Compounds > simvastatin
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simvastatin and Pulmonary Hypertension

simvastatin has been researched along with Pulmonary Hypertension in 49 studies

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's23 (46.94)29.6817
2010's25 (51.02)24.3611
2020's1 (2.04)2.80

Authors

AuthorsStudies
Chalupský, K; D Uris Ova, J; Hampl, V; Kaftanová, B; Krása, K; Miková, D; Minaříkova, M; Srbová, M; Vajnerova, O1
Liu, WH; Liu, ZH; Luo, Q; Wang, Y; Xi, QY; Xu, XH; Zhang, HL; Zhao, ZH1
Arzt, M; Blumberg, FC; Lange, TJ; Lehmann, H; Nowrotek, A; Pfeifer, M; Schroll, S; Sebah, D; Wensel, R1
Hou, WW; Li, J; Liu, S; Wang, SH; Wang, ZZ; Yang, JH1
Jasińska-Stroschein, M; Kącikowska, J; Orszulak-Michalak, D; Owczarek, J; Surowiecka, A1
Archer-Chicko, C; Bagiella, E; Girgis, RE; Hassoun, PM; Horn, EM; Kawut, SM; Lederer, DJ; Mathai, SC; Matura, LA; Palevsky, HI; Pinder, D; Roberts, KE; Tracy, RP; Ventetuolo, CE1
Jiang, X; Li, P; Sun, B; Sun, W; Wang, J; Wang, P; Yuan, L; Zhang, L1
Ivanovska, J; Jain, A; Jankov, RP; Kantores, C; Wong, MJ1
Chai, CY; Chen, IC; Chen, IJ; Chou, SH; Dai, ZK; Tan, MS; Wu, BN; Yeh, JL1
Li, M; Li, Z; Sun, X1
Hua, YM; Liu, B; Liu, HM; Qiao, LN; Shi, K; Wang, XM; Wang, XQ; Wei, L; Zhao, SS; Zhou, TF1
Satoh, A; Satoh, M1
Chen, CF; Chen, JS; Hsu, HH; Hsu, JY; Ko, WJ; Lai, IR; Lee, YC1
Ji, YQ; Li, G; Liu, CP; Lu, WX; Zhang, WH; Zhang, YJ1
Akagi, S; Date, H; Fujio, H; Ikeda, T; Ito, H; Kusano, KF; Matsubara, H; Miura, A; Miura, D; Nakamura, K; Ogawa, A; Ohe, T; Oto, T; Otsuka, F; Yamanaka, R1
Ali, O; Mamanova, L; Sebkhi, A; Wharton, J; Wilkins, MR; Wojciak-Stothard, B; Yang, Q; Zhao, L1
Liu, B; Liu, HM; Wang, XM; Wang, XQ; Yu, L; Zhou, TF1
Burg, ED; Huang, X; Kuang, T; Pang, B; Wang, C; Wang, J; Yuan, JX1
Ali, O; Bradlow, W; Ghofrani, HA; Gibbs, JS; Howard, L; Mohiaddin, RH; Nihoyannopoulos, P; Rhodes, CJ; Taegtmeyer, A; Wharton, J; Wilkins, MR1
Churg, AM; Golbidi, S; Laher, I; Marshall, C; Preobrazhenska, O; Sin, DD; Wright, JL; Zhou, S1
Day, RW; King, WT1
Chen, CF; Chen, JS; Hsu, HH; Hsu, JY; Ko, WJ; Lai, IR; Lee, YC; Ruan, T1
Al-Naamani, N; Bagiella, E; Barr, RG; Girgis, R; Hassoun, P; Horn, EM; Kawut, SM; Lederer, DJ; Post, W; Roberts, KE; Shimbo, D; Tracy, R1
Liu, B; Liu, HM; Liu, ZQ; Wang, J; Wang, XQ; Yu, L1
DeFilippis, A; Eberlein, M; Girgis, RE; Iacono, A; Jones, S; Lechtzin, N; Reed, RM1
Bagiella, E; Barr, RG; Girgis, RE; Hassoun, PM; Hill, NS; Horn, EM; Kawut, SM; Lederer, DJ; Palevsky, HI; Post, W; Roberts, KE; Rosenzweig, EB; Shimbo, D; Tracy, RP1
Li, DH; Mao, H; Wang, CJ; Zhang, SS1
Rich, S1
Liu, CP; Lu, WX; Yu, BX; Zhang, WH; Zhang, YJ1
Adeli, SH; Fereshtehnejad, SM; Mostafapour, E; Mousavi, SA; Namegh, B; Shahmiri, SS; Ziaeenejad, MT1
Han, D; Li, M; Li, S; Liu, Y; Lu, J; Shi, H; Wang, G; Wu, Y; Xie, X; Xu, J; Zhang, D; Zhang, Y1
Jiang, L; Liu, H; Zhou, T1
Ji, YQ; Liu, CP; Lu, WX; Zeng, Q; Zhang, WH; Zhang, YJ1
Chen, G; Liang, M; Ma, X; Tang, B; Wang, Z; Wu, Z; Xiong, M; Yao, J1
Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG; Qiu, D; Vaszar, LT1
Rubin, LJ1
Garcia, JG; Girgis, RE; Hassoun, PM; Johns, RA; Li, D; Tuder, RM; Zhan, X1
Benson, G; Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG; Qiu, D; Shi, L; Vaszar, LT; Zhao, G1
Kao, PN1
Choe, KH; Kim, EK; Kim, SE; Lee, DS; Lee, JH; Lee, SD; Lee, YS; Oh, YM; Shim, TS1
Garcia, JG; Girgis, RE; Grigoryev, DN; Hassoun, PM; Johns, RA; Li, D; Ma, SF; Tuder, RM; Ye, S1
Klinger, JR; Martin, KB; Rounds, SI1
Dou, H; Li, P; Su, J; Zhang, T; Zhao, L; Zhao, Y; Zhou, TF1
Burns, N; Choe, KH; Cool, C; Kasper, M; Scerbavicius, R; Taraseviciene-Stewart, L; Tuder, RM; Voelkel, NF; Wood, K1
Archer, SL; Michelakis, ED1
Gurbanov, E; Shiliang, X1
Champion, HC; Girgis, RE; Hassoun, PM; Johns, RA; Li, D; Mozammel, S; Peng, X; Shimoda, L; Tuder, RM1
Dou, H; Li, M; Liu, HM; Tang, ZH; Zhao, L; Zhou, TF1
Archer, SL; Bonnet, S; Haromy, A; McMurtry, MS; Michelakis, ED1

