simvastatin has been researched along with Disease Models, Animal in 494 studies
*Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (1.21) | 18.2507 |
| 2000's | 142 (28.74) | 29.6817 |
| 2010's | 297 (60.12) | 24.3611 |
| 2020's | 49 (9.92) | 2.80 |
| Authors | Studies |
|---|---|
| Alberts, AW; Bostedor, R; Chao, YS; Duggan, ME; Fitzpatrick, SL; Halczenko, W; Hartman, GD; Imagire, JS; Pitzenberger, SM; Smith, RL | 1 |
| Askew, V; Auerbach, B; Dillon, L; Hanselman, JC; Kennedy, RM; Kowala, MC; Larsen, SD; Lin, Z; Lu, GH; Miller, S; Park, WK; Robertson, A; Roth, BD; Sekerke, C; Song, Y; Steinbaugh, BA; Sun, K; Tait, BD; Trivedi, BK | 1 |
| Jacobs, T; Kobbe, R; May, J; Schreiber, N | 1 |
| Bienvenu, AL; Picot, S | 1 |
| Argüelles, N; Chamorro-Cevallos, G; Cruz, Mdel C; Garduño-Siciliano, L; Jiménez, F; Medina-Franco, JL; Mendieta, A; Sánchez-Sandoval, E; Tamariz, J; Villa-Tanaca, L | 1 |
| Kourounakis, AP; Ladopoulou, EM; Matralis, AN; Nikitakis, A | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Dulak, J; Kaziród, K; Mucha, O; Podkalicka, P; Samborowska, E; Łoboda, A | 1 |
| Aartsma-Rus, A; Verhaart, I; Wells, D | 1 |
| Adams, ME; Bible, KL; Froehner, SC; Kim, MJ; Whitehead, NP | 1 |
| Aghaloo, T; Chen, C; Fan, J; Lee, M; Zhang, X | 1 |
| Cheng, L; Fullerton, DA; Gergen, AK; Li, A; Madsen, HJ; Meng, X; Pratap, A; Weyant, MJ | 1 |
| Du, MY; Hu, Y; Luo, LL; Mei, H; Tang, L; Xu, M; Zhou, J | 1 |
| Afrin, S; Borahay, MA; El Sabeh, M; Kilic, GS; Motamedi, M; Ozpolat, B; Saada, J; Vincent, KL; Yang, J | 1 |
| Bertil-Froidevaux, E; Bordier, F; Bourg, N; Daniele, N; Georger, C; Guerchet, N; Israeli, D; Jaber, A; Lostal, W; Richard, I; Tanniou, G; Vu Hong, A | 1 |
| Barreto, EA; Bou-Habib, DC; Bozza, FA; Bozza, PT; Cesar-Silva, D; Cunha-Fernandes, T; de Almeida, CJG; de Freitas, CS; Dias, SSG; Ferreira, AC; Fintelman-Rodrigues, N; Gonçalves, BS; Hottz, ED; Mattos, M; Palhinha, L; Pão, CRR; Pereira-Dutra, FS; Reis, PA; Sacramento, CQ; Saraiva, EM; Soares, VC; Souza, TML; Teixeira, L; Temerozo, JR; Viola, JPB | 1 |
| Hamel, E; Royea, J; Tong, XK | 1 |
| Arnaboldi, F; Bitto, N; Colombo, M; Denti, L; Dondossola, D; Gagliano, N; La Mura, V; Latini, R; Liguori, E; Peyvandi, F; Procacci, P; Ristagno, G; Salerno, F; Sartori, P; Tripodi, A | 1 |
| Alberici, LC; Catalão, CHR; da Costa, LHA; de Oliveira Souza, A; Dos Santos, JR; Rocha, MJA; Santos-Junior, NN | 1 |
| Ge, X; Lu, Y; Meng, L; Meng, X; Sui, W; Wang, X; Zhang, Y; Zhong, M | 1 |
| Huy, TXN; Kim, H; Kim, S; Lee, H; Lee, J; Min, W; Nguyen, TT; Reyes, AWB | 1 |
| Alabed, M; Elemam, NM; Hafezi, S; Halwani, R; Kalaji, Z; Mdkhana, B; Saheb Sharif-Askari, F; Saheb Sharif-Askari, N; Salam Bayram, O; Selvakumar, B | 1 |
| Chen, YR; Liu, D; Peng, B; Sun, F; Xiang, XD; Xiao, BW; Yan, MY | 1 |
| León, CTG; Monroy, A; Montes, S; Morales-Montor, J; Ríos, C; Rubio, C; Rubio-Osornio, M | 1 |
| Nikbakhtzadeh, M; Roghani, M; Sanaeierad, A; Zahedi, E; Zamani, E | 1 |
| Liu, Y; Long, Y; Peng, M; Xie, W; Yi, L; Zhang, B | 1 |
| Davidopoulou, S; Kalogirou, TE; Meditskou, S; Pitoulias, AG; Pitoulias, GA; Savvas, I | 1 |
| Koumaravelou, K; Sarathchandiran, I; Selvasudha, N | 1 |
| Baxter, S; Binderup, T; Calcagno, C; Carlucci, G; Duivenvoorden, R; Fay, F; Fayad, ZA; Fisher, EA; Frederico, YCA; Granada, JF; Hutten, BA; Ishino, S; Karakatsanis, N; Kjaer, A; Lobatto, ME; Lyashchenko, S; Malkus, J; Mani, V; Mulder, WJM; Nahrendorf, M; Pérez-Medina, C; Ramachandran, S; Reiner, T; Robson, PM; Sanchez-Gaytan, B; Senders, ML; Soultanidis, G; Swirski, FK; Tang, J; Teunissen, AJP; van Leent, MMT; Zhao, Y | 1 |
| Hamel, E; Royea, J; Tong, XK; Trigiani, LJ | 1 |
| Agrawal, A; Ahmad, M; Ahmad, T; Ghosh, B; Khanna, K; Kulshreshtha, A; Singh, S | 1 |
| Alhambra-Expósito, MR; Barrera-Martín, A; Blanco-Acevedo, C; Castaño, JP; Dios, E; Fanciulli, A; Fuentes-Fayos, AC; Gahete, MD; Gálvez-Moreno, MA; Granata, R; Herrera-Martínez, AD; Kineman, RD; L-López, F; Luque, RM; Moreno-Moreno, P; Solivera, J; Soto-Moreno, A; Vázquez-Borrego, MC; Venegas-Moreno, E | 1 |
| Feng, C; Li, DY; Liao, W; Lu, AQ; Tang, TY; Wang, ZR; Xiao, L; Yu, JC | 1 |
| Fan, H; Huang, J; Lai, X; Liu, A; Qiao, L; Shen, M; Wu, J; Yan, J | 1 |
| Carneiro, FP; Duarte, WR; Ferreira, VMM; Oliveira, GJPL; Pinto, LNMP; Roriz, VM; Sousa, DN; Vianna, LMS | 1 |
| Cabral, LDM; Dos Santos, RS; Giusti-Paiva, A; Oliveira, MK; Vilela, FC | 1 |
| Alem, C; Bouhlali, EDT; Bourkhis, B; Filali-Zegzouti, Y; Harnafi, H; Hmidani, A; Khouya, T | 1 |
| Agunloye, OM; Oboh, G | 1 |
| Andrade, F; Augustin, S; Barberá, A; Bravo, M; Genescà, J; Gil, M; Gracia-Sancho, J; Hide, D; Martell, M; Rafael, D; Raurell, I; Schwartz, S; Vargas, V | 1 |
| Abuduwaili, N; Guli, A; Jiang, L; Liu, X; Maney, K; Nabi, X; Sailike, J; Sun, X; Tuoliuhan, H; Wang, Y; Wu, Y | 1 |
| Cui, K; Jiang, Q; Sheng, L; Sun, H | 1 |
| Chang, C; Cui, ZJ; Gao, Y; Guo, PF; Khan, I; Ma, Z; Meng, QN; Wang, XB; Yang, RQ | 1 |
| Bayar, MA; Celik, H; Erdem, Y; Karatay, M; Sahin, O; Sertbas, I; Tascioglu, T; Tekiner, A | 1 |
| Choi, HK; Chung, MY; Hong, S; Hwang, JT; Kim, HJ; Lee, J; Lee, SH; Park, JH; Park, SW | 1 |
| Aartsma-Rus, A; Bull, D; Cappellari, O; Hildyard, JCW; Nnorom, S; Plomp, JJ; Tanganyika-de Winter, CL; Verhaart, IEC; Wells, DJ; Wells, KE | 1 |
| Du, J; Jiang, Q; Li, H; Lin, S; Mei, L; Wen, J; Yang, R | 1 |
| Li, Q; Liu, SH; Song, FC; Yuan, JQ; Zhang, L; Zhao, C; Zhao, K; Zhu, MD | 1 |
| Jia, J; Leng, H; Song, C; Wang, H; Wu, C; Xu, Y; Zhang, C; Zhang, Q; Zhu, J | 1 |
| Chen, CC; Chen, HJ; Chen, JS; Liang, CL; Liu, KY; Wang, HK; Wang, KW; Yeh, LR | 1 |
| Li, J; Li, Y; Liu, Y; Mu, D; Qi, Y; Shen, S; Sun, X; Xu, B; Zhang, B | 1 |
| Li, R; Lu, H; Ma, C; Shi, J; Sun, F; Yang, X; Yu, L; Yu, Y; Zhang, F; Zhang, S | 1 |
| Bu, WG; Du, RW | 1 |
| Cai, SH; Gao, Y; Li, HX; Liang, XY; Wu, JH; Yuan, YP | 1 |
| Bai, WW; Dong, B; Fu, CN; Guo, T; Li, P; Liu, C; Song, JW; Song, ZP; Wang, QW; Wang, SX | 1 |
| Alfulaij, N; Berry, MJ; Hashimoto, AC; Maunakea, AK; Peres, R; Seale, LA; Sultana, R; Torres, DJ; Watanabe, LM | 1 |
| Chen, Y; Dong, H; Li, Y; Wang, S; Wang, X; Wu, J; Xu, Y; Zhang, B | 1 |
| Florean, EOPT; Guedes, MIF; Holanda, MO; Lima, CLS; Lira, SM; Marques, MMM; Mendes, FNP; Moura, LFWG; Oriá, RB; Paim, RTT; Rodrigues, PAS; Silva, BBD; Silva, JYGD; Vieira, IGP | 1 |
| Arruda de Faria, C; Bassi, M; Caetano Andrade Coelho, KB; Colombari, E; Ribeiro-Paes, JT; Silva Júnior, WA; Zanette, DL | 1 |
| Berke, M; Giannini, PJ; Jia, Z; Liu, J; Nawshad, A; Reinhardt, RA; Samson, K; Schmid, M; Wang, D; Wang, X; Willett, ES; Yu, F | 1 |
| Guo, J; Liu, Q; Lu, M; Luo, D; Rong, X; Tang, F; Wang, H; Yang, Y; Yin, M; Yu, L | 1 |
| Chen, F; Fang, SC; Hong, H; Hu, M; Kong, LY; Long, Y; Sun, HB; Tang, SS; Xie, H | 1 |
| Alderman Iii, M; D'Hooghe, TM; Duleba, AJ; Fazleabas, AT; Taylor, HS | 1 |
| Chen, XY; Chu, YT; Dong, Q; Hou, L; Li, CQ; Li, TT; Song, RS; Xia, B; Zhang, YY; Zhu, XY | 1 |
| Cridge, J; Doherty, GJ; Gao, M; Griffiths, M; Hall, BA; Kerr, EM; Martins, CP; Samarajiwa, S; Shorthouse, D; Speed, A; Thorpe, H; Turrell, FK | 1 |
| Wang, Y; Yang, W; Zhang, L; Zhang, R; Zhao, X | 1 |
| Carvalho, V; Castro-Faria-Neto, HC; Estato, V; Freitas, F; Lessa, MA; Reis, P; Tibirica, E; Torres, R | 1 |
| Ding, G; Ma, Y; Yang, J; Yang, Q; Yang, Y | 1 |
| Adegbolagun, OM; Fakeye, TO; Igbinoba, SI; Showande, SJ | 1 |
| Aboulfotouh, N; Aladeeb, NM; Elkaref, A; Elmasry, A | 1 |
| Wang, Y; Yang, W; Zhang, R; Zhao, X | 1 |
| Chen, Q; Chen, Z; Feng, H; Feng, Z; He, Z; Tan, Q; Tang, J; Wang, Y; Zhu, G | 1 |
| Furgała, A; Sałat, K; Sałat, R | 1 |
| Duan, F; Guo, Z; Liu, Y; Xian, Z; Xiao, H; Xu, W | 1 |
| Campos-Martorell, M; Hernandez-Guillamón, M; Montaner, J; Simats, A; Solé, M; Sun, P; Unzeta, M | 1 |
| Basu, S; Bews, HJ; Carlson, JC; Halayko, AJ; Jha, A; Oo, O; Ryu, MH; Schwartz, J; Wong, CS | 1 |
| Cui, R; Feng, Y; Liang, H; Liu, C; Qiu, M; Zhang, J | 1 |
| Chen, J; Chen, L; Fei, A; Gao, C; Liu, D; Liu, X; Pan, S; Wang, H; Wu, Z | 1 |
| Cosar, E; Duleba, A; Mamillapalli, R; Moridi, I; Taylor, HS | 1 |
| Han, SH; Hwang, JY; Kim, JH; Park, JW; Park, SJ; Ryu, JH; Sohn, HM | 1 |
| Ekladious, ST; El Sayed, NS | 1 |
| Haußmann-Vopel, S; Lehmann, C; Pavlovic, D; Wegner, A | 1 |
| Al-Ajmi, HN; Al-Amin, MA; Al-Rasheed, NM; Bassiouni, YA; Hasan, IH; Mahmoud, AM | 1 |
| Boskabady, MH; Jafari, M; Jahromi, GP; Khamse, S; Mohammadian, M; Nejad, AK; Sadeghipour, HR | 1 |
| Deng, A; Huang, H; Huang, J; Liu, C; Tan, X; Xie, Y; Zou, P | 1 |
| Li, P; Lu, YW; Wen, XD; Yang, J; Zhang, L; Zhu, YC | 1 |
| Gao, L; Lin, Z; Liu, X; Liu, Y; Wan, L; Wang, X; Zhang, L | 1 |
| Huang, X; Lai, CH; Li, L; Liu, Z; Luo, J; Qi, X; Senninger, N; Wang, W; Wang, Y; Xiaoli, F; Xiong, Y; Ye, Q; Ye, S; Zhang, X; Zhong, Z | 1 |
| Amidžić, L; Gajanin, R; Jaćević, V; Kuča, K; Nežić, L; Škrbić, R | 1 |
| Abreu, AG; Braga Filho, JAF; Cysne, DN; Fortes, TS; Guerra, RNM; Maciel, MCG; Nascimento, FRF; Nascimento, JR; Rios, CEP; Serezani, CH; Silva, DLF; Silva, LA; Trovão, LO | 1 |
| Boyle, AK; Norman, JE; Rinaldi, SF; Rossi, AG; Saunders, PTK | 1 |
| Araújo Filho, I; Azevedo, ÍM; Lima, ML; Medeiros, ADC; Moreira, MD | 1 |
| Fawzy Fahim, V; Ishak Attallah, M; Shafik, AN; Wadie, W | 1 |
| C Park, Y; Haworth, K; Lin, CY; Mahoney, E; Mercado-Shekhar, KP; Nguyen, K; Pan, HY; Zhang, Z | 1 |
| Bosch, J; Cogger, VC; Fernández-Iglesias, A; Gracia-Sancho, J; Hide, D; Le Couteur, DG; Maeso-Díaz, R; Peralta, C; Warren, A | 1 |
| Chevion, M; Drenger, B; Grievink, H; Kuzmina, N | 1 |
| Hamel, E; Tong, XK; Trigiani, LJ | 1 |
| Al Humayed, S; Alassiri, M; Aldera, H; Alkhateeb, MA; Shati, AA; Shatoor, AS; Shatoor, KA | 1 |
| Ahmad, A; Al Musaddi, SA; Alkhatib, MH; Alkreathy, HM; Balamash, KSA; Osman, NN | 1 |
| Ali, KH; Ansari, MM; Choe, YH; Din, FU; Khan, N; Kim, JK; Kim, KW; Muhammad, I; Qureshi, OS; Rizvi, SZH; Shah, FA; Zeb, A | 1 |
| Han, Q; Liu, Q; Lu, M; Tang, F; Wang, H; Zhang, H; Zhang, Y | 1 |
| Ghosh, SP; Hauer-Jensen, M; Kumar, VP; Pathak, R | 1 |
| Adams, ME; Bible, KL; Froehner, SC; Kim, MJ; Regnier, M; Whitehead, NP | 1 |
| Bader, RR; Bruch, D; Gahtan, V; Gruessner, AC; Helkin, A; Maier, KG; Wilson, DR | 1 |
| Deveci, B; İzol, BS; Laçin, N; Özkorkmaz, EG; Tuncer, MC | 1 |
| Abdalla, FH; Bernardes, VM; Braun, JBS; Casali, EA; Castilhos, LG; da Cruz, IBM; de Andrade, CM; de Oliveira, JS; Leal, DBR; Manzoni, AG; Passos, DF; Ruchel, JB | 1 |
| Babu, PP; Kapadia, B; Mandaliya, D; Misra, P; Muggalla, CS; Patel, S; Prajapati, B; Rapaka, N; Saxena, U; Seshadri, S | 1 |
| Hu, JL; Li, HB; Li, X; Li, YM; Ren, XM; Wang, KX; Wei, W; Zhang, CY | 1 |
| Absi, M; Ashton, N; Eid, BG; Gurney, AM; Hart, G | 1 |
| Belser, JA; Katz, JM; Szretter, KJ; Tumpey, TM | 1 |
| Abdel-Zaher, AO; Abudahab, LH; Elbakry, MH; Elkoussi, AE; Elsayed, EA | 2 |
| Ito, T; Makino, K; Otsuka, M; Takemasa, M | 1 |
| Chai, CY; Chen, IJ; Chung, PW; Huang, HT; Kuo, MS; Liu, CP; Wu, BN | 1 |
| Jing, H; Li, H; Qiang, Y; Wang, G; Wang, L; Wu, H; Yi, J | 1 |
| Bariskaner, H; Kiyan, E; Kiyici, A; Suerdem, M; Toy, H; Tulek, B | 1 |
| Kalonia, H; Kumar, A; Mishra, J; Sharma, N | 1 |
| Alkan, A; Aydın, MŞ; Ezirganlı, Ş; Kazancıoğlu, HO; Mihmanlı, A; Sharifov, R | 1 |
| Chao, YL; Hong, CY; Hou, KL; Kok, SH; Lai, EH; Lee, MS; Lin, LD; Lin, SK; Wang, JS; Yang, H | 1 |
| Altavilla, D; Bagnato, G; Bitto, A; Cinquegrani, M; Irrera, N; Matucci Cerinic, M; Pizzino, G; Roberts, WN; Saitta, A; Sangari, D; Squadrito, F | 1 |
| Bhattacharya, S; Janardhanan, R; Kong, H; Leof, EB; Mandrekar, J; Misra, S; Mukhopadhyay, D; Roy, B; Vohra, P; Withers, S; Yang, B | 1 |
| Han, L; Liu, ZH; Qi, H; Yang, X; Zhao, C; Zou, C | 1 |
| McLaurin, J; Stefanovic, B; Thomason, LA | 1 |
| Bui, T; Jiang, X; Kocher, J; LeRoith, T; Li, G; Li, Y; Liu, F; Tan, M; Wen, K; Xia, M; Yang, X; Yuan, L; Zhong, W | 1 |
| Atta, HM; Azzam, M; Motawi, TM; Sadik, NA | 1 |
| Bürki, A; Eckelt, U; Ferguson, SJ; Kautz, A; Kneissel, M; Korn, P; Kramer, I; Range, U; Schlottig, F; Schnabelrauch, M; Stadlinger, B; Tödtmann, N | 1 |
| Chang, CF; Cheng, PW; Cheng, WH; Ho, WY; Hong, LZ; Hsiao, M; Lu, PJ; Sun, GC; Tseng, CJ; Yeh, TC | 1 |
| Mirzaii-Dizgah, I; Salmanyan, B | 1 |
| Glück, B; Meerbach, A; Schmidtke, M; Walther, M; Wutzler, P | 1 |
| Gao, C; Li, M; Xiao, W; Xu, W; Yu, J | 1 |
| Hamel, E; Papadopoulos, P; Tong, XK | 1 |
| Byrnes, JR; Mackman, N; Owens, AP | 1 |
| Chen, W; Garcia, JG; Jacobson, JR; Rizzo, AN; Sharma, R; Siegler, JH | 1 |
| Haycraft, CJ; Huang, Y; Jin, J; Kirkwood, KL; Li, Q; Li, Y; Lopes-Virella, MF; Lu, Z; Yu, H; Zhang, X | 1 |
| Ahn, KS; Chen, L; Kumar, AP; Li, F; Manu, KA; Sethi, G; Shanmugam, MK; Siveen, KS | 1 |
| Costa, TP; Fávero, GM; Fernandes, D; Machado, WM; Mendes, RT; Olchanheski, LR; Otuki, MF; Prestes, AP; Santos, FA; Sordi, R; Vellosa, JC | 1 |
| Chen, L; Chen, WX; Lu, ZH; Qu, WJ; Zeng, YY; Zhi, WH | 1 |
| Khan, A; Kim, HM; Kyere, KA; La Marca, F; Lin, CY; Miyata, Y; Park, P; Park, YS; Rahman, SU; Than, KD; Than, TT; Wang, L; Zhang, H | 1 |
| Coelho, PG; Galli, S; Ichikawa, T; Jimbo, R; Kozai, Y; Naito, Y; Ozeki, T; Tagami, T; Terukina, T; Vandeweghe, S | 1 |
