Compounds > simvastatin
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simvastatin and Lung Injury, Acute

simvastatin has been researched along with Lung Injury, Acute in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (6.06)29.6817
2010's26 (78.79)24.3611
2020's5 (15.15)2.80

Authors

AuthorsStudies
Etemad, L; Hashemi, M; Mehmannavaz, F; Moshiri, M; Shabazi, N; Yazdian-Robati, R1
Amidžić, L; Dumanović, J; Gajanin, R; Jaćević, V; Mandić, D; Milovanović, Z; Nežić, L; Škrbić, R1
Antunes, GL; Bastos, MS; da Costa, MS; de Oliveira, JR; de Souza Basso, B; Donadio, MVF; Garcia, MC; Gracia-Sancho, J; Haute, GV; Kaiber, DB; Levorse, VGS; Luft, C; Matzenbacher, LS; Melo, D; Pedrazza, L; Rodrigues, KF; Silveira, J1
Cheng, X; Hou, L; Yan, X; Zhang, W1
Cai, SH; Gao, Y; Li, HX; Liang, XY; Wu, JH; Yuan, YP1
Chen, M; Chen, Q; Cheng, L; Geng, Y; Jiang, H; Lu, J; Wang, X1
Wang, Y; Yang, W; Zhang, R; Zhao, X1
Bao, XC; Fan, YH; Fang, YQ; Ma, J; Mao, AR; Wang, FF; You, P1
Chen, J; Chen, L; Fei, A; Gao, C; Liu, D; Liu, X; Pan, S; Wang, H; Wu, Z1
Du, Y; Hu, J; Jiang, S; Kang, X; Li, S; Lu, X; Qi, J; Wang, X; Wu, J; Xiao, Y; Xu, X1
Fu, P; Harijith, A; Jacobson, JR; Karginov, A; Natarajan, V; Shaaya, M1
Jing, H; Li, H; Qiang, Y; Wang, G; Wang, L; Wu, H; Yi, J1
Backman, JT; Calfee, CS; Duffy, MJ; Elborn, SJ; Griffiths, MJ; Johnston, JR; MacSweeney, R; Matthay, MM; McAuley, DF; McDowell, C; McGuigan, J; OʼKane, CM; Shields, MO; Shyamsundar, M1
Craig, TR; Dib, K; Herwald, H; McAuley, DF; O'Kane, CM; Shyamsundar, M1
Chen, W; Garcia, JG; Jacobson, JR; Rizzo, AN; Sharma, R; Siegler, JH1
Battersby, CL; Bryan, N; Hunt, JA1
McAuley, DF; O'Kane, CM; Shyamsundar, M1
Dhayat, S; Mehdorn, AS; Palmes, D1
Du, J; Gu, W; Jiang, J; Li, H; Wang, H; Yang, C; Yang, X; Zeng, L1
Chen, L; He, ZJ; Li, WC; Zheng, YK; Zhou, L; Zhou, MG; Zou, ZJ1
Gao, C; Jing, L; Yu, Y; Zhang, X1
Chen, L; Du, YZ; Hu, JB; Jiang, SP; Kang, XQ; Li, SJ; Wang, XJ; Xu, XL; Ying, XY1
Backman, JT; Brown, V; Craig, TR; Elborn, JS; Matthay, MA; McAuley, DF; McKeown, ST; O'Kane, CM; Shyamsundar, M; Taggart, CC; Thickett, DR1
Fessler, MB1
Basaran, O; Belli, S; Haberal, M; Karabay, G; Karakayali, H; Kut, A; Ozdemir, BH; Türkoğlu, S1
Craig, TR; Duffy, MJ; Elborn, JS; McAuley, DF; McDowell, C; O'Kane, CM; Shyamsundar, M1
Altintas, ND; Atilla, P; Iskit, AB; Topeli, A1
Bai, N; Eom, J; Jaw, JE; Li, Y; Man, SP; Mui, T; Ngan, D; Or, C; Sin, DD; Suda, K; Tam, S; Tsuruta, M; Van Eeden, S; Wang, X1
Armaganidis, A; Kopterides, P; Siempos, II1
Boyd, AR; Hinojosa, CA; Orihuela, CJ; Rodriguez, PJ1
Chen, W; Garcia, JG; Jacobson, JR; Ma, SF; Mitra, S; Sammani, S1
Binnebösel, M; Dembinski, R; Drechsler, M; Grommes, J; Hartwig, H; Jacobs, M; Koeppel, TA; Mörgelin, M; Soehnlein, O; Vijayan, S; Weber, C1
Crealey, G; Cross, M; Laffey, JG; McAuley, DF; McNally, C; Murphy, L; O'Kane, CM; Perkins, GD; Stevenson, M1

