simvastatin and Pregnancy

Topics: Aged; Cholesterol; Drug Interactions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins; Lovastatin; Male; Pravastatin; Pregnancy; Simvastatin

Topics: Animals; Depression; Female; Hippocampus; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Stress, Psychological

Topics: Cell Differentiation; Cells, Cultured; Female; Growth Differentiation Factor 2; Humans; Osteogenesis; Placenta; Pregnancy; Simvastatin; Stem Cells

Topics: Animals; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Skeletal; Neuromuscular Junction; Postpartum Period; Pregnancy; Rats; Rats, Wistar; Rosuvastatin Calcium; Simvastatin

Topics: Animals; Bronchopulmonary Dysplasia; Female; Gene Expression Profiling; Hyperoxia; Pregnancy; Premature Birth; Rabbits; Random Allocation; Respiratory Function Tests; Simvastatin; Survival Analysis

Topics: Cell Survival; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Pravastatin; Pre-Eclampsia; Pregnancy; Rosuvastatin Calcium; Simvastatin; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor Receptor-1

Topics: Adult; Cellular Senescence; Chorioallantoic Membrane; Extraembryonic Membranes; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pregnancy; Progesterone; Pyridines; Rosuvastatin Calcium; Simvastatin; Smoke; Young Adult

Topics: Animals; Female; Fetal Development; Hernias, Diaphragmatic, Congenital; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Phosphodiesterase 5 Inhibitors; Pregnancy; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Simvastatin; X-Ray Microtomography

Topics: Animals; Anticholesteremic Agents; Cells, Cultured; Disease Models, Animal; Drug Repositioning; Female; Humans; Inflammation; Lipopolysaccharides; Mice; Muscle, Smooth; Myometrium; Obstetric Labor, Premature; Pregnancy; Signal Transduction; Simvastatin; Uterine Contraction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Female; In Vitro Techniques; Muscle Contraction; Pregnancy; Pyridines; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Simvastatin

Topics: Animals; Dose-Response Relationship, Drug; Female; Fetus; Gestational Age; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Male; Organ Culture Techniques; Organogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Risk Assessment; Sex Differentiation; Sexual Development; Simvastatin; Testis; Testosterone

Topics: Animals; Antibodies, Neutralizing; Cells, Cultured; Cerebral Cortex; Complement Activation; Complement C5a; Female; Fetus; Gene Expression Regulation; Glutamic Acid; Humans; Infant, Newborn; Mice; Models, Animal; Neurons; Pravastatin; Pregnancy; Premature Birth; Receptor, Anaphylatoxin C5a; Receptors, Glutamate; Signal Transduction; Simvastatin

Topics: Animals; Dose-Response Relationship, Drug; Down-Regulation; Female; Fetal Blood; Gene Expression Regulation, Developmental; Gestational Age; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Maternal Exposure; Phthalic Acids; Pregnancy; Rats, Sprague-Dawley; Sex Differentiation; Simvastatin; Testis; Testosterone; Tissue Culture Techniques

Topics: Adult; Doxycycline; Drug Prescriptions; Female; Humans; Netherlands; Norethindrone; Paroxetine; Practice Patterns, Physicians'; Pregnancy; Simvastatin; Teratogens; Time Factors; Triptorelin Pamoate

Topics: Animals; Apoptosis; Bone Morphogenetic Protein Receptors, Type II; Female; Hernias, Diaphragmatic, Congenital; Lung; Lung Diseases; Phenyl Ethers; Pregnancy; Rats, Sprague-Dawley; Simvastatin; Vascular Remodeling

Topics: Cytokines; Embryo Culture Techniques; Extraembryonic Membranes; Female; Fetus; Humans; Inflammation; Lipopolysaccharides; Pregnancy; Receptors, Cytokine; Simvastatin; Tissue Inhibitor of Metalloproteinase-2

Topics: Endoglin; Female; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Rosuvastatin Calcium; Simvastatin; Trophoblasts; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1

Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-10; Malondialdehyde; MAP Kinase Signaling System; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Pre-Eclampsia; Pregnancy; Rats; Simvastatin; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Animals; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Disease Models, Animal; Factor VIIa; Female; Fetal Death; Gene Deletion; Gene Expression Regulation; Humans; Immunoglobulin G; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Activation; Neutrophils; Phagocytosis; Pregnancy; Reactive Oxygen Species; Receptor, PAR-1; Receptor, PAR-2; Respiratory Burst; Signal Transduction; Simvastatin; Thromboplastin

Topics: Adult; Cholesterol Ester Storage Disease; Contraindications; Female; Humans; Lipids; Pregnancy; Pregnancy Complications; Simvastatin

Topics: Abortion, Habitual; Animals; Antibodies, Antiphospholipid; Female; Injections, Intraperitoneal; Mice; Mice, Knockout; Mice, Transgenic; Neutrophil Activation; Neutrophils; Pravastatin; Pregnancy; Receptor, PAR-2; Simvastatin; Thromboplastin

Topics: Carbon Monoxide; Cells, Cultured; Down-Regulation; Endothelial Cells; ErbB Receptors; Factor Xa; Female; Gene Expression; Heme Oxygenase-1; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; MAP Kinase Signaling System; Pre-Eclampsia; Pregnancy; Protein Kinase C; Proto-Oncogene Proteins pp60(c-src); Receptor, PAR-2; Simvastatin; Solubility; Umbilical Veins; Vascular Endothelial Growth Factor Receptor-1

Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Cognition Disorders; Diet, High-Fat; Female; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Lactation; Male; Maternal Nutritional Physiological Phenomena; Neurogenesis; Neurons; Neuroprotective Agents; Nootropic Agents; Pregnancy; Rats; Rats, Sprague-Dawley; Simvastatin

Topics: Animals; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mice; Pravastatin; Pregnancy; Premature Birth; Simvastatin

Topics: Abnormalities, Drug-Induced; Atorvastatin; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant, Newborn; Lovastatin; Pregnancy; Pregnancy Outcome; Pyrroles; Simvastatin

Topics: Apoptosis; Caspase 3; Caspases; Cell Movement; Cell Proliferation; Collagen; Drug Combinations; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunohistochemistry; Ki-67 Antigen; Laminin; Placenta; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Progesterone; Proteoglycans; Simvastatin; Teratogens; Time Factors; Trophoblasts

Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Anticholesteremic Agents; Female; Fetal Death; Humans; Lovastatin; Maternal-Fetal Exchange; Pregnancy; Pregnancy Outcome; Prospective Studies; Retrospective Studies; Simvastatin

Topics: Blotting, Western; Cell Movement; Collagen; Drug Combinations; Female; Gestational Age; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Laminin; Matrix Metalloproteinase 2; Molecular Chaperones; Neoplasm Proteins; Placenta; Pregnancy; Proteoglycans; Receptor, IGF Type 1; RNA, Messenger; Simvastatin; Trophoblasts

Topics: Animals; Anticholesteremic Agents; Cell Death; Cells, Cultured; Cerebral Cortex; Cholesterol; Female; Membrane Microdomains; Neurons; Neuroprotective Agents; Neurotoxins; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Simvastatin; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

Topics: Animals; Anticholesteremic Agents; Blood Proteins; Cells, Cultured; Cholesterol; Drug Stability; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Protein Binding; Rats; Rats, Sprague-Dawley; Simvastatin

Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Cholesterol; Female; Gonadal Steroid Hormones; Immunohistochemistry; Mammary Neoplasms, Experimental; Neoplasms, Radiation-Induced; Pituitary Gland; Pregnancy; Prolactin; Rats; Rats, Wistar; Receptors, Estrogen; Receptors, Progesterone; Simvastatin; Triglycerides

Topics: Anticholesteremic Agents; Cholelithiasis; Double-Blind Method; Female; Fenofibrate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Middle Aged; Pravastatin; Pregnancy; Risk Factors; Simvastatin

Topics: Anticholesteremic Agents; Contraindications; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Pregnancy; Simvastatin