| Anderson, GD; Bammler, TK; Elmore, BE; Farin, FM; Hoane, MR; Kantor, ED; MacDonald, JW; Moore, LH; Vonder Haar, C; Wright, AM | 1 |
| Huang, Y; Jin, J; Kirkwood, KL; Li, Y; Lopes-Virella, MF; Lu, Z; Machado, ER; Yu, H; Zhang, X | 1 |
| Al-Gayyar, MM; El-Gayar, AM; Hassan, HM; Ibrahim, TM | 1 |
| Hara, H; Horie, T; Ikeda, T; Kida, T; Morishita, S; Oku, H; Okubo, A; Sugiyama, T; Takai, S; Tonari, M | 1 |
| Barathi, VA; Guymer, RH; Luu, CD; Wong, TY; Yeo, SW | 1 |
| Borthwick, F; Jacome-Sosa, M; Mangat, R; Proctor, SD; Vine, DF; Warnakula, S | 1 |
| Del Rio, R; Haack, KK; Marcus, NJ; Schultz, HD; Zucker, IH | 1 |
| Deng, C; Gao, H; Huang, XF; Li, J; Liao, J; Liu, X; Qin, B; Tang, B; Wang, Q; Wei, X; Yu, Y | 1 |
| Duarte, WR; Ferreira, VM; Santana, WM; Sousa, DN | 2 |
| Chi, J; Gologorsky, Y | 1 |
| Battistetti, GD; da Costa, KF; Faccioni, DM; Kottwitz, LB; Marconato, J; Marin, CF; Nahsan, FP; Nassar, CA; Nassar, PO; Olegário, J | 1 |
| Dao Trong, ML; Gottschalk, O; Jansson, V; Jauch, KW; Metz, P; Piltz, S; Schmitt-Sody, M; Wallmichrath, J | 1 |
| Bruiners, N; Gennaro, ML; Karakousis, PC; Pine, R; Pinn, ML; Skerry, C | 1 |
| Akhyari, P; Assmann, A; Barth, M; Delfs, C; Horstkötter, K; Lichtenberg, A; Munakata, H; Schiffer, F; Zwirnmann, K | 1 |
| Chiaro, JA; Haskins, ME; Malhotra, NR; O'Donnell, P; Ponder, KP; Shore, EM; Smith, LJ | 1 |
| Allon, DM; Allon, I; Anavi, Y | 1 |
| Jin, YH; Li, TH; Liu, M; Shi, LH; Zhu, BQ | 1 |
| Chang, HF; Chang, JK; Chen, HT; Chuang, SC; Feng, CW; Ho, ML; Hsieh, KC; Kao, CL; Wang, GJ; Wen, ZH; Wu, SM | 1 |
| Chen, H; Liu, XQ; Lu, EY; Qin, A; Xu, XC; Zhai, ZJ; Zhang, X | 1 |
| Abdollahifar, MA; Jahanabadi, Z; Noorafshan, A; Shirazi, M; Soltani, MR; Tanideh, N | 1 |
| Cong, D; Huang, Q; Liang, H; Wang, X; Wang, Y; Xie, C; Zhang, X | 1 |
| Caglayan, AB; Caglayan, B; Demirci, S; Dogan, A; Ekimci, N; Ethemoglu, MS; Kilic, E; Kilic, U; Oztezcan, S; Sahin, F; Seker, FB; Yilmaz, B | 1 |
| Abraldes, JG; Bosch, J; García-Cardena, G; García-Pagán, JC; Gracia-Sancho, J; Maeso-Díaz, R; Marrone, G | 1 |
| Dai, L; Hu, M; Shen, Z; Wang, Y; Wu, H; Xu, M; Xue, L; Yuan, D; Zhao, H | 1 |
| Holwegner, C; Marx, DB; Reinhardt, AL; Reinhardt, RA; Schmid, MJ | 1 |
| Hamel, E; Tong, XK | 1 |
| Güney, A; Kafadar, İH; Karaman, İ; Karaman, ZF; Koçer, A; Koçer, D; Öner, M | 1 |
| Jiang, X; Li, Z; Sun, W; Wang, L; Wang, Y; Zhang, L | 1 |
| Dubovický, M; Kašparová, S; Kucharská, J; Liptaj, T; Lipták, B; Sumbalová, Z; Szomolányi, P; Trattnig, S; Tušková, R; Uličná, O; Vančová, O | 1 |
| Balaha, M; Kandeel, S | 1 |
| Cao, X; Chen, Z; Shi, Q; Tang, B; Wang, T; Zhang, T | 1 |
| Dos Santos Kotake, BG; Ervolino, E; Gonçalves Gonzaga, M; Ingraci de Lucia, C; Issa, JP; Macedo, AP; Mizusaki Iyomasa, D; Tocchini de Figueiredo, FA | 1 |
| Azma, K; Moshiri, A; Oryan, A; Shahrezaee, M; Shekarchi, B | 1 |
| Armaganidis, A; Dimopoulou, I; Kotanidou, A; Magkou, C; Maniatis, NA; Manitsopoulos, N; Nikitopoulou, I; Orfanos, SE; Siempos, I; Zakynthinos, SG | 1 |
| D'Hooge, R; Gieselmann, V; Matzner, U; Stein, A; Stroobants, S | 1 |
| Chen, T; Li, MQ; Liu, L; Zhang, WW | 1 |
| Cui, Y; Fu, X; Guo, Q; Leng, H; Ma, T; Song, C; Tan, J; Yang, N; Yin, X | 1 |
| Pariente, A | 1 |
| Chen, L; Chen, T; Li, G; Sha, S; Wang, C; Zhou, L | 1 |
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| Chen, KJ; Guo, CY; Huang, Y; Ma, XJ; Shi, DZ; Wu, CF; Xue, M; Yin, HJ | 1 |
| Charish, J; Hosseini, SK; Kaka, GR; Keshavarz, M; Pirzad Jahromi, G; Sadr, SS; Seidi, S; Shabanzadeh, AP; Sohanaki, H | 1 |
| Ahmad, M; Aslam, B; Faisal, I; Javed, I; Khan, MZ; Muhammad, F; Rahman, Z; Shahzadi, A | 1 |
| Anagnostopoulos, CE; Angouras, DC; Chamogeorgakis, TP; Mastoraki, ST; Papalois, A; Rokkas, CK; Tiniakos, D; Toumpoulis, IK | 1 |
| Dawson, HN; Indraswari, F; James, ML; Kernagis, D; Laskowitz, DT; Lei, B; Wang, H; Warner, DS | 1 |
| Arici, A; Basar, M; Cakmak, H; Duleba, AJ; Lockwood, CJ; Osteen, KG; Seval-Celik, Y; Taylor, HS | 1 |
| Hong, SJ; Kim, PS; Ko, JH; Mustoe, TA; Zhao, Y | 1 |
| Bai, W; Li, H; Zheng, X; Zhou, L | 1 |
| Cao, D; Fukuchi, K; Kou, J; Li, L; Lim, JE; Pattanayak, A; Song, M; Yang, J | 1 |
| Cao, R; Dong, XW; Jiang, JX; Li, FF; Shen, HJ; Shen, LL; Sun, Y; Xie, QM; Xu, L; Yao, HY | 1 |
| Iafisco, M; Ito, T; Otsuka, M; Prat, M; Rimondini, L; Saito, M; Senna, M; Uchino, T | 1 |
| Guan, YY; Li, SY; Ma, MM; Wang, M | 1 |
| Anastasiou-Nana, M; Andreadou, I; Farmakis, D; Iliodromitis, EK; Kremastinos, DT; Papalois, A; Papapetropoulos, A; Prokovas, E; Sigala, F; Spyridaki, K; Zoga, A | 1 |
| Han, JI; Han, S; Hwang, J | 1 |
| Adami, M; Cabrini, DA; Horinouchi, CD; Mendes, DA; Otuki, MF; Prudente, Ada S | 1 |
| Bramanti, P; Capuano, A; Cuzzocrea, S; Donniacuo, M; Esposito, E; Impellizzeri, D; Mazzon, E; Paterniti, I; Rinaldi, B | 1 |
| Alizadeh, AM; Alizadeh, F; Khori, V; Moheimani, HR; Najafi, SA; Nayebpour, M; Shakiba, D | 1 |
| Boyd, AR; Hinojosa, CA; Orihuela, CJ; Rodriguez, PJ | 1 |
| Almeida-Leite, CM; Bahia, MT; Leite, R; Shrestha-Bajracharya, D; Silva, RR; Talvani, A | 1 |
| El-Azab, MF; Hazem, RM; Moustafa, YM | 1 |
| Gupta, A; Kalonia, H; Kumar, A; Mishra, J; Sharma, N | 1 |
| Chung, MH; Lee, CS; Lee, JK; Lee, JW; Lee, YJ; Shin, MK; Sung, SH; Won, C; Yang, YM; Ye, SK; Yi, EH | 1 |
| Chang, KO; Jung, K; Kim, Y; Saif, LJ; Scheuer, K; Shen, Q; Wang, Q; Zhang, Z | 1 |
| Basraon, SK; Costantine, MM; Hankins, GD; Longo, M; Makhlouf, M; Menon, R; Saade, GR | 1 |
| Ji, YQ; Liu, CP; Lu, WX; Zeng, Q; Zhang, WH; Zhang, YJ | 1 |
| Bosch, J; García-Cardeña, G; García-Pagán, JC; Gracia-Sancho, J; Hide, D; Marrone, G; Rosado, E; Russo, L | 1 |
| Chen, J; Chopp, M; Cui, X; Dai, J; Kuzmin-Nichols, N; Ning, R; Roberts, C; Sanberg, CD; Shehadah, A; Yan, T; Zacharek, A; Zhang, C | 1 |
| De Almeida, P; De Godoi, V; Frigo, L; Leal-Junior, EC; Leonardo, PS; Lopes-Martins, RÁ; Pallotta, RC; Rossi, RP; Tomazoni, SS | 1 |
| Constantin-Teodosiu, D; Davies, WJ; Glaves, PD; Greenhaff, PL; Mallinson, JE; Martin, EA; Sidaway, JE; Westwood, FR | 1 |
| Chen, G; Liang, M; Ma, X; Tang, B; Wang, Z; Wu, Z; Xiong, M; Yao, J | 1 |
| Abraldes, JG; Bosch, J; García-Pagán, JC; Gracia-Sancho, J; Hide, D; La Mura, V; Meireles, CZ; Miquel, R; Pasarín, M; Rodríguez-Vilarrupla, A | 1 |
| Bu, X; Cheng, P; Guo, X; Jiang, J; Yan, Z | 1 |
| Chang, CC; Hong, CY; Hou, KL; Hsiao, M; Kok, SH; Lai, EH; Lin, LD; Lin, SK; Wang, JH | 1 |
| Chen, G; Wang, Z; Zhu, Y | 1 |
| Anderson, M; Bruner-Tran, KL; Duleba, AJ; Ortega, I; Osteen, KG; Sokalska, A; Villanueva, J | 1 |
| Iwata, H; Kodama, T | 1 |
| Granger, DN; Jin, R; Li, G; Liu, L; Nanda, A; Zhu, X | 1 |
| Bonetti, PO; Holmes, DR; Lerman, A; Lerman, LO; Rodriguez-Porcel, M; Wilson, SH | 1 |
| Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG; Qiu, D; Vaszar, LT | 1 |
| Aspenberg, P; Forslund, C; Skoglund, B | 1 |
| Laskowitz, DT; Lynch, JR; McGirt, MJ; Parra, A; Pearlstein, RD; Pelligrino, DA; Sheng, H; Warner, DS | 1 |
| Campbell, C; Crilly, A; Gracie, JA; Leung, BP; Liew, FY; Madhok, R; McCarey, DW; McInnes, IB; Payne, H; Prach, M; Sattar, N | 1 |
| Asdente, M; Balduini, W; Calvio, AM; Cimino, M; Guerrini, U; Lodetti, B; Paoletti, R; Sironi, L; Tremoli, E | 1 |
| Chade, AR; Feldstein, A; Lerman, A; Lerman, LO; Napoli, C; Sawamura, T; Wilson, SH | 1 |
| Fujisaki, K; Itoh, Y; Maiguma, T; Makino, K; Oishi, R; Sasaguri, T; Takahashi-Yanaga, F; Teshima, D | 1 |
| Amano, Y; Imura, Y; Ishikawa, E; Nishimoto, T; Sugiyama, Y; Tozawa, Ri | 1 |
| Cornish, KG; Peuler, JD; Pliquett, RU; Zucker, IH | 1 |
| Bea, F; Blessing, E; Rosenfeld, ME; Shelley, MI; Shultz, JM | 1 |
| Balduini, W; Carloni, S; Cimino, M; De Simoni, MG; Mazzoni, E; Perego, C; Sironi, L | 1 |
| Farivar, AS; Fraga, C; Mulligan, MS; Naidu, BV; Thomas, R; Woolley, SM | 1 |
| Makita, S; Oshima, K; Wajima, T | 1 |
| Leung, BP; Liew, FY; McInnes, IB; McKay, A; Thomson, NC | 1 |
| Ashitkov, T; Birnbaum, Y; Hu, ZY; Motamedi, M; Tavackoli, S; Uretsky, BF | 1 |
| Aktan, F; Ceylan, A; Karasu, C; Ozansoy, G | 1 |
| Busso, N; Chobaz, V; Gabay, C; Palmer, G; So, A; Talabot-Ayer, D; Taylor, S | 1 |
| Abe, K; Deguchi, K; Hayashi, T; Nagano, I; Nagotani, S; Sato, K; Shoji, M; Zhang, W | 1 |
| Ito, T; Shiomi, M; Yamada, S | 1 |
| Amin-Hanjani, S; Asahi, M; Huang, PL; Huang, Z; Liao, JK; Lo, EH; Mori, T; Moskowitz, MA; Qiu, J; Sumii, T; Thomas, S; Yoshimura, S | 1 |
| Kopecky, M; Nachtigal, P; Semecky, V; Solichova, D; Zdansky, P | 1 |
| Cui, Y; Liu, H; Ning, Z; Qing, X; Wu, C; Yang, J; Yu, S; Zhao, D | 1 |
| Cheng, X; Ge, H; Guo, Z; Li, B; Liao, YH; Liu, Y; Lu, B; Wang, M; Yang, Y; Zhang, J; Zhang, L | 1 |
| McLachlan, C; Wang, PH; Wang, Q; Wong, PT | 1 |
| Balduini, W; Carloni, S; Cimino, M; Gelosa, P; Guerrini, U; Sironi, L; Tremoli, E | 1 |
| Kellomäki, M; Keski-Nisula, L; Mikkonen, J; Nevalainen, T; Parkkinen, J; Salenius, JP; Törmälä, P; Uurto, I | 1 |
| Choe, KH; Kim, EK; Kim, SE; Lee, DS; Lee, JH; Lee, SD; Lee, YS; Oh, YM; Shim, TS | 1 |
| Dellê, H; Fujihara, CK; Malheiros, DM; Mantovani, E; Mattar, AL; Noronha, IL; Rodrigues, LT; Vieira, JM; Zatz, R | 1 |
| Cornish, KG; Gao, L; Li, YL; Liu, D; Schultz, HD; Wang, W; Zucker, IH | 1 |
| Caprio, TW; Drummond, E; Entenman, K; Inman, SR; Mueller, M | 1 |
| Briestensky, J; Jamborova, G; Jaynes, R; Kopecky, M; Nachtigal, P; Pospechova, K; Pospisilova, N; Santar, I; Semecky, V; Smahelova, A; Solichova, D; Zdansky, P | 1 |
| Mareev, VIu | 1 |
| Laverty, R; Ledingham, JM | 1 |
| Correa-Cerro, LS; Fliesler, SJ; Grinberg, A; Kratz, L; Miller, GF; Munasinghe, JP; Porter, FD; Wassif, CA | 1 |
| Banes-Berceli, AK; Brands, M; Caldwell, RW; Eaton, DC; Fulton, D; Ma, G; Marrero, MB; Shaw, S; Stern, DM | 1 |
| Banfi, C; Brioschi, M; Cimino, M; Gelosa, P; Gianella, A; Guerrini, U; Nobili, E; Paoletti, R; Sironi, L; Tremoli, E | 1 |
| Chen, ZJ; Gao, RL; Jing, ZC; Wu, YJ; Yang, YJ; You, SJ; Zhao, JL | 1 |
| Baier, M; Bamme, T; Gültner, S; Lütjohann, D; Mok, SW; Riemer, C; Thelen, KM | 1 |
| Aprahamian, T; Bonegio, R; Lefer, DJ; Perlman, H; Rifkin, IR; Rizzo, J; Walsh, K | 1 |
| Agrawal, VK; Bulsara, KR; Coates, JR; Durham, HE; Eifler, DM; Fine, DM; Toft, K; Wagner-Mann, CC | 1 |
| Kim, DY; Lee, YS; Lim, JE; Ro, JY; Ryu, SY | 1 |
| Aukrust, P; Boullier, A; Breland, U; Damås, JK; Fevang, B; Frøland, SS; Gullestad, L; Halvorsen, B; Hansson, GK; Kjekshus, J; Ovchinnikova, O; Quehenberger, O; Robertson, AK; Sandberg, WJ; Smith, C; Taskén, K; Waehre, T; Yndestad, A; Øie, E | 1 |
| Cao, D; Fukuchi, K; Kim, H; Lester, R; Li, L | 1 |
| Champion, HC; Girgis, RE; Hassoun, PM; Johns, RA; Li, D; Mozammel, S; Peng, X; Shimoda, L; Tuder, RM | 1 |
| Akyol, H; Bingul, S; Eser, M; Kaptanoglu, L; Kucuk, HF; Kurt, N; Torlak, OA; Uzun, H | 1 |
| Croxen, RL; Fenstermacher, JD; Knight, RA; Konda, KP; Nagaraja, TN | 1 |
| Araújo Filho, I; Azevedo, IM; Brandão-Neto, J; Dominici, VA; Egito, ES; Medeiros, AC; Rego, AC; Souza Neto, JL | 1 |
| Chen, X; Li, Z; Meng, L; Qin, XW; Ruan, YM; Yang, YJ; Zhang, HD | 1 |
| Chen, KJ; Guo, Y; Shi, DZ; Yin, HJ | 1 |
| Cheng, X; Feng, X; Jing, H; Li, Z; Shao, H; Yin, R; Zhu, J | 1 |
| Adah, F; Benghuzzi, H; England, B; Russell, G; Tucci, M | 1 |
| Bate, C; Kempster, S; Williams, A | 1 |
| Guyton, JR; Laskowitz, DT; Lynch, JR; Mace, B; Song, P; Wang, H; Warner, DS; Yang, HJ; Yates, RB | 1 |
| Chan, CY; Chang, FY; Chen, YC; Chu, CJ; Huang, HC; Lee, FY; Lee, SD; Lin, HC; Wang, SS | 1 |
| Liu, C; Sun, H; Wu, Z; Zang, G | 1 |
| Gvozdjáková, A; Kucharská, J; Simko, F | 1 |
| Kunes, J; L'upták, I; Matúsková, J; Pechánová, O; Simko, F; Török, J; Zicha, J | 1 |
| Ayer, R; Jadhav, V; Sugawara, T; Zhang, JH | 1 |
| Aspenberg, P; Skoglund, B | 1 |
| Chen, T; Hui, J; Jiang, B; Jiang, TB; Jiang, WP; Liu, ZH; Song, JP; Yan, JF; Yang, XJ | 1 |
| Crockett, JC; Hughes, A; Idris, AI; Rogers, MJ | 1 |
| Basal, S; Caglar, K; Eyileten, T; Ipcioglu, OM; Kaya, A; Korkmaz, A; Oguz, Y; Sonmez, A; Topal, T; Vural, A; Yenicesu, M; Yilmaz, MI | 1 |
| Kanagarajan, N; Murthy, S; Nam, JH; Noah, ZA | 1 |
| Skoglund, B | 1 |
| Birnbaum, Y; Lin, Y; Merla, R; Perez-Polo, JR; Uretsky, BF; Ye, Y | 1 |
| Drüeke, TB; Ivanovski, O; Joki, N; Ketteler, M; Lacour, B; Maizel, J; Massy, ZA; Mothu, N; Nguyen-Khoa, T; Nikolov, IG; Szumilak, D; Westenfeld, R | 1 |
| Aoki, T; Hashimoto, N; Ishibashi, R; Kataoka, H; Nozaki, K | 1 |
| Furuuchi, M; Ishizaka, A; Minematsu, N; Nakajima, T; Nakamura, H; Nakamura, M; Seki, M; Shirahata, T; Shiraishi, Y; Takahashi, S; Tateno, H; Tsujimura, S; Yamamoto, M; Yamasaki, M | 1 |
| Altavilla, D; Bitto, A; Bonaiuto, M; Calò, M; Caputi, AP; Fiumara, T; Galeano, M; Lo Cascio, P; Marini, H; Migliorato, A; Minutoli, L; Polito, F; Squadrito, F | 1 |
| Aparicio, C; Blanco-Colio, LM; Egido, J; Esbrit, P; Martin-Ventura, JL; Ortega, L | 1 |
| Liu, Y; Yan, F; Yu, H; Zhang, C; Zhang, Y; Zhao, Y | 1 |
| Wang, J; Wang, L; Wang, Y; Xu, Y; Yang, J | 1 |
| Davis, P; Exner, M; Kerjaschki, D; Neale, TJ; Ojha, PP; Poczewski, H; Rüger, B; Witztum, JL | 1 |
| Emura, S; Fukuoka, M; Kato, H; Kawazoye, S; Kishikawa, H; Ohmori, K; Okada, R; Oogushi, K; Takashima, T | 1 |
| Barsotti, A; Barsotti, L; Di Napoli, P; Maggi, A; Palka, G; Spina, R; Stuppia, L; Taccardi, AA; Vianale, G | 1 |
