Page last updated: 2024-08-23

simvastatin and Multiple Sclerosis, Chronic Progressive

simvastatin has been researched along with Multiple Sclerosis, Chronic Progressive in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (83.33)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Chataway, J; Eshaghi, A; Frost, C; Heslegrave, A; Holdsworth, KP; Katsanouli, T; Nicholas, JM; Wellington, H; Williams, TE; Zetterberg, H1
Abushamma, A; Corbett, AM; Gagle, S; Johnson, A; Nagarajan, D; Sharma, N; Sulehria, T1
Binks, S; Cardoso, MJ; Chan, D; Chataway, J; Frost, C; Nicholas, JM; Nicholas, R; Ourselin, S; Wilkie, D1
Feinstein, A1
Alexander, DC; Barkhof, F; Cardoso, MJ; Chan, D; Chataway, J; Ciccarelli, O; Eshaghi, A; Greenwood, J; Kievit, RA; Nicholas, J; Nicholas, R; Ourselin, S; Prados, F; Sudre, CH; Thompson, AJ1
Kmietowicz, Z1
Palace, J; Robertson, N1
Alsanousi, A; Anderson, V; Bangham, CR; Calder, VL; Chan, D; Chataway, J; Clegg, S; Fox, NC; Frost, C; Greenwood, J; Hunter, K; MacManus, D; Nicholas, JM; Nicholas, R; Nielsen, C; Schuerer, N; Wilkie, D1
Malkki, H1
Auer, J; Berent, R1
Baker, D; Giovannoni, G; Schmierer, K1
Chataway, J1

Trials

4 trial(s) available for simvastatin and Multiple Sclerosis, Chronic Progressive

ArticleYear
Assessing Neurofilaments as Biomarkers of Neuroprotection in Progressive Multiple Sclerosis: From the MS-STAT Randomized Controlled Trial.
    Neurology(R) neuroimmunology & neuroinflammation, 2022, Volume: 9, Issue:2

    Topics: Adult; Biomarkers; Female; Humans; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Neurofilament Proteins; Neuroprotective Agents; Outcome Assessment, Health Care; Simvastatin

2022
Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial.
    The Lancet. Neurology, 2017, Volume: 16, Issue:8

    Topics: Adult; Cognitive Dysfunction; Double-Blind Method; Executive Function; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Memory Disorders; Middle Aged; Multiple Sclerosis, Chronic Progressive; Outcome Assessment, Health Care; Quality of Life; Simvastatin

2017
Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.
    Lancet (London, England), 2014, Jun-28, Volume: 383, Issue:9936

    Topics: Administration, Oral; Adolescent; Adult; Aged; Atrophy; Brain; Cytokines; Disabled Persons; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Simvastatin; Young Adult

2014
Multiple sclerosis: could simvastatin slow down secondary progressive MS?
    Nature reviews. Neurology, 2014, Volume: 10, Issue:5

    Topics: Anticholesteremic Agents; Female; Humans; Magnetic Resonance Imaging; Male; Multiple Sclerosis, Chronic Progressive; Simvastatin; Time Factors

2014

Other Studies

8 other study(ies) available for simvastatin and Multiple Sclerosis, Chronic Progressive

ArticleYear
Increasing Progenitor Cell Proliferation in the Sub-Ventricular Zone: A Therapeutic Treatment for Progressive Multiple Sclerosis?
    Recent patents on drug delivery & formulation, 2020, Volume: 14, Issue:3

    Topics: Animals; Ascorbic Acid; Cell Proliferation; Drug Therapy, Combination; Female; Fluoxetine; Lateral Ventricles; Male; Multiple Sclerosis, Chronic Progressive; Neural Stem Cells; Neurogenesis; Rats, Sprague-Dawley; Sex Factors; Simvastatin

2020
Multiple sclerosis: Treatment of cognitive impairment in secondary progressive MS.
    Nature reviews. Neurology, 2017, Volume: 13, Issue:9

    Topics: Clinical Trials, Phase II as Topic; Cognitive Dysfunction; Depression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Multiple Sclerosis, Chronic Progressive; Simvastatin

2017
Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 05-28, Volume: 116, Issue:22

    Topics: Adult; Atrophy; Brain; Causality; Cholesterol; Clinical Trials as Topic; Disease Progression; Humans; Middle Aged; Models, Statistical; Multiple Sclerosis, Chronic Progressive; Simvastatin

2019
Simvastatin shows promise in treating progressive multiple sclerosis, study finds.
    BMJ (Clinical research ed.), 2014, Mar-18, Volume: 348

    Topics: Adolescent; Adult; Aged; Humans; Middle Aged; Multiple Sclerosis, Chronic Progressive; Randomized Controlled Trials as Topic; Simvastatin; Young Adult

2014
Modifying disability in progressive multiple sclerosis.
    Lancet (London, England), 2014, Jun-28, Volume: 383, Issue:9936

    Topics: Brain; Disabled Persons; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Multiple Sclerosis, Chronic Progressive; Simvastatin

2014
Simvastatin in patients with progressive multiple sclerosis.
    Lancet (London, England), 2014, Sep-13, Volume: 384, Issue:9947

    Topics: Brain; Disabled Persons; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Multiple Sclerosis, Chronic Progressive; Simvastatin

2014
Simvastatin in patients with progressive multiple sclerosis.
    Lancet (London, England), 2014, Sep-13, Volume: 384, Issue:9947

    Topics: Brain; Disabled Persons; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Multiple Sclerosis, Chronic Progressive; Simvastatin

2014
Simvastatin in patients with progressive multiple sclerosis--Authors' reply.
    Lancet (London, England), 2014, Sep-13, Volume: 384, Issue:9947

    Topics: Brain; Disabled Persons; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Multiple Sclerosis, Chronic Progressive; Simvastatin

2014