Reviews

1 review(s) available for simvastatin and Lung Injury, Acute

ArticleYear
[Statin in the treatment of ALI/ARDS: a systematic review and Meta-analysis based on international databases].
    Zhonghua wei zhong bing ji jiu yi xue, 2017, Volume: 29, Issue:1

    Topics: Acute Lung Injury; Cohort Studies; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intensive Care Units; Length of Stay; Respiration, Artificial; Respiratory Distress Syndrome; Simvastatin

2017

Trials

5 trial(s) available for simvastatin and Lung Injury, Acute

ArticleYear
Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.
    Annals of surgery, 2014, Volume: 259, Issue:1

    Topics: Acute Lung Injury; Aged; Double-Blind Method; Endothelium; Esophageal Neoplasms; Esophagectomy; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Middle Aged; Pulmonary Alveoli; Simvastatin

2014
Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury.
    BMC pulmonary medicine, 2013, Jul-19, Volume: 13

    Topics: Acute Lung Injury; Administration, Oral; Adult; Aged; Antimicrobial Cationic Peptides; Blood Proteins; Carrier Proteins; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intensive Care Units; Male; Middle Aged; Prospective Studies; Simvastatin; Survival Rate; Treatment Outcome

2013
Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.
    American journal of respiratory and critical care medicine, 2009, Jun-15, Volume: 179, Issue:12

    Topics: Acute Lung Injury; Adult; Bronchoalveolar Lavage Fluid; Cytokines; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Female; Flow Cytometry; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Male; Matrix Metalloproteinases; Neutrophils; NF-kappa B; Reference Values; Simvastatin; Treatment Outcome

2009
A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study).
    American journal of respiratory and critical care medicine, 2011, Mar-01, Volume: 183, Issue:5

    Topics: Acute Lung Injury; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Cytokines; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Middle Aged; Multiple Organ Failure; Simvastatin; Treatment Outcome

2011
Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial.
    Trials, 2012, Sep-17, Volume: 13

    Topics: Acute Lung Injury; Clinical Protocols; Cost-Benefit Analysis; Double-Blind Method; Drug Costs; Hospital Costs; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ireland; Length of Stay; Lung; Prospective Studies; Quality of Life; Recovery of Function; Research Design; Respiration, Artificial; Simvastatin; Time Factors; Treatment Outcome; United Kingdom

2012

Other Studies

27 other study(ies) available for simvastatin and Lung Injury, Acute

ArticleYear
Evaluation of the efficiency of simvastatin loaded PLGA nanoparticles against acute paraquat-intoxicated rats.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2022, Jan-01, Volume: 168

    Topics: Acute Lung Injury; Animals; Lung; Male; Nanoparticles; Paraquat; Rats; Rats, Sprague-Dawley; Rats, Wistar; Simvastatin

2022
Amelioration of Endotoxin-Induced Acute Lung Injury and Alveolar Epithelial Cells Apoptosis by Simvastatin Is Associated with Up-Regulation of Survivin/NF-kB/p65 Pathway.
    International journal of molecular sciences, 2022, Feb-26, Volume: 23, Issue:5

    Topics: Acute Lung Injury; Alveolar Epithelial Cells; Apoptosis; Caspase 3; Cytochromes c; Endotoxins; Humans; Lipopolysaccharides; Lung; NF-kappa B; Simvastatin; Survivin; Up-Regulation

2022
Simvastatin attenuates inflammatory process on LPS-induced acute lung injury in mice.
    Respiratory physiology & neurobiology, 2023, Volume: 309

    Topics: Acute Lung Injury; Animals; Cytokines; Lipopolysaccharides; Lung; Mice; Simvastatin

2023
Preparation of Simvastatin Loaded Nanostructured Lipid Carriers and Its Therapeutic Effect on Patients with Severe Acute Lung Injury.
    Journal of nanoscience and nanotechnology, 2021, 02-01, Volume: 21, Issue:2

    Topics: Acute Lung Injury; Animals; Drug Carriers; Humans; Lipids; Mice; Mice, Inbred C57BL; Nanostructures; Particle Size; Simvastatin

