simvastatin has been researched along with HbS Disease in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoppe, C; Jacob, E; Kuypers, F; Larkin, S; Styles, L; Vichinsky, E | 1 |
| Borges, VM; da Guarda, CC; Goncalves, MS; Pitanga, TN; Santana, SS; Santiago, RP; Zanette, DL | 1 |
| Canalli, AA; Conran, N; Costa, FF; Franco-Penteado, CF; Proença, RF; Saad, ST; Sakamoto, TM; Traina, F | 1 |
| Hagar, W; Hoppe, C; Kuypers, F; Larkin, S; Styles, L; Vichinsky, E | 1 |
2 trial(s) available for simvastatin and HbS Disease
| Article | Year |
|---|---|
Simvastatin reduces vaso-occlusive pain in sickle cell anaemia: a pilot efficacy trial.
Topics: Adolescent; Adult; Analgesics; Anemia, Sickle Cell; Arterial Occlusive Diseases; Biomarkers; C-Reactive Protein; Child; E-Selectin; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Male; Nitric Oxide; Pain; Simvastatin; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A; Young Adult | 2017 |
A pilot study of the short-term use of simvastatin in sickle cell disease: effects on markers of vascular dysfunction.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Biomarkers; Blood Coagulation; C-Reactive Protein; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Interleukin-6; Lipids; Nitric Oxide; Pilot Projects; Simvastatin; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A; Young Adult | 2011 |
2 other study(ies) available for simvastatin and HbS Disease
| Article | Year |
|---|---|
Heme changes HIF-α, eNOS and nitrite production in HUVECs after simvastatin, HU, and ascorbic acid therapies.
Topics: Anemia, Sickle Cell; Ascorbic Acid; Cells, Cultured; Dose-Response Relationship, Drug; Heme; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyurea; Hypoxia-Inducible Factor 1, alpha Subunit; Nitric Oxide Synthase Type III; Nitrites; Simvastatin | 2016 |
Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin.
Topics: Adult; Anemia, Sickle Cell; Antibodies, Monoclonal; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chemotaxis; Endothelial Cells; Endothelium, Vascular; Female; Humans; Hypolipidemic Agents; Integrins; Male; Middle Aged; Neutrophils; Simvastatin; Tumor Necrosis Factor-alpha; Young Adult | 2011 |