Page last updated: 2024-08-23

simvastatin and Pericementitis

simvastatin has been researched along with Pericementitis in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (10.00)29.6817
2010's14 (70.00)24.3611
2020's4 (20.00)2.80

Authors

AuthorsStudies
Alam, M; Farooq, U; Iqbal, Z; Jain, P; Kuruniyan, MS; Mirza, MA; Nainwal, LM; Poonkuzhi, NP1
Chatzopoulos, GS; Koidou, VP; Tsalikis, L1
Arash, S; Chen, N; Jia, Z; Killeen, AC; Lele, SM; Reinhardt, RA; Wang, D; Xu, X1
Asadullah, K; Hasan, F; Iftakhar, K; Ikram, R; Simjee, SU1
Chen, N; Lele, SM; Li, G; Mukundan, R; Reinhardt, RA; Ren, R; Wang, D; Wei, X; Xu, X; Zhao, G; Zhao, Z1
Bertl, K; Buhlin, K; Klinge, B; Pandis, N; Parllaku, A; Stavropoulos, A1
Almoshari, Y; Jia, Z; Lele, SM; Reinhardt, RA; Wang, D; Wang, X1
Bak, EJ; Cha, JH; Kim, A; Kim, AR; Kim, JH; Sohn, Y; Yoo, YJ1
Dziubla, TD; Peyyala, R; Puleo, DA; Sundararaj, SC; Thomas, MV1
Costa, TP; Fávero, GM; Fernandes, D; Machado, WM; Mendes, RT; Olchanheski, LR; Otuki, MF; Prestes, AP; Santos, FA; Sordi, R; Vellosa, JC1
Huang, Y; Jin, J; Kirkwood, KL; Li, Y; Lopes-Virella, MF; Lu, Z; Machado, ER; Yu, H; Zhang, X1
Chen, H; Liu, XQ; Lu, EY; Qin, A; Xu, XC; Zhai, ZJ; Zhang, X1
Acharya, AB; Surve, SM; Thakur, SL1
Bradley, AD; Jia, Z; Pranke, L; Reinhardt, RA; Schmid, MJ; Wang, D; Wang, X; Zhang, Y; Zhao, G1
Clemens, J; Fisher, PD; Puleo, DA; Zach Hilt, J1
Brinson, CW; Huang, Y; Lauer, AW; Leite, RS; Li, Y; Lu, Z; Pierce, TC; Poston, CJ1
Brito, GA; Dalcico, R; de Menezes, AM; Deocleciano, OB; Oriá, RB; Ribeiro, RA; Vale, ML1
Le, HO; Marx, DB; Narayana, N; Powell, SE; Price, U; Reinhardt, RA; Schmid, MJ; Wang, D; Zhang, Y1
Dehpour, AR; Eslami, B; Khojasteh, A; Mashhadi-Abbas, F; Naserhojjati-Roodsari, R; Tahsili-Fahadan, N; Vaziri, H1
Hama, H; Horibe, M; Nagata, T; Ohba, H; Seto, H; Tokunaga, K1

Reviews

2 review(s) available for simvastatin and Pericementitis

ArticleYear
Local drug delivery in the treatment of furcation defects in periodontitis: a systematic review.
    Clinical oral investigations, 2023, Volume: 27, Issue:3

    Topics: Alendronate; Dental Scaling; Furcation Defects; Humans; Periodontitis; Root Planing; Rosuvastatin Calcium; Simvastatin; Treatment Outcome

2023
The effect of local and systemic statin use as an adjunct to non-surgical and surgical periodontal therapy-A systematic review and meta-analysis.
    Journal of dentistry, 2017, Volume: 67

    Topics: Atorvastatin; Databases, Factual; Drug Administration Routes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Meta-Analysis as Topic; Periodontal Attachment Loss; Periodontal Diseases; Periodontal Index; Periodontal Pocket; Periodontitis; Rosuvastatin Calcium; Simvastatin

2017

Trials

1 trial(s) available for simvastatin and Pericementitis

ArticleYear
Effectiveness of Simvastatin 1% oral gel and mouthwash used as an adjunct treatment of scaling and root planning in the treatment of periodontal diseases.
    Pakistan journal of pharmaceutical sciences, 2019, Volume: 32, Issue:6

    Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Combined Modality Therapy; Dental Scaling; Female; Gels; Gingivitis; Humans; Male; Mouthwashes; Periodontal Attachment Loss; Periodontal Diseases; Periodontal Pocket; Periodontitis; Root Planing; Simvastatin; Tooth Mobility

2019

Other Studies

17 other study(ies) available for simvastatin and Pericementitis

ArticleYear
    Combinatorial chemistry & high throughput screening, 2022, Volume: 25, Issue:13

    Topics: Anti-Bacterial Agents; Celecoxib; Doxycycline; Humans; Hydroxyapatites; Matrix Metalloproteinase 13; Matrix Metalloproteinase 8; Matrix Metalloproteinase Inhibitors; Metronidazole; Minocycline; Molecular Docking Simulation; Osteopontin; Periodontitis; Simvastatin

2022
The Development of Thermoresponsive Polymeric Simvastatin Prodrug for the Treatment of Experimental Periodontitis in Rats.
    Molecular pharmaceutics, 2023, 11-06, Volume: 20, Issue:11

    Topics: Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Periodontitis; Polymers; Prodrugs; Rats; Simvastatin

2023
Thermoresponsive Hydrogel-Based Local Delivery of Simvastatin for the Treatment of Periodontitis.
    Molecular pharmaceutics, 2021, 05-03, Volume: 18, Issue:5

    Topics: Alveolar Bone Loss; Alveolar Process; Animals; Drug Carriers; Drug Liberation; Female; Humans; Hydrogels; Injections, Intralesional; Mice; Models, Animal; Periodontitis; Poloxamer; Rats; RAW 264.7 Cells; Simvastatin; Solubility; X-Ray Microtomography

2021
Local Application of Pyrophosphorylated Simvastatin Prevents Experimental Periodontitis.
    Pharmaceutical research, 2018, Jun-25, Volume: 35, Issue:8

    Topics: Alveolar Process; Animals; Cell Line; Cytokines; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Maxilla; Mice; Periodontitis; Phosphorylation; Prodrugs; Rats, Sprague-Dawley; RAW 264.7 Cells; Simvastatin; Solubility

2018
Simvastatin attenuates tibial bone loss in rats with type 1 diabetes and periodontitis.
    Journal of translational medicine, 2018, 11-09, Volume: 16, Issue:1

    Topics: Alveolar Bone Loss; Animals; Blood Glucose; Body Weight; Bone Morphogenetic Proteins; Bone Resorption; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fasting; Genetic Markers; Lipoproteins, LDL; Male; Osteoclasts; Periodontitis; Rats, Inbred F344; Simvastatin; Tibia; Triglycerides

2018
Design of a multiple drug delivery system directed at periodontitis.
    Biomaterials, 2013, Volume: 34, Issue:34

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Cellulose; Delayed-Action Preparations; Doxycycline; Drug Design; Humans; Ketoprofen; Metronidazole; Models, Theoretical; Periodontitis; Poloxamer; Simvastatin

2013
The effect of simvastatin on systemic inflammation and endothelial dysfunction induced by periodontitis.
    Journal of periodontal research, 2014, Volume: 49, Issue:5

    Topics: Acetylcholine; Alveolar Bone Loss; Animals; Arterial Pressure; C-Reactive Protein; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Interleukin-6; Leukocyte Count; Lipids; Male; Nitroprusside; Periodontitis; Random Allocation; Rats; Rats, Wistar; Simvastatin; Vasodilator Agents

2014
Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome.
    Journal of dental research, 2014, Volume: 93, Issue:3

    Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Blood Glucose; Chemotaxis, Leukocyte; Cholesterol; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Resistance; Interleukin-6; Leukocytes; Lipopolysaccharides; Metabolic Syndrome; Osteoclasts; Palmitic Acid; Periodontitis; RANK Ligand; Rats; Rats, Zucker; Simvastatin; Triglycerides; X-Ray Microtomography