2021
Simvastatin attenuates acute lung injury by activation of A2B adenosine receptor.
    Toxicology and applied pharmacology, 2021, 07-01, Volume: 422

    Topics: Acute Lung Injury; Adenosine A2 Receptor Agonists; Animals; Claudin-4; Claudins; Cystic Fibrosis Transmembrane Conductance Regulator; Cytokines; Disease Models, Animal; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Neutrophil Infiltration; Pulmonary Edema; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Signal Transduction; Simvastatin

2021
Experimental Study of the Protective Effect of Simvastatin on Lung Injury in Rats with Sepsis.
    Inflammation, 2018, Volume: 41, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Caspase 3; Cytokines; Cytoprotection; Deoxyguanosine; Disease Models, Animal; Inflammation Mediators; Lipocalin-2; Lung; Male; Malondialdehyde; Oxidative Stress; Pulmonary Edema; Rats, Wistar; Sepsis; Signal Transduction; Simvastatin; Superoxide Dismutase; Toll-Like Receptor 4; Transcription Factor RelA

2018
Simvastatin decreases hyperbaric oxygen-induced acute lung injury by upregulating eNOS.
    American journal of physiology. Lung cellular and molecular physiology, 2018, 02-01, Volume: 314, Issue:2

    Topics: Acute Lung Injury; Animals; Anticholesteremic Agents; Gene Expression Regulation; Hyperbaric Oxygenation; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Simvastatin; Transcriptional Activation

2018
Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury.
    BioMed research international, 2017, Volume: 2017

    Topics: Acute Lung Injury; Animals; CD11c Antigen; Disease Models, Animal; Enzyme Inhibitors; Humans; Intestines; Lipopolysaccharides; p21-Activated Kinases; Rats; Simvastatin; Tumor Necrosis Factor-alpha

2017
Combined delivery of angiopoietin-1 gene and simvastatin mediated by anti-intercellular adhesion molecule-1 antibody-conjugated ternary nanoparticles for acute lung injury therapy.
    Nanomedicine : nanotechnology, biology, and medicine, 2019, Volume: 15, Issue:1

    Topics: A549 Cells; Acute Lung Injury; Angiopoietin-1; Animals; Antibodies; Anticholesteremic Agents; Cells, Cultured; Combined Modality Therapy; Drug Carriers; Drug Delivery Systems; Endothelial Cells; Genetic Therapy; Humans; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Simvastatin

2019
Sphingolipids Signaling in Lamellipodia Formation and Enhancement of Endothelial Barrier Function.
    Current topics in membranes, 2018, Volume: 82

    Topics: Acute Lung Injury; Endothelium, Vascular; Humans; Lysophospholipids; Phosphotransferases (Alcohol Group Acceptor); Pseudopodia; Reactive Oxygen Species; Signal Transduction; Simvastatin; Sphingolipids; Sphingosine

2018
Repair of lipopolysaccharide-induced acute lung injury in mice by endothelial progenitor cells, alone and in combination with simvastatin.
    Chest, 2013, Volume: 144, Issue:3

    Topics: Acute Lung Injury; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Simvastatin; Stem Cell Transplantation; Treatment Outcome

2013
Role of claudin-5 in the attenuation of murine acute lung injury by simvastatin.
    American journal of respiratory cell and molecular biology, 2014, Volume: 50, Issue:2

    Topics: Acute Lung Injury; Animals; beta Catenin; Capillary Permeability; Cells, Cultured; Claudin-5; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Gene Silencing; Humans; Lung; Mice; Mice, Inbred C57BL; Simvastatin; Tight Junctions

2014
Effect of Simvastatin on Physiological and Biological Outcomes in Patients Undergoing Esophagectomy: A Randomized Placebo-controlled Trial.
    Annals of surgery, 2015, Volume: 262, Issue:6

    Topics: Acute Lung Injury; Esophageal Neoplasms; Esophagectomy; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Simvastatin

2015
Reply to Letter: "Effect of Simvastatin on Physiological and Biological Outcomes in Patients Undergoing Esophagectomy: A Randomized Placebo-controlled Trial".
    Annals of surgery, 2015, Volume: 262, Issue:6

    Topics: Acute Lung Injury; Esophageal Neoplasms; Esophagectomy; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Simvastatin