Reviews

3 review(s) available for simvastatin and Pulmonary Hypertension

ArticleYear
Pulmonary arterial hypertension: new insights and new hope.
    Respirology (Carlton, Vic.), 2006, Volume: 11, Issue:1

    Topics: Animals; Dichloroacetic Acid; Drug Design; Drugs, Investigational; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Potassium Channels; Serotonin Antagonists; Simvastatin; Vascular Resistance; Vasodilator Agents

2006
An evidence-based approach to the management of pulmonary arterial hypertension.
    Current opinion in cardiology, 2006, Volume: 21, Issue:4

    Topics: Antihypertensive Agents; Benzamides; Bosentan; Calcium Channel Blockers; Comorbidity; Dichloroacetic Acid; Drug Therapy, Combination; Epoprostenol; Evidence-Based Medicine; Fluoxetine; Humans; Hypertension, Pulmonary; Iloprost; Imatinib Mesylate; Isoxazoles; Phosphodiesterase Inhibitors; Piperazines; Prostaglandins, Synthetic; Pulmonary Artery; Purines; Pyrimidines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Simvastatin; Sulfonamides; Sulfones; Thiophenes; Vasodilator Agents

2006
The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2006, Volume: 30, Issue:3

    Topics: Apoptosis; Dichloroacetic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Lovastatin; MAP Kinase Kinase Kinase 5; Microtubule-Associated Proteins; Muscle, Smooth, Vascular; Neoplasm Proteins; Pancreatic Elastase; PPAR gamma; Protein Serine-Threonine Kinases; Pulmonary Circulation; Receptor, Bradykinin B2; rho-Associated Kinases; Simvastatin; Survivin; Thrombosis; Vasoconstriction

2006

Trials

5 trial(s) available for simvastatin and Pulmonary Hypertension

ArticleYear
Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension.
    Annals of the American Thoracic Society, 2015, Volume: 12, Issue:3

    Topics: Administration, Oral; Aspirin; Biomarkers; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Interleukin-6; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Pulmonary Wedge Pressure; Quality of Life; Simvastatin; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha

2015
Simvastatin as a treatment for pulmonary hypertension trial.
    American journal of respiratory and critical care medicine, 2010, May-15, Volume: 181, Issue:10

    Topics: Adult; Aged; Antihypertensive Agents; Double-Blind Method; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Simvastatin; Ultrasonography; Young Adult

