Page last updated: 2024-08-23

simvastatin and Neoplasm Metastasis

simvastatin has been researched along with Neoplasm Metastasis in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (6.25)29.6817
2010's15 (93.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baiano, S; Carnuccio, R; De Cicco, R; Fuggetta, MP; Morelli, A; Morelli, F; Tatè, R; Trotta, V; Urciuoli, M; Zona, E1
Bizama, C; Brañes, J; Bravo, ML; Cerda-Infante, J; Cuello, MA; García, K; Gejman, R; Gonzalez, P; Henríquez, J; Ibañez, C; Kato, S; Liberona, MF; Montecinos, V; Owen, GI; Roa, JC; Sánchez, M1
Fang, J; Fang, Z; Guo, X; Guo, Z; Jiao, W; Liu, Z; Tang, Y; Wang, W; Xing, Z; Xu, Z; Zhou, Z1
Chen, H; Fang, X; Huang, L; Jiang, Y; Li, N; Liu, Y; Mei, L; Sun, S; Wang, H; Wang, Z; Wu, Y; Zhang, F; Zhang, X; Zhang, Y; Zheng, Y1
Bae-Jump, VL; Gehrig, PA; Gilliam, TP; Han, X; Kim, K; Schointuch, MN; Stine, JE; Zhou, C1
Hohenegger, M; Höller, C; Künzl, M; Minichsdorfer, C; Wasinger, C; Zellner, M1
Babcook, MA; Daneshgari, F; Flask, CA; Fu, P; Gupta, S; Lindner, DJ; MacLennan, GT; Molter, JP; Oak, CZ; Parker, Y; Puchowicz, MA; Shukla, S; Vazquez, EJ1
Atil, B; Hohenegger, M; Minichsdorfer, C; Sieczkowski, E; Wasinger, C1
Baas, JM; Batman, E; Bos, MM; Gelderblom, H; Guchelaar, HJ; Krens, LL; Morreau, H; Portielje, JE; van Wezel, T1
Bae-Jump, VL; Gehrig, PA; Gilliam, TP; Guo, H; Han, X; Schointuch, MN; Sheng, X; Stine, JE; Zhou, C1
Han, SW; Hong, YS; Hwang, IG; Jung, SH; Kang, HJ; Kang, WK; Kim, HS; Kim, ST; Kim, TW; Lee, J; Lee, JY; Lee, KH; Lim, HY; Lim, SH; Park, JO; Park, SH; Park, YS1
Bambhroliya, A; Bertucci, F; Birnbaum, D; Chu, K; Debeb, BG; Diagaradjan, P; Diehl, M; Finetti, P; Hittelman, W; Huang, X; Lacerda, L; Larson, R; Levental, I; Ruffell, B; Trenton, NJ; Ueno, NT; Van Laere, S; Wolfe, AR; Woodward, WA1
Baba, Y; Kato, Y; Maeda, T; Nishimura, Y; Suzuki, A; Yuzawa, S1
Go, YJ; Han, JY; Joo, J; Lee, GK; Lee, JS; Lee, KH; Lee, SH; Lee, Y; Lim, KY1
Ahn, JB; Byun, JH; Hong, YS; Im, SA; Jung, KH; Kang, WK; Kim, TW; Lee, J; Lee, N; Lim, HY; Oh, DY; Park, JO; Park, SH; Park, YS; Shin, DB; Shin, SJ1
Choudhury, GG; Ghosh-Choudhury, N; Mandal, CC; Yoneda, T1

Trials

4 trial(s) available for simvastatin and Neoplasm Metastasis

ArticleYear
Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients.
    Anti-cancer drugs, 2015, Volume: 26, Issue:8

    Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Mutation; Neoplasm Metastasis; Panitumumab; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Simvastatin

2015
A randomised, double-blind, placebo-controlled multi-centre phase III trial of XELIRI/FOLFIRI plus simvastatin for patients with metastatic colorectal cancer.
    British journal of cancer, 2015, Nov-17, Volume: 113, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Double-Blind Method; Drug Administration Schedule; Female; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Republic of Korea; Simvastatin; Survival Analysis; Treatment Outcome

2015
Randomized Phase II Study of Afatinib Plus Simvastatin Versus Afatinib Alone in Previously Treated Patients with Advanced Nonadenocarcinomatous Non-small Cell Lung Cancer.
    Cancer research and treatment, 2017, Volume: 49, Issue:4

