simvastatin has been researched along with Obesity in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (3.64) | 18.2507 |
| 2000's | 11 (20.00) | 29.6817 |
| 2010's | 26 (47.27) | 24.3611 |
| 2020's | 16 (29.09) | 2.80 |
| Authors | Studies |
|---|---|
| Gou, Y; Hu, Y; Li, H; Lian, Q; Tian, F; Zhang, L | 1 |
| Abdelfattah, MS; Aldin, DE; Aleid, GM; Fareid, MA; Hameed, RA; Khaled, AM; Moneim, AEA; Othman, MS | 1 |
| Ahn, YM; Bang, OS; Jung, J; Kim, HL; Lee, SM; Park, SH; Seo, CS | 1 |
| da Rocha, IG; da Silva Júnior, JG; da Silva Neto, JC; de Araújo, HDA; de Menezes Lima, VL; de Oliveira Assis, SP; Oliveira, RN | 1 |
| Malakul, W; Phetrungnapha, A; Termkwancharoen, C; Tunsophon, S | 1 |
| Barta, A; Cebova, M; Danko, M; Eckstein-Andicsova, A; Koneracka, M; Mosnacek, J; Pechanova, O; Şaman, E; Zavisova, V | 1 |
| Eibl, G; Hines, OJ; Lugea, A; Pandol, SJ; Rozengurt, E; Sinnett-Smith, J; Sun, X; Teper, Y; Waldron, RT; Ye, L | 1 |
| Chen, J; Chen, L; Chen, Y; Liu, J; Lu, Y; Pan, W; Yan, C; Zhang, C; Zhang, W | 1 |
| Alem, C; Bouhlali, EDT; Bourkhis, B; Filali-Zegzouti, Y; Harnafi, H; Hmidani, A; Khouya, T | 1 |
| Alves, OL; Carmo, GMD; Cordenonsi, LM; Davies, S; de Oliveira, AL; Lorenzoni, R; Mezzomo, NJ; Raffin, RP; Rech, VC; Vaucher, RA; Viçosa, JADS | 1 |
| Armas Flórez, CD; Concepción-Zavaleta, MJ; Gonzáles Yovera, JG; Moreno Marreros, DM | 1 |
| Du, J; Jiang, Q; Li, H; Lin, S; Mei, L; Wen, J; Yang, R | 1 |
| Chae, WR; Ettrich, B; Friede, T; Gold, SM; Grabe, HJ; Hegerl, U; Hinkelmann, K; Hofmann, T; Janowitz, D; Junghanns, K; Kaczmarczyk, M; Kahl, KG; Klein, JP; Krueger, THC; Leicht, G; Lischewski, S; Märschenz, S; Nowacki, J; Otte, C; Piber, D; Prvulovic, D; Reif, A; Roepke, S; Schmidt, S; Schoettle, D; Strauss, M; Westermair, A | 1 |
| Alfulaij, N; Berry, MJ; Hashimoto, AC; Maunakea, AK; Peres, R; Seale, LA; Sultana, R; Torres, DJ; Watanabe, LM | 1 |
| Albrahim, T; Alonazi, MA | 1 |
| He, W; Mei, X; Wang, Y; Wei, W; Yang, M | 1 |
| Cai, M; Kalavagunta, PK; Liu, Q; Lv, W; Pan, Q; Qin, G; Shang, J; Wang, T; Wu, H; Xia, Z; Zhou, L | 1 |
| Cebova, M; Kosutova, M; Pechanova, O; Rehakova, R | 1 |
| Cheung, LK; Chow, DS; El-Zailik, A; Sherman, V; Wang, Y | 1 |
| Christopher-Stine, L; Isackson, PJ; Kitzmiller, JP; Luzum, JA; Ma, C; Nguyen, LM; Ochs-Balcom, HM; Peltier, W; Tarnopolsky, M; Vladutiu, GD; Weisman, M; Wortmann, RL | 1 |
| Abbas, AM; Sakr, HF | 1 |
| Brudi, P; Hanson, ME; Jimenez, JG; Massaad, R; Pirags, V; Rosen, JB; Triscari, J; Vides, H | 1 |