2010
Rationale and design of a phase II clinical trial of aspirin and simvastatin for the treatment of pulmonary arterial hypertension: ASA-STAT.
    Contemporary clinical trials, 2011, Volume: 32, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-Reactive Protein; Data Interpretation, Statistical; Double-Blind Method; Familial Primary Pulmonary Hypertension; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; P-Selectin; Quality of Life; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome

2011
Randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension: ASA-STAT.
    Circulation, 2011, Jun-28, Volume: 123, Issue:25

    Topics: Adult; Aspirin; Cholesterol; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Retrospective Studies; Simvastatin; Treatment Outcome; Walking

2011
[Clinical study on simvastatin treatment of pulmonary hypertension in patients with coal worker's pneumoconiosis].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2011, Volume: 29, Issue:3

    Topics: Aged; Aged, 80 and over; Anthracosis; Coal Mining; Humans; Hypertension, Pulmonary; Male; Middle Aged; Simvastatin

2011

Other Studies

41 other study(ies) available for simvastatin and Pulmonary Hypertension

ArticleYear
Simvastatin and dehydroepiandrosterone sulfate effects against hypoxic pulmonary hypertension are not additive.
    Physiological research, 2022, Dec-16, Volume: 71, Issue:6

    Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hypertension, Pulmonary; Hypoxia; Male; Pulmonary Artery; Rats; Simvastatin

2022
Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2018, Volume: 40, Issue:3

    Topics: Animals; Blood Pressure; Cell Proliferation; Cells, Cultured; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Male; Mevalonic Acid; Monocrotaline; Polyisoprenyl Phosphates; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Signal Transduction; Simvastatin; Vascular Remodeling

2018
Effects of simvastatin on pulmonary fibrosis, pulmonary hypertension and exercise capacity in bleomycin-treated rats.
    Acta physiologica (Oxford, England), 2013, Volume: 208, Issue:2

    Topics: Animals; Bleomycin; Hydroxyproline; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung Compliance; Male; Motor Activity; Natriuretic Peptide, Brain; Pulmonary Fibrosis; Random Allocation; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Simvastatin

2013
[Protective effects of beraprost plus simvastatin on monocrotaline-induced pulmonary arterial hypertension in rats].
    Zhonghua yi xue za zhi, 2013, Jun-11, Volume: 93, Issue:22

    Topics: Animals; Drug Therapy, Combination; Epoprostenol; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Simvastatin

2013
HMG-COA reductase inhibitors: An opportunity for the improvement of imatinib safety. An experimental study in rat pulmonary hypertension.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:1

    Topics: Animals; Drug Synergism; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Organ Size; Rats; Rats, Wistar; Rosuvastatin Calcium; Simvastatin

2015
Effect of Simvastatin on 5-HT and 5-HTT in a Rat Model of Pulmonary Artery Hypertension.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 37, Issue:5

    Topics: Animals; Blood Pressure; Body Weight; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Simvastatin; Smoking

2015
Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling.
    American journal of physiology. Lung cellular and molecular physiology, 2016, 11-01, Volume: 311, Issue:5

    Topics: Animals; Animals, Newborn; Biosynthetic Pathways; Blood Pressure; Cholesterol; Chronic Disease; Female; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; Myelin Sheath; Nitric Oxide Synthase Type III; Organ Size; Physical Conditioning, Animal; Polyisoprenyl Phosphates; Pulmonary Artery; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Sesquiterpenes; Signal Transduction; Simvastatin; Vascular Remodeling

2016
Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho-kinase pathway and NADPH oxidase.
    Pediatric pulmonology, 2017, Volume: 52, Issue:4

    Topics: Animals; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; NADPH Oxidases; Rats; Rats, Wistar; Reactive Oxygen Species; rho-Associated Kinases; Simvastatin; Ventricular Dysfunction, Left

2017
Statins suppress MMP2 secretion via inactivation of RhoA/ROCK pathway in pulmonary vascular smooth muscles cells.
    European journal of pharmacology, 2008, Sep-04, Volume: 591, Issue:1-3

    Topics: Angiotensin II; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin

2008
[Expression of connective tissue growth factor and its down-regulation by simvastatin administration in pulmonary hypertensive rats].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2008, Volume: 46, Issue:5

    Topics: Animals; Connective Tissue Growth Factor; Down-Regulation; Hypertension, Pulmonary; Male; Rats; Rats, Sprague-Dawley; Simvastatin

2008
3-Hydroxy-3-methylglutaryl (HMG)-COA reductase inhibitors and phosphodiesterase type V inhibitors attenuate right ventricular pressure and remodeling in a rat model of pulmonary hypertension.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2009, Feb-04, Volume: 11, Issue:2

