Page last updated: 2024-08-23

simvastatin and Liver Steatosis

simvastatin has been researched along with Liver Steatosis in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (38.10)29.6817
2010's11 (52.38)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Cao, J; Fan, W; Jiang, Q; Li, M; Loor, JJ; Tian, Y; Wang, S; Xu, C; Yang, W; Zhang, B; Zhao, Y1
Arumugam, S; Ramalingam, S; Solairaja, S; Subbiah, V; Thiyagaraj, A; Venkatabalasubramanian, S; Venkatasubramanian, A1
Bonsignore, P; Calamia, S; Cintorino, D; Costanzo, F; di Francesco, F; Gruttadauria, S; Khouzam, S; Li Petri, S; Luca, A; Oliva, E; Pagano, D; Ricotta, C; Tropea, A; Tuzzolino, F1
Deng, C; Hu, CH; Liu, XM; Zeng, YP; Zhao, XM1
Abraldes, JG; Bosch, J; García-Calderó, H; García-Pagán, JC; Gracia-Sancho, J; Guixé-Muntet, S; Hide, D; Marrone, G; Peralta, C1
Björnsson, E; Enders, F; Lindor, KD; Suwanwalaikorn, S; Treeprasertsuk, S1
Shen, C; Wang, W; Wang, Y; Zhao, C; Zhen, Z; Zhou, J1
Qin, S; Sang, H; Si, Y; Wang, J; Xu, X; Yang, N; Yao, S; Zhai, L; Zhang, Y; Zu, D1
Aramin, H; Eslami, L; Malekzadeh, R; Merat, S; Nasseri-Moghaddam, S1
Canet, MJ; Cherrington, NJ; Clarke, JD; Hardwick, RN; Lake, AD1
Chootip, K; Tunsophon, S1
Jiang, JD; Kong, WJ; Pan, HN; Song, DQ; Wang, YM; Wei, J; You, XF; Zhao, LX; Zuo, ZY1
Ji, G; Liang, X; Liu, J; Liu, T; Ma, Z; Wu, H; Xin, L; Zheng, P1
Abel, T; Dinya, E; Fehér, J; Gamal Eldin, M; Kovács, A1
Abel, T; Dinya, E; Eldin, MG; Fehér, J; Kovács, A1
Derosa, G; Fogari, R; Lazzari, P; Maffioli, P; Mugellini, A; Zoppi, A1
Cao, W; Wang, W; Yan, L; Zhao, CY1
Blé-Castillo, JL; Díaz-Zagoya, JC; Juárez-Oropeza, MA; Miranda-Zamora, R; Rodríguez-Hernández, A1
Fan, HZ; Huang, ZY; Rui, YC; Yang, PY; Yu, YL1
Ahmed, MH; Osman, MM; Saad, RA1
Jia, X; Lu, R; Meng, F; Yan, M; Zhao, X1

Reviews

1 review(s) available for simvastatin and Liver Steatosis

ArticleYear
Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
    The Cochrane database of systematic reviews, 2013, Dec-27, Issue:12

    Topics: Alanine Transaminase; Atorvastatin; Fatty Liver; Fenofibrate; gamma-Glutamyltransferase; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Non-alcoholic Fatty Liver Disease; Pyrroles; Simvastatin

2013

Trials

5 trial(s) available for simvastatin and Liver Steatosis

ArticleYear
The addition of simvastatin administration to cold storage solution of explanted whole liver grafts for facing ischemia/reperfusion injury in an area with a low rate of deceased donation: a monocentric randomized controlled double-blinded phase 2 study.
    BMC surgery, 2018, Dec-27, Volume: 18, Issue:1

    Topics: Double-Blind Method; Fatty Liver; Humans; Liver; Liver Transplantation; Prospective Studies; Protective Agents; Reperfusion Injury; Simvastatin

2018
Combination of simvastatin with berberine improves the lipid-lowering efficacy.
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:8