| Alfon, J; Badimon, L; Berrozpe, M; Guasch, JF | 1 |
| Aoki, T; Kitahara, M; Saito, Y; Sato, F; Suzuki, H; Tamaki, T | 1 |
| Emeis, JJ; Lankelma, J; Nègre-Aminou, P; van Hinsbergh, VW; van Nieuw Amerongen, GP; Vermeer, MA | 1 |
| Burton, CA; Chao, YS; Detmers, PA; Hassing, H; Hermanowski-Vosatka, A; Hernandez, M; Mundt, S; Patel, S; Peterson, L; Rosa, R; Sparrow, CP; Wang, PR; Wright, SD; Zhang, D | 1 |
| Abdellatif, M; Entman, ML; Kopelen, HA; Lutucuta, S; Marian, AJ; Nagueh, SF; Patel, R; Quinones, MA; Roberts, R; Tsybouleva, N; Zoghbi, WA | 1 |
| Balduini, W; Cimino, M; De Angelis, V; Mazzoni, E | 1 |
| Jia, X; Lu, R; Meng, F; Yan, M; Zhao, X | 1 |
| da Cunha, V; Dole, W; Hinchman, J; Huw, LY; Kauser, K; Martin-McNulty, B; Post, J; Sullivan, ME; Vergona, R; Wang, YX | 1 |
| Abbate, M; Cattaneo, D; Corna, D; Remuzzi, G; Rottoli, D; Tomasoni, S; Zanchi, C; Zoja, C | 1 |
8 review(s) available for simvastatin and Disease Models, Animal
| Article | Year |
|---|---|
Cerebrovascular contributions to Alzheimer's disease pathophysiology and potential therapeutic interventions in mouse models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Hemorrhage; Cerebrum; Disease Models, Animal; Inositol; Mice; Simvastatin | 2013 |
Hyperlipidemia, tissue factor, coagulation, and simvastatin.
Topics: Animals; Blood Coagulation; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Simvastatin; Thromboplastin; Thrombosis | 2014 |
Pitfalls in the assessment of murine atherosclerosis.
Topics: Animals; Anticholesteremic Agents; Aorta; Arteriosclerosis; Cholesterol; Disease Models, Animal; Humans; Mice; Simvastatin; Tunica Intima | 2009 |
The pathogenetic features of cerebral cavernous malformations: a comprehensive review with therapeutic implications.
Topics: Animals; Apoptosis Regulatory Proteins; Carrier Proteins; Disease Models, Animal; Hemangioma, Cavernous, Central Nervous System; Humans; KRIT1 Protein; Membrane Proteins; Mice; Microtubule-Associated Proteins; Proto-Oncogene Proteins; Signal Transduction; Simvastatin | 2010 |
Mechanisms of statin treatment in cerebral vasospasm.
Topics: Animals; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Rats; Review Literature as Topic; Simvastatin; Time Factors; Vasospasm, Intracranial | 2011 |
Effects of ezetimibe on atherosclerosis in preclinical models.
Topics: Animals; Anticholesteremic Agents; Apolipoproteins B; Apolipoproteins E; Atherosclerosis; Azetidines; Cardiovascular Diseases; Cholesterol, LDL; Disease Models, Animal; Drug Evaluation, Preclinical; Ezetimibe; Mice; Mice, Knockout; Rabbits; Risk; Simvastatin | 2011 |
Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia.
Topics: Aging; Animals; Animals, Newborn; Brain Ischemia; Disease Models, Animal; Enzyme Activation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Nitric Oxide Synthase Type III; Simvastatin; Stroke | 2005 |
[Treatment of chronic heart failure. The time of statins?].
Topics: Aged; Animals; Anticholesteremic Agents; Cholesterol; Controlled Clinical Trials as Topic; Costs and Cost Analysis; Disease Models, Animal; Female; Fluorobenzenes; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Male; Prognosis; Pyrimidines; Risk Factors; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Time Factors | 2005 |
4 trial(s) available for simvastatin and Disease Models, Animal
| Article | Year |
|---|---|
Pre-treatment and continuous administration of simvastatin during sepsis improve metabolic parameters and prevent CNS injuries in survivor rats.
Topics: Animals; Cytokines; Disease Models, Animal; Gliosis; Rats; Sepsis; Simvastatin; Survivors | 2022 |
In vivo pharmacodynamic and pharmacokinetic interactions of Hibiscus sabdariffa calyces extracts with simvastatin.
Topics: Adult; Animals; Cross-Over Studies; Disease Models, Animal; Female; Herb-Drug Interactions; Hibiscus; Humans; Hypolipidemic Agents; Male; Plant Extracts; Rats; Rats, Wistar; Simvastatin; Young Adult | 2017 |
Effect of simvastatin on the antihypertensive activity of losartan in hypertensive hypercholesterolemic animals and patients: role of nitric oxide, oxidative stress, and high-sensitivity C-reactive protein.
Topics: Adult; Aged; Animals; Anticholesteremic Agents; Antihypertensive Agents; Aorta; Blood Pressure; C-Reactive Protein; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Hypertension; In Vitro Techniques; Isometric Contraction; Losartan; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Rabbits; Rats, Wistar; Simvastatin; Treatment Outcome | 2014 |
Simvastatin enhances the antihypertensive effect of ramipril in hypertensive hypercholesterolemic animals and patients. Possible role of nitric oxide, oxidative stress, and high sensitivity C-reactive protein.
Topics: Adult; Aged; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; C-Reactive Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypertension; In Vitro Techniques; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Rabbits; Ramipril; Rats; Rats, Wistar; Simvastatin; Treatment Outcome; Vasodilation | 2012 |
482 other study(ies) available for simvastatin and Disease Models, Animal
| Article | Year |
|---|---|
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Disease Models, Animal; Dogs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Magnetic Resonance Spectroscopy; Rats; Simvastatin; Structure-Activity Relationship | 1992 |
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
Topics: Animals; Atorvastatin; Combinatorial Chemistry Techniques; Disease Models, Animal; Fluorobenzenes; Hepatocytes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Molecular Structure; Muscle Cells; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides | 2008 |
Simvastatin treatment shows no effect on the incidence of cerebral malaria or parasitemia during experimental malaria.
Topics: Animals; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Parasitemia; Plasmodium berghei; Plasmodium falciparum; Simvastatin; Treatment Outcome | 2008 |
Statins alone are ineffective in cerebral malaria but potentiate artesunate.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Atorvastatin; Disease Models, Animal; Drug Synergism; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Malaria, Cerebral; Malaria, Falciparum; Mice; Neuroprotective Agents; Pravastatin; Pyrroles; Simvastatin | 2008 |
Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Binding Sites; Computer Simulation; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Design; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred ICR; Schizosaccharomyces | 2010 |
Antihyperlipidemic morpholine derivatives with antioxidant activity: An investigation of the aromatic substitution.
Topics: Animals; Antioxidants; Binding Sites; Catalytic Domain; Disease Models, Animal; Farnesyl-Diphosphate Farnesyltransferase; Hyperlipidemias; Hypolipidemic Agents; Inhibitory Concentration 50; Microsomes, Liver; Molecular Docking Simulation; Morpholines; Rats | 2015 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy.
Topics: Animals; Disease Models, Animal; Dystrophin; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Simvastatin | 2021 |
Author's Response to: Rebuttal to: Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy, Verhaart et al. 2020.
Topics: Animals; Disease Models, Animal; Mice; Muscles; Muscular Dystrophy, Duchenne; Simvastatin | 2021 |
Rebuttal to: Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy, Verhaart et al. 2020.
Topics: Animals; Disease Models, Animal; Mice; Muscles; Muscular Dystrophy, Duchenne; Simvastatin | 2021 |
Co-delivery of simvastatin and demineralized bone matrix hierarchically from nanosheet-based supramolecular hydrogels for osteogenesis.
Topics: Animals; Biocompatible Materials; Bone Diseases; Bone Matrix; Bone Morphogenetic Protein 2; Bone Regeneration; Cell Differentiation; Cell Line; Disease Models, Animal; Drug Carriers; Hydrogels; Mesenchymal Stem Cells; Mice; Mice, Nude; Nanostructures; Osteogenesis; Prostheses and Implants; Simvastatin; Skull; Static Electricity | 2021 |
Simvastatin Inhibits Histologic Changes Associated with Gastroduodenal Reflux in a Murine Model.
Topics: Adenocarcinoma; Animals; Annexin A5; Barrett Esophagus; Caspase 3; Disease Models, Animal; Esophageal Neoplasms; Esophagitis, Peptic; Gastroesophageal Reflux; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Simvastatin | 2022 |
Simvastatin Improves Outcomes of Endotoxin-induced Coagulopathy by Regulating Intestinal Microenvironment.
Topics: Animals; Blood Coagulation Disorders; Disease Models, Animal; Endotoxemia; Endotoxins; Gastrointestinal Microbiome; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Diseases; Male; Mice; Mice, Inbred C57BL; Simvastatin | 2022 |
Simvastatin-loaded liposome nanoparticles treatment for uterine leiomyoma in a patient-derived xenograft mouse model: a pilot study.
Topics: Animals; Disease Models, Animal; Heterografts; Humans; Ki-67 Antigen; Leiomyoma; Liposomes; Mice; Nanoparticles; Pilot Projects; Simvastatin | 2022 |
Co-Administration of Simvastatin Does Not Potentiate the Benefit of Gene Therapy in the mdx Mouse Model for Duchenne Muscular Dystrophy.
Topics: Animals; Disease Models, Animal; Genetic Therapy; Male; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Simvastatin | 2022 |
Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts.
Topics: Animals; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Down-Regulation; Humans; Inflammation; Lung; Membrane Microdomains; Mice; Mice, Transgenic; SARS-CoV-2; Simvastatin; Virus Replication | 2022 |
Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; beta Catenin; Disease Models, Animal; Hippocampus; Ki-67 Antigen; Mice; Neurogenesis; Neurons; Simvastatin; Wnt Signaling Pathway | 2022 |
Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Endotoxemia; Fibrin; Hemostatics; Lipopolysaccharides; Liver Diseases; Male; Necrosis; Rats; Rats, Wistar; Sepsis; Simvastatin; Thrombosis; von Willebrand Factor | 2022 |
Statin therapy protects against abdominal aortic aneurysms by inducing the accumulation of regulatory T cells in ApoE
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Dysbiosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Knockout; Simvastatin; T-Lymphocytes, Regulatory | 2022 |
Simvastatin Inhibits
Topics: Animals; Brucella abortus; Brucellosis; CD8-Positive T-Lymphocytes; Disease Models, Animal; Mevalonic Acid; Mice; Mice, Inbred ICR; RAW 264.7 Cells; Simvastatin | 2022 |
Simvastatin reduced infiltration of memory subsets of T lymphocytes in the lung tissue during Th2 allergic inflammation.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Simvastatin; Th2 Cells | 2022 |
Simvastatin Reduces NETosis to Attenuate Severe Asthma by Inhibiting PAD4 Expression.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; DNA; Extracellular Traps; Histones; Inflammation; Lipopolysaccharides; Lung; Mice; Neutrophils; Ovalbumin; RNA, Messenger; Simvastatin | 2023 |
Repurposing Simvastatin in Parkinson's Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the
Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Parkinson Disease; Proteomics; Rats; Simvastatin; Substantia Nigra | 2023 |
Simvastatin improves learning and memory impairment via gut-brain axis regulation in an ovariectomized/D-galactose Alzheimer's rat model.
Topics: Alzheimer Disease; Animals; Brain-Gut Axis; Disease Models, Animal; Female; Galactose; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Memory Disorders; Rats; Simvastatin | 2023 |
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
Topics: Animals; Caspase 1; Colonic Neoplasms; Disease Models, Animal; HCT116 Cells; Humans; Mice; Mice, Nude; Phosphate-Binding Proteins; Pore Forming Cytotoxic Proteins; Pyroptosis; Reactive Oxygen Species; Simvastatin | 2023 |
Investigating the Possible Protective Role of Direct Intra-arterial Administration of Mannitol and N-Acetylcysteine and Per Os Administration of Simvastatin Against Contrast-Induced Nephropathy: An Experimental Study in a Rabbit Model.
Topics: Acetylcysteine; Acute Kidney Injury; Administration, Oral; Animals; Contrast Media; Disease Models, Animal; Diuretics, Osmotic; Humans; Infusions, Intra-Arterial; Iohexol; Male; Mannitol; Rabbits; Simvastatin | 2019 |
Interaction pattern and
Topics: Administration, Oral; Animals; Chitosan; Cholesterol, Dietary; Delayed-Action Preparations; Disease Models, Animal; Drug Administration Schedule; Drug Carriers; Drug Compounding; Drug Liberation; Female; Humans; Hyperlipidemias; Mice; Molecular Docking Simulation; Nanoparticles; Particle Size; Proton Magnetic Resonance Spectroscopy; Simvastatin; Spectroscopy, Fourier Transform Infrared | 2019 |
Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Female; Imaging, Three-Dimensional; Immunotherapy; Lipoproteins, HDL; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Nanomedicine; Positron-Emission Tomography; Rabbits; Simvastatin; Species Specificity; Swine; Tissue Distribution | 2019 |
Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia.
Topics: Animals; Cerebrovascular Circulation; Cognitive Dysfunction; Dementia; Disease Models, Animal; Inflammation; Mice; Microglia; Physical Conditioning, Animal; Simvastatin | 2019 |
Simvastatin mediates inhibition of exosome synthesis, localization and secretion via multicomponent interventions.
Topics: Animals; Asthma; Atherosclerosis; Cell Line; Cholesterol; Disease Models, Animal; Exosomes; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Monocytes; Simvastatin | 2019 |
Statins Directly Regulate Pituitary Cell Function and Exert Antitumor Effects in Pituitary Tumors.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Metformin; Mice; Middle Aged; Neuroendocrine Tumors; Papio anubis; Pituitary Gland; Pituitary Neoplasms; Rats; Simvastatin; Somatostatin; Young Adult | 2020 |
Simvastatin promotes osteogenic differentiation of mesenchymal stem cells in rat model of osteoporosis through BMP-2/Smads signaling pathway.
Topics: Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Hypolipidemic Agents; Mesenchymal Stem Cells; Osteogenesis; Osteoporosis; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; Smad Proteins | 2020 |
Simvastatin Improves Behavioral Disorders and Hippocampal Inflammatory Reaction by NMDA-Mediated Anti-inflammatory Function in MPTP-Treated Mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dopaminergic Neurons; Hippocampus; Inflammation; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Parkinson Disease; Simvastatin | 2020 |
Local effect of simvastatin combined with different osteoconductive biomaterials and collagen sponge on new bone formation in critical defects in rat calvaria.
Topics: Animals; Anticholesteremic Agents; Biocompatible Materials; Bone Regeneration; Bone Substitutes; Bone Transplantation; Cattle; Collagen; Disease Models, Animal; Female; Osteogenesis; Rats; Rats, Wistar; Simvastatin; Skull | 2020 |
Simvastatin attenuated sickness behavior and fever in a murine model of endotoxemia.
Topics: Animals; Disease Models, Animal; Endotoxemia; Fever; Humans; Illness Behavior; Male; Mice; Simvastatin | 2020 |
Effect of Phoenix dactylifera seeds (dates) extract in triton WR-1339 and high fat diet induced hyperlipidaemia in rats: A comparison with simvastatin.
Topics: Animals; Antioxidants; Biomarkers; Diet, High-Fat; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Lipid Peroxidation; Lipids; Male; Obesity; Phoeniceae; Plant Extracts; Polyethylene Glycols; Polyphenols; Rats, Wistar; Seeds; Simvastatin; Solvents; Weight Gain | 2020 |
High cholesterol diet promotes dysfunction of arginase and cholinergic enzymatic system in rats: ameliorative role of caffeic and chlorogenic acids.
Topics: Acetylcholinesterase; Animals; Antioxidants; Arginase; Butyrylcholinesterase; Caffeic Acids; Chlorogenic Acid; Cholesterol; Diet; Disease Models, Animal; Enzyme Inhibitors; Hypercholesterolemia; Phenols; Rats; Simvastatin | 2020 |
Simvastatin-loaded polymeric micelles are more effective and less toxic than conventional statins in a pre-clinical model of advanced chronic liver disease.
Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Cirrhosis; Micelles; Polymers; Rats; Simvastatin; Tissue Distribution | 2020 |
Ziziphora clinopodioides flavonoids based on network pharmacology attenuates atherosclerosis in rats induced by high-fat emulsion combined with vitamin D
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Aortic Diseases; Atherosclerosis; Cholecalciferol; Disease Models, Animal; Fat Emulsions, Intravenous; Flavonoids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lamiaceae; Lipids; Male; NF-kappa B; Oxidative Stress; Plant Extracts; Plaque, Atherosclerotic; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; Vascular Endothelial Growth Factor A | 2020 |
Downregulation of lncRNA H19 alleviates atherosclerosis through inducing the apoptosis of vascular smooth muscle cells.
Topics: Animals; Apoptosis; Atherosclerosis; Cell Line; Cell Proliferation; Diet, High-Fat; Disease Models, Animal; Gene Knockdown Techniques; Humans; Male; Mice; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; RNA, Long Noncoding; Signal Transduction; Simvastatin; Up-Regulation | 2020 |
Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury.
Topics: Animals; Caspase 3; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Lung; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Smoke Inhalation Injury; Superoxide Dismutase; Treatment Outcome | 2020 |
Simvastatin in an experimental spinal cord injury model: a histopathological and biochemical evidence based study.
Topics: Animals; Disease Models, Animal; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Simvastatin; Spinal Cord; Spinal Cord Injuries | 2020 |
Piceatannol reduces resistance to statins in hypercholesterolemia by reducing PCSK9 expression through p300 acetyltransferase inhibition.
Topics: Animals; Cholesterol, LDL; Disease Models, Animal; Down-Regulation; Drug Resistance; Hep G2 Cells; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Mice, Inbred C57BL; p300-CBP Transcription Factors; Proprotein Convertase 9; Protein Stability; Receptors, LDL; Rosuvastatin Calcium; Simvastatin; Stilbenes | 2020 |
Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy.
Topics: Animals; Disease Models, Animal; Fibrosis; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Animal; Muscular Dystrophy, Duchenne; Simvastatin | 2021 |
Effect of high fat diet and excessive compressive mechanical force on pathologic changes of temporomandibular joint.
Topics: Animals; Chondrocytes; Diet, High-Fat; Disease Models, Animal; Interleukin-1beta; Leptin; Male; Mandible; Matrix Metalloproteinase 3; Mice; Mice, Inbred C57BL; Obesity; Phenazines; Risk Factors; Simvastatin; Stress, Mechanical; Temporomandibular Joint | 2020 |
Ameliorative effects of the traditional Chinese medicine formula
Topics: Animals; Arteriosclerosis Obliterans; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Inflammation; Male; Medicine, Chinese Traditional; NF-kappa B; Rabbits; Simvastatin; Tandem Mass Spectrometry | 2020 |
Osteogenic effects in a rat osteoporosis model and femur defect model by simvastatin microcrystals.
Topics: Animals; Bone Density; Crystallization; Disease Models, Animal; Drug Compounding; Female; Femur; Osteogenesis; Osteoporosis; Ovariectomy; Particle Size; Poloxamer; Rats; Rats, Sprague-Dawley; Simvastatin; X-Ray Microtomography | 2021 |
Simvastatin-Ezetimibe enhances growth factor expression and attenuates neuron loss in the hippocampus in a model of intracerebral hemorrhage.
Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Drug Therapy, Combination; Ezetimibe; Hippocampus; Intercellular Signaling Peptides and Proteins; Male; Maze Learning; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Simvastatin | 2021 |
Hyaluronic acid-coated polymeric micelles with hydrogen peroxide scavenging to encapsulate statins for alleviating atherosclerosis.
Topics: Animals; Antioxidants; Atherosclerosis; Disease Models, Animal; Hyaluronic Acid; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Mice; Micelles; Oxidative Stress; Polyethylene Glycols; RAW 264.7 Cells; Simvastatin | 2020 |
Diosgenin alleviates hypercholesterolemia via SRB1/CES-1/CYP7A1/FXR pathway in high-fat diet-fed rats.
Topics: Animals; Anticholesteremic Agents; Biomarkers; Carboxylic Ester Hydrolases; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Diet, High-Fat; Diosgenin; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Male; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Scavenger Receptors, Class B; Signal Transduction; Simvastatin | 2021 |
Simvastatin Prevents Neurodegeneration in the MPTP Mouse Model of Parkinson's Disease via Inhibition of A1 Reactive Astrocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Disease Models, Animal; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neuroprotective Agents; Parkinson Disease; Simvastatin | 2021 |
Simvastatin attenuates acute lung injury by activation of A2B adenosine receptor.
Topics: Acute Lung Injury; Adenosine A2 Receptor Agonists; Animals; Claudin-4; Claudins; Cystic Fibrosis Transmembrane Conductance Regulator; Cytokines; Disease Models, Animal; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Neutrophil Infiltration; Pulmonary Edema; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Signal Transduction; Simvastatin | 2021 |
Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1.
Topics: Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; MAP Kinase Kinase Kinase 1; Mice; Mice, Knockout, ApoE; MicroRNAs; Muscle Fibers, Skeletal; Muscular Diseases; Physical Conditioning, Animal; Primary Cell Culture; RNA, Small Interfering; Simvastatin; Up-Regulation | 2021 |
Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase.
Topics: Animals; Creatinine; Diet, High-Fat; Disease Models, Animal; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Liver; Lyases; Male; Mice; Mice, Knockout; Mice, Obese; Muscle, Skeletal; Obesity; Oxidative Stress; Selenium; Selenoproteins; Sex Characteristics; Simvastatin | 2021 |
Simvastatin increases circulating endothelial progenitor cells and inhibits the formation of intracranial aneurysms in rats with diet-induced hyperhomocysteinemia.
Topics: Animals; Biomarkers; Disease Models, Animal; Endothelial Progenitor Cells; Endothelium, Vascular; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Intracranial Aneurysm; Male; Rats; Rats, Sprague-Dawley; Simvastatin; Vascular Remodeling | 2021 |
Hypolipidemic and reduced nitrergic effects of p-hydroxycinnamic diesters extracted from Copernicia prunifera in mice challenged by a high-fat diet.
Topics: Administration, Oral; Animals; Arecaceae; Biomarkers; Body Weight; Coumaric Acids; Diet, High-Fat; Disease Models, Animal; Female; Hyperlipidemias; Hypolipidemic Agents; Inflammation; Interleukin-1beta; Lipid Metabolism; Lipids; Liver; Liver X Receptors; Male; Mice, Inbred C57BL; Plant Extracts; Simvastatin | 2021 |
Mesenchymal stromal cells-based therapy in a murine model of elastase-induced emphysema: Simvastatin as a potential adjuvant in cellular homing.
Topics: Animals; Disease Models, Animal; Emphysema; Female; Lung; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Pancreatic Elastase; Pulmonary Emphysema; Simvastatin | 2021 |
Standardized Rat Model Testing Effects of Inflammation and Grafting on Extraction Healing.
Topics: Alveolar Bone Loss; Animals; Bone Remodeling; Bone Transplantation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Maxilla; Molar; Rats; Simvastatin; Tooth Extraction; Tooth Socket; Wound Healing; X-Ray Microtomography | 2017 |
Downregulations of CD36 and Calpain-1, Inflammation, and Atherosclerosis by Simvastatin in Apolipoprotein E Knockout Mice.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Calpain; CD36 Antigens; Disease Models, Animal; Down-Regulation; Genetic Predisposition to Disease; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Interleukin-6; Lipoproteins, LDL; Male; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Plaque, Atherosclerotic; Simvastatin; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2017 |
Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Blood Glucose; Brain; Cytokines; Diabetes Mellitus, Experimental; Disease Models, Animal; Hypolipidemic Agents; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Neurotoxicity Syndromes; Peptide Fragments; Signal Transduction; Simvastatin | 2017 |
Effect of simvastatin on baboon endometriosis.
Topics: Animals; Disease Models, Animal; Endometriosis; Endometrium; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neopterin; Papio; Pilot Projects; Proliferating Cell Nuclear Antigen; Random Allocation; RNA, Messenger; Simvastatin | 2017 |
[Hemostatic Effect of Spleen-invigorating, Qi-replenishing and Blood-containing Formula on Simvastatin-induced Zebrafish Hemorrhage Model].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Hemorrhage; Hemostatics; Qi; Simvastatin; Spleen; Zebrafish | 2017 |
Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genotype; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Lung Neoplasms; Mice; Molecular Targeted Therapy; Mutation; Piperazines; Simvastatin; Tumor Suppressor Protein p53 | 2017 |
An experimental study of the protective effect of simvastatin on sepsis-induced myocardial depression in rats.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardium; Myocytes, Cardiac; NF-kappa B; Rats; Rats, Wistar; Sepsis; Signal Transduction; Simvastatin; Toll-Like Receptor 4; Transcription Factor RelA | 2017 |
Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension.
Topics: Angiotensin II; Animals; Cerebrovascular Circulation; Disease Models, Animal; Hypertension; Male; Microcirculation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Simvastatin | 2017 |
Angiotensin II induces cholesterol accumulation and injury in podocytes.
Topics: Angiotensin II; Animals; Apoptosis; Cholesterol; Cytoskeleton; Disease Models, Animal; Gene Expression; Lipid Metabolism; Perilipin-2; Podocytes; Renal Insufficiency, Chronic; Simvastatin | 2017 |
Simvastatin exerts antifibrotic effect and potentiates the antischistosomal effects of praziquantel in a murine model: Role of IL10.
Topics: Animals; Anthelmintics; Antifibrinolytic Agents; Disease Models, Animal; Drug Therapy, Combination; Interleukin-10; Male; Mice; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Simvastatin; Snails; Treatment Outcome | 2017 |
Experimental Study of the Protective Effect of Simvastatin on Lung Injury in Rats with Sepsis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Caspase 3; Cytokines; Cytoprotection; Deoxyguanosine; Disease Models, Animal; Inflammation Mediators; Lipocalin-2; Lung; Male; Malondialdehyde; Oxidative Stress; Pulmonary Edema; Rats, Wistar; Sepsis; Signal Transduction; Simvastatin; Superoxide Dismutase; Toll-Like Receptor 4; Transcription Factor RelA | 2018 |
Simvastatin accelerates hematoma resolution after intracerebral hemorrhage in a PPARγ-dependent manner.
Topics: Anilides; Animals; Anticholesteremic Agents; Antigens, CD; Cell Count; Cerebral Hemorrhage; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Hematoma; Male; Microglia; Neurologic Examination; Phagocytosis; PPAR gamma; Protein Transport; Rats; Rats, Sprague-Dawley; Simvastatin; Time Factors | 2018 |
Evaluation of cebranopadol, a dually acting nociceptin/orphanin FQ and opioid receptor agonist in mouse models of acute, tonic, and chemotherapy-induced neuropathic pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Indoles; Male; Mice; Morphine; Neuralgia; Nociceptin; Opioid Peptides; Pain Measurement; Receptors, Opioid; Simvastatin; Spiro Compounds | 2018 |
The Anti-hyperlipidemia Effects of Raw Polygonum multiflorum Extract in Vivo.
Topics: Acetyl-CoA Carboxylase; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal; Fallopia multiflora; Fatty Acid Synthase, Type I; Hepatocytes; Humans; Hydroxymethylglutaryl CoA Reductases; Hyperlipidemias; Hypolipidemic Agents; Lipid Metabolism; Liver; Male; Medicine, Chinese Traditional; Rats, Sprague-Dawley; Simvastatin; Triglycerides | 2017 |
Simvastatin blocks soluble SSAO/VAP-1 release in experimental models of cerebral ischemia: Possible benefits for stroke-induced inflammation control.
Topics: Amine Oxidase (Copper-Containing); Animals; Brain; Brain Ischemia; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Disease Models, Animal; E-Selectin; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Wistar; Simvastatin; Stroke; Vascular Cell Adhesion Molecule-1 | 2018 |
Prophylactic benefits of systemically delivered simvastatin treatment in a house dust mite challenged murine model of allergic asthma.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Cytokines; Disease Models, Animal; Eosinophils; Female; Lung; Mice, Inbred BALB C; Neutrophils; Pyroglyphidae; Simvastatin | 2018 |
Simvastatin protects against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidative Stress; Protective Agents; Simvastatin; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2018 |
Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury.
Topics: Acute Lung Injury; Animals; CD11c Antigen; Disease Models, Animal; Enzyme Inhibitors; Humans; Intestines; Lipopolysaccharides; p21-Activated Kinases; Rats; Simvastatin; Tumor Necrosis Factor-alpha | 2017 |
Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis.
Topics: Animals; Biomarkers; Disease Models, Animal; Endometriosis; Female; MicroRNAs; Papio; Simvastatin | 2019 |
The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats.
Topics: Animals; Disease Models, Animal; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin; Spinal Cord; Treatment Outcome | 2018 |
Effect of pioglitazone and simvastatin in lipopolysaccharide-induced amyloidogenesis and cognitive impairment in mice: possible role of glutamatergic pathway and oxidative stress.
Topics: Amyloid beta-Peptides; Animals; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Glutamic Acid; Lipopolysaccharides; Male; Maze Learning; Mice; Neuroprotective Agents; Nitrates; Oxidative Stress; Peptide Fragments; Pioglitazone; Recognition, Psychology; Signal Transduction; Simvastatin | 2019 |
Impact of lipid modulation on the intestinal microcirculation in experimental sepsis.
Topics: Animals; Anti-Inflammatory Agents; Bezafibrate; Blood Flow Velocity; Capillaries; Cytokines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Intestines; Intravital Microscopy; Leukocyte Rolling; Lipid Metabolism; Lipopolysaccharides; Lipoproteins, HDL; Male; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Rats, Inbred Lew; Regional Blood Flow; Sepsis; Simvastatin | 2018 |
Simvastatin ameliorates diabetic nephropathy by attenuating oxidative stress and apoptosis in a rat model of streptozotocin-induced type 1 diabetes.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Caspase 3; Collagen; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Models, Animal; Down-Regulation; Hyperglycemia; Hypertrophy; Kidney; Kidney Function Tests; Male; Oxidative Stress; Rats, Wistar; Simvastatin; Streptozocin | 2018 |
Simvastatin and bone marrow-derived mesenchymal stem cells (BMSCs) affects serum IgE and lung cytokines levels in sensitized mice.
Topics: Animals; Asthma; Bone Marrow; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulin E; Interleukin-13; Lung; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Ovalbumin; Simvastatin; Transforming Growth Factor beta | 2019 |
Bone-targeted delivery of simvastatin-loaded PEG-PLGA micelles conjugated with tetracycline for osteoporosis treatment.
Topics: Animals; Bone and Bones; Disease Models, Animal; Drug Carriers; Drug Compounding; Human Umbilical Vein Endothelial Cells; Humans; Micelles; Osteoporosis; Particle Size; Polyesters; Polyethylene Glycols; Rats; Simvastatin; Tetracycline | 2018 |
Ilexgenin A enhances the effects of simvastatin on non-alcoholic fatty liver disease without changes in simvastatin pharmacokinetics.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cytochrome P-450 CYP3A; Diet, High-Fat; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Lipids; Liver; Male; Molecular Structure; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; Simvastatin; Transcription, Genetic; Triterpenes | 2018 |
Hypolipidemic effect of Fragarianilgerrensis Schlecht. medicine compound on hyperlipidemic rats.