    Topics: Animals; Atorvastatin; Disease Models, Animal; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Pravastatin; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Simvastatin

2009
Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats.
    Respiratory research, 2009, May-02, Volume: 10

    Topics: Animals; Female; Heme Oxygenase (Decyclizing); Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Rats; Rats, Wistar; Signal Transduction; Simvastatin; Treatment Outcome

2009
[Simvastatin prevents the development of pulmonary hypertension in the rats through reduction of inflammation].
    Zhonghua yi xue za zhi, 2009, Mar-31, Volume: 89, Issue:12

    Topics: Animals; Chemokine CCL2; Disease Models, Animal; Hypertension, Pulmonary; Interleukin-6; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha

2009
Inhibitory effects of simvastatin on platelet-derived growth factor signaling in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension.
    Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:1

    Topics: Adolescent; Adult; Aged; Cell Movement; Cell Proliferation; Child; Cyclin-Dependent Kinase Inhibitor p27; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Middle Aged; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Pulmonary Artery; Signal Transduction; Simvastatin; Young Adult

2010
Simvastatin and sildenafil combine to attenuate pulmonary hypertension.
    The European respiratory journal, 2009, Volume: 34, Issue:4

    Topics: Animals; Cyclic GMP; Disease Models, Animal; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Circulation; Purines; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Signal Transduction; Sildenafil Citrate; Simvastatin; Sulfones

2009
Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.
    Experimental lung research, 2009, Volume: 35, Issue:5

    Topics: Animals; Blood Pressure; Blotting, Western; Cell Proliferation; Disease Models, Animal; Down-Regulation; GATA6 Transcription Factor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Time Factors

2009
Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats.
    Pulmonary pharmacology & therapeutics, 2010, Volume: 23, Issue:5

    Topics: Animals; Anticholesteremic Agents; Disease Models, Animal; Drug Therapy, Combination; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Simvastatin; Sulfones

2010
Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling.
    American journal of respiratory and critical care medicine, 2011, Jan-01, Volume: 183, Issue:1

    Topics: Airway Remodeling; Animals; Disease Models, Animal; Guinea Pigs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Prognosis; Pulmonary Artery; Pulmonary Emphysema; Pulmonary Wedge Pressure; Simvastatin; Smoking; Vasoconstriction

2011
Treatment of pediatric pulmonary hypertension with simvastatin: an observational study.
    Pediatric pulmonology, 2011, Volume: 46, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Retrospective Studies; Simvastatin

2011
Effects of simvastatin on pulmonary C-fiber sensitivity in rats with monocrotaline-induced pulmonary hypertension.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2011, Volume: 30, Issue:3

    Topics: Animals; Disease Models, Animal; Heme Oxygenase (Decyclizing); Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Nerve Fibers, Unmyelinated; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Simvastatin

2011
Simvastatin has beneficial effect on pulmonary artery hypertension by inhibiting NF-κB expression.
    Molecular and cellular biochemistry, 2011, Volume: 354, Issue:1-2

    Topics: Animals; Arterioles; Blood Pressure; Cell Proliferation; Cells, Cultured; Drug Evaluation, Preclinical; Hypertension, Pulmonary; Lung; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Simvastatin; Transcription, Genetic

2011
Statin therapy is associated with decreased pulmonary vascular pressures in severe COPD.
    COPD, 2011, Volume: 8, Issue:2

    Topics: Aged; Atorvastatin; Cross-Sectional Studies; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Pulmonary Wedge Pressure; Pyrroles; Regression Analysis; Simvastatin

2011
Future of clinical trials for pulmonary hypertension.
    Circulation, 2011, Jun-28, Volume: 123, Issue:25

    Topics: Aspirin; Drug Therapy, Combination; Exercise Tolerance; Humans; Hypertension, Pulmonary; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome; Walking

2011
Simvastatin protects against the development of monocrotaline-induced pulmonary hypertension in rats via a heme oxygenase-1-dependent pathway.
    Experimental lung research, 2011, Volume: 37, Issue:8

    Topics: Animals; Arterioles; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Lung; Monocrotaline; Protoporphyrins; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin

2011
Evaluation of the simvastatin effects in the treatment of pulmonary hypertension (PH).
    Lijecnicki vjesnik, 2009, Volume: 131 Suppl 6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Middle Aged; Pulmonary Artery; Simvastatin; Young Adult