2014
Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy.
    Journal of translational medicine, 2014, Oct-01, Volume: 12

    Topics: Alveolar Bone Loss; Animals; Biomarkers; Biomechanical Phenomena; Cell Count; Dental Cementum; Dental Enamel; Disease Models, Animal; Female; Femur; Osteocalcin; Osteoclasts; Osteogenesis; Ovariectomy; Periodontitis; Rats, Sprague-Dawley; Simvastatin; X-Ray Microtomography

2014
Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing.
    Drug metabolism and personalized therapy, 2015, Volume: 30, Issue:4

    Topics: Administration, Buccal; Adult; Atorvastatin; Case-Control Studies; Chronic Disease; Dental Scaling; Gels; Gingival Crevicular Fluid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1alpha; Middle Aged; Periodontitis; Root Planing; Simvastatin; Treatment Outcome

2015
Effect of Simvastatin Prodrug on Experimental Periodontitis.
    Journal of periodontology, 2016, Volume: 87, Issue:5

    Topics: Alveolar Bone Loss; Animals; Anticholesteremic Agents; Female; Periodontitis; Prodrugs; Rats; Rats, Sprague-Dawley; Simvastatin; X-Ray Microtomography

2016
Multifunctional poly(β-amino ester) hydrogel microparticles in periodontal in situ forming drug delivery systems.
    Biomedical materials (Bristol, England), 2016, Mar-07, Volume: 11, Issue:2

    Topics: Biocompatible Materials; Biomechanical Phenomena; Doxycycline; Drug Delivery Systems; Drug Implants; Humans; Hydrogels; Lactic Acid; Materials Testing; Particle Size; Periodontitis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Simvastatin; X-Ray Microtomography

2016
Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis.
    Oral diseases, 2016, Volume: 22, Issue:5

    Topics: Adult; Aged; Blood Glucose; Collagenases; Diabetes Complications; Diabetes Mellitus; Female; Gingival Crevicular Fluid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 8; Matrix Metalloproteinase 9; Middle Aged; Periodontal Attachment Loss; Periodontitis; Simvastatin; Up-Regulation

2016
Protective mechanisms of simvastatin in experimental periodontal disease.
    Journal of periodontology, 2013, Volume: 84, Issue:8

    Topics: Alanine Transaminase; Alkaline Phosphatase; Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Bone Morphogenetic Protein 2; Female; Gingiva; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-10; Interleukin-1beta; Malondialdehyde; Matrix Metalloproteinase 1; Matrix Metalloproteinase 8; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Osteoprotegerin; Oxidative Stress; Periodontitis; Peroxidase; RANK Ligand; Rats; Rats, Wistar; Receptor Activator of Nuclear Factor-kappa B; Simvastatin; Tumor Necrosis Factor-alpha

2013
Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss.
    Journal of periodontal research, 2013, Volume: 48, Issue:5

    Topics: Alendronate; Alveolar Bone Loss; Animals; beta-Cyclodextrins; Bone Density Conservation Agents; Drug Combinations; Endotoxins; Escherichia coli; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imaging, Three-Dimensional; Injections; Lipopolysaccharides; Maxillary Diseases; Molar; Osteoclasts; Palate; Periodontitis; Premedication; Rats; Rats, Sprague-Dawley; Sequestering Agents; Simvastatin; X-Ray Microtomography

2013
Effect of simvastatin administration on periodontitis-associated bone loss in ovariectomized rats.
    Journal of periodontology, 2007, Volume: 78, Issue:8

    Topics: Alveolar Bone Loss; Alveolar Process; Animals; Bone Density; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Injections; Mandible; Osteogenesis; Ovariectomy; Periodontal Attachment Loss; Periodontitis; Rats; Simvastatin

2007
Topical administration of simvastatin recovers alveolar bone loss in rats.
    Journal of periodontal research, 2008, Volume: 43, Issue:3

    Topics: Administration, Topical; Alkaline Phosphatase; Alveolar Bone Loss; Animals; Bone Regeneration; Cells, Cultured; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Osteoblasts; Periodontitis; Rats; Rats, Inbred F344; Simvastatin; Skull; Tomography

2008