simvastatin and Neoplasm Metastasis

Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Mutation; Neoplasm Metastasis; Panitumumab; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Simvastatin

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Double-Blind Method; Drug Administration Schedule; Female; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Republic of Korea; Simvastatin; Survival Analysis; Treatment Outcome

Topics: Adult; Afatinib; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Metastasis; Neoplasm Staging; Quinazolines; Retreatment; Simvastatin; Survival Analysis; Treatment Outcome

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Simvastatin

Topics: Carcinoma, Embryonal; Cytoskeleton; Fluorescent Antibody Technique; Hep G2 Cells; Humans; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Pluripotent Stem Cells; Prenylation; Simvastatin

Topics: Cell Line, Tumor; Cell Movement; Cell Plasticity; Epithelial-Mesenchymal Transition; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Metastasis; Neoplastic Stem Cells; Ovarian Neoplasms; Simvastatin

Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; In Situ Nick-End Labeling; Janus Kinase 2; MAP Kinase Signaling System; Mice; Mice, Nude; Neoplasm Metastasis; Phosphorylation; RNA Interference; Simvastatin; STAT3 Transcription Factor; TOR Serine-Threonine Kinases

Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hippo Signaling Pathway; Humans; Hyaluronan Receptors; Mevalonic Acid; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Transplantation; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Simvastatin; Transcription Factors; YAP-Signaling Proteins

Topics: Apoptosis; Cell Adhesion; Cell Proliferation; Endometrial Neoplasms; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; Simvastatin; Tumor Cells, Cultured

Topics: Apoptosis; Autocrine Communication; Caspase 8; Cell Line, Tumor; Cells, Cultured; Fatty Acid-Binding Proteins; Gene Knockdown Techniques; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Oxidoreductases; Lipocalins; Melanocytes; Melanoma; Neoplasm Metastasis; Prostaglandin D2; Simvastatin

Topics: Animals; Anticholesteremic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Movement; Drug Synergism; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Neoplasm Metastasis; Prostatic Neoplasms, Castration-Resistant; Simvastatin

Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; bcl-X Protein; Binding Sites; Caspase 3; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Melanoma; Neoplasm Metastasis; Proto-Oncogene Proteins c-bcl-2; Simvastatin; Skin Neoplasms; STAT3 Transcription Factor; Wound Healing

Topics: Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; DNA Damage; Female; G1 Phase Cell Cycle Checkpoints; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Mice, Knockout; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Ovarian Neoplasms; Reactive Oxygen Species; Signal Transduction; Simvastatin; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice, SCID; Middle Aged; Neoplasm Metastasis; Simvastatin; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

Topics: Actins; Animals; cdc42 GTP-Binding Protein; Cytochalasin D; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrogen-Ion Concentration; Matrix Metalloproteinase 9; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neuropeptides; Phospholipase D; Promoter Regions, Genetic; rac1 GTP-Binding Protein; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Simvastatin

Topics: Amino Acid Substitution; Animals; Anticholesteremic Agents; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Mice; Mice, Nude; Mutation, Missense; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Osteolysis; Simvastatin; Transcription, Genetic; Transplantation, Heterologous; Tumor Suppressor Protein p53