    Topics: Adult; Afatinib; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Metastasis; Neoplasm Staging; Quinazolines; Retreatment; Simvastatin; Survival Analysis; Treatment Outcome

2017
Simvastatin plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) as first-line chemotherapy in metastatic colorectal patients: a multicenter phase II study.
    Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Simvastatin

2009

Other Studies

12 other study(ies) available for simvastatin and Neoplasm Metastasis

ArticleYear
Simvastatin inhibits the expression of stemness‑related genes and the metastatic invasion of human cancer cells via destruction of the cytoskeleton.
    International journal of oncology, 2017, Volume: 51, Issue:6

    Topics: Carcinoma, Embryonal; Cytoskeleton; Fluorescent Antibody Technique; Hep G2 Cells; Humans; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Pluripotent Stem Cells; Prenylation; Simvastatin

2017
Simvastatin interferes with cancer 'stem-cell' plasticity reducing metastasis in ovarian cancer.
    Endocrine-related cancer, 2018, Volume: 25, Issue:10

    Topics: Cell Line, Tumor; Cell Movement; Cell Plasticity; Epithelial-Mesenchymal Transition; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Metastasis; Neoplastic Stem Cells; Ovarian Neoplasms; Simvastatin

2018
Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; In Situ Nick-End Labeling; Janus Kinase 2; MAP Kinase Signaling System; Mice; Mice, Nude; Neoplasm Metastasis; Phosphorylation; RNA Interference; Simvastatin; STAT3 Transcription Factor; TOR Serine-Threonine Kinases

2013
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Jan-07, Volume: 111, Issue:1

    Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hippo Signaling Pathway; Humans; Hyaluronan Receptors; Mevalonic Acid; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Transplantation; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Simvastatin; Transcription Factors; YAP-Signaling Proteins

2014
Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer.
    Gynecologic oncology, 2014, Volume: 134, Issue:2

    Topics: Apoptosis; Cell Adhesion; Cell Proliferation; Endometrial Neoplasms; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; Simvastatin; Tumor Cells, Cultured

2014
Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells.
    British journal of pharmacology, 2014, Volume: 171, Issue:24

    Topics: Apoptosis; Autocrine Communication; Caspase 8; Cell Line, Tumor; Cells, Cultured; Fatty Acid-Binding Proteins; Gene Knockdown Techniques; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Oxidoreductases; Lipocalins; Melanocytes; Melanoma; Neoplasm Metastasis; Prostaglandin D2; Simvastatin

2014
Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:10

    Topics: Animals; Anticholesteremic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Movement; Drug Synergism; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Neoplasm Metastasis; Prostatic Neoplasms, Castration-Resistant; Simvastatin

2014
Tocilizumab unmasks a stage-dependent interleukin-6 component in statin-induced apoptosis of metastatic melanoma cells.
    Melanoma research, 2015, Volume: 25, Issue:4

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; bcl-X Protein; Binding Sites; Caspase 3; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Melanoma; Neoplasm Metastasis; Proto-Oncogene Proteins c-bcl-2; Simvastatin; Skin Neoplasms; STAT3 Transcription Factor; Wound Healing

2015
The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer.
    Oncotarget, 2016, Jan-05, Volume: 7, Issue:1

    Topics: Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; DNA Damage; Female; G1 Phase Cell Cycle Checkpoints; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Mice, Knockout; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Ovarian Neoplasms; Reactive Oxygen Species; Signal Transduction; Simvastatin; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2016
Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a.
    Breast cancer research and treatment, 2015, Volume: 154, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice, SCID; Middle Aged; Neoplasm Metastasis; Simvastatin; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2015
RhoA mediates the expression of acidic extracellular pH-induced matrix metalloproteinase-9 mRNA through phospholipase D1 in mouse metastatic B16-BL6 melanoma cells.
    International journal of oncology, 2016, Volume: 48, Issue:3

    Topics: Actins; Animals; cdc42 GTP-Binding Protein; Cytochalasin D; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydrogen-Ion Concentration; Matrix Metalloproteinase 9; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neuropeptides; Phospholipase D; Promoter Regions, Genetic; rac1 GTP-Binding Protein; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Simvastatin

2016
Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.
    The Journal of biological chemistry, 2011, Apr-01, Volume: 286, Issue:13

    Topics: Amino Acid Substitution; Animals; Anticholesteremic Agents; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Mice; Mice, Nude; Mutation, Missense; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Osteolysis; Simvastatin; Transcription, Genetic; Transplantation, Heterologous; Tumor Suppressor Protein p53

2011