simvastatin has been researched along with Neoplasm Metastasis in 16 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (6.25) | 29.6817 |
2010's | 15 (93.75) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Baiano, S; Carnuccio, R; De Cicco, R; Fuggetta, MP; Morelli, A; Morelli, F; Tatè, R; Trotta, V; Urciuoli, M; Zona, E | 1 |
Bizama, C; Brañes, J; Bravo, ML; Cerda-Infante, J; Cuello, MA; García, K; Gejman, R; Gonzalez, P; Henríquez, J; Ibañez, C; Kato, S; Liberona, MF; Montecinos, V; Owen, GI; Roa, JC; Sánchez, M | 1 |
Fang, J; Fang, Z; Guo, X; Guo, Z; Jiao, W; Liu, Z; Tang, Y; Wang, W; Xing, Z; Xu, Z; Zhou, Z | 1 |
Chen, H; Fang, X; Huang, L; Jiang, Y; Li, N; Liu, Y; Mei, L; Sun, S; Wang, H; Wang, Z; Wu, Y; Zhang, F; Zhang, X; Zhang, Y; Zheng, Y | 1 |
Bae-Jump, VL; Gehrig, PA; Gilliam, TP; Han, X; Kim, K; Schointuch, MN; Stine, JE; Zhou, C | 1 |
Hohenegger, M; Höller, C; Künzl, M; Minichsdorfer, C; Wasinger, C; Zellner, M | 1 |
Babcook, MA; Daneshgari, F; Flask, CA; Fu, P; Gupta, S; Lindner, DJ; MacLennan, GT; Molter, JP; Oak, CZ; Parker, Y; Puchowicz, MA; Shukla, S; Vazquez, EJ | 1 |
Atil, B; Hohenegger, M; Minichsdorfer, C; Sieczkowski, E; Wasinger, C | 1 |
Baas, JM; Batman, E; Bos, MM; Gelderblom, H; Guchelaar, HJ; Krens, LL; Morreau, H; Portielje, JE; van Wezel, T | 1 |
Bae-Jump, VL; Gehrig, PA; Gilliam, TP; Guo, H; Han, X; Schointuch, MN; Sheng, X; Stine, JE; Zhou, C | 1 |
Han, SW; Hong, YS; Hwang, IG; Jung, SH; Kang, HJ; Kang, WK; Kim, HS; Kim, ST; Kim, TW; Lee, J; Lee, JY; Lee, KH; Lim, HY; Lim, SH; Park, JO; Park, SH; Park, YS | 1 |
Bambhroliya, A; Bertucci, F; Birnbaum, D; Chu, K; Debeb, BG; Diagaradjan, P; Diehl, M; Finetti, P; Hittelman, W; Huang, X; Lacerda, L; Larson, R; Levental, I; Ruffell, B; Trenton, NJ; Ueno, NT; Van Laere, S; Wolfe, AR; Woodward, WA | 1 |
Baba, Y; Kato, Y; Maeda, T; Nishimura, Y; Suzuki, A; Yuzawa, S | 1 |
Go, YJ; Han, JY; Joo, J; Lee, GK; Lee, JS; Lee, KH; Lee, SH; Lee, Y; Lim, KY | 1 |
Ahn, JB; Byun, JH; Hong, YS; Im, SA; Jung, KH; Kang, WK; Kim, TW; Lee, J; Lee, N; Lim, HY; Oh, DY; Park, JO; Park, SH; Park, YS; Shin, DB; Shin, SJ | 1 |
Choudhury, GG; Ghosh-Choudhury, N; Mandal, CC; Yoneda, T | 1 |
4 trial(s) available for simvastatin and Neoplasm Metastasis
Article | Year |
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Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients.
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Mutation; Neoplasm Metastasis; Panitumumab; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Simvastatin | 2015 |
A randomised, double-blind, placebo-controlled multi-centre phase III trial of XELIRI/FOLFIRI plus simvastatin for patients with metastatic colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Double-Blind Method; Drug Administration Schedule; Female; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Republic of Korea; Simvastatin; Survival Analysis; Treatment Outcome | 2015 |
Randomized Phase II Study of Afatinib Plus Simvastatin Versus Afatinib Alone in Previously Treated Patients with Advanced Nonadenocarcinomatous Non-small Cell Lung Cancer.
