Page last updated: 2024-08-23

simvastatin and MS (Multiple Sclerosis)

simvastatin has been researched along with MS (Multiple Sclerosis) in 18 studies

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (61.11)	29.6817
2010's	6 (33.33)	24.3611
2020's	1 (5.56)	2.80

Authors

Authors	Studies
Alasmari, AF; Alharbi, M; Alshammari, A; Assiri, MA; Kalfin, R; Kapoor, T; Kumar, N; Mehan, S; Narula, AS; Sharma, N; Suri, M	1
Bitarafan, S; Toghi, M	1
Filippi, M; Rocca, MA	1
Alexiou, C; Cicha, I; Friedrich, RP; Janko, C; Lyer, S; Pöttler, M	1
Câmara, NO; Cenedeze, MA; de Oliveira, DM; de Oliveira, EM; Ferrari, Mde F; Hiyane, MI; Pacheco-Silva, A; Peron, JP; Semedo, P	1
Awad, AB; Desai, F; Fink, CS; Ramanathan, M; Weinstock-Guttman, B; Wilding, GE	1
de Cássia Mascarenhas Netto, R; de Freitas, MV; de Oliveira, MR; dos Santos, DF; Fenelon, SB; Penha-Silva, N	1
Luo, H; Luo, M; Wang, J; Xiao, Y	1
Archelos, JJ; Hartung, HP; Kieseier, BC	1
Darlington, CL	1
Auger, C; Bernard, M; Bouthillier, A; Cayrol, R; Duquette, P; Ifergan, I; Kébir, H; Moumdjian, R; Prat, A; Wosik, K	1
Hellings, N; Hendriks, JJ; Stinissen, P; Vanderlocht, J; Venken, K	1
Morais, MG; Pedrosa, R; Sena, A	1
Antel, JP; Jarjour, AA; Kennedy, TE; Miron, VE; Rajasekharan, S; Zamvil, SS	1
Hartung, HP; Neuhaus, O	1
Jin, J; Markovic-Plese, S; Peng, X; Ramgolam, VS; Zhang, X	1
Markovic-Plese, S; Zhang, X	1

Reviews

4 review(s) available for simvastatin and MS (Multiple Sclerosis)

Article	Year
Statins for multiple sclerosis. The Cochrane database of systematic reviews, 2011, Dec-07, Issue:12 Topics: Atorvastatin; Disease Progression; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-beta; Multiple Sclerosis; Pyrroles; Randomized Controlled Trials as Topic; Secondary Prevention; Simvastatin	2011
The potential role for statins in the treatment of multiple sclerosis. Current opinion in investigational drugs (London, England : 2000), 2005, Volume: 6, Issue:7 Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Multiple Sclerosis; Simvastatin; Treatment Outcome	2005
Evaluation of atorvastatin and simvastatin for treatment of multiple sclerosis. Expert review of neurotherapeutics, 2007, Volume: 7, Issue:5 Topics: Atorvastatin; Drug Evaluation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Multiple Sclerosis; Pyrroles; Simvastatin	2007
Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. Immunologic research, 2008, Volume: 41, Issue:3 Topics: Antigen-Presenting Cells; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Differentiation; Cytokines; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Interleukin-17; Membrane Microdomains; Monocytes; Multiple Sclerosis; Simvastatin; Th1 Cells; Th2 Cells	2008

Trials

1 trial(s) available for simvastatin and MS (Multiple Sclerosis)

Article	Year
Beneficial effect of statins in multiple sclerosis: is it dose-dependent? Atherosclerosis, 2007, Volume: 191, Issue:2 Topics: Atorvastatin; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Lovastatin; Multiple Sclerosis; Pyrroles; Simvastatin; Treatment Outcome	2007

Other Studies

13 other study(ies) available for simvastatin and MS (Multiple Sclerosis)

