simvastatin has been researched along with Osteogenic Sarcoma in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, Q; Li, Y; Xian, M; Yang, B; Ying, M | 1 |
| Hanschen, M; Kalbitz, M; Kany, S; Kneip, N; Relja, B; Sturm, R; Woschek, M | 1 |
| Fernández-Pérez, L; García-Castellano, JM; Guerra, B; Hernández-Perera, O; Sánchez-Gómez, M; Sandoval-Usme, MC; Umaña-Pérez, A | 1 |
| Fukuchi, Y; Kamel, WA; Maki, K; Matsuo, K; Muto, A; Nobusue, H; Onishi, N; Saya, H; Shimizu, T; Sugihara, E; Yamaguchi-Iwai, S | 1 |
| Xu, ZR; Yang, YM; Zhang, Q; Zhao, XH | 1 |
| Chaisuparat, R; Thunyakitpisal, PD | 1 |
| de Gortázar, AR; Esbrit, P; Guillén, C | 1 |
| Auberger, P; Bouvet, S; Fromigué, O; Haÿ, E; Jacquel, A; Marie, PJ; Modrowski, D | 1 |
| Balcells, S; Blanch, J; Carreras, R; Díez-Perez, A; Enjuanes, A; Grinberg, D; Mellibovsky, L; Monllau, JC; Nogues, X; Pedro-Botet, J; Ruiz-Gaspa, S | 1 |
| Abe, K; Asami, S; Kodama, T; Konishi, K; Oikawa, S; Sugiyama, M | 1 |
10 other study(ies) available for simvastatin and Osteogenic Sarcoma
| Article | Year |
|---|---|
Inhibition of KLF4 by Statins Reverses Adriamycin-Induced Metastasis and Cancer Stemness in Osteosarcoma Cells.
Topics: Animals; Antibiotics, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Down-Regulation; Doxorubicin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Neoplastic Stem Cells; Osteosarcoma; RNA Interference; RNA, Small Interfering; Simvastatin; Transcription Factors; Transplantation, Heterologous | 2017 |
Simvastatin exerts anticancer effects in osteosarcoma cell lines via geranylgeranylation and c-Jun activation.
Topics: Apoptosis; Bone Neoplasms; Cell Cycle Checkpoints; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; MAP Kinase Kinase 4; Mevalonic Acid; Osteosarcoma; Polyisoprenyl Phosphates; Prenylation; Proto-Oncogene Proteins c-jun; Sesquiterpenes; Simvastatin | 2018 |
Simvastatin impairs growth hormone-activated signal transducer and activator of transcription (STAT) signaling pathway in UMR-106 osteosarcoma cells.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Growth Hormone; Humans; Janus Kinases; Osteosarcoma; Rats; Rats, Inbred BUF; Signal Transduction; Simvastatin; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription, Genetic; Transcriptional Activation | 2014 |
Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Xenograft Model Antitumor Assays | 2017 |
Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling.
Topics: Anticholesteremic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Down-Regulation; Humans; Hydrogen Peroxide; Mitochondria; Osteosarcoma; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Simvastatin | 2012 |
Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Matrix Metalloproteinase 9; Osteoblasts; Osteosarcoma; Parietal Bone; Rats; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
The interleukin-6/soluble interleukin-6 receptor system induces parathyroid hormone-related protein in human osteoblastic cells.
Topics: Aged; Alkaline Phosphatase; Alkyl and Aryl Transferases; Bone Neoplasms; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; MAP Kinase Signaling System; Osteoblasts; Osteocalcin; Osteogenesis; Osteosarcoma; Parathyroid Hormone-Related Protein; ras Proteins; Receptors, Interleukin; Receptors, Interleukin-6; Recombinant Fusion Proteins; RNA, Messenger; Simvastatin; Tumor Cells, Cultured; Up-Regulation | 2004 |
RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation.
Topics: Anticholesteremic Agents; Apoptosis; Atorvastatin; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Caspases; Cell Differentiation; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Humans; Osteosarcoma; Phenotype; Phosphorylation; Polyisoprenyl Phosphates; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrroles; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Simvastatin; Transforming Growth Factor beta | 2006 |
Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures.
Topics: Aged; Atorvastatin; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Collagen Type I; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Osteoblasts; Osteocalcin; Osteosarcoma; Pyrroles; Simvastatin; Transforming Growth Factor beta | 2007 |
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells.
Topics: Anti-Bacterial Agents; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Bone Neoplasms; Cloning, Molecular; Disulfides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Indole Alkaloids; Lovastatin; Mevalonic Acid; Osteoporosis; Osteosarcoma; Pravastatin; Promoter Regions, Genetic; RNA, Messenger; Simvastatin; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |