simvastatin has been researched along with Endotoxemia in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 5 (45.45) | 2.80 |
| Authors | Studies |
|---|---|
| Du, MY; Hu, Y; Luo, LL; Mei, H; Tang, L; Xu, M; Zhou, J | 1 |
| Arnaboldi, F; Bitto, N; Colombo, M; Denti, L; Dondossola, D; Gagliano, N; La Mura, V; Latini, R; Liguori, E; Peyvandi, F; Procacci, P; Ristagno, G; Salerno, F; Sartori, P; Tripodi, A | 1 |
| Dray, EL; Drnevich, J; Hussain, J; Krauklis, SA; McKim, DB; Ousley, CG | 1 |
| Cabral, LDM; Dos Santos, RS; Giusti-Paiva, A; Oliveira, MK; Vilela, FC | 1 |
| Ates, G; Kaptan, E; Ozkok, E; Tamer, S; Yorulmaz, H | 1 |
| Ates, G; Demir, G; Ertugrul Yalcin, I; Olgac, V; Ozkok, E; Tamer, S; Yorulmaz, H | 1 |
| Laschke, MW; Menger, MD; Schilling, MK; Slotta, JE; Thorlacius, H; Wang, Y | 1 |
| Carter, EA; Fischman, A; Fukaya, M; Inoue, Y; Kaneki, M; Ming-Yu, Y; Shinozaki, S; Tompkins, R; Yang, W; Yu, YM | 1 |
| Abraldes, JG; Bosch, J; García-Pagán, JC; Gracia-Sancho, J; Hide, D; La Mura, V; Meireles, CZ; Miquel, R; Pasarín, M; Rodríguez-Vilarrupla, A | 1 |
| Kapiotis, S; Marsik, C; Mittermayer, F; Pleiner, J; Polterauer, S; Schaller, G; Wolzt, M; Zorn, S | 1 |
| Goronzy, JJ; Huber, K; Kopp, CW; Maurer, G; Niessner, A; Pleiner, J; Seidinger, D; Speidl, WS; Steiner, S; Weyand, CM; Wojta, J; Wolzt, M | 1 |
2 trial(s) available for simvastatin and Endotoxemia
| Article | Year |
|---|---|
Simvastatin prevents vascular hyporeactivity during inflammation.
Topics: Acetylcholine; Adult; Double-Blind Method; Endotoxemia; Endotoxins; Forearm; Humans; Inflammation; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroglycerin; Norepinephrine; Oxidative Stress; Respiratory Burst; Simvastatin; Tumor Necrosis Factor-alpha; Vasodilation | 2004 |
Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Endotoxemia; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intravenous; Leukocyte Count; Lipopolysaccharides; Male; Monocytes; Polymerase Chain Reaction; Reference Values; RNA, Messenger; Simvastatin; Toll-Like Receptor 2; Toll-Like Receptor 4; Transcription, Genetic; Treatment Outcome; Up-Regulation | 2006 |
9 other study(ies) available for simvastatin and Endotoxemia
| Article | Year |
|---|---|
Simvastatin Improves Outcomes of Endotoxin-induced Coagulopathy by Regulating Intestinal Microenvironment.
Topics: Animals; Blood Coagulation Disorders; Disease Models, Animal; Endotoxemia; Endotoxins; Gastrointestinal Microbiome; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Diseases; Male; Mice; Mice, Inbred C57BL; Simvastatin | 2022 |
Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Endotoxemia; Fibrin; Hemostatics; Lipopolysaccharides; Liver Diseases; Male; Necrosis; Rats; Rats, Wistar; Sepsis; Simvastatin; Thrombosis; von Willebrand Factor | 2022 |
Prophylactic simvastatin increased survival during endotoxemia and inhibited granulocyte trafficking in a cell-intrinsic manner.
Topics: Animals; Cross-Sectional Studies; Endotoxemia; Granulocytes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Mice; Simvastatin | 2023 |
Simvastatin attenuated sickness behavior and fever in a murine model of endotoxemia.
Topics: Animals; Disease Models, Animal; Endotoxemia; Fever; Humans; Illness Behavior; Male; Mice; Simvastatin | 2020 |
Therapeutic effects of simvastatin on Galectin-3 and oxidative stress parameters in endotoxemic lung tissue.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Endotoxemia; Galectin 3; Gene Expression Regulation; Glutathione Peroxidase; Glutathione Reductase; Injections, Intraperitoneal; Lipopolysaccharides; Lung; Male; Oxidative Stress; Pneumonia; Rats; Rats, Wistar; Signal Transduction; Simvastatin; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2018 |
Pretreatment of simvastatin on liver trace element levels during endotoxemia.
Topics: Animals; Anti-Inflammatory Agents; Copper; Endotoxemia; Hepatocytes; Iron; Lipopolysaccharides; Liver; Magnesium; Male; Manganese; Rats; Rats, Wistar; Selenium; Simvastatin; Trace Elements; Zinc | 2020 |
Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury.
Topics: Animals; Apoptosis; Endotoxemia; Hepatocytes; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Simvastatin | 2009 |
Farnesyltransferase inhibitor improved survival following endotoxin challenge in mice.
Topics: Animals; Apoptosis; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Liver; Male; MAP Kinase Kinase 4; Methionine; Mice; Mice, Inbred C57BL; Simvastatin; Spleen | 2010 |
Effects of simvastatin administration on rodents with lipopolysaccharide-induced liver microvascular dysfunction.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Liver; Liver Circulation; Male; Microcirculation; Rats; Rats, Wistar; Simvastatin; Vascular Resistance | 2013 |