simvastatin has been researched along with Invasiveness, Neoplasm in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 16 (76.19) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Ji, L; Li, B; Qiang, T; Tian, H; Wang, J | 1 |
| Casado, E; Colmenarejo, G; Fernández, LP; Gómez de Cedrón, M; Merino, M; Moreno-Rubio, J; Quijada-Freire, A; Ramírez de Molina, A; Reglero, G; Sánchez-Martínez, R; Sereno, M | 1 |
| Baiano, S; Carnuccio, R; De Cicco, R; Fuggetta, MP; Morelli, A; Morelli, F; Tatè, R; Trotta, V; Urciuoli, M; Zona, E | 1 |
| Cai, WY; Li, T; Song, WT; Sun, JH; Yan, F; Zhuang, Y | 1 |
| Banciu, M; Bulzu, P; Licarete, E; Luput, L; Patras, L; Rakosy-Tican, E; Rauca, VF; Sesarman, A | 1 |
| Hu, W; Huang, W; Jiang, L; Li, M; Li, Y; Lu, L; Wu, X; Yuan, D | 1 |
| Bae-Jump, VL; Gehrig, PA; Gilliam, TP; Han, X; Kim, K; Schointuch, MN; Stine, JE; Zhou, C | 1 |
| Chan, CW; Goh, BC; Hartman, M; Lee, SC; Loh, X; Seah, S; Wang, T | 1 |
| Batra, SK; Chen, HT; Hsieh, KC; Ingersoll, MA; Kao, CL; Lin, MF; Martinez, O; Miller, DR; Simha, MV; Wakefield, CB | 1 |
| Hida, T; Horio, Y; Murakami-Tonami, Y; Osada, H; Sekido, Y; Tanaka, K | 1 |
| Cao, R; Dan, HC; Jiang, W; Ju, L; Qian, G; Wang, G; Wang, X; Wang, Y; Wu, M; Xiao, Y | 1 |
| Furuya, Y; Kato, H; Koike, H; Miyazawa, Y; Sekine, Y; Suzuki, K | 1 |
| Gaggioli, C; Hooper, S; Sahai, E | 1 |
| Baba, H; Fukushima, M; Funakosi, A; Hirota, M; Imamura, Y; Ishikawa, S; Koga, Y; Masuda, T; Nagai, Y; Nakamura, T; Takamori, H | 1 |
| Matsuura, M; Saito, T; Suzuki, T | 1 |
| Isozaki, M; Itoh, T; Kaneko, J; Kidera, Y; Nakamura, H; Nishida, S; Ogaki, M; Satou, T; Shoji, K; Tanimori, Y; Tsubaki, M; Yamazoe, Y; Yanae, M | 1 |
| Al-Husein, B; Goc, A; Kochuparambil, ST; Soliman, S; Somanath, PR | 1 |
| Choudhury, GG; Ghosh-Choudhury, N; Mandal, CC; Yoneda, T | 1 |
| Arnold, H; Gliemroth, J; Terzis, AJ; Zulewski, H | 1 |
| Kakehata, S; Maruya, S; Mizukami, H; Myers, JN; Shinkawa, H; Shirasaki, T; Takahata, T; Takeda, I; Yagihashi, S | 1 |
| Clynes, M; Eustace, AJ; Glynn, SA; O'Donovan, N; O'Sullivan, D | 1 |
21 other study(ies) available for simvastatin and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Simvastatin regulates the proliferation, apoptosis, migration and invasion of human acute myeloid leukemia cells via miR-19a-3p/HIF-1α axis.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Leukemic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; MicroRNAs; Neoplasm Invasiveness; Signal Transduction; Simvastatin | 2021 |
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer.
Topics: Aged; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coenzyme A Ligases; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Precision Medicine; Prognosis; Simvastatin; Survival Analysis | 2020 |
Simvastatin inhibits the expression of stemness‑related genes and the metastatic invasion of human cancer cells via destruction of the cytoskeleton.
Topics: Carcinoma, Embryonal; Cytoskeleton; Fluorescent Antibody Technique; Hep G2 Cells; Humans; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Pluripotent Stem Cells; Prenylation; Simvastatin | 2017 |
Effect of survivin downregulation by simvastatin on the growth and invasion of salivary adenoid cystic carcinoma.
Topics: Apoptosis; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Neoplasm Invasiveness; Neoplasm Proteins; Salivary Gland Neoplasms; Simvastatin; Survivin | 2018 |
Combination therapy of simvastatin and 5, 6-dimethylxanthenone-4-acetic acid synergistically suppresses the aggressiveness of B16.F10 melanoma cells.
Topics: Angiogenesis Inhibitors; Animals; Cell Communication; Cell Movement; Cell Proliferation; Coculture Techniques; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Macrophages; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Neovascularization, Pathologic; Simvastatin; Tumor Microenvironment; Xanthones | 2018 |
Kruppel-like factor 2 mediated anti-proliferative and anti-metastasis effects of simvastatin in p53 mutant colon cancer.