Article	Year
Forskolin, an Adenylcyclase/cAMP/CREB Signaling Activator Restoring Myelin-Associated Oligodendrocyte Destruction in Experimental Ethidium Bromide Model of Multiple Sclerosis. Cells, 2022, 09-06, Volume: 11, Issue:18 Topics: Adenylyl Cyclases; Animals; Colforsin; Cytokines; Demyelinating Diseases; Donepezil; Ethidium; Fingolimod Hydrochloride; Gliotoxin; Memantine; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Nerve Growth Factors; Neurodegenerative Diseases; Oligodendroglia; Rats; Rats, Wistar; Simvastatin	2022
Simvastatin Therapy in Multiple Sclerosis Patients with Respect to Gut Microbiome-Friend or Foe? Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2019, Volume: 14, Issue:4 Topics: Gastrointestinal Microbiome; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Multiple Sclerosis; Remyelination; Simvastatin	2019
Simvastatin and cognition in multiple sclerosis. The Lancet. Neurology, 2017, Volume: 16, Issue:8 Topics: Cognition; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Multiple Sclerosis; Simvastatin	2017
Treat or track: nanoagents in the service of health. Nanomedicine (London, England), 2017, Volume: 12, Issue:24 Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Cell Tracking; Drug Delivery Systems; Embryonic Stem Cells; Humans; Multiple Sclerosis; Nanomedicine; Nanoparticles; Optical Imaging; Plaque, Atherosclerotic; Protein Corona; Simvastatin	2017
Simvastatin ameliorates experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration. Inflammopharmacology, 2015, Volume: 23, Issue:6 Topics: Animals; Cell Differentiation; Cell Proliferation; Central Nervous System; Chemokine CCL5; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Interleukin-12 Subunit p40; Interleukin-6; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Simvastatin; Th1 Cells; Th17 Cells; Transforming Growth Factor beta	2015
Comparison of the immunomodulatory effects of the plant sterol beta-sitosterol to simvastatin in peripheral blood cells from multiple sclerosis patients. International immunopharmacology, 2009, Volume: 9, Issue:1 Topics: Adolescent; Adult; Aged; Blood Cells; Cell Proliferation; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Interleukin-10; Interleukin-12; Interleukin-5; Middle Aged; Multiple Sclerosis; Simvastatin; Sitosterols; Tumor Necrosis Factor-alpha; Young Adult	2009
Influence of the use of statin on the stability of erythrocyte membranes in multiple sclerosis. The Journal of membrane biology, 2010, Volume: 233, Issue:1-3 Topics: Adult; Central Nervous System Depressants; Erythrocyte Membrane; Ethanol; Female; Hemolysis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Multiple Sclerosis; Simvastatin	2010
Different effects of simvastatin and interferon beta on the proteolytic activity of matrix metalloproteinases. Archives of neurology, 2004, Volume: 61, Issue:6 Topics: Adult; Enzyme Inhibitors; Female; Humans; Hydrolysis; Interferon-beta; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Multiple Sclerosis; Peptide Hydrolases; Simvastatin	2004
Statins may slow MS progression. Health news (Waltham, Mass.), 2004, Volume: 10, Issue:7 Topics: Anticholesteremic Agents; Disease Progression; Humans; Multiple Sclerosis; Simvastatin	2004
Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Annals of neurology, 2006, Volume: 60, Issue:1 Topics: Adult; Blood-Brain Barrier; Capillary Permeability; Cell Movement; Cells, Cultured; Chemokine CCL2; Chemokine CXCL10; Chemokines, CXC; Endothelial Cells; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Leukocytes; Lovastatin; Male; Membrane Proteins; Monocytes; Multiple Sclerosis; Occludin; Phosphoproteins; Protein Prenylation; Simvastatin; Tight Junctions; Zonula Occludens-1 Protein	2006
Effects of IFN-beta, leptin and simvastatin on LIF secretion by T lymphocytes of MS patients and healthy controls. Journal of neuroimmunology, 2006, Volume: 177, Issue:1-2 Topics: Adult; Aged; CD4-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Cytoprotection; Down-Regulation; Female; Humans; Interferon-beta; Interleukin-6; Leptin; Leukemia Inhibitory Factor; Male; Middle Aged; Multiple Sclerosis; Neuroprotective Agents; Reference Values; Simvastatin; T-Lymphocytes; Up-Regulation	2006
Simvastatin regulates oligodendroglial process dynamics and survival. Glia, 2007, Jan-15, Volume: 55, Issue:2 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Cell Death; Cell Differentiation; Cell Movement; Cell Survival; Cells, Cultured; Central Nervous System; Cholesterol; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Intracellular Signaling Peptides and Proteins; Multiple Sclerosis; Nerve Fibers, Myelinated; Nerve Regeneration; Oligodendroglia; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Simvastatin; Species Specificity; Stem Cells; Terpenes	2007
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. Journal of immunology (Baltimore, Md. : 1950), 2008, May-15, Volume: 180, Issue:10 Topics: Blotting, Western; CD4-Positive T-Lymphocytes; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gene Expression; Humans; Immunologic Factors; Interleukin-17; Male; Monocytes; Multiple Sclerosis; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; T-Lymphocyte Subsets	2008