Topics: Animals; Antioxidants; Centella; Cholesterol, HDL; Disease Models, Animal; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipid Metabolism; Lipids; Liver; Plant Extracts; Rats; Simvastatin; Triglycerides; Triterpenes | 2018 |
Simvastatin ameliorates total liver ischemia/reperfusion injury via KLF2-mediated mechanism in rats.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Disease Models, Animal; Hepatocytes; Inflammation Mediators; Kruppel-Like Transcription Factors; Liver; Male; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin; Superoxide Dismutase; Thrombomodulin; Up-Regulation; Warm Ischemia | 2019 |
Simvastatin Protects Cardiomyocytes Against Endotoxin-induced Apoptosis and Up-regulates Survivin/NF-κB/p65 Expression.
Topics: Administration, Oral; Animals; Apoptosis; Cardiomyopathies; Caspase 3; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Escherichia coli; Heart; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Wistar; Sepsis; Signal Transduction; Simvastatin; Survivin; Transcription Factor RelA; Up-Regulation | 2018 |
Prophylactic Treatment With Simvastatin Modulates the Immune Response and Increases Animal Survival Following Lethal Sepsis Infection.
Topics: Animals; CD4-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Hydrogen Peroxide; Male; Mice; Sepsis; Simvastatin | 2018 |
Repurposing simvastatin as a therapy for preterm labor: evidence from preclinical models.
Topics: Animals; Anticholesteremic Agents; Cells, Cultured; Disease Models, Animal; Drug Repositioning; Female; Humans; Inflammation; Lipopolysaccharides; Mice; Muscle, Smooth; Myometrium; Obstetric Labor, Premature; Pregnancy; Signal Transduction; Simvastatin; Uterine Contraction | 2019 |
Effects of simvastatin on 5-fluorouracil-induced gastrointestinal mucositis in rats.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Disease Models, Animal; Fluorouracil; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Male; Mucositis; Random Allocation; Rats; Rats, Wistar; Simvastatin; Tumor Necrosis Factor-alpha | 2018 |
Role of simvastatin and insulin in memory protection in a rat model of diabetes mellitus and dementia.
Topics: Amyloid beta-Peptides; Animals; Blood Glucose; Cholesterol; Dementia; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hippocampus; Insulin; Maze Learning; Memory; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin | 2019 |
Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment.
Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Extracorporeal Shockwave Therapy; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intervertebral Disc; Intervertebral Disc Degeneration; Nanoparticles; Rabbits; Simvastatin | 2019 |
Ischemia/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly.
Topics: Age Factors; Animals; Disease Models, Animal; Endothelial Cells; Liver; Male; Nitric Oxide; Phenotype; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Tyrosine | 2020 |
Sevoflurane postconditioning is not mediated by ferritin accumulation and cannot be rescued by simvastatin in isolated streptozotocin-induced diabetic rat hearts.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Ferritins; Gene Expression Regulation; Heart; Iron; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Nitric Oxide; Rats; Sevoflurane; Simvastatin; Streptozocin | 2019 |
High cholesterol triggers white matter alterations and cognitive deficits in a mouse model of cerebrovascular disease: benefits of simvastatin.
Topics: Animals; Cerebrovascular Disorders; Cognition Disorders; Disease Models, Animal; Hypercholesterolemia; Male; Mice; Mice, Transgenic; Simvastatin; White Matter | 2019 |
Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein.
Topics: Animals; Antioxidants; Aorta; Crataegus; Diet, High-Fat; Disease Models, Animal; Glutathione; Inflammation; Lipids; Lipoproteins, LDL; Male; Plant Extracts; Rats; Rats, Wistar; Simvastatin; Superoxide Dismutase; Tunica Media; Vascular Diseases | 2019 |
Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma.
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma, Ehrlich Tumor; Disease Models, Animal; Doxorubicin; Drug Carriers; Drug Synergism; Emulsions; Female; Kidney; Liver; Mice; Nanostructures; Simvastatin; Survival Rate | 2019 |
Simvastatin-loaded solid lipid nanoparticles for enhanced anti-hyperlipidemic activity in hyperlipidemia animal model.
Topics: Administration, Oral; Animals; Crystallization; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug Liberation; Hyperlipidemias; Hypolipidemic Agents; Lipids; Male; Nanoparticles; Particle Size; Rats; Rats, Sprague-Dawley; Simvastatin | 2019 |
Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-κB (NF-κB).
Topics: Animals; Calpain; Cardiomegaly; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Inflammation; Intercellular Adhesion Molecule-1; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Simvastatin; Streptozocin; Vascular Cell Adhesion Molecule-1 | 2019 |
Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin.
Topics: Animals; Chromans; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Occupational Exposure; Radiation, Ionizing; Simvastatin; Survival Analysis; Vitamin E | 2019 |
Simvastatin provides long-term improvement of left ventricular function and prevents cardiac fibrosis in muscular dystrophy.
Topics: Animals; Autonomic Nervous System; Calcium-Binding Proteins; Cardiomyopathies; Disease Models, Animal; Fibrosis; Heart; Heart Rate; Male; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Myocytes, Cardiac; Phosphorylation; Recovery of Function; Simvastatin; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Intraluminal Delivery of Simvastatin Attenuates Intimal Hyperplasia After Arterial Injury.
Topics: Administration, Oral; Animals; Caproates; Carotid Artery Injuries; Carotid Artery, Common; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Drug Carriers; Drug Compounding; Humans; Hyaluronic Acid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Micelles; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Polymers; Rats, Sprague-Dawley; Sialic Acids; Simvastatin; Tunica Intima; Vascular Remodeling | 2019 |
The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study.
Topics: Animals; Autografts; Bone Regeneration; Bone Remodeling; Disease Models, Animal; Male; Osteoblasts; Osteoclasts; Rats; Rats, Wistar; Simvastatin; Tibia | 2019 |
Lipotoxicity-associated inflammation is prevented by guarana (
Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperlipidemias; Inflammation; Lymphocytes; Male; Rats; Rats, Wistar; Simvastatin; Theobromine; Theophylline | 2021 |
Statins exacerbate glucose intolerance and hyperglycemia in a high sucrose fed rodent model.
Topics: Animals; Atorvastatin; Diet; Disease Models, Animal; Fatty Acids; Feeding Behavior; Gene Expression Regulation; Glucose Intolerance; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Insulin; Muscles; Rats; Signal Transduction; Simvastatin; Sucrose | 2019 |
Simvastatin alleviates inflammation and oxidative stress in rats with cerebral hemorrhage through Nrf2-ARE signaling pathway.
Topics: Animals; Antioxidant Response Elements; Cerebral Hemorrhage; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Interleukin-1beta; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; Toll-Like Receptor 4 | 2019 |
Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium Channel Blockers; Calcium Channels; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Phenylephrine; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar; rho-Associated Kinases; Simvastatin | 2019 |
Simvastatin and oseltamivir combination therapy does not improve the effectiveness of oseltamivir alone following highly pathogenic avian H5N1 influenza virus infection in mice.
Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N1 Subtype; Lung; Mice; Orthomyxoviridae Infections; Oseltamivir; Simvastatin; Survival Analysis; Treatment Outcome; Viral Load | 2013 |
Preparation of calcium phosphate nanocapsules including simvastatin/deoxycholic acid assembly, and their therapeutic effect in osteoporosis model mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Bone Density Conservation Agents; Calcium Phosphates; Cell Line; Deoxycholic Acid; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Female; Humans; Hypolipidemic Agents; Mice; Mice, Inbred Strains; Micelles; Nanocapsules; Osteoporosis, Postmenopausal; Random Allocation; Simvastatin; Surface Properties; Surface-Active Agents | 2013 |
NO-releasing xanthine KMUP-1 bonded by simvastatin attenuates bleomycin-induced lung inflammation and delayed fibrosis.
Topics: Animals; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; Clarithromycin; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Piperidines; Pneumonia; Pulmonary Fibrosis; Signal Transduction; Simvastatin; Time Factors; Xanthines | 2014 |
Repair of lipopolysaccharide-induced acute lung injury in mice by endothelial progenitor cells, alone and in combination with simvastatin.
Topics: Acute Lung Injury; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Simvastatin; Stem Cell Transplantation; Treatment Outcome | 2013 |
Effects of simvastatin on bleomycin-induced pulmonary fibrosis in female rats.
Topics: Animals; Anti-Inflammatory Agents; Bleomycin; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Simvastatin; Transforming Growth Factor beta1 | 2012 |
Synergistical neuroprotection of rofecoxib and statins against malonic acid induced Huntington's disease like symptoms and related cognitive dysfunction in rats.
Topics: Animals; Atorvastatin; Behavior, Animal; Brain; Cognition Disorders; Cyclooxygenase 2 Inhibitors; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Heptanoic Acids; Huntington Disease; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Male; Malonates; Neurons; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Simvastatin; Sulfones | 2013 |
The effect of local simvastatin application on critical size defects in the diabetic rats.
Topics: Administration, Topical; Animals; Bone Regeneration; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin; Skull; Tomography, X-Ray Computed; Wound Healing | 2014 |
Simvastatin suppresses osteoblastic expression of Cyr61 and progression of apical periodontitis through enhancement of the transcription factor Forkhead/winged helix box protein O3a.
Topics: 3T3 Cells; Alveolar Bone Loss; Animals; Cell Line; Chemokine CCL2; Chemotaxis; Cysteine-Rich Protein 61; Disease Models, Animal; Disease Progression; Forkhead Box Protein O3; Forkhead Transcription Factors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Mice; Osteoblasts; Periapical Periodontitis; Radiography, Dental, Digital; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha | 2013 |
Simvastatin attenuates the development of pulmonary and cutaneous fibrosis in a murine model of systemic sclerosis.
Topics: Animals; Biopsy, Needle; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Immunohistochemistry; Mice; Mice, Inbred BALB C; Pulmonary Fibrosis; Random Allocation; Reactive Oxygen Species; Scleroderma, Systemic; Sensitivity and Specificity; Simvastatin; Skin Diseases; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2013 |
Simvastatin reduces venous stenosis formation in a murine hemodialysis vascular access model.
Topics: Actins; Animals; Apoptosis; Arteriovenous Shunt, Surgical; Carotid Arteries; Caspase 3; Cell Movement; Cell Proliferation; Cell Transdifferentiation; Constriction, Pathologic; Disease Models, Animal; Graft Occlusion, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; Hypoxia-Inducible Factor 1, alpha Subunit; Jugular Veins; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Myofibroblasts; Neointima; NIH 3T3 Cells; Renal Dialysis; Signal Transduction; Simvastatin; Time Factors; Vascular Endothelial Growth Factor A | 2013 |
Simvastatin activates the PPARγ-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling.
Topics: Animals; Disease Models, Animal; Fibrosis; Heart Failure; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Myocardium; PPAR gamma; Rabbits; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Simvastatin; Transcription Factor RelA; Ultrasonography | 2013 |
Median infectious dose of human norovirus GII.4 in gnotobiotic pigs is decreased by simvastatin treatment and increased by age.
Topics: Age Factors; Animals; Caliciviridae Infections; Disease Models, Animal; Disease Susceptibility; Genotype; Germ-Free Life; Humans; Hypolipidemic Agents; Intestines; Molecular Sequence Data; Norovirus; RNA, Viral; Sequence Analysis, DNA; Simvastatin; Swine; Viral Load | 2013 |
The therapeutic effects of bone marrow-derived mesenchymal stem cells and simvastatin in a rat model of liver fibrosis.
Topics: Animals; Bone Marrow Cells; Collagen Type I; Collagen Type II; Disease Models, Animal; Endoglin; Female; Gene Expression Regulation; Hypolipidemic Agents; Intracellular Signaling Peptides and Proteins; Liver; Liver Cirrhosis; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Wistar; Severity of Illness Index; Sex-Determining Region Y Protein; Simvastatin; Tissue Inhibitor of Metalloproteinase-1 | 2014 |
Osseointegration of biochemically modified implants in an osteoporosis rodent model.
Topics: Animals; Biomechanical Phenomena; Diphosphonates; Disease Models, Animal; Female; Fluorescent Dyes; Imidazoles; Implants, Experimental; Osseointegration; Osteoporosis; Rats; Rats, Wistar; Simvastatin; X-Ray Microtomography; Zoledronic Acid | 2013 |
Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Kidney; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; ras Proteins; Rats; Rats, Inbred SHR; Ribosomal Protein S6 Kinases; Signal Transduction; Simvastatin; Solitary Nucleus; Sympathetic Nervous System; Time Factors | 2013 |
Renal function in a rat model of neurogenic bladder, effect of statins and phosphodiesterase-5 inhibitors.
Topics: Analysis of Variance; Animals; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Male; Organ Size; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Simvastatin; Sulfones; Tadalafil; Urinary Bladder; Urinary Bladder, Neurogenic; Urine | 2013 |
Simvastatin treatment showed no prophylactic effect in influenza virus-infected mice.
Topics: Animals; Body Weight; Chemoprevention; Disease Models, Animal; Female; Immunologic Factors; Influenza A virus; Lung; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Simvastatin; Survival Analysis; Trachea; Viral Load | 2013 |
Simvastatin decreases stent-induced in-stent restenosis rate via downregulating the expression of PCNA and upregulating that of p27kip1.
Topics: Animals; Blotting, Western; Cell Cycle; Cell Proliferation; Coronary Artery Disease; Coronary Restenosis; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Down-Regulation; Immunohistochemistry; Immunosuppressive Agents; Male; Muscle, Smooth, Vascular; Proliferating Cell Nuclear Antigen; Rabbits; Random Allocation; Simvastatin; Stents; Up-Regulation | 2013 |
Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Early Growth Response Protein 1; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; Mutation; Nitric Oxide; Simvastatin; Transforming Growth Factor beta1 | 2014 |
Role of claudin-5 in the attenuation of murine acute lung injury by simvastatin.
Topics: Acute Lung Injury; Animals; beta Catenin; Capillary Permeability; Cells, Cultured; Claudin-5; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Gene Silencing; Humans; Lung; Mice; Mice, Inbred C57BL; Simvastatin; Tight Junctions | 2014 |
Simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease.
Topics: Acid Phosphatase; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Gingiva; Gingivitis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Isoenzymes; Lipopolysaccharides; Matrix Metalloproteinase 9; Maxillary Diseases; Osteoclasts; Periodontal Diseases; Rats; Rats, Sprague-Dawley; Simvastatin; Tartrate-Resistant Acid Phosphatase; Toll-Like Receptors; X-Ray Microtomography | 2014 |
Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Capecitabine; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; DNA; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Mice; Mice, Nude; Neovascularization, Pathologic; NF-kappa B; Protein Binding; Simvastatin; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2014 |
The effect of simvastatin on systemic inflammation and endothelial dysfunction induced by periodontitis.
Topics: Acetylcholine; Alveolar Bone Loss; Animals; Arterial Pressure; C-Reactive Protein; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Interleukin-6; Leukocyte Count; Lipids; Male; Nitroprusside; Periodontitis; Random Allocation; Rats; Rats, Wistar; Simvastatin; Vasodilator Agents | 2014 |
Simvastatin exerts antiamnesic effect in Aβ25-35 -injected mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Animals, Newborn; Anticholesteremic Agents; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; MAP Kinase Signaling System; Maze Learning; Mice; Mice, Inbred ICR; Oncogene Protein v-akt; Patch-Clamp Techniques; Peptide Fragments; Phosphorylation; Pyramidal Cells; Simvastatin | 2014 |
Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease.
Topics: Animals; Bone Morphogenetic Protein 2; Disease Models, Animal; Extracellular Matrix; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Spinal; Intervertebral Disc; Intervertebral Disc Degeneration; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Regeneration; Simvastatin; Up-Regulation | 2014 |
The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria.
Topics: Animals; Bone and Bones; Bone Cements; Capsules; Disease Models, Animal; Emulsions; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; Simvastatin; Skull; Solvents; Time Factors | 2014 |
Comparison of the effect of minocycline and simvastatin on functional recovery and gene expression in a rat traumatic brain injury model.
Topics: Animals; Brain Injuries; Disease Models, Animal; Male; Minocycline; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Recovery of Function; Simvastatin; Transcriptome | 2014 |
Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Blood Glucose; Chemotaxis, Leukocyte; Cholesterol; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Resistance; Interleukin-6; Leukocytes; Lipopolysaccharides; Metabolic Syndrome; Osteoclasts; Palmitic Acid; Periodontitis; RANK Ligand; Rats; Rats, Zucker; Simvastatin; Triglycerides; X-Ray Microtomography | 2014 |
Effect of simvastatin on inflammatory cytokines balance in air pouch granuloma model.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; C-Reactive Protein; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Granuloma; Inflammation Mediators; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Simvastatin | 2014 |
Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-κB activation.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Cell Count; Cell Survival; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Endothelin-1; Enzyme Activation; Immunohistochemistry; Male; NF-kappa B; Optic Nerve Injuries; Rats; Retinal Ganglion Cells; Simvastatin; Tumor Necrosis Factor-alpha | 2014 |
Effects of simvastatin on retinal structure and function of a high-fat atherogenic mouse model of thickened Bruch's membrane.
Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Bruch Membrane; Disease Models, Animal; Electroretinography; Follow-Up Studies; Macular Degeneration; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Pigment Epithelium of Eye; Simvastatin; Treatment Outcome | 2014 |
Simvastatin treatment upregulates intestinal lipid secretion pathways in a rodent model of the metabolic syndrome.
Topics: Animals; Anticholesteremic Agents; Cardiovascular Diseases; Cholesterol; Disease Models, Animal; Dyslipidemias; Food Deprivation; Gene Expression Regulation; Hydrolysis; Intestines; Lipids; Lipoprotein Lipase; Male; Metabolic Syndrome; Postprandial Period; Rats; Simvastatin; Triglycerides; Up-Regulation | 2014 |
Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure.
Topics: Animals; Arrhythmias, Cardiac; Carotid Body; Chronic Disease; Disease Models, Animal; Heart Failure; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Transcription Factors; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Respiration; Simvastatin; Sleep Apnea Syndromes | 2014 |
Simvastatin reverses the downregulation of M1/4 receptor binding in 6-hydroxydopamine-induced parkinsonian rats: the association with improvements in long-term memory.
Topics: Animals; Brain; Disease Models, Animal; Down-Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Maze Learning; Memory, Long-Term; Muscarinic Antagonists; Oxidopamine; Parkinson Disease; Pirenzepine; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Simvastatin; Sympatholytics; Tritium | 2014 |
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats.
Topics: Animals; Anticholesteremic Agents; Anxiety; Behavior, Animal; Bone Regeneration; Cognition; Disease Models, Animal; Female; Locomotion; Memory; Motor Activity; Rats, Wistar; Simvastatin; Skull; Time Factors | 2014 |
Statins for disc degeneration.
Topics: Animals; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intervertebral Disc Degeneration; Rats; Simvastatin | 2014 |
Evaluation of the effect of simvastatin on the progression of alveolar bone loss in experimental periodontitis--an animal study.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Chronic Periodontitis; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Radiography; Random Allocation; Rats; Rats, Wistar; Simvastatin | 2014 |
Simvastatin reduces leucocyte- and platelet-endothelial cell interaction in murine antigen-induced arthritis in vivo.
