Faberová, V; Kuzelová, M; Svec, P1
Gao, F; Song, T; Wu, JM; Zhang, J; Zhou, FY1
Cakmak, A; Demirpençe, E; Deniz Dinçer, U; Köksoy, A; Köksoy, C; Okcu-Heper, A; Oziş, E; Yazgan, U1
Croxen, RL; Fenstermacher, JD; Knight, RA; Konda, KP; Nagaraja, TN1
Cowled, PA; Field, JB; Fitridge, RA; Khanna, A; Laws, PE; Varelias, A1
Huang, H; Jing, H; Li, Z; Qian, J; Wang, Z; Yin, R; Zhu, J1
Chang, KJ; Chen, CF; Lai, IR; Tsai, HW1
Berti, F; Civelli, M; Manfredi, B; Razzetti, R; Rossoni, G1
Barsotti, A; Conti, P; Di Muzio, M; Di Napoli, P; Maggi, A; Taccardi, AA1

Trials

2 trial(s) available for simvastatin and Reperfusion Injury

ArticleYear
The addition of simvastatin administration to cold storage solution of explanted whole liver grafts for facing ischemia/reperfusion injury in an area with a low rate of deceased donation: a monocentric randomized controlled double-blinded phase 2 study.
    BMC surgery, 2018, Dec-27, Volume: 18, Issue:1

    Topics: Double-Blind Method; Fatty Liver; Humans; Liver; Liver Transplantation; Prospective Studies; Protective Agents; Reperfusion Injury; Simvastatin

2018
Donor Simvastatin Treatment in Heart Transplantation.
    Circulation, 2019, 08-20, Volume: 140, Issue:8

    Topics: Adolescent; Adult; Aged; Allografts; Chemokine CXCL10; Double-Blind Method; Female; Graft Rejection; Heart Transplantation; Hemodynamics; Humans; Inflammation; Male; Middle Aged; Reperfusion Injury; Simvastatin; Tissue Donors; Transplantation, Homologous; Troponin T; Young Adult

2019

Other Studies

54 other study(ies) available for simvastatin and Reperfusion Injury

ArticleYear
Simvastatin protects against intestinal ischemia/reperfusion-induced pulmonary artery dysfunction.
    Life sciences, 2022, Oct-01, Volume: 306

    Topics: Animals; Intestinal Diseases; Ischemia; Male; Mesenteric Ischemia; Nitric Oxide Synthase Type II; Pulmonary Artery; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury; Simvastatin

2022
Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat.
    Oxidative medicine and cellular longevity, 2017, Volume: 2017

    Topics: Animals; Anticholesteremic Agents; Death; Kruppel-Like Transcription Factors; Liver Transplantation; Male; Organ Preservation; Organ Preservation Solutions; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Tissue Donors

2017
The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats.
    BMC anesthesiology, 2018, 03-27, Volume: 18, Issue:1

    Topics: Animals; Disease Models, Animal; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin; Spinal Cord; Treatment Outcome

2018
Simvastatin improves cerebrovascular injury caused by ischemia‑reperfusion through NF‑κB‑mediated apoptosis via MyD88/TRIF signaling.
    Molecular medicine reports, 2018, Volume: 18, Issue:3

    Topics: Adaptor Proteins, Vesicular Transport; Animals; Anticholesteremic Agents; Apoptosis; Blood-Brain Barrier; Cells, Cultured; Cerebrovascular Trauma; Male; Mice; Myeloid Differentiation Factor 88; Neuroprotective Agents; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Simvastatin

2018
Simvastatin ameliorates total liver ischemia/reperfusion injury via KLF2-mediated mechanism in rats.
    Clinics and research in hepatology and gastroenterology, 2019, Volume: 43, Issue:2

    Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Disease Models, Animal; Hepatocytes; Inflammation Mediators; Kruppel-Like Transcription Factors; Liver; Male; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin; Superoxide Dismutase; Thrombomodulin; Up-Regulation; Warm Ischemia

2019
Ischemia/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2020, 01-20, Volume: 75, Issue:2

    Topics: Age Factors; Animals; Disease Models, Animal; Endothelial Cells; Liver; Male; Nitric Oxide; Phenotype; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Tyrosine

2020
Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways.
    Transplantation proceedings, 2019, Volume: 51, Issue:8

    Topics: Animals; Anticholesteremic Agents; Apoptosis; Biomarkers; Caspase 3; High-Temperature Requirement A Serine Peptidase 2; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mitochondrial Proteins; Pyrimidinones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Simvastatin; Superoxide Dismutase; Thiones

2019
Combined donor simvastatin and methylprednisolone treatment prevents ischemia-reperfusion injury in rat cardiac allografts through vasculoprotection and immunomodulation.
    Transplantation, 2013, May-15, Volume: 95, Issue:9

    Topics: Animals; Glucuronosyltransferase; Graft Survival; Heart Transplantation; Hyaluronan Synthases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Immunomodulation; Methylprednisolone; rac GTP-Binding Proteins; Rats; Rats, Inbred WF; Reperfusion Injury; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Simvastatin; Tissue Donors; Transplantation, Homologous

2013
Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2013, Volume: 13, Issue:8

    Topics: Acute Kidney Injury; Animals; Graft Survival; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunity, Innate; Kidney; Kidney Transplantation; Male; Microvessels; Rats; Rats, Inbred WF; Reperfusion Injury; Simvastatin

2013
Mitophagy is required for acute cardioprotection by simvastatin.
    Antioxidants & redox signaling, 2014, Nov-10, Volume: 21, Issue:14

    Topics: Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Cardiotonic Agents; Cell Line; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mitophagy; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Signal Transduction; Simvastatin; TOR Serine-Threonine Kinases

2014
Challenges in the design of drug therapy study on rats.
    Journal of cardiothoracic and vascular anesthesia, 2013, Volume: 27, Issue:5

    Topics: Animals; Male; Neuroprotective Agents; Reperfusion Injury; Simvastatin; Spinal Cord Ischemia

2013
Reply to Yesil et al.
    Journal of cardiothoracic and vascular anesthesia, 2013, Volume: 27, Issue:5

    Topics: Animals; Male; Neuroprotective Agents; Reperfusion Injury; Simvastatin; Spinal Cord Ischemia

2013
Simvastatin inhibits inflammation in ischemia-reperfusion injury.
    Inflammation, 2014, Volume: 37, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Hindlimb; Inflammation; Male; Mice; Mice, Inbred C57BL; Random Allocation; Reperfusion Injury; Simvastatin

2014
[Effect of simvastatin on retinal Bcl-2/Bax expression and cell apoptosis in rats with ischemia-reperfusion injury].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2014, Volume: 50, Issue:11

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cerebral Arteries; In Situ Nick-End Labeling; Male; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Reperfusion Injury; Retina; Simvastatin; Time Factors

2014
Simvastatin inhibits ischemia/reperfusion injury-induced apoptosis of retinal cells via downregulation of the tumor necrosis factor-α/nuclear factor-κB pathway.
    International journal of molecular medicine, 2015, Volume: 36, Issue:2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Down-Regulation; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; NF-kappa B; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Signal Transduction; Simvastatin; Tumor Necrosis Factor-alpha

2015
Intensive perioperative simvastatin treatment protects from chronic kidney allograft injury.
    American journal of nephrology, 2015, Volume: 41, Issue:4-5

    Topics: Allografts; Animals; Creatinine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Transplantation; Perioperative Care; Proteinuria; Rats; Renal Insufficiency, Chronic; Reperfusion Injury; Simvastatin; Tissue Donors; Transplant Recipients

2015
A comparative study on the cardioprotective potential of atorvastatin and simvastatin in hyperhomocysteinemic rat hearts.
    European journal of pharmacology, 2015, Oct-05, Volume: 764

    Topics: Animals; Atorvastatin; Cardiotonic Agents; Female; Hyperhomocysteinemia; Male; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin

2015
Protective effects of simvastatin administered in the experimental hepatic ischemia-reperfusion injury rat model.
    The Journal of surgical research, 2015, Volume: 199, Issue:2

    Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Diseases; Male; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin

2015
A combination of simvastatin and methylprednisolone improves the quality of vitrified-warmed ovarian tissue after auto-transplantation.
    Human reproduction (Oxford, England), 2015, Volume: 30, Issue:11

    Topics: Animals; Anticholesteremic Agents; Cryopreservation; Drug Therapy, Combination; Female; Glucocorticoids; Methylprednisolone; Mice; Ovary; Reperfusion Injury; Simvastatin; Tissue Transplantation; Transplantation, Autologous; Vitrification

2015
Effects of simvastatin on malondialdehyde level and esterase activity in plasma and tissue of normolipidemic rats.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:5

    Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Carotid Artery, Common; Cytokines; Diabetes Mellitus, Experimental; Glutamic Acid; Hippocampus; Male; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Pioglitazone; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Simvastatin; Thiazolidinediones

2015
Effects of warm ischemia and reperfusion on the liver microcirculatory phenotype of rats: underlying mechanisms and pharmacological therapy.
    Scientific reports, 2016, Feb-24, Volume: 6

    Topics: Animals; Cells, Cultured; Drug Evaluation, Preclinical; Hepatocytes; Kruppel-Like Transcription Factors; Kupffer Cells; Liver; Male; Microcirculation; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Wistar; Reperfusion Injury; Simvastatin; Warm Ischemia

2016
Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion.
    Transplant immunology, 2016, Volume: 37

    Topics: Animals; Apoptosis; Caspase 9; Cells, Cultured; Endothelial Cells; Graft Rejection; Heart Transplantation; L-Lactate Dehydrogenase; Male; Protein Serine-Threonine Kinases; Rats; Rats, Inbred WF; Receptor-Interacting Protein Serine-Threonine Kinases; Reperfusion Injury; Simvastatin; Transplantation, Homologous

2016
Simvastatin protects ischemic spinal cord injury from cell death and cytotoxicity through decreasing oxidative stress: in vitro primary cultured rat spinal cord model under oxygen and glucose deprivation-reoxygenation conditions.
    Journal of orthopaedic surgery and research, 2017, Feb-27, Volume: 12, Issue:1

    Topics: Animals; Cell Death; Cell Hypoxia; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glucose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Motor Neurons; Neuroprotective Agents; Oxidative Stress; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin; Spinal Cord Injuries

2017
The effects of simvastatin on ischemia-reperfusion injury of sciatic nerve in adult rats.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sciatic Nerve; Simvastatin

2008
Acute protective effects of simvastatin in the rat model of renal ischemia-reperfusion injury: it is never too late for the pretreatment.
    Journal of pharmacological sciences, 2008, Volume: 107, Issue:4

    Topics: Animals; Creatinine; Disease Models, Animal; Drug Administration Schedule; Edema; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intravenous; Kidney; Kidney Tubular Necrosis, Acute; Male; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Sodium; Time Factors

2008
Molecular analysis of endoplasmic reticulum stress response after global forebrain ischemia/reperfusion in rats: effect of neuroprotectant simvastatin.
    Cellular and molecular neurobiology, 2009, Volume: 29, Issue:2

    Topics: Activating Transcription Factor 6; Animals; DNA-Binding Proteins; Endoplasmic Reticulum; Gene Expression Regulation; Heat-Shock Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Male; Molecular Chaperones; Neuroprotective Agents; Oxidative Stress; Protein Folding; Rats; Rats, Wistar; Regulatory Factor X Transcription Factors; Reperfusion Injury; RNA, Messenger; Simvastatin; Time Factors; Transcription Factors; Up-Regulation; X-Box Binding Protein 1

2009
Simvastatin decreases hepatic ischaemia/reperfusion-induced liver and lung injury in rats.
    Folia morphologica, 2008, Volume: 67, Issue:4

    Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Liver Diseases; Lung Injury; Rats; Reperfusion Injury; Simvastatin; Tumor Necrosis Factor-alpha

2008
Simvastatin attenuates intestinal ischemia/reperfusion induced injury in rat.
    Folia morphologica, 2009, Volume: 68, Issue:3

    Topics: Animals; Antioxidants; Disease Models, Animal; Down-Regulation; Free Radical Scavengers; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Diseases; Ischemia; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Regional Blood Flow; Reperfusion Injury; Simvastatin; Superoxide Dismutase; Treatment Outcome; Tumor Necrosis Factor-alpha

2009
Effect of simvastatin on intestinal recovery following gut ischemia-reperfusion injury in a rat.
    Pediatric surgery international, 2010, Volume: 26, Issue:1

    Topics: Administration, Oral; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Enterocytes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Diseases; Intestines; Male; Rats; Rats, Sprague-Dawley; Recovery of Function; Reperfusion Injury; Simvastatin; Treatment Outcome

2010
Preliminary observations from preliminary trial results: have we finally had enough?
    Circulation. Cardiovascular quality and outcomes, 2008, Volume: 1, Issue:1

    Topics: Adult; Anticholesteremic Agents; Aortic Valve Stenosis; Azetidines; Cardiovascular Surgical Procedures; Ezetimibe; Heart Failure; Humans; Incidence; Neoplasms; Randomized Controlled Trials as Topic; Reperfusion Injury; Research Design; Simvastatin; Survival Analysis; Treatment Outcome

