Page last updated: 2024-08-23

simvastatin and Polycystic Ovarian Syndrome

simvastatin has been researched along with Polycystic Ovarian Syndrome in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (18.18)29.6817
2010's15 (68.18)24.3611
2020's3 (13.64)2.80

Authors

AuthorsStudies
Hao, SL; Meng, XY; Zhang, CL1
Meng, J; Zhu, Y1
Chen, L; Liu, Y; Shao, Y; Xie, J; Zhu, G1
Akiyama, I; Chang, RJ; Harada, M; Iwase, A; Nakamura, T; Nakashima, A; Ono, Y; Osuga, Y; Saito, S; Shima, T; Shimasaki, S; Ushijima, A; Yamada-Nomoto, K; Yoshino, O1
Abd Al Ghaney, A; Al Gelany, S; Hefzy, E; Ibrahim, EM; Khalifa, EM; Mohamed, MAA; Seyam, E; Youseff, AM1
Mahmud, G; Malik, M; Tasnim, N1
Hefzy, E; Seyam, E1
Gu, YY; Guan, QB; Jing, F; Yang, S; Yu, CX1
Banaszewska, B; Duleba, A; Karakas, SE; Pawelczyk, L; Spaczynski, RZ1
Gao, Q; Shen, S; Wang, Y; Xia, Yj; Yi, L; Zhang, C; Zhang, X1
Krysiak, R; Okopien, B; Zmuda, W1
Berker, B; Cengiz, SD; Cesur, M; Demirtaş, S; Erdoğan, G; Kaya, C1
Banaszewska, B; Duleba, AJ; Pawelczyk, L; Spaczynski, RZ3
Asadi, N; Dehbashi, S; Ghaffarpasand, F; Kazerooni, T; Kazerooni, Y; Shojaei-Baghini, A1
Cengiz, SD; Dünder, I; Kaya, C; Pabuccu, R1
Cress, A; Duleba, AJ; Piotrowski, PC; Rzepczynska, IJ; Sokalska, A1
Abediasl, J; Rahmanpour, H; Rashidi, B; Sills, ES; Tehraninejad, E1
Hart, RJ; Hunter, T; Raval, AD; Stuckey, B1
Fouladi, RF; Navali, N; Nikpour, MA; Pourabolghasem, S1
Banaszewska, B; Duleba, AJ; Dziura, J; Pawelczyk, L; Spaczynski, RZ1

Reviews

5 review(s) available for simvastatin and Polycystic Ovarian Syndrome

ArticleYear
Comparison of different drug for reducing testosterone levels in women with polycystic ovary syndrome: A systematic review and network meta-analysis.
    Medicine, 2023, Oct-13, Volume: 102, Issue:41

    Topics: Atorvastatin; Female; Humans; Metformin; Network Meta-Analysis; Polycystic Ovary Syndrome; Simvastatin; Spironolactone; Testosterone

2023
Efficacy of simvastatin plus metformin for polycystic ovary syndrome: A meta-analysis of randomized controlled trials.
    European journal of obstetrics, gynecology, and reproductive biology, 2021, Volume: 257

    Topics: Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Simvastatin

2021
The efficacy and safety of metformin combined with simvastatin in the treatment of polycystic ovary syndrome: A meta-analysis and systematic review.
    Medicine, 2021, Aug-06, Volume: 100, Issue:31

    Topics: Blood Glucose; Cholesterol; Drug Therapy, Combination; Female; Gonadal Steroid Hormones; Humans; Insulin; Lipoproteins, LDL; Metformin; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Simvastatin; Triglycerides

2021
The Effect of Statins on Levels of Dehydroepiandrosterone (DHEA) in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Jan-20, Volume: 25

    Topics: Adult; Atorvastatin; China; Dehydroepiandrosterone; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Middle Aged; Polycystic Ovary Syndrome; Simvastatin

2019
Statins for women with polycystic ovary syndrome not actively trying to conceive.
    The Cochrane database of systematic reviews, 2011, Oct-05, Issue:10

    Topics: Adult; Atorvastatin; Female; Heptanoic Acids; Hirsutism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperandrogenism; Hypoglycemic Agents; Menstruation Disturbances; Metformin; Polycystic Ovary Syndrome; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Young Adult

2011

Trials

13 trial(s) available for simvastatin and Polycystic Ovarian Syndrome

ArticleYear
Evaluation of prolonged use of statins on the clinical and biochemical abnormalities and ovulation dysfunction in single young women with polycystic ovary syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2018, Volume: 34, Issue:7

    Topics: Adolescent; Adult; Biomarkers; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Menstruation Disturbances; Ovulation; Placebos; Polycystic Ovary Syndrome; Simvastatin; Time Factors; Young Adult

2018
Effect of Metformin Alone Compared with Metformin Plus Simvastatin on Polycystic Ovarian Syndrome in Pakistani Women.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:3

    Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Follicle Stimulating Hormone; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Lipids; Metformin; Middle Aged; Ovary; Pakistan; Polycystic Ovary Syndrome; Simvastatin; Testosterone; Treatment Outcome

2018
Long-term effects of combined simvastatin and metformin treatment on the clinical abnormalities and ovulation dysfunction in single young women with polycystic ovary syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2018, Volume: 34, Issue:12

    Topics: Adolescent; Anticholesteremic Agents; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Metformin; Ovary; Polycystic Ovary Syndrome; Simvastatin; Young Adult

2018
Free fatty acid binding protein-4 and retinol binding protein-4 in polycystic ovary syndrome: response to simvastatin and metformin therapies.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2013, Volume: 29, Issue:5