| Andrade, VL; Eleuterio, NM; Fernandes, KS; Sandrim, VC; Sertório, JT; Tanus-Santos, JE | 1 |
| Andrade, VL; do Valle, IB; Sandrim, VC | 1 |
| Golden, SH; Joseph, JJ | 1 |
| Bosco, AA; Eleuterio, N; Petreanu, M; Sandrim, VC | 1 |
| Andrade, VL; Eccard, B; Jordão, AA; Sandrim, VC; Sertório, JT; Silva, IF; Silveira, JN; Tanus-Santos, JE; Villela, MP | 1 |
| Laursen, JO; Thomsen, LL | 1 |
| Andrade, VL; Béla, SR; de Assis Martins-Filho, O; de Moraes, TF; Fernandes, KS; Sandrim, VC | 1 |
| Adámková, V; Češka, R; Dlouhá, D; Hrubá, P; Hubáček, JA; Viklický, O; Vrablík, M; Zlatohlavek, L | 1 |
| D'Angelo, A; Derosa, G; Maffioli, P; Mugellini, A; Pesce, RM | 1 |
| de-Madaria, E | 1 |
| Januszek, R | 1 |
| Frydrychowicz, C; Mueller, W; Pasieka, B; Petros, S; Pierer, M; Weidhase, L | 1 |
| Han, W; Li, J; Sun, L; Tang, H | 1 |
| Dallinga-Thie, GM; Hajer, GR; van Vark-van der Zee, LC; Visseren, FL | 1 |
| de Bree, P; Doevendans, PA; Hajer, GR; Hoefer, IE; Olijhoek, JK; Rafii, S; Verhaar, MC; Visseren, FL; Westerweel, PE | 1 |
| Chodick, G; Gerber, Y; Heymann, AD; Kokia, E; Shalev, V; Silber, H; Simah, V | 1 |
| Imig, JD; Knight, SF; Roy, S; Yuan, J | 1 |
| Itakura, H; Kita, T; Mabuchi, H; Matsuzaki, M; Matsuzawa, Y; Nakaya, N; Oikawa, S; Saito, Y; Sasaki, J; Shimamoto, K | 1 |
| Almeida, S; Dal-Pizzol, F; Lima, LO; Rosendo, AB | 1 |
| Cramariuc, D; Gerdts, E; Gohlke-Bärwolf, C; Lund, BP; Rieck, AE; Rossebø, AB | 1 |
| Barrett, PH; Berthold, HK; Birnbaum, J; Brämswig, S; Gouni-Berthold, I; Mertens, J; Sudhop, T; von Bergmann, K | 1 |
| Wilke, RA | 1 |
| Ahmed, HH; Assaf, N; Salem, NA | 1 |
| Hoogwerf, BJ; Nambi, V; Sprecher, DL | 1 |
| Frei, B; Higdon, JV | 1 |
| Ito, MK; Pieper, JA; Talbert, RL | 1 |
| Jacobson, MS; Kohn, M | 1 |
| Harris, WS; Isley, WL; Miles, JM; Patterson, BW | 1 |
| Nesto, RW; Singh, PP | 1 |
| Dallinga-Thie, GM; Hajer, GR; Olijhoek, JK; van Vark-van der Zee, LC; Visseren, FL | 1 |
| Bézard, J; Blond, JP; Georges, B; Maniongui, C | 1 |
| Mann, JI | 1 |
| Bennani-Kabchi, N; Cherrah, Y; El Bouayadi, F; Fdhil, H; Kehel, L; Marquie, G | 1 |
5 review(s) available for simvastatin and Obesity
| Article | Year |
|---|---|
Type 2 diabetes and cardiovascular disease: what next?
Topics: Anticholesteremic Agents; Aspirin; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Therapy, Combination; Exercise; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Obesity; Risk Factors; Risk Reduction Behavior; Simvastatin; Sleep Wake Disorders; Socioeconomic Factors; Stress, Psychological | 2014 |
[Latest advances in acute pancreatitis].
Topics: Aneurysm, False; Clostridioides difficile; Clostridium Infections; Combined Modality Therapy; Comorbidity; Diabetes Mellitus; Drainage; Fat Necrosis; Heparin, Low-Molecular-Weight; Humans; Liver Cirrhosis; Multiple Organ Failure; Nutritional Support; Obesity; Pancreatitis, Acute Necrotizing; Positron Emission Tomography Computed Tomography; Severity of Illness Index; Simvastatin | 2015 |
High-density lipoprotein (HDL) cholesterol: leveraging practice-based biobank cohorts to characterize clinical and genetic predictors of treatment outcome.
Topics: Apolipoprotein A-I; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Databases, Nucleic Acid; Dose-Response Relationship, Drug; Dyslipidemias; Electronic Health Records; Genetic Association Studies; Genetic Markers; Heptanoic Acids; Humans; Obesity; Pravastatin; Pyrroles; Risk Assessment; Simvastatin; Treatment Outcome | 2011 |
A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia.
Topics: Angiotensin-Converting Enzyme Inhibitors; Female; Humans; Hyperinsulinism; Hypertension; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Male; Metabolic Syndrome; Metformin; Motor Activity; Obesity; Simvastatin; Thiazoles; Thiazolidinediones; Weight Loss | 2002 |
Cholesterol (and cardiovascular risk) in adolescence.
Topics: Adolescent; Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Humans; Lovastatin; Obesity; Risk Factors; Simvastatin | 2004 |
11 trial(s) available for simvastatin and Obesity
| Article | Year |
|---|---|
Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial.
Topics: Berlin; Citalopram; Depression; Depressive Disorder, Major; Double-Blind Method; Humans; Multicenter Studies as Topic; Obesity; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome | 2020 |
Consistency of effect of ezetimibe/simvastatin compared with intensified lipid-lowering treatment strategies in obese and non-obese diabetic subjects.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoproteins B; Atorvastatin; Azetidines; Cholesterol, LDL; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Ezetimibe; Female; Fluorobenzenes; Heptanoic Acids; Humans; Male; Middle Aged; Obesity; Peptide Fragments; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Treatment Outcome; Young Adult | 2013 |
Simvastatin therapy decreases MMP-9 levels in obese women.
Topics: Adult; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Obesity; Simvastatin; Thiobarbituric Acid Reactive Substances; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2013 |
Effect of simvastatin treatment on plasma visfatin levels in obese women.
Topics: Adult; Body Mass Index; Cholesterol; Cytokines; Female; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Middle Aged; Nicotinamide Phosphoribosyltransferase; Obesity; Simvastatin; Triglycerides | 2014 |
Perindopril and barnidipine alone or combined with simvastatin on hepatic steatosis and inflammatory parameters in hypertensive patients.
Topics: Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Hypolipidemic Agents; Male; Nifedipine; Non-alcoholic Fatty Liver Disease; Obesity; Perindopril; Simvastatin | 2015 |
The effect of statin alone or in combination with ezetimibe on postprandial lipoprotein composition in obese metabolic syndrome patients.
Topics: Adolescent; Adult; Aged; Azetidines; Cross-Over Studies; Double-Blind Method; Ezetimibe; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Lipoproteins; Male; Metabolic Syndrome; Middle Aged; Obesity; Postprandial Period; Simvastatin | 2009 |
Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy.
Topics: Anticholesteremic Agents; Azetidines; Cross-Over Studies; Drug Therapy, Combination; Endothelial Cells; Endothelium, Vascular; Ezetimibe; Humans; Male; Metabolic Syndrome; Middle Aged; Obesity; Postprandial Period; Simvastatin; Stem Cells | 2008 |
Effect of obesity on left ventricular mass and systolic function in patients with asymptomatic aortic stenosis (a Simvastatin Ezetimibe in Aortic Stenosis [SEAS] substudy).
Topics: Aged; Aged, 80 and over; Angiography; Aortic Valve Stenosis; Azetidines; Body Mass Index; Double-Blind Method; Drug Therapy, Combination; Echocardiography, Doppler; Ezetimibe; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Logistic Models; Male; Middle Aged; Multivariate Analysis; Obesity; Probability; Prognosis; Risk Assessment; Severity of Illness Index; Simvastatin; Stroke Volume; Systole; Treatment Outcome | 2010 |
Influence of simvastatin on apoB-100 secretion in non-obese subjects with mild hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoprotein B-100; Cholesterol, LDL; Cross-Over Studies; Humans; Hypercholesterolemia; Male; Middle Aged; Obesity; Simvastatin | 2010 |
The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Kinetics; Lipoprotein Lipase; Lipoproteins; Male; Middle Aged; Obesity; Simvastatin; Single-Blind Method; Triglycerides | 2006 |
Lipid-lowering therapy does not affect the postprandial drop in high density lipoprotein-cholesterol (HDL-c) plasma levels in obese men with metabolic syndrome: a randomized double blind crossover trial.
Topics: Adolescent; Adult; Aged; Azetidines; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Cross-Over Studies; Dietary Fats; Double-Blind Method; Drug Combinations; Ezetimibe; Fasting; Humans; Male; Metabolic Syndrome; Middle Aged; Obesity; Postprandial Period; Simvastatin | 2008 |
39 other study(ies) available for simvastatin and Obesity
| Article | Year |
|---|---|
The combined anti-osteoporotic effects of simvastatin and exercise in ovariectomized mice fed a high-fat diet.
Topics: Animals; Diet, High-Fat; Estrogens; Female; Humans; Mice; Mice, Inbred C57BL; Obesity; Osteoporosis; Ovariectomy; Simvastatin; X-Ray Microtomography | 2022 |
Evaluation of antiobesity and hepatorenal protective activities of Salvia officinalis extracts pre-treatment in high-fat diet-induced obese rats.
Topics: Animals; Antioxidants; Biomarkers; Body Weight; Creatinine; Diet, High-Fat; Flavonoids; Inflammation Mediators; Insulins; Interleukin-1beta; Leptin; Lipids; NF-E2-Related Factor 2; Nitric Oxide; Obesity; Oxidative Stress; Plant Extracts; PPAR gamma; Rats; Salvia officinalis; Simvastatin; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Urea | 2022 |
Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice.
Topics: Adipogenesis; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Protein-alpha; Cholesterol; Diet, High-Fat; Hyperlipidemias; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Plant Extracts; PPAR gamma; Simvastatin; Water | 2022 |
Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance.
Topics: Animals; Carboxymethylcellulose Sodium; Cholesterol, LDL; Diabetes Mellitus, Type 2; Dyslipidemias; Hormones; Hypolipidemic Agents; Insulin Resistance; Insulins; Lipoproteins, VLDL; Mice; Obesity; Phthalimides; Simvastatin; Transaminases; Triglycerides; Uric Acid | 2022 |
Naringin Ameliorates Skeletal Muscle Atrophy and Improves Insulin Resistance in High-Fat-Diet-Induced Insulin Resistance in Obese Rats.
Topics: Animals; Antioxidants; Diet, High-Fat; Flavanones; Glucose; Glucose Transporter Type 4; Glycogen; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Skeletal; Muscular Atrophy; Obesity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin | 2022 |
Combined Therapy with Simvastatin- and Coenzyme-Q10-Loaded Nanoparticles Upregulates the Akt-eNOS Pathway in Experimental Metabolic Syndrome.
Topics: Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Metabolic Syndrome; NF-kappa B; Nitric Oxide Synthase Type III; Obesity; Proto-Oncogene Proteins c-akt; Rats; Rats, Zucker; Simvastatin | 2022 |
Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice.
Topics: Adenocarcinoma in Situ; Animals; Carcinoma, Pancreatic Ductal; Female; Male; Mice; Obesity; Pancreatic Neoplasms; Simvastatin | 2023 |
Sarcodon aspratus polysaccharides ameliorated obesity-induced metabolic disorders and modulated gut microbiota dysbiosis in mice fed a high-fat diet.
Topics: Adipose Tissue; Animals; Basidiomycota; Diet, High-Fat; Dietary Supplements; Gastrointestinal Microbiome; Glucose Intolerance; Hypolipidemic Agents; Inflammation; Lipid Metabolism; Liver; Metabolic Diseases; Mice; Obesity; Oxidative Stress; Polysaccharides; Simvastatin; Weight Gain | 2020 |
Effect of Phoenix dactylifera seeds (dates) extract in triton WR-1339 and high fat diet induced hyperlipidaemia in rats: A comparison with simvastatin.
Topics: Animals; Antioxidants; Biomarkers; Diet, High-Fat; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Lipid Peroxidation; Lipids; Male; Obesity; Phoeniceae; Plant Extracts; Polyethylene Glycols; Polyphenols; Rats, Wistar; Seeds; Simvastatin; Solvents; Weight Gain | 2020 |
Lipid-core nanocapsules containing simvastatin improve the cognitive impairment induced by obesity and hypercholesterolemia in adult rats.
Topics: Animals; Cognitive Dysfunction; Hypercholesterolemia; Lipids; Nanocapsules; Obesity; Rats; Simvastatin | 2020 |
Statins in liver cirrhosis in a developing country: benefits overweigh the risk?
Topics: Chemical and Drug Induced Liver Injury; Contraindications, Drug; Developing Countries; Hepatitis, Viral, Human; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver Cirrhosis; Meta-Analysis as Topic; Non-alcoholic Fatty Liver Disease; Obesity; Peru; Risk Assessment; Simvastatin | 2020 |
Effect of high fat diet and excessive compressive mechanical force on pathologic changes of temporomandibular joint.
Topics: Animals; Chondrocytes; Diet, High-Fat; Disease Models, Animal; Interleukin-1beta; Leptin; Male; Mandible; Matrix Metalloproteinase 3; Mice; Mice, Inbred C57BL; Obesity; Phenazines; Risk Factors; Simvastatin; Stress, Mechanical; Temporomandibular Joint | 2020 |
Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase.
Topics: Animals; Creatinine; Diet, High-Fat; Disease Models, Animal; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Liver; Lyases; Male; Mice; Mice, Knockout; Mice, Obese; Muscle, Skeletal; Obesity; Oxidative Stress; Selenium; Selenoproteins; Sex Characteristics; Simvastatin | 2021 |
Lycopene corrects metabolic syndrome and liver injury induced by high fat diet in obese rats through antioxidant, anti-inflammatory, antifibrotic pathways.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Chemical and Drug Induced Liver Injury; Cytokines; Diet, High-Fat; Fibrinolytic Agents; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Lipid Metabolism; Lipids; Liver Cirrhosis; Lycopene; Male; Metabolic Syndrome; Obesity; Rats; Rats, Wistar; Simvastatin; Weight Gain | 2021 |
Exenatide Attenuates Obesity-Induced Mitochondrial Dysfunction by Activating SIRT1 in Renal Tubular Cells.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Line; Diet, High-Fat; Down-Regulation; Exenatide; Humans; Hypoglycemic Agents; In Vitro Techniques; Kidney Tubules; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Obesity; Palmitates; Reactive Oxygen Species; Simvastatin; Sirtuin 1 | 2021 |
Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation.
Topics: Animals; Behavior, Animal; Brain; Depression; Diet, High-Fat; Hippocampus; Hyperlipidemias; Inflammation; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Obesity; Serotonin; Simvastatin | 2019 |
Simvastatin Does Not Affect Nitric Oxide Generation Increased by Sesame Oil in Obese Zucker Rats.
Topics: Animals; Aorta; Heart Ventricles; Lipids; Liver; Male; Nitric Oxide; Nitric Oxide Synthase; Obesity; Phosphorylation; Rats, Zucker; Sesame Oil; Simvastatin; Thiobarbituric Acid Reactive Substances | 2018 |
Simultaneous LC-MS/MS analysis of simvastatin, atorvastatin, rosuvastatin and their active metabolites for plasma samples of obese patients underwent gastric bypass surgery.
Topics: Adult; Atherosclerosis; Atorvastatin; Calibration; Chromatography, High Pressure Liquid; Female; Gastric Bypass; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Middle Aged; Obesity; Postoperative Period; Preoperative Period; Reproducibility of Results; Rosuvastatin Calcium; Simvastatin; Tandem Mass Spectrometry | 2019 |
Clinical features related to statin-associated muscle symptoms.
Topics: Aged; Atorvastatin; Female; Heart Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Logistic Models; Lovastatin; Male; Medical History Taking; Middle Aged; Muscle Weakness; Muscular Diseases; Myalgia; Obesity; Odds Ratio; Pravastatin; Retrospective Studies; Rhabdomyolysis; Risk Factors; Rosuvastatin Calcium; Simvastatin; Smoking; White People | 2019 |
Simvastatin and vitamin E effects on cardiac and hepatic oxidative stress in rats fed on high fat diet.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Diet, High-Fat; Dietary Fats; Drug Synergism; Glutathione Peroxidase; Glutathione Transferase; Hypercholesterolemia; Hypolipidemic Agents; Liver; Male; Obesity; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin E | 2013 |
Simvastatin treatment increases nitrite levels in obese women: modulation by T(-786)C polymorphism of eNOS.
Topics: Anticholesteremic Agents; Female; Humans; Hypercholesterolemia; Nitric Oxide Synthase Type III; Nitrites; Obesity; Polymorphism, Single Nucleotide; Simvastatin; Thiobarbituric Acid Reactive Substances | 2013 |
Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin.
Topics: Adult; Alleles; Biomarkers; C-Reactive Protein; Cholesterol; Female; Genotype; Homocysteine; Humans; Lipoproteins, LDL; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nitrites; Obesity; Polymorphism, Genetic; Risk Factors; Simvastatin; Thiobarbituric Acid Reactive Substances; Young Adult | 2014 |
[Spontaneous bilateral quadriceps tendon rupture in obese patient medicated with statin].
Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Knee Injuries; Male; Middle Aged; Obesity; Radiography; Risk Factors; Rupture; Simvastatin; Tendon Injuries; Tennis; Ultrasonography | 2014 |
Simvastatin does not reduce chemokine production in obesity without comorbidities.
Topics: Adipose Tissue; Adult; Biomarkers; C-Reactive Protein; Chemokine CCL2; Chemokine CCL5; Chemokine CXCL10; Chemokine CXCL9; Chemokines; Cholesterol; Comorbidity; Female; Humans; Hypolipidemic Agents; Inflammation; Interleukin-8; Middle Aged; Obesity; Simvastatin; Triglycerides; Young Adult | 2015 |
SLCO1B1 polymorphism is not associated with risk of statin-induced myalgia/myopathy in a Czech population.
Topics: Aged; Atorvastatin; Czech Republic; Diabetes Mellitus; Dose-Response Relationship, Drug; Dyslipidemias; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver-Specific Organic Anion Transporter 1; Male; Middle Aged; Models, Genetic; Muscular Diseases; Myalgia; Obesity; Organic Anion Transporters; Polymorphism, Single Nucleotide; Simvastatin; Smoking | 2015 |
Paraoxonase-1 activity and pleiotropic properties of simvastatin in obese and non-obese patients with stable coronary artery disease (CAD).
Topics: Adult; Aged; Aryldialkylphosphatase; C-Reactive Protein; Coronary Artery Disease; Dinoprost; Female; Humans; Male; Middle Aged; Obesity; Polymorphism, Single Nucleotide; Simvastatin; Tumor Necrosis Factor-alpha | 2016 |
Colchicine triggered severe rhabdomyolysis after long-term low-dose simvastatin therapy: a case report.
Topics: Acute Kidney Injury; Aged; Colchicine; Ezetimibe; Gout Suppressants; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Obesity; Rhabdomyolysis; Simvastatin; Treatment Outcome | 2017 |
Treatment of obese asthma in a mouse model by simvastatin is associated with improving dyslipidemia and decreasing leptin level.