Topics: Adult; Afatinib; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Metastasis; Neoplasm Staging; Quinazolines; Retreatment; Simvastatin; Survival Analysis; Treatment Outcome | 2017 |
Simvastatin plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) as first-line chemotherapy in metastatic colorectal patients: a multicenter phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Simvastatin | 2009 |
12 other study(ies) available for simvastatin and Neoplasm Metastasis
Article | Year |
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Simvastatin inhibits the expression of stemness‑related genes and the metastatic invasion of human cancer cells via destruction of the cytoskeleton.
Topics: Carcinoma, Embryonal; Cytoskeleton; Fluorescent Antibody Technique; Hep G2 Cells; Humans; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Pluripotent Stem Cells; Prenylation; Simvastatin | 2017 |
Simvastatin interferes with cancer 'stem-cell' plasticity reducing metastasis in ovarian cancer.
Topics: Cell Line, Tumor; Cell Movement; Cell Plasticity; Epithelial-Mesenchymal Transition; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Metastasis; Neoplastic Stem Cells; Ovarian Neoplasms; Simvastatin | 2018 |
Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; In Situ Nick-End Labeling; Janus Kinase 2; MAP Kinase Signaling System; Mice; Mice, Nude; Neoplasm Metastasis; Phosphorylation; RNA Interference; Simvastatin; STAT3 Transcription Factor; TOR Serine-Threonine Kinases | 2013 |
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility.
Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hippo Signaling Pathway; Humans; Hyaluronan Receptors; Mevalonic Acid; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Transplantation; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Simvastatin; Transcription Factors; YAP-Signaling Proteins | 2014 |
Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer.
Topics: Apoptosis; Cell Adhesion; Cell Proliferation; Endometrial Neoplasms; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; Simvastatin; Tumor Cells, Cultured | 2014 |
Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells.
Topics: Apoptosis; Autocrine Communication; Caspase 8; Cell Line, Tumor; Cells, Cultured; Fatty Acid-Binding Proteins; Gene Knockdown Techniques; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Oxidoreductases; Lipocalins; Melanocytes; Melanoma; Neoplasm Metastasis; Prostaglandin D2; Simvastatin | 2014 |
Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer.
Topics: Animals; Anticholesteremic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Movement; Drug Synergism; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Neoplasm Metastasis; Prostatic Neoplasms, Castration-Resistant; Simvastatin | 2014 |
Tocilizumab unmasks a stage-dependent interleukin-6 component in statin-induced apoptosis of metastatic melanoma cells.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; bcl-X Protein; Binding Sites; Caspase 3; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Melanoma; Neoplasm Metastasis; Proto-Oncogene Proteins c-bcl-2; Simvastatin; Skin Neoplasms; STAT3 Transcription Factor; Wound Healing | 2015 |
The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; DNA Damage; Female; G1 Phase Cell Cycle Checkpoints; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Mice, Knockout; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Ovarian Neoplasms; Reactive Oxygen Species; Signal Transduction; Simvastatin; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2016 |
Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice, SCID; Middle Aged; Neoplasm Metastasis; Simvastatin; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2015 |
RhoA mediates the expression of acidic extracellular pH-induced matrix metalloproteinase-9 mRNA through phospholipase D1 in mouse metastatic B16-BL6 melanoma cells.
Topics: Actins; Animals; cdc42 GTP-Binding Protein; Cytochalasin D; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrogen-Ion Concentration; Matrix Metalloproteinase 9; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neuropeptides; Phospholipase D; Promoter Regions, Genetic; rac1 GTP-Binding Protein; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Simvastatin | 2016 |
Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.
Topics: Amino Acid Substitution; Animals; Anticholesteremic Agents; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Mice; Mice, Nude; Mutation, Missense; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Osteolysis; Simvastatin; Transcription, Genetic; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2011 |