Topics: Cell Proliferation; Colonic Neoplasms; Down-Regulation; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Transcription Factors; Mutation; Neoplasm Invasiveness; Simvastatin; Tumor Suppressor Protein p53; Up-Regulation | 2019 |
Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer.
Topics: Apoptosis; Cell Adhesion; Cell Proliferation; Endometrial Neoplasms; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; Simvastatin; Tumor Cells, Cultured | 2014 |
Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway.
Topics: Adult; Aged; Apoptosis; Blotting, Western; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Mevalonic Acid; Middle Aged; Mitogen-Activated Protein Kinases; Neoplasm Grading; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Prognosis; Prospective Studies; Proto-Oncogene Proteins c-akt; Simvastatin; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2016 |
Statin derivatives as therapeutic agents for castration-resistant prostate cancer.
Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholesterol; Docetaxel; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neoplasm Invasiveness; Prostatic Neoplasms, Castration-Resistant; Proto-Oncogene Proteins c-akt; Receptors, Androgen; S Phase Cell Cycle Checkpoints; Signal Transduction; Simvastatin; Taxoids | 2016 |
Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation, Neoplastic; Hippo Signaling Pathway; Humans; Hyaluronan Receptors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mevalonic Acid; Mutation; Neoplasm Invasiveness; Neoplastic Stem Cells; Neurofibromin 2; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; RNA Interference; Signal Transduction; Simvastatin; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Tumor Suppressor Proteins; Ubiquitin Thiolesterase; YAP-Signaling Proteins | 2017 |
Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway.
Topics: Anilides; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Enzyme Activation; Epithelial-Mesenchymal Transition; ErbB Receptors; G1 Phase Cell Cycle Checkpoints; Glycogen Synthase Kinase 3 beta; Humans; Neoplasm Invasiveness; Oxazoles; PPAR gamma; Proto-Oncogene Proteins c-akt; Simvastatin; Tyrosine; Urinary Bladder; Urinary Bladder Neoplasms | 2016 |
Simvastatin Up-Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen-Independent Human Prostate Cancer Cells.
Topics: Animals; Annexins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Prostatic Neoplasms, Castration-Resistant; Simvastatin; Up-Regulation | 2017 |
A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.
Topics: Actomyosin; Carcinoma, Squamous Cell; Extracellular Matrix; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Integrin alpha5; Lovastatin; Muscle Contraction; Neoplasm Invasiveness; rab GTP-Binding Proteins; Simvastatin | 2010 |
The role of oxysterol binding protein-related protein 5 in pancreatic cancer.
Topics: Anticholesteremic Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Invasiveness; Pancreatic Neoplasms; Receptors, Steroid; Simvastatin; Sterol Regulatory Element Binding Protein 2 | 2010 |
Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy.
Topics: Adenocarcinoma, Clear Cell; Cell Line, Tumor; Extracellular Matrix; Female; Humans; Integrins; Neoplasm Invasiveness; Osteopontin; Ovarian Neoplasms; RNA Interference; Simvastatin | 2010 |
Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Blotting, Western; Cell Adhesion; Cell Movement; Cell Survival; Extracellular Matrix Proteins; Fatty Acids, Monounsaturated; Female; Fluvastatin; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Integrins; Lim Kinases; Lung Neoplasms; Matrix Metalloproteinases; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Myosin Light Chains; Neoplasm Invasiveness; Phosphorylation; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Simvastatin; Time Factors | 2010 |
Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Neoplasm Invasiveness; Phosphorylation; Prostate-Specific Antigen; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; RNA, Messenger; Simvastatin; Xenograft Model Antitumor Assays | 2011 |
Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.
Topics: Amino Acid Substitution; Animals; Anticholesteremic Agents; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Mice; Mice, Nude; Mutation, Missense; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Osteolysis; Simvastatin; Transcription, Genetic; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2011 |
Migration, proliferation, and invasion of human glioma cells following treatment with simvastatin.
Topics: Animals; Brain; Cell Division; Cell Movement; Coculture Techniques; Dose-Response Relationship, Drug; Glioma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Invasiveness; Rats; Rats, Wistar; Simvastatin; Spheroids, Cellular; Time Factors; Tumor Cells, Cultured | 2003 |
Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.
Topics: Anticholesteremic Agents; Carcinoma, Squamous Cell; Caspase 3; Cell Proliferation; Cell Survival; Focal Adhesion Kinase 1; G1 Phase; Head and Neck Neoplasms; Humans; Integrin beta1; Mevalonic Acid; Neoplasm Invasiveness; Phosphorylation; Signal Transduction; Simvastatin; Tumor Cells, Cultured | 2007 |
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells.
Topics: Apoptosis; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Lung Neoplasms; Male; Melanoma; Neoplasm Invasiveness; Simvastatin; Skin Neoplasms | 2008 |