Topics: Animals; Anti-Inflammatory Agents; Antigens; Arthritis, Experimental; Blood Platelets; Capillaries; Cell Communication; Disease Models, Animal; Endothelium, Vascular; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Knee Joint; Leukocytes; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Simvastatin | 2014 |
Simvastatin increases the in vivo activity of the first-line tuberculosis regimen.
Topics: Animals; Antitubercular Agents; Bacterial Load; Cell Line; Colony Count, Microbial; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Isoniazid; Lung; Macrophages; Mice, Inbred BALB C; Pyrazinamide; Rifampin; Simvastatin; Treatment Outcome; Tuberculosis | 2014 |
Simvastatin does not diminish the in vivo degeneration of decellularized aortic conduits.
Topics: Animals; Aortic Valve; Bioprosthesis; Calcinosis; Calcium; Diet; Disease Models, Animal; Heart Valve Diseases; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rats, Sprague-Dawley; Rats, Wistar; Simvastatin; Treatment Failure; Ultrasonography | 2014 |
Effects of neonatal enzyme replacement therapy and simvastatin treatment on cervical spine disease in mucopolysaccharidosis I dogs.
Topics: Animals; Disease Models, Animal; Dog Diseases; Dogs; Enzyme Replacement Therapy; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iduronidase; Intervertebral Disc Degeneration; Male; Mucopolysaccharidosis I; Simvastatin | 2014 |
Topical simvastatin improves the pro-angiogenic and pro-osteogenic properties of bioglass putty in the rat calvaria critical-size model.
Topics: Administration, Topical; Angiogenesis Inducing Agents; Animals; Bone Diseases; Bone Matrix; Bone Substitutes; Capillaries; Ceramics; Collagen; Disease Models, Animal; Inflammation; Male; Osteocytes; Osteogenesis; Rats; Rats, Wistar; Simvastatin; Skull | 2014 |
[Effect of simvastatin on atherosclerosis and central aortic pressure in ApoE gene knockout mice].
Topics: Animals; Apolipoproteins E; Arterial Pressure; Atherosclerosis; Cholesterol; Disease Models, Animal; Lipoproteins, HDL; Lipoproteins, LDL; Male; Mice; Mice, Knockout; Simvastatin; Triglycerides | 2014 |
A novel anabolic agent: a simvastatin analogue without HMG-CoA reductase inhibitory activity.
Topics: Acyl Coenzyme A; Anabolic Agents; Animals; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Molecular Structure; Osteogenesis; Simvastatin; Solid-Phase Synthesis Techniques; Zebrafish | 2014 |
Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy.
Topics: Alveolar Bone Loss; Animals; Biomarkers; Biomechanical Phenomena; Cell Count; Dental Cementum; Dental Enamel; Disease Models, Animal; Female; Femur; Osteocalcin; Osteoclasts; Osteogenesis; Ovariectomy; Periodontitis; Rats, Sprague-Dawley; Simvastatin; X-Ray Microtomography | 2014 |
Stereological comparison of the effects of pentoxifylline, captopril, simvastatin, and tamoxifen on kidney and bladder structure after partial urethral obstruction in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Disease Models, Animal; Estrogen Antagonists; Free Radical Scavengers; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Male; Pentoxifylline; Rats; Simvastatin; Tamoxifen; Urethral Obstruction; Urinary Bladder Neck Obstruction | 2014 |
The effect of simvastatin treatment on proliferation and differentiation of neural stem cells after traumatic brain injury.
Topics: Amyloid Precursor Protein Secretases; Animals; Brain; Brain Injuries; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Male; Nestin; Neural Stem Cells; Neurogenesis; Neurons; Neuroprotective Agents; Random Allocation; Rats, Wistar; Receptor, Notch1; Recovery of Function; Simvastatin; Time Factors; Treatment Outcome | 2015 |
HMG-CoA reductase inhibitor rosuvastatin improves abnormal brain electrical activity via mechanisms involving eNOS.
Topics: Animals; Anticonvulsants; Atorvastatin; bcl-2-Associated X Protein; Blood-Brain Barrier; Brain; Capillary Permeability; Caspase 3; Disease Models, Animal; Epilepsy; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide Synthase Type III; Penicillin G; Random Allocation; Rats, Sprague-Dawley; RNA, Messenger; Rosuvastatin Calcium; Simvastatin; Tumor Suppressor Protein p53 | 2015 |
KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins.
Topics: Animals; Antifibrinolytic Agents; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Hepatic Stellate Cells; Humans; Kruppel-Like Transcription Factors; Liver Cirrhosis; Male; Molecular Targeted Therapy; Phenotype; Protective Agents; Random Allocation; Rats; Rats, Wistar; Sensitivity and Specificity; Simvastatin; Up-Regulation | 2015 |
The functional mechanism of simvastatin in experimental osteoporosis.
Topics: Animals; Bone Density; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Osteoblasts; Osteoporosis; Simvastatin | 2016 |
Impact of local steroid or statin treatment of experimental temporomandibular joint arthritis on bone growth in young rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Juvenile; Bone Density; Cephalometry; Disease Models, Animal; Drug Carriers; Drug Combinations; Ethanol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imaging, Three-Dimensional; Injections, Intra-Articular; Male; Mandible; Mandibular Condyle; Organ Size; Rats; Rats, Sprague-Dawley; Simvastatin; Temporomandibular Joint Disorders; Triamcinolone Acetonide; X-Ray Microtomography | 2015 |
Simvastatin restored vascular reactivity, endothelial function and reduced string vessel pathology in a mouse model of cerebrovascular disease.
Topics: Animals; Blotting, Western; Brain; Cerebral Arteries; Cerebrovascular Disorders; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Contraction; Muscle, Smooth, Vascular; Neuroprotective Agents; Rats; Simvastatin | 2015 |
The effects of locally applied simvastatin on an experimental mouse femur nonunion model.
Topics: Alkaline Phosphatase; Analysis of Variance; Animals; Chi-Square Distribution; Disease Models, Animal; Femoral Fractures; Follow-Up Studies; Fracture Healing; Fractures, Ununited; Injections, Intralesional; Male; Mice; Mice, Inbred Strains; Osteocalcin; Osteotomy; Postoperative Care; Radiography; Random Allocation; Reference Values; Risk Assessment; Simvastatin | 2014 |
Simvastatin mitigates functional and structural impairment of lung and right ventricle in a rat model of cigarette smoke-induced COPD.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lung; Male; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; RNA-Binding Proteins; Simvastatin; Smoking | 2014 |
Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Dementia; Dipeptides; Disease Models, Animal; Galactose; Inositol; Magnetic Resonance Spectroscopy; Male; Nootropic Agents; Organ Size; Phosphorus Isotopes; Protons; Rats, Wistar; Simvastatin; Spatial Learning; Spatial Memory; Thiobarbituric Acid Reactive Substances; Treatment Outcome; Ubiquinone | 2015 |
The possible protective effect of simvastatin and pioglitazone separately and in combination on bleomycin-induced changes in mice thin skin.
Topics: Animals; Bleomycin; Disease Models, Animal; Hypoglycemic Agents; Mice; Pioglitazone; PPAR gamma; Simvastatin; Skin; Thiazolidinediones | 2015 |
Effect of simvastatin on L-DOPA-induced abnormal involuntary movements of hemiparkinsonian rats.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Levodopa; Male; MAP Kinase Signaling System; Oncogene Proteins v-fos; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Simvastatin; Time Factors | 2015 |
The effect of simvastatin treatment on bone repair of femoral fracture in animal model.
Topics: Animals; Bone and Bones; Disease Models, Animal; Female; Femoral Fractures; Fracture Healing; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunohistochemistry; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Osteoporosis; Rats; Rats, Wistar; Simvastatin; Stainless Steel | 2015 |
Three-Dimensional Porous Gelapin-Simvastatin Scaffolds Promoted Bone Defect Healing in Rabbits.
Topics: Animals; Bone and Bones; Bone Density; Bone Regeneration; Bone Transplantation; Collagen; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Osteogenesis; Porosity; Rabbits; Simvastatin; Tissue Engineering; Tissue Scaffolds; X-Ray Microtomography | 2015 |
Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation.
Topics: Airway Resistance; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Capillary Permeability; Disease Models, Animal; Elasticity; Endothelial Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Lung; Lung Compliance; Male; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Pneumonia; Pulmonary Edema; Simvastatin; Time Factors; Ventilator-Induced Lung Injury | 2015 |
Anti-inflammatory Therapy With Simvastatin Improves Neuroinflammation and CNS Function in a Mouse Model of Metachromatic Leukodystrophy.
Topics: Animals; Anti-Inflammatory Agents; Central Nervous System; Chemokine CCL2; Chemokine CCL4; Demyelinating Diseases; Disease Models, Animal; Humans; Inflammation; Leukodystrophy, Metachromatic; Mice; Simvastatin; Spinal Cord; Tumor Necrosis Factor-alpha | 2015 |
[Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models].
Topics: Animals; Calpain; Disease Models, Animal; Epilepsy; Hippocampus; Levetiracetam; Pilocarpine; Piracetam; Rats; Seizures; Simvastatin | 2015 |
Single-dose local simvastatin injection improves implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model.
Topics: Absorptiometry, Photon; Animals; Blood Vessels; Bone Density; Bone Morphogenetic Protein 2; Bone Screws; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Femur; Gene Expression Regulation; Humans; Injections, Intralesional; Neovascularization, Physiologic; Osseointegration; Osteogenesis; Osteoporosis, Postmenopausal; Ovariectomy; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley; Simvastatin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; von Willebrand Factor | 2015 |
[Statin against cirrhosis].
Topics: Adenoviridae; Animals; Cells, Cultured; Disease Models, Animal; Gene Knockout Techniques; Genetic Vectors; Hepatitis C, Chronic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Transcription Factors; Liver Cirrhosis; Nitric Oxide; Rats; Simvastatin | 2015 |
Simvastatin prevents β-amyloid(25-35)-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Mice, Inbred ICR; Neurogenesis; Neuroprotective Agents; Peptide Fragments; Phosphatidylinositol 3-Kinases; Polyisoprenyl Phosphates; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Simvastatin | 2015 |
Captopril inhibits maturation of dendritic cells and maintains their tolerogenic property in atherosclerotic rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antigens, CD; Aorta; Atherosclerosis; Captopril; Cholesterol; Cytokines; Dendritic Cells; Diet, Atherogenic; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lipids; Male; Rats, Sprague-Dawley; Simvastatin; T-Lymphocytes, Regulatory | 2015 |
Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition.
Topics: Animals; Disease Models, Animal; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intraabdominal Infections; Kidney; Liver; Lung; Radionuclide Imaging; Radiopharmaceuticals; Random Allocation; Rats, Wistar; Reproducibility of Results; Sepsis; Simvastatin; Technetium Tc 99m Sestamibi; Time Factors; Treatment Outcome | 2015 |
Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.
Topics: Animals; Apoptosis; Atherosclerosis; Disease Models, Animal; Endoplasmic Reticulum Stress; Humans; Hydrogen; Macrophages; Mice; Mice, Knockout; NF-E2-Related Factor 2; Plaque, Atherosclerotic; Reactive Oxygen Species; Receptors, LDL; Receptors, Oxidized LDL; Simvastatin | 2015 |
Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway.
Topics: Animals; Biomarkers; Cardiomegaly; Creatine Kinase, MB Form; Cytoprotection; Disease Models, Animal; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Isoproterenol; Janus Kinases; Lipids; Male; Myocytes, Cardiac; NF-kappa B; Phosphorylation; Rats, Wistar; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Troponin I | 2015 |
Long-term administration of simvastatin reduces ventilator-induced lung injury and upregulates heme oxygenase 1 expression in a rat model.
Topics: Animals; Disease Models, Animal; Heme Oxygenase (Decyclizing); Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Malondialdehyde; Peroxidase; Random Allocation; Rats, Sprague-Dawley; Respiration, Artificial; Simvastatin; Superoxide Dismutase; Up-Regulation; Ventilator-Induced Lung Injury | 2015 |
Protective effects of simvastatin administered in the experimental hepatic ischemia-reperfusion injury rat model.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Diseases; Male; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin | 2015 |
Metabolic and structural bone disturbances induced by hyperlipidic diet in mice treated with simvastatin.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Diet, High-Fat; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Mice; Mice, Inbred C57BL; Simvastatin | 2015 |
Synergistic local drug delivery in a piglet model of ischemic osteonecrosis: a preliminary study.
Topics: Animals; Bone Density Conservation Agents; Clodronic Acid; Disease Models, Animal; Drug Delivery Systems; Drug Therapy, Combination; Femur Head; Femur Head Necrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Male; Pilot Projects; Simvastatin; Swine; Swine, Miniature; Treatment Outcome; X-Ray Microtomography | 2015 |
Simvastatin promotes alveolar epithelial cell proliferation and attenuates cigarette smoke‑induced emphysema in rats.
Topics: Alveolar Epithelial Cells; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Proliferating Cell Nuclear Antigen; Pulmonary Emphysema; Rats; Simvastatin; Smoking; Vascular Endothelial Growth Factor A | 2015 |
Statin-induced calcific Achilles tendinopathy in rats: comparison of biomechanical and histopathological effects of simvastatin, atorvastatin and rosuvastatin.
Topics: Achilles Tendon; Aged, 80 and over; Animals; Atorvastatin; Biomechanical Phenomena; Bone Density; Calcinosis; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Rats, Wistar; Risk Factors; Rosuvastatin Calcium; Rupture, Spontaneous; Simvastatin; Tendinopathy | 2017 |
Icariin Attenuates High-cholesterol Diet Induced Atherosclerosis in Rats by Inhibition of Inflammatory Response and p38 MAPK Signaling Pathway.
Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diet, High-Fat; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Dyslipidemias; Flavonoids; Inflammation; Interleukin-6; Lipids; Male; Malondialdehyde; MAP Kinase Signaling System; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; RNA, Messenger; Simvastatin; Superoxide Dismutase; Triglycerides; Tumor Necrosis Factor-alpha | 2016 |
Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Aorta; Aortic Diseases; Atherosclerosis; Biomarkers; Cholesterol, Dietary; Dietary Supplements; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Malondialdehyde; Oxidative Stress; Plaque, Atherosclerotic; Rabbits; Sesquiterpenes; Simvastatin; Superoxide Dismutase; Time Factors | 2015 |
The effects of combined human parathyroid hormone (1-34) and simvastatin treatment on osseous integration of hydroxyapatite-coated titanium implants in the femur of ovariectomized rats.
Topics: Animals; Arthroplasty, Replacement, Hip; Bone Density Conservation Agents; Bone Regeneration; Coated Materials, Biocompatible; Disease Models, Animal; Drug Therapy, Combination; Durapatite; Female; Femur; Implants, Experimental; Osseointegration; Osteoporosis; Ovariectomy; Parathyroid Hormone; Rats; Rats, Sprague-Dawley; Simvastatin; Titanium | 2015 |
Simvastatin inhibits neural cell apoptosis and promotes locomotor recovery via activation of Wnt/β-catenin signaling pathway after spinal cord injury.
Topics: Animals; Apoptosis; beta Catenin; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Locomotion; Male; Movement Disorders; Neurons; Rats; Rats, Sprague-Dawley; Recovery of Function; Signal Transduction; Simvastatin; Spinal Cord; Spinal Cord Injuries; Time Factors; Wnt Proteins | 2016 |
Application of Response Surface Methodology for Design and Optimization of Reservoir-type Transdermal Patch of Simvastatin.
Topics: Administration, Cutaneous; Animals; Biomarkers; Cyclohexenes; Disease Models, Animal; Drug Compounding; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Limonene; Lipids; Male; Middle Aged; Models, Statistical; Permeability; Poloxamer; Rats, Sprague-Dawley; Simvastatin; Skin; Skin Absorption; Technology, Pharmaceutical; Terpenes; Time Factors; Transdermal Patch | 2016 |
Neuroprotective Effect of Simvastatin via Inducing the Autophagy on Spinal Cord Injury in the Rat Model.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain-Derived Neurotrophic Factor; Cardiovascular Diseases; Disease Models, Animal; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Humans; Microtubule-Associated Proteins; Neuroprotective Agents; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Simvastatin; Spinal Cord Injuries; TOR Serine-Threonine Kinases | 2015 |
Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
Topics: Animals; Biomarkers; Brain Injuries, Traumatic; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recovery of Function; Simvastatin; Ubiquitin Thiolesterase | 2016 |
Intravenous Administration of Simvastatin Improves Cognitive Outcome following Severe Traumatic Brain Injury in Rats.
Topics: Administration, Intravenous; Animals; Behavior, Animal; Biomarkers; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; Head Injuries, Penetrating; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rats; Rats, Sprague-Dawley; Simvastatin | 2016 |
Effect of Simvastatin on 5-HT and 5-HTT in a Rat Model of Pulmonary Artery Hypertension.
Topics: Animals; Blood Pressure; Body Weight; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Simvastatin; Smoking | 2015 |
Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Biofilms; Cytokines; Disease Models, Animal; Drug Synergism; Female; Gram-Negative Bacteria; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Inflammation Mediators; Metabolic Networks and Pathways; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Proteolysis; Simvastatin; Staphylococcal Skin Infections; Staphylococcus | 2015 |
Retinoic acid promotes the endogenous repair of lung stem/progenitor cells in combined with simvastatin after acute lung injury: a stereological analysis.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Lung; Rats, Sprague-Dawley; Regeneration; Simvastatin; Stem Cells; Tretinoin | 2015 |
Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Models, Animal; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Integrin beta4; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; Permeability; Phosphorylation; Protein Structure, Tertiary; Pulmonary Artery; Simvastatin; Stress, Mechanical; Ventilator-Induced Lung Injury | 2015 |
Inhibition of Atherosclerosis Progression, Intimal Hyperplasia, and Oxidative Stress by Simvastatin and Ivabradine May Reduce Thoracic Aorta's Stiffness in Hypercholesterolemic Rabbits.
Topics: Animals; Antioxidants; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Benzazepines; Diet, Atherogenic; Disease Models, Animal; Disease Progression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperplasia; Ivabradine; Male; Neointima; Oxidative Stress; Plaque, Atherosclerotic; Rabbits; Simvastatin; Vascular Stiffness | 2016 |
Protective effect of simvastatin on impaired intestine tight junction protein ZO-1 in a mouse model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Parkinson Disease; Simvastatin; Zonula Occludens-1 Protein | 2015 |
Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet.
Topics: Animals; Antioxidants; Aorta; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Heme Oxygenase-1; Hippocampus; Immunohistochemistry; Male; Oxidative Stress; Rabbits; RNA, Messenger; Simvastatin | 2016 |
Rat strain determines statin effect on intimal hyperplasia after carotid balloon injury.