    Topics: Adult; Drug Therapy, Combination; Fatty Acid-Binding Proteins; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Metformin; Polycystic Ovary Syndrome; Retinol-Binding Proteins, Plasma; Simvastatin; Young Adult

2013
Comparative effects of atorvastatin and simvastatin on the plasma total homocysteine levels in women with polycystic ovary syndrome: a prospective randomized study.
    Fertility and sterility, 2009, Volume: 92, Issue:2

    Topics: Adult; Anticholesteremic Agents; Atorvastatin; Female; Heptanoic Acids; Homocysteine; Humans; Hyperhomocysteinemia; Metabolic Clearance Rate; Polycystic Ovary Syndrome; Pyrroles; Retrospective Studies; Simvastatin; Treatment Outcome

2009
Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: prospective randomized trial.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:12

    Topics: Adult; Cardiovascular Diseases; Dehydroepiandrosterone Sulfate; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperandrogenism; Hypoglycemic Agents; Lipids; Metformin; Polycystic Ovary Syndrome; Prospective Studies; Risk Factors; Sex Hormone-Binding Globulin; Simvastatin; Testosterone

2009
Effects of metformin plus simvastatin on polycystic ovary syndrome: a prospective, randomized, double-blind, placebo-controlled study.
    Fertility and sterility, 2010, Volume: 94, Issue:6

    Topics: Adolescent; Adult; Anticholesteremic Agents; Cholesterol, HDL; Double-Blind Method; Drug Therapy, Combination; Female; Follicle Stimulating Hormone; Humans; Hypoglycemic Agents; Insulin Resistance; Luteinizing Hormone; Metformin; Placebos; Polycystic Ovary Syndrome; Simvastatin; Testosterone; Young Adult

2010
Comparison of the effects of atorvastatin and simvastatin in women with polycystic ovary syndrome: A prospective, randomized study.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2010, Volume: 118, Issue:3

    Topics: Adult; Atorvastatin; C-Reactive Protein; Fasting; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperandrogenism; Inflammation; Insulin; Insulin Resistance; Luteinizing Hormone; Oxidative Stress; Polycystic Ovary Syndrome; Prospective Studies; Pyrroles; Simvastatin; Testosterone; Young Adult

2010
Simvastatin effects on androgens, inflammatory mediators, and endogenous pituitary gonadotropins among patients with PCOS undergoing IVF: results from a prospective, randomized, placebo-controlled clinical trial.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2011, Volume: 59, Issue:6

    Topics: Administration, Oral; Adult; Androgens; Anticholesteremic Agents; Double-Blind Method; Female; Fertilization in Vitro; Gonadotropins; Gonadotropins, Pituitary; Humans; Inflammation; Ovulation Induction; Pituitary Gland; Polycystic Ovary Syndrome; Prospective Studies; Simvastatin; Testosterone

2011
Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:11

    Topics: Adult; C-Reactive Protein; Drug Therapy, Combination; Female; Hirsutism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperandrogenism; Hypoglycemic Agents; Lipoproteins, LDL; Metformin; Polycystic Ovary Syndrome; Simvastatin; Treatment Outcome

2011
Therapeutic effects of biguanide vs. statin in polycystic ovary syndrome: a randomized clinical trial.
    Pakistan journal of biological sciences : PJBS, 2011, Jun-01, Volume: 14, Issue:11

    Topics: Adult; Anticholesteremic Agents; Biguanides; Blood Glucose; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Simvastatin; Treatment Outcome; Young Adult

2011
Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial.
    Fertility and sterility, 2006, Volume: 85, Issue:4

    Topics: Adult; Female; Humans; Polycystic Ovary Syndrome; Prospective Studies; Simvastatin

2006
Effects of simvastatin and oral contraceptive agent on polycystic ovary syndrome: prospective, randomized, crossover trial.
    The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:2

    Topics: Adult; Contraceptives, Oral, Combined; Cross-Over Studies; Desogestrel; Drug Therapy, Combination; Estrogens; Ethinyl Estradiol; Female; Humans; Hypolipidemic Agents; Pituitary Hormones; Polycystic Ovary Syndrome; Prospective Studies; Simvastatin; Testosterone; Treatment Outcome

2007

Other Studies

4 other study(ies) available for simvastatin and Polycystic Ovarian Syndrome

ArticleYear
PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-β and TNF-α in mononuclear cells by insulin-sensitizing drugs.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2017, Volume: 78, Issue:1

    Topics: Ascitic Fluid; Cell Line; Female; Granulosa Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Leukocytes, Mononuclear; Lipopolysaccharides; Ovarian Follicle; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Protein Kinase Inhibitors; RNA, Messenger; Simvastatin; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2017
Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats.
    Human reproduction (Oxford, England), 2013, Volume: 28, Issue:11

    Topics: Animals; Dehydroepiandrosterone; Female; Fibrosis; Hypoglycemic Agents; Hypolipidemic Agents; Metformin; Ovarian Diseases; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Simvastatin; Transforming Growth Factor beta; Uterine Diseases

2013
The effect of ezetimibe on androgen production in hypercholesterolemic women with polycystic ovary syndrome.
    Cardiovascular therapeutics, 2014, Volume: 32, Issue:5

    Topics: Adult; Anticholesteremic Agents; Azetidines; Cholesterol, LDL; Ezetimibe; Female; Humans; Hypercholesterolemia; Insulin Resistance; Middle Aged; Polycystic Ovary Syndrome; Simvastatin; Testosterone

2014
Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability.
    The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:12

    Topics: Adult; Cell Division; Cell Survival; Cholesterol; Factor VIII; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Keratins; Polycystic Ovary Syndrome; Premenopause; Simvastatin; Theca Cells; Thymidine; Vimentin

2010