    Topics: Animals; Berberine; Cholesterol, LDL; Drug Synergism; Drug Therapy, Combination; Fatty Liver; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Rats; Rats, Wistar; Receptors, LDL; RNA, Messenger; Simvastatin; Triglycerides; Up-Regulation

2008
[Efficacy and safety of ezetimibe/simvastatin combination therapy in patients with type 2 diabetes and nonalcoholic fatty liver disease].
    Orvosi hetilap, 2009, May-24, Volume: 150, Issue:21

    Topics: Aged; Alanine Transaminase; Anticholesteremic Agents; Aspartate Aminotransferases; Azetidines; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Diabetes Complications; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Ezetimibe; Fatty Liver; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Simvastatin; Time Factors; Treatment Outcome; Waist Circumference

2009
Safety and efficacy of combined ezetimibe/simvastatin treatment and simvastatin monotherapy in patients with non-alcoholic fatty liver disease.
    Medical science monitor : international medical journal of experimental and clinical research, 2009, Volume: 15, Issue:12

    Topics: Aged; Alanine Transaminase; Anticholesteremic Agents; Aspartate Aminotransferases; Azetidines; Cardiovascular Diseases; Cholesterol; Creatine Kinase; Drug Combinations; Ezetimibe; Ezetimibe, Simvastatin Drug Combination; Fatty Liver; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Male; Metabolic Syndrome; Middle Aged; Retrospective Studies; Risk Factors; Simvastatin; Triglycerides

2009
Effects of losartan and amlodipine alone or combined with simvastatin in hypertensive patients with nonalcoholic hepatic steatosis.
    European journal of gastroenterology & hepatology, 2012, Volume: 24, Issue:2

    Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Body Mass Index; Body Weight; Double-Blind Method; Drug Therapy, Combination; Fatty Liver; Female; Glucose Clamp Technique; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Inflammation Mediators; Insulin Resistance; Lipids; Losartan; Male; Middle Aged; Simvastatin; Ultrasonography

2012

Other Studies

15 other study(ies) available for simvastatin and Liver Steatosis

ArticleYear
Regulation of cholesterol metabolism during high fatty acid-induced lipid deposition in calf hepatocytes.
    Journal of dairy science, 2023, Volume: 106, Issue:8

    Topics: Animals; Cattle; Cattle Diseases; Cholesterol; Fatty Acids; Fatty Liver; Female; Hepatocytes; Lactation; Lipid Metabolism; Lipoproteins, LDL; Liver; RNA, Messenger; Simvastatin; Transcription Factors

2023
Ameliorative role of ellagic acid against acute liver steatosis in adult zebrafish experimental model.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2021, Volume: 247

    Topics: Acute Disease; Animals; Ellagic Acid; Fatty Liver; Simvastatin; Zebrafish

2021
Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway.
    Acta pharmacologica Sinica, 2019, Volume: 40, Issue:8

    Topics: Animals; Down-Regulation; Dyslipidemias; Fatty Liver; Female; Hep G2 Cells; Humans; Lipogenesis; Liver; Olanzapine; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; Sterol Regulatory Element Binding Protein 1; TOR Serine-Threonine Kinases

2019
Simvastatin maintains function and viability of steatotic rat livers procured for transplantation.
    Journal of hepatology, 2013, Volume: 58, Issue:6

    Topics: Animals; Cryopreservation; Fatty Liver; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Circulation; Liver Transplantation; Male; Organ Preservation; Rats; Rats, Sprague-Dawley; Simvastatin

2013
NAFLD fibrosis score: a prognostic predictor for mortality and liver complications among NAFLD patients.
    World journal of gastroenterology, 2013, Feb-28, Volume: 19, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Biopsy; Cause of Death; Chi-Square Distribution; Decision Support Techniques; Fatty Liver; Female; Heart Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Liver Cirrhosis; Logistic Models; Male; Metformin; Middle Aged; Minnesota; Multivariate Analysis; Non-alcoholic Fatty Liver Disease; Odds Ratio; Predictive Value of Tests; Prognosis; Risk Factors; Severity of Illness Index; Simvastatin; Time Factors; Young Adult