Topics: Administration, Oral; Angioplasty, Balloon; Animals; Carotid Arteries; Carotid Artery Injuries; Disease Models, Animal; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; Indoles; Male; Neointima; Rats, Sprague-Dawley; Rats, Zucker; Simvastatin; Species Specificity | 2016 |
Effects of simvastatin on the expression of inducible NOS in acute lung injury in septic rats.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Sepsis; Simvastatin | 2015 |
Simvastatin prevents vascular complications in the chronic reactive oxygen species murine model of systemic sclerosis.
Topics: Animals; Aorta; Carotid Intima-Media Thickness; Cell Differentiation; Collagen; Disease Models, Animal; Gene Expression Regulation; Humans; Hypochlorous Acid; Kidney; Mice; Myofibroblasts; Platelet Endothelial Cell Adhesion Molecule-1; Reactive Oxygen Species; Scleroderma, Systemic; Simvastatin; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Atorvastatin; Brain; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; MAP Kinase Signaling System; Neprilysin; Rats, Sprague-Dawley; Simvastatin | 2016 |
In vivo evaluation of a simvastatin-loaded nanostructured lipid carrier for bone tissue regeneration.
Topics: Animals; Bone Diseases; Bone Regeneration; Disease Models, Animal; Humans; Lipids; Materials Testing; Nanostructures; Rabbits; Simvastatin; Skull | 2016 |
Simvastatin ameliorates renal lipidosis through the suppression of renal CXCL16 expression in mice with adriamycin-induced nephropathy.
Topics: Animals; Chemokine CXCL16; Chemokine CXCL6; Cholesterol; Disease Models, Animal; Down-Regulation; Doxorubicin; Endocytosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Kidney Glomerulus; Lipidoses; Lipoproteins, LDL; Male; Mice, Inbred BALB C; NF-kappa B; Proteinuria; Signal Transduction; Simvastatin | 2015 |
Antioxidant activity of simvastatin prevents ifosfamide-induced nephrotoxicity.
Topics: Animals; Antioxidants; Biomarkers; Creatinine; Cytoprotection; Disease Models, Animal; Ifosfamide; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Rats, Sprague-Dawley; Simvastatin | 2016 |
Simvastatin ameliorates ventricular remodeling via the TGF‑β1 signaling pathway in rats following myocardial infarction.
Topics: Animals; Biomarkers; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; MAP Kinase Kinase Kinases; Myocardial Infarction; Rats; Signal Transduction; Simvastatin; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1; Ventricular Function, Left; Ventricular Remodeling | 2016 |
Evaluation of Simvastatin and Bone Marrow-Derived Mesenchymal Stem Cell Combination Therapy on Airway Remodeling in a Mouse Asthma Model.
Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cell Movement; Collagen; Combined Modality Therapy; Disease Models, Animal; Eosinophils; Fibrosis; Goblet Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; Leukocyte Count; Male; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Pneumonia; Simvastatin | 2016 |
The Evaluation of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Femoral Fractures; Fractures, Closed; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Micelles; Prodrugs; Simvastatin; Treatment Outcome | 2016 |
Effect of treatment with simvastatin on bone microarchitecture of the femoral head in an osteoporosis animal model.
Topics: Animals; Disease Models, Animal; Femur Head; Osteoporosis; Ovariectomy; Photomicrography; Rats; Rats, Wistar; Simvastatin | 2016 |
Pleiotropic Effects of Simvastatin on Wound Healing in Diabetic Mice.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Physiologic; Simvastatin; Wound Healing | 2016 |
Simvastatin ameliorates deep vein thrombosis in rabbits by regulating the fibrinolytic system.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Fibrinolysis; Fibrinolytic Agents; Gene Expression Regulation; Heparin, Low-Molecular-Weight; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; P-Selectin; Plasminogen Activator Inhibitor 1; Rabbits; Simvastatin; Treatment Outcome; Urokinase-Type Plasminogen Activator; Vena Cava, Superior; Venous Thrombosis | 2016 |
Simvastatin Inhibits IL-5-Induced Chemotaxis and CCR3 Expression of HL-60-Derived and Human Primary Eosinophils.
Topics: Animals; Chemotaxis; Disease Models, Animal; Eosinophils; Gene Expression Regulation; HL-60 Cells; Humans; Interleukin-5; Male; Rats; Rats, Sprague-Dawley; Receptors, CCR3; Rhinitis, Allergic; Simvastatin | 2016 |
Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects.
Topics: Animals; Anticholesteremic Agents; Bone Matrix; Collagen; Disease Models, Animal; Female; Hydroxyapatites; Osteogenesis; Rats, Wistar; Simvastatin; Skull; Wound Healing | 2016 |
Comparison of the Effect of Platelet-Rich Plasma and Simvastatin on Healing of Critical-Size Calvarial Bone Defects.
Topics: Animals; Bone Diseases; Bone Regeneration; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Osteoblasts; Osteogenesis; Platelet-Rich Plasma; Rats; Simvastatin; Skull; Wound Healing | 2016 |
Effect of Simvastatin on Proliferation of Vascular Smooth Muscle Cells During Delayed Cerebral Vasospasm After Subarachnoid Hemorrhage.
Topics: Animals; Basilar Artery; Cell Proliferation; Cerebral Angiography; Disease Models, Animal; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Rabbits; Simvastatin; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2016 |
Simvastatin Therapy in the Acute Stage of Traumatic Brain Injury Attenuates Brain Trauma-Induced Depression-Like Behavior in Rats by Reducing Neuroinflammation in the Hippocampus.
Topics: Acute Disease; Animals; Behavior, Animal; Brain Injuries, Traumatic; Depression; Disease Models, Animal; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Injections, Intraperitoneal; Male; Rats; Rats, Sprague-Dawley; Simvastatin | 2017 |
Alterations in zebrafish development induced by simvastatin: Comprehensive morphological and physiological study, focusing on muscle.
Topics: Animals; Anticholesteremic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Microscopy, Electrochemical, Scanning; Muscle, Skeletal; Simvastatin; Zebrafish | 2016 |
Involvement of inhibition of RhoA/Rho kinase signaling in simvastatin-induced amelioration of neuropathic pain.
Topics: Analgesics; Animals; Astrocytes; Calcium-Binding Proteins; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Intracellular Signaling Peptides and Proteins; Lumbar Vertebrae; Male; Membrane Proteins; Mice, Inbred ICR; Microfilament Proteins; Microglia; Myristoylated Alanine-Rich C Kinase Substrate; Neuralgia; Protein Kinase Inhibitors; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Sciatic Nerve; Simvastatin; Spinal Cord | 2016 |
Neuroprotective Effects of Simvastatin and Cilostazol in L-Methionine-Induced Vascular Dementia in Rats.
Topics: Animals; Brain; Cilostazol; Dementia, Vascular; Disease Models, Animal; Endothelium, Vascular; Male; Maze Learning; Memory; Methionine; Neuroprotective Agents; Oxidative Stress; Rats, Wistar; Simvastatin; Tetrazoles | 2017 |
Simvastatin enhances the hippocampal klotho in a rat model of streptozotocin-induced cognitive decline.
Topics: Animals; Antibiotics, Antineoplastic; Cholesterol; Cognition Disorders; Disease Models, Animal; Glucuronidase; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraventricular; Klotho Proteins; Male; Maze Learning; Motor Activity; Rats; Rats, Wistar; Reaction Time; RNA, Messenger; Simvastatin; Streptozocin; Superoxide Dismutase | 2017 |
Efficacy of simvastatin in reducing postoperative adhesions after thyroidectomy: an experimental study.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Humans; Immunohistochemistry; Injections, Intralesional; Male; Postoperative Complications; Random Allocation; Rats; Rats, Wistar; Reference Values; Simvastatin; Statistics, Nonparametric; Thyroidectomy; Tissue Adhesions; Treatment Outcome | 2017 |
Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma.
Topics: Adenine; Airway Remodeling; Animals; Asthma; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cytokines; Disease Models, Animal; Extracellular Matrix; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interferon-gamma; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Myocytes, Smooth Muscle; Ovalbumin; Simvastatin; Up-Regulation | 2017 |
Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Xenograft Model Antitumor Assays | 2017 |
Simvastatin Alleviates Pathology in a Rat Model of Preeclampsia Involving ERK/MAPK Pathway.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-10; Malondialdehyde; MAP Kinase Signaling System; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Pre-Eclampsia; Pregnancy; Rats; Simvastatin; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2017 |
RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Neoplasms; Disease Models, Animal; Female; Hemangioma, Cavernous, Central Nervous System; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Transgenic; Protein Kinase Inhibitors; rho-Associated Kinases; Simvastatin | 2017 |
Anti-atherosclerosis and cardio-protective effects of the Angong Niuhuang Pill on a high fat and vitamin D3 induced rodent model of atherosclerosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta, Thoracic; Aortic Diseases; Apoptosis; Atherosclerosis; Biomarkers; Carotid Artery Diseases; Cholecalciferol; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal; Enzymes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Inflammation Mediators; Lipids; Male; Myocardium; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Simvastatin; Tablets; Time Factors | 2017 |
Hypolipidemic effect of β-caryophyllene to treat hyperlipidemic rats.
Topics: Animals; Antioxidants; Biomarkers; Catalase; Disease Models, Animal; Female; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Liver; Oxidative Stress; Polycyclic Sesquiterpenes; Polyethylene Glycols; Rats, Wistar; Reactive Oxygen Species; Sesquiterpenes; Simvastatin; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2017 |
Simvastatin Exposure and Rotator Cuff Repair in a Rat Model.
Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Orthopedic Procedures; Osteogenesis; Rats; Rats, Sprague-Dawley; Rotator Cuff; Rotator Cuff Injuries; Simvastatin; Tendons; Wound Healing | 2017 |
Simvastatin augments revascularization and reperfusion in a murine model of hind limb ischemia - Multimodal imaging assessment.
Topics: Animals; Capillaries; Disease Models, Animal; Gene Expression Regulation; Hindlimb; Ischemia; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred BALB C; Multimodal Imaging; Muscles; Neovascularization, Physiologic; Oligopeptides; Regional Blood Flow; Simvastatin; Technetium; Tomography, Emission-Computed, Single-Photon; Vascular Endothelial Growth Factor A | 2017 |
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
Topics: Animals; Anticholesteremic Agents; Arachidonate 5-Lipoxygenase; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; E-Selectin; Endothelium; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Lipoxins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Myocardium; Nitroimidazoles; Parasitemia; Simvastatin; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vascular Cell Adhesion Molecule-1 | 2017 |
Simvastatin is associated with decreased risk of Parkinson disease.
Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Parkinson Disease; Simvastatin | 2017 |
Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho-kinase pathway and NADPH oxidase.
Topics: Animals; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; NADPH Oxidases; Rats; Rats, Wistar; Reactive Oxygen Species; rho-Associated Kinases; Simvastatin; Ventricular Dysfunction, Left | 2017 |
Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats.
Topics: Animals; Cacao; Cocos; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Liver; Lung; Rats; Rats, Wistar; Resuscitation; Sepsis; Shock, Hemorrhagic; Simvastatin; Sodium Chloride; Water | 2016 |
Simvastatin Promotes Hematoma Absorption and Reduces Hydrocephalus Following Intraventricular Hemorrhage in Part by Upregulating CD36.
Topics: Animals; Brain; CD11b Antigen; CD36 Antigens; Cell Count; Cerebral Hemorrhage; Disease Models, Animal; Ependyma; Ferritins; Follow-Up Studies; Hematoma; Hydrocephalus; Hypolipidemic Agents; Lateral Ventricles; Magnetic Resonance Imaging; Male; Maze Learning; Microscopy, Electron, Transmission; Neurologic Examination; Neurons; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation | 2017 |
Simvastatin ameliorates graft-vs-host disease by regulating angiopoietin-1 and angiopoietin-2 in a murine model.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Aorta; Disease Models, Animal; Endothelial Cells; Gene Expression; Graft vs Host Disease; Mice; Simvastatin | 2017 |
Treatment of obese asthma in a mouse model by simvastatin is associated with improving dyslipidemia and decreasing leptin level.
Topics: Animals; Asthma; Blood Glucose; Body Weight; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dyslipidemias; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leptin; Leukocyte Count; Lipids; Lung; Mice; Mice, Inbred C57BL; Obesity; Simvastatin | 2017 |
Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy.
Topics: Animals; Cholesterol; Coculture Techniques; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Flow Cytometry; Human Umbilical Vein Endothelial Cells; Humans; Hyaluronic Acid; Hyaluronoglucosaminidase; Lactic Acid; Lipoproteins, HDL; Macrophages; Male; Mice; Nanoparticles; Particle Size; Plaque, Atherosclerotic; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; RAW 264.7 Cells; Simvastatin; Static Electricity; Tunica Intima | 2017 |
Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells.
Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; DNA Damage; DNA Replication; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression; Gene Knockdown Techniques; Histones; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Minichromosome Maintenance Complex Component 7; Retinoblastoma Protein; Simvastatin; Tamoxifen; Xenograft Model Antitumor Assays | 2017 |
Progression and Characterization of the Accelerated Atherosclerosis in Iliac Artery of New Zealand White Rabbits: Effect of Simvastatin.
Topics: Angioplasty, Balloon; Animals; Atherosclerosis; Biomarkers; Diet, High-Fat; Disease Models, Animal; Disease Progression; Endothelium, Vascular; Extracellular Matrix; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iliac Artery; Inflammation Mediators; Lipids; Macrophages; Male; Plaque, Atherosclerotic; Rabbits; Simvastatin; Time Factors; Vascular Remodeling; Vasoconstriction; Vasodilation | 2017 |
Simvastatin treatment aggravates the glucocorticoid insufficiency associated with hypocholesterolemia in mice.
Topics: Adrenal Cortex Function Tests; Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Animals; Apolipoprotein A-I; Biomarkers; Cholesterol; Corticosterone; Disease Models, Animal; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Receptors, LDL; Simvastatin | 2017 |
Induced neuroprotection independently from PrPSc accumulation in a mouse model for prion disease treated with simvastatin.
Topics: Animals; Brain; Disease Models, Animal; Female; Mice; Neuroprotective Agents; Prion Diseases; PrPSc Proteins; Simvastatin; Survival Analysis | 2008 |
Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Drug Therapy, Combination; Fenofibrate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; PPAR alpha; Rats; Rats, Sprague-Dawley; Simvastatin | 2008 |
Simvastatin abates development of renal fibrosis in experimental renovascular disease.
Topics: Animals; Atherosclerosis; Blood Pressure; Disease Models, Animal; Epithelial Cells; Fibrosis; Glomerular Filtration Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Renal; Mesenchymal Stem Cells; Renal Artery Obstruction; Renal Circulation; Simvastatin; Sus scrofa | 2008 |
Statin pretreatment in experimental acute pancreatitis.
Topics: Acute Disease; Animals; Ceruletide; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-10; Interleukin-6; Lung; Male; Pancreatitis; Peroxidase; Rats; Simvastatin; Survival Rate; Taurocholic Acid; Tumor Necrosis Factor-alpha | 2008 |
Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase.
Topics: Androstadienes; Animals; Carotid Stenosis; Cerebral Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Simvastatin; Subarachnoid Hemorrhage; Up-Regulation; Vasospasm, Intracranial; Wortmannin | 2008 |
Acute protective effects of simvastatin in the rat model of renal ischemia-reperfusion injury: it is never too late for the pretreatment.
Topics: Animals; Creatinine; Disease Models, Animal; Drug Administration Schedule; Edema; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intravenous; Kidney; Kidney Tubular Necrosis, Acute; Male; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Sodium; Time Factors | 2008 |
Reduction of ischemic brain injury in rats with normothermic and hyperthermic conditions.
Topics: Animals; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Combined Modality Therapy; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Male; Rats; Rats, Sprague-Dawley; Simvastatin | 2008 |
Attenuation of inflammation and expansive remodeling by Valsartan alone or in combination with Simvastatin in high-risk coronary atherosclerotic plaques.
Topics: Animals; Antihypertensive Agents; Atherosclerosis; Blood Pressure; Coronary Artery Disease; Disease Models, Animal; Endothelium, Vascular; Inflammation; Lipids; Male; Rabbits; Risk; Simvastatin; Stress, Mechanical; Tetrazoles; Valine; Valsartan | 2009 |
Simvastatin ameliorates glomerulosclerosis in Adriamycin-induced-nephropathy rats.
Topics: Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Doxorubicin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Kidney; Kidney Diseases; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Sclerosis; Simvastatin; Transforming Growth Factor beta1 | 2008 |
Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome.
Topics: Animals; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Disease Models, Animal; Factor VIIa; Female; Fetal Death; Gene Deletion; Gene Expression Regulation; Humans; Immunoglobulin G; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Activation; Neutrophils; Phagocytosis; Pregnancy; Reactive Oxygen Species; Receptor, PAR-1; Receptor, PAR-2; Respiratory Burst; Signal Transduction; Simvastatin; Thromboplastin | 2008 |
Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke.
Topics: Animals; Brain; Cell Movement; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Microcirculation; Myocytes, Smooth Muscle; Neovascularization, Physiologic; Organ Culture Techniques; Presenilin-1; Rats; Rats, Wistar; Receptor, Notch1; Recovery of Function; Signal Transduction; Simvastatin; Stroke; Treatment Outcome; Up-Regulation | 2009 |
Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart.
Topics: Animals; Cardiotonic Agents; Coronary Circulation; Disease Models, Animal; Drug Administration Schedule; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Perfusion; Rats; Rats, Wistar; Simvastatin; Ventricular Function, Left; Ventricular Pressure | 2008 |
Simvastatin reduces endotoxin-induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol.
Topics: Animals; Anticholesteremic Agents; Cholesterol, LDL; Disease Models, Animal; Endotoxins; Guinea Pigs; Humans; Hydroxymethylglutaryl CoA Reductases; Liver; Male; NF-kappa B; Sepsis; Simvastatin; Tumor Necrosis Factors | 2009 |
Statin therapy and cognitive deficits associated with neurofibromatosis type 1.
Topics: Animals; Child; Cognition; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Neurologic Mutants; Neurofibromatosis 1; Simvastatin | 2008 |
Study of cholesterol-lowering effect and safety of simvaglisin on rabbit model of hypercholesterolemia.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Creatine Kinase; Disease Models, Animal; Glycyrrhizic Acid; Hypercholesterolemia; Male; Rabbits; Simvastatin | 2008 |
[Effects and potential mechanisms of short-term use of simvastatin on myocardial no-reflow after ischemia-reperfusion in rats].
Topics: Animals; Disease Models, Animal; Endothelium, Vascular; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Simvastatin | 2008 |
[Simvastatin attenuated cardiac hypertrophy via inhibiting JAK-STAT pathways].
Topics: Animals; Cardiomegaly; Cytokines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Janus Kinases; Male; Myocardium; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; STAT Transcription Factors | 2008 |
Simvastatin attenuates leukocyte recruitment in experimental bacterial meningitis.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocyte Count; Leukocytes; Meningitis, Pneumococcal; Mice; Simvastatin | 2009 |
Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-kappaB pathway.