2009
Statins inhibit pulmonary artery smooth muscle cell proliferation by upregulation of HO-1 and p21WAF1.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:10

    Topics: Animals; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Heme Oxygenase-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Serotonin; Simvastatin; Transfection; Up-Regulation

2012
Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.
    Die Pharmazie, 2012, Volume: 67, Issue:6

    Topics: Actins; Animals; Arterioles; Blood Vessels; Cell Proliferation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Immunochemistry; Immunohistochemistry; KATP Channels; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pinacidil; Poisons; Polymerase Chain Reaction; Pulmonary Circulation; Rats; Simvastatin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Vasodilator Agents

2012
Additive effect of tadalafil and simvastatin on monocrotaline-induced pulmonary hypertension rats.
    Scandinavian cardiovascular journal : SCJ, 2012, Volume: 46, Issue:6

    Topics: Animals; Antihypertensive Agents; Arterial Pressure; Arterioles; Carbolines; Disease Models, Animal; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Simvastatin; Tadalafil; Time Factors; Vasodilator Agents

2012
Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and -9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2012, Volume: 42, Issue:5

    Topics: Animals; Arteriovenous Shunt, Surgical; Biomarkers; Blood Pressure; Blotting, Western; Carotid Arteries; Disease Models, Animal; Down-Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Jugular Veins; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Simvastatin; Treatment Outcome

2012
Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.
    American journal of respiratory and critical care medicine, 2002, Nov-15, Volume: 166, Issue:10

    Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Disease Models, Animal; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Organ Size; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Treatment Outcome; Tunica Intima

2002
Therapy of pulmonary hypertension: the evolution from vasodilators to antiproliferative agents.
    American journal of respiratory and critical care medicine, 2002, Nov-15, Volume: 166, Issue:10

    Topics: Animals; Anticholesteremic Agents; Antineoplastic Agents; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Simvastatin; Treatment Outcome; Vasodilator Agents

2002
Attenuation of chronic hypoxic pulmonary hypertension by simvastatin.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:3

    Topics: Animals; Chronic Disease; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypoxia; Lung; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Simvastatin

2003
Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells.
    Circulation, 2003, Sep-30, Volume: 108, Issue:13

    Topics: Animals; Apoptosis; Arterial Occlusive Diseases; Cell Division; Gene Expression Profiling; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Lung; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Simvastatin; Survival Analysis; Tunica Intima

2003
Simvastatin treatment of pulmonary hypertension: an observational case series.
    Chest, 2005, Volume: 127, Issue:4

    Topics: Adult; Aged; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Middle Aged; Simvastatin

2005
Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs.
    American journal of respiratory and critical care medicine, 2005, Oct-15, Volume: 172, Issue:8

    Topics: Administration, Oral; Analysis of Variance; Animals; Biopsy; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Nitric Oxide Synthase; Pulmonary Artery; Pulmonary Emphysema; Rats; Rats, Sprague-Dawley; Risk Factors; Simvastatin; Smoking; Time Factors

2005
Differential gene expression in chronic hypoxic pulmonary hypertension: effect of simvastatin treatment.
    Chest, 2005, Volume: 128, Issue:6 Suppl

    Topics: Animals; Chronic Disease; Gene Expression; Hypertension, Pulmonary; Hypoxia; Microarray Analysis; Rats; Rats, Sprague-Dawley; Simvastatin

2005
[The change of mast cells and macrophages in the lung of rat with pulmonary hypertension].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2006, Volume: 37, Issue:2

    Topics: Animals; Cell Count; Hypertension, Pulmonary; Hypolipidemic Agents; Lung; Macrophages; Male; Mast Cells; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin

2006
Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 291, Issue:4

    Topics: Animals; Apoptosis; Caspase 3; Caspases; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Male; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Signal Transduction; Simvastatin

2006
Regression of chronic hypoxic pulmonary hypertension by simvastatin.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:5

    Topics: Animals; Blood Pressure; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Male; Protein Serine-Threonine Kinases; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Simvastatin

2007
[Effect of simvastatin on rat pulmonary hypertension induced by high pulmonary blood flow and injected monocrotaline].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2007, Volume: 38, Issue:3

    Topics: Animals; Cholesterol; Hemodynamics; Hypertension, Pulmonary; Immunohistochemistry; Injections; Male; Monocrotaline; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Simvastatin

2007
Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 293, Issue:4

    Topics: Animals; Atorvastatin; Blood Pressure; Disease Progression; Dose-Response Relationship, Drug; Drug Synergism; Echocardiography; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphorylation; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Simvastatin; Sirolimus

2007