Topics: Animals; Asthma; Blood Glucose; Body Weight; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dyslipidemias; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leptin; Leukocyte Count; Lipids; Lung; Mice; Mice, Inbred C57BL; Obesity; Simvastatin | 2017 |
Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in Israel.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cohort Studies; Diabetes Mellitus; Drug Costs; Emigrants and Immigrants; Female; Follow-Up Studies; Health Maintenance Organizations; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Israel; Male; Medication Adherence; Middle Aged; Obesity; Organizations, Nonprofit; Patient Compliance; Retrospective Studies; Simvastatin; Social Class; Time Factors | 2008 |
Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension.
Topics: Albuminuria; Animals; Antioxidants; Cholesterol; Cyclic N-Oxides; Dietary Fats; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney Failure, Chronic; Male; Obesity; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Risk Factors; Simvastatin; Spin Labels | 2010 |
Obesity as a risk factor for coronary events in Japanese patients with hypercholesterolemia on low-dose simvastatin therapy.
Topics: Adult; Aged; Anticholesteremic Agents; Body Mass Index; Cohort Studies; Coronary Artery Disease; Female; Humans; Hypercholesterolemia; Japan; Male; Middle Aged; Obesity; Risk Factors; Simvastatin | 2010 |
Lipid and C-reactive protein levels, cardiovascular disease risk factors and simvastatin treatment in Brazilian individuals.
Topics: Adult; Aged; Anthropometry; Blood Glucose; Brazil; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Europe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lipids; Male; Middle Aged; Obesity; Risk Factors; Simvastatin; Smoking; Triglycerides | 2010 |
Pleiotropic effects of rimonabant and simvastatin on obesity associated multiple metabolic risk factors in rats.
Topics: Animals; Chemokine CCL2; Lipids; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Risk Factors; Simvastatin; Tumor Necrosis Factor-alpha | 2012 |
Obesity and oxidative stress: a direct link to CVD?
Topics: Adipose Tissue; Adult; Aged; Aged, 80 and over; Antioxidants; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; F2-Isoprostanes; Female; Humans; Hypercholesterolemia; Interleukin-6; Liver; Male; Middle Aged; Obesity; Oxidative Stress; Risk Factors; Simvastatin | 2003 |
Niacin and the National Cholesterol Education Program Adult Treatment Panel III Guidelines: case studies.
Topics: Aspirin; Atenolol; Blood Chemical Analysis; Coronary Disease; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Niacin; Obesity; Risk Factors; Simvastatin | 2003 |
Diabetes and residual risk of coronary heart disease.
Topics: Anticholesteremic Agents; Atorvastatin; Coronary Disease; Diabetes Complications; Diabetes Mellitus; Heptanoic Acids; Humans; Insulin Resistance; Obesity; Pyrroles; Risk Factors; Simvastatin | 2007 |
Effect of simvastatin on desaturase activities in liver from lean and obese Zucker rats.
Topics: Animals; Anticholesteremic Agents; Delta-5 Fatty Acid Desaturase; Fatty Acid Desaturases; Fatty Acids; Fatty Acids, Unsaturated; In Vitro Techniques; Linoleoyl-CoA Desaturase; Lovastatin; Male; Microsomes, Liver; Obesity; Phospholipids; Rats; Rats, Zucker; Simvastatin | 1993 |
The role of nutritional modifications in the prevention of macrovascular complications of diabetes.
Topics: Antioxidants; Body Mass Index; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diet Therapy; Energy Intake; Energy Metabolism; Humans; Lovastatin; Minerals; Obesity; Simvastatin; Vitamins | 1997 |
[Therapeutic effect of Olea europea var. oleaster leaves on carbohydrate and lipid metabolism in obese and prediabetic sand rats (Psammomys obesus)].
Topics: Animals; Anticholesteremic Agents; Blood Glucose; Cholesterol, LDL; Cholesterol, VLDL; Diabetes Mellitus; Gerbillinae; Insulin Resistance; Obesity; Phytotherapy; Plant Leaves; Plants, Medicinal; Prediabetic State; Simvastatin | 2000 |