2008
Simvastatin improves retinal ganglion cell survival and spatial vision after acute retinal ischemia/reperfusion in mice.
    Investigative ophthalmology & visual science, 2011, Apr-20, Volume: 52, Issue:5

    Topics: Acute Disease; Animals; Behavior, Animal; Cell Count; Cell Survival; Contrast Sensitivity; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Simvastatin; Spatial Behavior; Vision, Ocular; Visual Acuity

2011
Reduction of spinal cord ischemia/reperfusion injury with simvastatin in rats.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:3

    Topics: Animals; Aorta, Thoracic; Balloon Occlusion; Disease Models, Animal; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Motor Activity; Motor Neurons; Muscle, Skeletal; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Simvastatin; Spinal Cord; Spinal Cord Ischemia; Time Factors

2011
[Effects of simvastatin on pulmonary nuclear factor-κB and intercellular adhesion molecule-1 in rats with lung injury induced by ischemia-reperfusion of the hind limbs].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011, Volume: 31, Issue:7

    Topics: Animals; Hindlimb; Intercellular Adhesion Molecule-1; Ischemia; Lung; Lung Injury; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Simvastatin; Transcription Factor RelA

2011
Simvastatin upregulates Bcl-2 expression and protects retinal neurons from early ischemia/reperfusion injury in the rat retina.
    Experimental eye research, 2011, Volume: 93, Issue:5

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Count; Cell Survival; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Intravitreal Injections; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Simvastatin; Stilbamidines; Up-Regulation

2011
Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection.
    Circulation, 2011, Sep-06, Volume: 124, Issue:10

    Topics: Animals; Endothelial Cells; Endothelin-1; Enzyme Inhibitors; Gap Junctions; Graft Rejection; Heart Transplantation; Heme Oxygenase-1; Hypoxia-Inducible Factor 1, alpha Subunit; Major Histocompatibility Complex; Male; Microvessels; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; No-Reflow Phenomenon; Polyisoprenyl Phosphates; Primary Graft Dysfunction; Rats; Rats, Inbred WF; Reperfusion Injury; rho-Associated Kinases; Simvastatin

2011
Simvastatin induces the expression of hemeoxygenase-1 against ischemia-reperfusion injury on the testes in rats.
    Toxicology letters, 2011, Dec-15, Volume: 207, Issue:3

    Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Enzyme Induction; Heme Oxygenase-1; In Situ Nick-End Labeling; Injections, Intraperitoneal; Ischemia; Male; Metalloporphyrins; Protoporphyrins; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Testis

2011
Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers.
    Hepatology (Baltimore, Md.), 2012, Volume: 55, Issue:3

    Topics: Adenosine; Allopurinol; Animals; Cells, Cultured; Cryoprotective Agents; Endothelium, Vascular; Glutathione; Insulin; Kruppel-Like Transcription Factors; Liver; Liver Transplantation; Male; Models, Animal; Organ Preservation; Organ Preservation Solutions; Phenotype; Raffinose; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin

2012
Effect of pretreatment with simvastatin on spinal cord ischemia-reperfusion injury in rats.
    Journal of cardiothoracic and vascular anesthesia, 2013, Volume: 27, Issue:1

    Topics: Animals; Disease Models, Animal; Male; Neuroprotective Agents; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin; Spinal Cord Ischemia; Treatment Outcome

2013
Restoration of alveolar type II cell function contributes to simvastatin-induced attenuation of lung ischemia-reperfusion injury.
    International journal of molecular medicine, 2012, Volume: 30, Issue:6

    Topics: Alveolar Epithelial Cells; Androstadienes; Animals; Apoptosis; Cell Hypoxia; Cell Line; Cell Proliferation; Cell Transdifferentiation; Drug Evaluation, Preclinical; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Male; Mevalonic Acid; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Pulmonary Surfactant-Associated Protein C; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Secretory Vesicles; Signal Transduction; Simvastatin; Wortmannin

2012
Pleiotropic effects of simvastatin are associated with mitigation of apoptotic component of cell death upon lethal myocardial reperfusion-induced injury.
    Physiological research, 2012, Volume: 61, Issue:Suppl 2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Death; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin

2012
Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion.
    The Journal of thoracic and cardiovascular surgery, 2003, Volume: 126, Issue:2

    Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cell Count; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Ischemia; Lung; Lung Diseases; Male; Models, Cardiovascular; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Long-Evans; Reperfusion Injury; Simvastatin; Statistics as Topic; Time Factors; Transcription Factors; Treatment Outcome

2003
Simvastatin attenuates renal ischemia/reperfusion injury in rats administered cyclosporine A.
    The American journal of the medical sciences, 2003, Volume: 326, Issue:3

    Topics: Analysis of Variance; Animals; Body Weight; Cyclosporine; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Hemodynamics; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Iohexol; Ischemia; Kidney; Male; Microcirculation; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Time Factors; Vasoconstrictor Agents

2003
Simvastatin and L-arginine preserve renal function after ischemia/reperfusion injury.
    The American journal of the medical sciences, 2005, Volume: 329, Issue:1

    Topics: Animals; Arginine; Cyclosporine; Drug Therapy, Combination; Glomerular Filtration Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Kidney Diseases; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin

2005
Pretreatment with simvastatin reduces lung injury related to intestinal ischemia-reperfusion in rats.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:1

    Topics: Animals; Intestinal Mucosa; Intestines; Lung; Lung Injury; Male; Premedication; Rats; Rats, Wistar; Reperfusion Injury; Respiratory Distress Syndrome; Simvastatin

2006
Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats.
    Die Pharmazie, 2006, Volume: 61, Issue:9

    Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Cholesterol; Cholesterol, Dietary; Clofibrate; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Sterol O-Acyltransferase

2006
[Effects of xuezhikang and simvastatin on cerebral ischemia-reperfusion injury in rat].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:17

    Topics: Animals; Brain; Brain Ischemia; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin

2006
Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat.
    Journal of pharmacological sciences, 2006, Volume: 102, Issue:4

    Topics: Animals; Creatinine; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intravenous; Kidney; Male; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Sodium; Urea

2006
Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model.
    Journal of vascular surgery, 2007, Volume: 45, Issue:3

    Topics: Animals; Diabetes Mellitus, Experimental; Edema; Glutathione; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Male; Malondialdehyde; Muscle, Skeletal; Necrosis; Peroxidase; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Severity of Illness Index; Simvastatin; Time Factors; Tourniquets

2007
Acute neurovascular unit protection by simvastatin in transient cerebral ischemia.
    Neurological research, 2006, Volume: 28, Issue:8

    Topics: Aminoisobutyric Acids; Animals; Anticholesteremic Agents; Autoradiography; Blood-Brain Barrier; Brain Edema; Brain Infarction; Capillary Permeability; Carbon Isotopes; Cholesterol; Disease Models, Animal; Functional Laterality; Ischemic Attack, Transient; Male; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury; Simvastatin

2006
Statins inhibit neutrophil infiltration in skeletal muscle reperfusion injury.
    The Journal of surgical research, 2007, Volume: 141, Issue:2

    Topics: Animals; Collagen Type IV; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Matrix Metalloproteinase 9; Muscle, Skeletal; Neutrophil Infiltration; Ornithine; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin

2007
Simvastatin attenuates cardiac isograft ischemia-reperfusion injury by down-regulating CC chemokine receptor-2 expression.
    The Journal of thoracic and cardiovascular surgery, 2007, Volume: 134, Issue:3

    Topics: Animals; Down-Regulation; Heart Transplantation; Male; Rats; Rats, Inbred Lew; Receptors, CCR2; Receptors, Chemokine; Reperfusion Injury; Simvastatin

2007
Pharmacological preconditioning with simvastatin protects liver from ischemia-reperfusion injury by heme oxygenase-1 induction.
    Transplantation, 2008, Mar-15, Volume: 85, Issue:5

    Topics: Alanine Transaminase; Animals; Apoptosis; Enzyme Induction; Female; Heme Oxygenase-1; Hemodynamics; Immunohistochemistry; Ischemic Preconditioning; Liver; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin

2008
Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Cholesterol; Creatine Kinase; Dihydropyridines; Epoprostenol; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Lipids; Male; Nitrobenzenes; Piperazines; Rats; Reperfusion Injury; Simvastatin; Thromboxane B2; Triglycerides; Tumor Necrosis Factor-alpha

2008
Simvastatin reduces postischemic coronary dysfunction: ultrastructural and functional findings after acute administration.
    Microvascular research, 2000, Volume: 59, Issue:1

    Topics: Animals; Capillaries; Coronary Vessels; Dose-Response Relationship, Drug; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Microcirculation; Microscopy, Electron; Mitochondria; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin

2000