2015
Effect of Simvastatin on Physiological and Biological Outcomes in Patients Undergoing Esophagectomy.
    Annals of surgery, 2015, Volume: 262, Issue:6

    Topics: Acute Lung Injury; Esophageal Neoplasms; Esophagectomy; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Simvastatin

2015
Retinoic acid promotes the endogenous repair of lung stem/progenitor cells in combined with simvastatin after acute lung injury: a stereological analysis.
    Respiratory research, 2015, Nov-11, Volume: 16

    Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Lung; Rats, Sprague-Dawley; Regeneration; Simvastatin; Stem Cells; Tretinoin

2015
Effects of simvastatin on the expression of inducible NOS in acute lung injury in septic rats.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:11

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Sepsis; Simvastatin

2015
Simvastatin Attenuates Acute Lung Injury via Regulating CDC42-PAK4 and Endothelial Microparticles.
    Shock (Augusta, Ga.), 2017, Volume: 47, Issue:3

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage; cdc42 GTP-Binding Protein; Cell-Derived Microparticles; Endothelial Cells; Male; Mice; Mice, Inbred C57BL; p21-Activated Kinases; Simvastatin

2017
Targeting delivery of simvastatin using ICAM-1 antibody-conjugated nanostructured lipid carriers for acute lung injury therapy.
    Drug delivery, 2017, Volume: 24, Issue:1

    Topics: A549 Cells; Acute Lung Injury; Animals; Antibodies; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Humans; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred BALB C; Nanostructures; Particle Size; Random Allocation; Simvastatin

2017
Simvastatin as a potential therapeutic for acute respiratory distress syndrome.
    American journal of respiratory and critical care medicine, 2009, Nov-15, Volume: 180, Issue:10

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Lovastatin; Lung; Mevalonic Acid; Mice; Neutrophils; Respiratory Distress Syndrome; Simvastatin

2009
Protective role of simvastatin on lung damage caused by burn and cotton smoke inhalation in rats.
    The Journal of surgical research, 2011, May-15, Volume: 167, Issue:2

    Topics: Acute Lung Injury; Animals; Apoptosis; Burns; Cotton Fiber; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Malondialdehyde; Models, Animal; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Simvastatin; Smoke Inhalation Injury

2011
Long-term simvastatin attenuates lung injury and oxidative stress in murine acute lung injury models induced by oleic Acid and endotoxin.
    Respiratory care, 2011, Volume: 56, Issue:8

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Endotoxins; Follow-Up Studies; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Mice; Oleic Acid; Oxidative Stress; Simvastatin; Time Factors

2011
Endotoxin-induced cardiovascular dysfunction in mice: effect of simvastatin.
    Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 111, Issue:4

    Topics: Acetylcholine; Acute Lung Injury; Animals; Aorta; Bronchoalveolar Lavage Fluid; Cardiovascular Diseases; Cell Differentiation; Endothelium, Vascular; Heart; Inflammation; Interleukin-6; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Nitroprusside; Permeability; Simvastatin; Vasodilation; Vasodilator Agents; Veins

2011
Additional experimental evidence that statins protect against acute lung injury.
    Respiratory care, 2012, Volume: 57, Issue:2

    Topics: Acute Lung Injury; Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Oxidative Stress; Simvastatin

2012
Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia.
    BMC microbiology, 2012, May-15, Volume: 12

    Topics: Acute Lung Injury; Administration, Oral; Animals; Anticholesteremic Agents; Cytokines; Disease Models, Animal; Edema; Female; Histocytochemistry; Lung; Mice; Mice, Inbred BALB C; Pneumonia, Pneumococcal; Simvastatin; Streptococcus pneumoniae; Survival Analysis

2012
Critical role for integrin-β4 in the attenuation of murine acute lung injury by simvastatin.
    American journal of physiology. Lung cellular and molecular physiology, 2012, Aug-15, Volume: 303, Issue:4

    Topics: Acute Lung Injury; Animals; Chemokine CCL2; Endothelial Cells; Gene Expression Regulation; Humans; Inflammation; Integrin beta4; Interleukin-6; Interleukin-8; Lipopolysaccharides; Mice; Phosphorylation; Phosphotyrosine; Simvastatin

2012
Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Acute Lung Injury; Aerosols; Albumins; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Cell Adhesion; Endotoxins; Flow Cytometry; Fluorescein-5-isothiocyanate; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Neutrophils; Permeability; Reactive Oxygen Species; Simvastatin

2012