2013
Simvastatin ameliorates liver fibrosis via mediating nitric oxide synthase in rats with non-alcoholic steatohepatitis-related liver fibrosis.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Actins; Animals; Cells, Cultured; Collagen Type I; Diet, High-Fat; Enzyme Inhibitors; Fatty Liver; Gene Expression; Hepatic Stellate Cells; Humans; Hypolipidemic Agents; Liver; Liver Cirrhosis; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Simvastatin; Transforming Growth Factor beta1

2013
Celastrus orbiculatus Thunb. ameliorates high-fat diet-induced non-alcoholic fatty liver disease in guinea pigs.
    Die Pharmazie, 2013, Volume: 68, Issue:10

    Topics: Animals; Body Weight; Celastrus; Cholesterol; Cholesterol, LDL; Diet, High-Fat; Fatty Liver; Guinea Pigs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Liver; Liver Function Tests; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Organ Size; Real-Time Polymerase Chain Reaction; Simvastatin; Superoxide Dismutase

2013
Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 348, Issue:3

    Topics: Animals; Down-Regulation; Fatty Liver; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Male; Non-alcoholic Fatty Liver Disease; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Simvastatin

2014
Comparative effects of piperine and simvastatin in fat accumulation and antioxidative status in high fat-induced hyperlipidemic rats.
    Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:12

    Topics: Adipose Tissue; Alkaloids; Animals; Antioxidants; Benzodioxoles; Diet, High-Fat; Dietary Fats; Fatty Liver; Hyperlipidemias; Male; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Simvastatin

2016
Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways.
    The American journal of Chinese medicine, 2009, Volume: 37, Issue:1

    Topics: Animals; Cholesterol; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Liver; Inflammation; Isoflavones; Janus Kinase 2; Leptin; Lipid Metabolism; Liver; Male; Phytotherapy; Plant Extracts; Pueraria; Rats; Rats, Wistar; Receptors, Leptin; RNA, Messenger; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Triglycerides

2009
[Simvastatin inhibits activation of hepatic stellate cells and promotes activation of adenosine monophosphate-activated protein kinase].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2012, Volume: 20, Issue:4

    Topics: Adenylate Kinase; Animals; Cell Line; Fatty Liver; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Male; Rats; Rats, Wistar; Simvastatin

2012
Arthrospira maxima prevents the acute fatty liver induced by the administration of simvastatin, ethanol and a hypercholesterolemic diet to mice.
    Life sciences, 2002, Apr-19, Volume: 70, Issue:22

    Topics: Acute Disease; Animals; Anticholesteremic Agents; Bacterial Proteins; Cholesterol, Dietary; Diet; Dose-Response Relationship, Drug; Ethanol; Fatty Liver; Hypercholesterolemia; Lipoproteins; Male; Mice; Simvastatin; Spirulina; Triglycerides

2002
[Studies on the simvastatin effect on the artery of atherosclerotic rabbit using proteomics approaches].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2003, Volume: 38, Issue:7

    Topics: Animals; Arteries; Arteriosclerosis; Diet, Atherogenic; Fatty Liver; Hypolipidemic Agents; Male; Proteins; Rabbits; Random Allocation; Simvastatin

2003
Ezetimibe: effective and safe treatment for dyslipidaemia associated with nonalcoholic fatty liver disease. Response to: Toth PP, Davidson MH: simvastatin and ezetimibe: combination therapy for the management of dyslipidaemia. Expert Opin. Pharmacother. (
    Expert opinion on drug safety, 2006, Volume: 5, Issue:4

    Topics: Anticholesteremic Agents; Azetidines; Drug Combinations; Dyslipidemias; Ezetimibe; Ezetimibe, Simvastatin Drug Combination; Fatty Liver; Humans; Insulin Resistance; Simvastatin

2006
[Different serum lipid adjustment drugs for the treatment of hyperlipidemic fatty liver].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2001, Volume: 9, Issue:6

    Topics: Animals; Cholesterol; Disease Models, Animal; Fatty Liver; Rats; Simvastatin; Triglycerides

2001