Topics: Analysis of Variance; Animals; Apoptosis; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cytokines; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Male; Movement Disorders; NF-kappa B; Rats; Rats, Wistar; Rotarod Performance Test; Signal Transduction; Simvastatin; Time Factors; Toll-Like Receptor 4 | 2009 |
3-Hydroxy-3-methylglutaryl (HMG)-COA reductase inhibitors and phosphodiesterase type V inhibitors attenuate right ventricular pressure and remodeling in a rat model of pulmonary hypertension.
Topics: Animals; Atorvastatin; Disease Models, Animal; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Pravastatin; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Simvastatin | 2009 |
Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Indomethacin; Inflammation; Male; Neutrophil Infiltration; Rats; Rats, Wistar; Simvastatin | 2009 |
Statin-induced myopathy in the rat: relationship between systemic exposure, muscle exposure and myopathy.
Topics: Animals; Disease Models, Animal; Female; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Muscle, Skeletal; Muscular Diseases; Pyridines; Pyrimidines; Rats; Rats, Wistar; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2009 |
Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways.
Topics: Animals; Cholesterol; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Liver; Inflammation; Isoflavones; Janus Kinase 2; Leptin; Lipid Metabolism; Liver; Male; Phytotherapy; Plant Extracts; Pueraria; Rats; Rats, Wistar; Receptors, Leptin; RNA, Messenger; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Triglycerides | 2009 |
Ezetimibe reduces plaque inflammation in a rabbit model of atherosclerosis and inhibits monocyte migration in addition to its lipid-lowering effect.
Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Azetidines; C-Reactive Protein; Cell Line; Cell Movement; Chemokine CCL2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ezetimibe; Femoral Artery; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Lipids; Macrophages; Male; Monocytes; NF-kappa B; Rabbits; Simvastatin | 2009 |
Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy.
Topics: Animals; Atorvastatin; Azetidines; Brain; Capillary Permeability; Diet; Disease Models, Animal; Ezetimibe; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunohistochemistry; Maze Learning; Mice; Mice, Transgenic; Neurofibrillary Tangles; Pyrroles; Simvastatin; Spinal Cord; Tauopathies | 2009 |
Anti-atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase-1.
Topics: Animals; Aorta; Arginine; Atherosclerosis; Atorvastatin; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Heme Oxygenase-1; Hemin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Male; Malondialdehyde; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protoporphyrins; Pyrroles; Rabbits; Simvastatin; Time Factors | 2009 |
Simvastatin increases osteoblasts and osteogenic proteins in ovariectomized rats.
Topics: Analysis of Variance; Animals; Bone and Bones; Bone Density; Bone Morphogenetic Proteins; Disease Models, Animal; Female; Osteoblasts; Ovariectomy; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin | 2009 |
Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Lipopolysaccharides; Male; Microdialysis; Nerve Endings; Neuroprotective Agents; Parkinson Disease; Perfusion; Rats; Rats, Wistar; Simvastatin | 2009 |
Simvastatin protects against the development of endometriosis in a nude mouse model.
Topics: Adolescent; Adult; Animals; Anticholesteremic Agents; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Endometriosis; Estradiol; Female; Humans; Matrix Metalloproteinase 3; Mice; Mice, Nude; Middle Aged; Simvastatin; Time Factors; Transplantation, Heterologous; Uterine Diseases; Young Adult | 2009 |
Simvastatin attenuates cerebral vasospasm and improves outcomes by upregulation of PI3K/Akt pathway in a rat model of subarachnoid hemorrhage.
Topics: Analysis of Variance; Animals; Carotid Artery, Internal; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; Subarachnoid Hemorrhage; Up-Regulation; Vasospasm, Intracranial | 2008 |
Simvastatin treatment in surgically induced brain injury in rats.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Capillary Permeability; Disease Models, Animal; Dose-Response Relationship, Drug; Frontal Lobe; Functional Laterality; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neurologic Examination; Rats; Rats, Sprague-Dawley; Simvastatin | 2008 |
Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.
Topics: Animals; Atherosclerosis; Atorvastatin; Capillary Permeability; Cattle; Cells, Cultured; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Farnesol; Female; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, LDL; Protein Kinase C; Protein Kinase Inhibitors; Protein-Lysine 6-Oxidase; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Risk Factors; RNA, Messenger; Simvastatin; Swine; Transfection; Tumor Necrosis Factor-alpha | 2009 |
Simvastatin as a novel strategy to alleviate periapical lesions.
Topics: Alveolar Bone Loss; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blotting, Western; Cell Count; Cell Line; Chemokine CCL2; Chemotaxis; Cysteine-Rich Protein 61; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Macrophages; Osteoblasts; Periapical Periodontitis; Radiography, Dental, Digital; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha | 2009 |
Inhibition of type 2A secretory phospholipase A2 reduces death of cardiomyocytes in acute myocardial infarction.
Topics: Animals; Apoptosis; Caspase 3; Cell Membrane; Cell Movement; Disease Models, Animal; Enzyme Inhibitors; Group II Phospholipases A2; Heart Function Tests; Immunohistochemistry; Macrophages; Myocardial Infarction; Myocytes, Cardiac; Neutrophils; Rats; Rats, Wistar; Simvastatin; Solubility | 2009 |
Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet.
Topics: Acids; Animals; Anticholesteremic Agents; Aorta; Arthropods; Atherosclerosis; Diet, Atherogenic; Disease Models, Animal; Endothelin-1; Hemorheology; Hypolipidemic Agents; Lipid Peroxidation; Lipids; Male; Malondialdehyde; Medicine, Chinese Traditional; Nitric Oxide; Proteins; Rats; Rats, Sprague-Dawley; Simvastatin; Superoxide Dismutase | 2009 |
Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration.
Topics: Animals; Disease Models, Animal; Electron Transport Chain Complex Proteins; Free Radicals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mass Spectrometry; Mitochondria; Mitochondrial Diseases; Mitochondrial Proteins; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Recovery of Function; Rotenone; Simvastatin; Substantia Nigra; Uncoupling Agents | 2009 |
The role of nitric oxide in the expression of renal aquaporin 2 in a cirrhotic rat model: does an AVP-independent mechanism exist for the regulation of AQP2 expression?
Topics: Analysis of Variance; Animals; Aquaporin 2; Biopterins; Cyclic GMP; Disease Models, Animal; Immunoenzyme Techniques; Isosorbide Dinitrate; Kidney; Liver Cirrhosis; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Statistics, Nonparametric; Thioacetamide | 2010 |
Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Encephalitis; Humans; Learning Disabilities; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroimmunomodulation; Neurons; Neuroprotective Agents; Oxidative Stress; Plaque, Amyloid; Protease Nexins; Receptors, Cell Surface; Simvastatin; Space Perception | 2009 |
Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adipose Tissue; Animals; Atherosclerosis; Blood Glucose; Body Composition; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; Dyslipidemias; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Male; Metabolic Syndrome; Mice; Mice, Knockout; Rosiglitazone; Simvastatin; Thiazolidinediones; Triglycerides | 2009 |
Chinese medicine tongxinluo significantly lowers serum lipid levels and stabilizes vulnerable plaques in a rabbit model.
Topics: Aminoglycosides; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Cholesterol; Cholesterol, LDL; Diet; Disease Models, Animal; Drugs, Chinese Herbal; Endothelium, Vascular; Fidaxomicin; Hypolipidemic Agents; Magnoliopsida; Rabbits; Random Allocation; Simvastatin; Triglycerides; Tunica Intima | 2009 |
Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury.
Topics: Analysis of Variance; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Brain Injuries; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Male; Microglia; Rats; Rats, Wistar; Simvastatin; Time Factors | 2009 |
Long-term benefits after treatment of traumatic brain injury with simvastatin in rats.
Topics: Animals; Brain Injuries; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neurons; Rats; Rats, Wistar; Simvastatin; Time Factors | 2009 |
Simvastatin improves wound strength after intestinal anastomosis in the rat.
Topics: Analysis of Variance; Anastomosis, Surgical; Animals; Colectomy; Collagen; Compressive Strength; Disease Models, Animal; Immunohistochemistry; Intestines; Male; Random Allocation; Rats; Rats, Wistar; Reference Values; Simvastatin; Wound Healing | 2009 |
Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke.
Topics: Analysis of Variance; Animals; Blood Vessels; Bone Marrow Cells; Bone Marrow Transplantation; Bromodeoxyuridine; Cell Movement; Chemokine CXCL12; Disease Models, Animal; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Male; Neovascularization, Physiologic; Neurologic Examination; Rats; Rats, Wistar; Receptors, CXCR4; Recovery of Function; Simvastatin; Stromal Cells | 2009 |
[Simvastatin prevents the development of pulmonary hypertension in the rats through reduction of inflammation].
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Hypertension, Pulmonary; Interleukin-6; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha | 2009 |
Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage.
Topics: Animals; Apoptosis; Atorvastatin; Biomarkers; Brain; Brain Infarction; Bromodeoxyuridine; Cerebral Hemorrhage; Cytoprotection; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Microtubule-Associated Proteins; Nerve Degeneration; Neurogenesis; Neuronal Plasticity; Neuropeptides; Neuroprotective Agents; Pyrroles; Rats; Rats, Wistar; Regeneration; Simvastatin; Treatment Outcome | 2009 |
Simvastatin attenuates experimental small airway remodelling in rats.
Topics: Airway Remodeling; Animals; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxyproline; Lung; Male; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Smad Proteins; Tobacco Smoke Pollution; Transforming Growth Factor beta1 | 2009 |
Antiatherogenic effect of simvastatin is not due to decrease of LDL cholesterol in ovariectomized golden Syrian hamster.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Cricetinae; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Mesocricetus; Ovariectomy; Simvastatin; Time Factors; Triglycerides | 2010 |
Simvastatin attenuates intestinal ischemia/reperfusion induced injury in rat.
Topics: Animals; Antioxidants; Disease Models, Animal; Down-Regulation; Free Radical Scavengers; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Diseases; Ischemia; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Regional Blood Flow; Reperfusion Injury; Simvastatin; Superoxide Dismutase; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Benzamides; Blood Pressure; Blotting, Western; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; MAP Kinase Kinase Kinase 3; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Random Allocation; Reference Values; Renin-Angiotensin System; Simvastatin | 2009 |
Atherosclerosis regression study in rabbits upon olive pomace polar lipid extract administration.
Topics: Analysis of Variance; Animals; Atherosclerosis; Cholesterol; Diet, Atherogenic; Dietary Supplements; Disease Models, Animal; Dyslipidemias; Male; Olea; Olive Oil; Plant Oils; Platelet Aggregation; Rabbits; Regression Analysis; Simvastatin | 2010 |
Ezetimibe - new anti-atherogenic properties?
Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Azetidines; C-Reactive Protein; Cell Movement; Chemokine CCL2; Disease Models, Animal; Drug Therapy, Combination; Ezetimibe; Femoral Artery; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Lipids; Macrophages; Monocytes; NF-kappa B; Rabbits; Simvastatin | 2009 |
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin reduces thrombolytic-induced intracerebral hemorrhage in embolized rabbits.
Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Fibrinolytic Agents; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Embolism; Male; Preoperative Care; Rabbits; Rats; Simvastatin; Thrombolytic Therapy; Tissue Plasminogen Activator | 2009 |
Simvastatin and sildenafil combine to attenuate pulmonary hypertension.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Circulation; Purines; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Signal Transduction; Sildenafil Citrate; Simvastatin; Sulfones | 2009 |
Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain Injuries; Disease Models, Animal; Hippocampus; Humans; Maze Learning; Mice; Neuroprotective Agents; Postural Balance; Risk Factors; Simvastatin; Tissue Distribution | 2009 |
Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aortic Diseases; Aortic Rupture; Atherosclerosis; Biomarkers; Catheterization; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation; Gene Transfer Techniques; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunohistochemistry; Inflammation Mediators; Lipids; Male; Rabbits; RNA, Messenger; Simvastatin; Time Factors; Tumor Suppressor Protein p53; Ultrasonography, Doppler, Duplex; Ultrasonography, Interventional; Viper Venoms | 2009 |
Simvastatin reverses podocyte injury but not mesangial expansion in early stage type 2 diabetes mellitus.
Topics: Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glomerular Mesangium; Immunohistochemistry; Kidney Function Tests; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Organ Size; Podocytes; Probability; Random Allocation; Risk Factors; Severity of Illness Index; Simvastatin | 2009 |
Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.
Topics: Animals; Blood Pressure; Blotting, Western; Cell Proliferation; Disease Models, Animal; Down-Regulation; GATA6 Transcription Factor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Time Factors | 2009 |
Effect of simvastatin on intestinal recovery following gut ischemia-reperfusion injury in a rat.
Topics: Administration, Oral; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Enterocytes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Diseases; Intestines; Male; Rats; Rats, Sprague-Dawley; Recovery of Function; Reperfusion Injury; Simvastatin; Treatment Outcome | 2010 |
Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Animals; Cell Survival; Disease Models, Animal; Dopamine; Humans; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neuroglia; Neurons; Neuroprotective Agents; Neurotransmitter Agents; NF-kappa B; Parkinson Disease; Parkinsonian Disorders; Pravastatin; Proto-Oncogene Proteins p21(ras); Simvastatin; Substantia Nigra | 2009 |
Can low doses of simvastatin enhance fracture healing? An experimental study in rabbits.
Topics: Animals; Biomechanical Phenomena; Bone Density; Disease Models, Animal; Dose-Response Relationship, Drug; Fracture Healing; Male; Rabbits; Simvastatin; Ulna Fractures | 2010 |
Attenuation of astrogliosis and modulation of endothelial growth factor receptor in lipid rafts by simvastatin after traumatic brain injury.
Topics: Animals; Astrocytes; Brain Injuries; Caveolin 1; Cell Hypoxia; Cell Survival; Cells, Cultured; Disease Models, Animal; Gliosis; Glucose; Interleukin-1; Male; Membrane Microdomains; Neurons; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar; Receptors, Vascular Endothelial Growth Factor; Simvastatin | 2010 |
Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension.
Topics: Albuminuria; Animals; Antioxidants; Cholesterol; Cyclic N-Oxides; Dietary Fats; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney Failure, Chronic; Male; Obesity; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Risk Factors; Simvastatin; Spin Labels | 2010 |
Lack of robust neurologic benefits with simvastatin or atorvastatin treatment after acute thoracic spinal cord contusion injury.
Topics: Analysis of Variance; Animals; Atorvastatin; Benzenesulfonates; Dietary Sucrose; Disease Models, Animal; Drug Administration Routes; Ectodysplasins; Exploratory Behavior; Food, Formulated; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Motor Activity; Nervous System Diseases; Pain Measurement; Pain Threshold; Psychomotor Performance; Pyrroles; Rats; Rats, Sprague-Dawley; Sacrococcygeal Region; Simvastatin; Spinal Cord Injuries | 2010 |
Farnesyltransferase inhibitor improved survival following endotoxin challenge in mice.
Topics: Animals; Apoptosis; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Liver; Male; MAP Kinase Kinase 4; Methionine; Mice; Mice, Inbred C57BL; Simvastatin; Spleen | 2010 |
HMG-CoA reductase inhibition causes increased necrosis and apoptosis in an in vivo mouse glioblastoma multiforme model.
Topics: Acyl Coenzyme A; Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Glioblastoma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Mice; Mice, Inbred C57BL; Necrosis; Neoplasms, Experimental; Neovascularization, Physiologic; Simvastatin | 2009 |
Protective effect of simvastatin in the cyclophosphamide-induced hemorrhagic cystitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Cyclophosphamide; Cystitis; Cytokines; Disease Models, Animal; Hemorrhage; Male; Random Allocation; Rats; Rats, Wistar; Simvastatin; Urinary Tract | 2010 |
Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Anticholesteremic Agents; Disease Models, Animal; Drug Therapy, Combination; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Simvastatin; Sulfones | 2010 |
Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis.
Topics: Animals; Anticholesteremic Agents; Arthritis, Experimental; Cell Line, Tumor; Cells, Cultured; Chemokine CCL2; Cyclic AMP Response Element-Binding Protein; Cysteine-Rich Protein 61; Cytokines; Disease Models, Animal; Disease Progression; Humans; Injections, Intra-Articular; Male; Osteoblasts; Rats; Rats, Sprague-Dawley; Simvastatin; Treatment Outcome | 2011 |
Simvastatin decreases endothelial progenitor cell apoptosis in the kidney of hypertensive hypercholesterolemic pigs.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cell Survival; Disease Models, Animal; Endothelial Cells; Fibrosis; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension, Renovascular; Inflammation; Kidney; Lipoproteins, LDL; Macrophages; Oxidative Stress; Renal Circulation; Simvastatin; Stem Cells; Sus scrofa | 2010 |
Multiplex coherent anti-stokes Raman spectroscopy images intact atheromatous lesions and concomitantly identifies distinct chemical profiles of atherosclerotic lipids.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Azo Compounds; Brachiocephalic Trunk; Coloring Agents; Crystallization; Disease Models, Animal; Disease Progression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Image Processing, Computer-Assisted; Immunohistochemistry; Lipid Metabolism; Lipids; Male; Mice; Mice, Knockout; Microspectrophotometry; Molecular Structure; Reproducibility of Results; Simvastatin; Spectrum Analysis, Raman; Staining and Labeling; Time Factors | 2010 |
Microscopic and electrophysiological changes on regenerating sciatic nerves of rats treated with simvastatin.
Topics: Animals; Anticholesteremic Agents; Axons; Denervation; Disease Models, Animal; Electric Stimulation; Electromyography; Male; Muscle, Skeletal; Myelin Sheath; Nerve Regeneration; Rats; Rats, Wistar; Sciatic Neuropathy; Simvastatin | 2010 |
Simvastatin attenuates hypomyelination induced by hypoxia-ischemia in neonatal rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weight; CD11b Antigen; Demyelinating Diseases; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Myelin Basic Protein; Rats; Rats, Sprague-Dawley; Simvastatin | 2010 |
Effects of combined therapy with ezetimibe plus simvastatin after drug-eluting stent implantation in a porcine coronary restenosis model.
Topics: Animals; Anticholesteremic Agents; Azetidines; Coronary Restenosis; Disease Models, Animal; Drug Combinations; Drug Implants; Drug-Eluting Stents; Ezetimibe; Female; Graft Occlusion, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Simvastatin; Swine; Treatment Outcome | 2010 |
Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Brain; Brain Ischemia; Calcium-Binding Proteins; Delayed-Action Preparations; Disease Models, Animal; Drug Therapy, Combination; GPI-Linked Proteins; Infarction, Middle Cerebral Artery; Male; Microfilament Proteins; Microglia; Myelin Proteins; Neuroprotective Agents; Niacin; Nogo Receptor 1; Random Allocation; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Peptide; Simvastatin; Stroke; Treatment Outcome | 2010 |
Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia.
Topics: Administration, Oral; Animals; Anti-Obesity Agents; Apocynaceae; Cardiovascular Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Feeding Behavior; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Lipids; Liver; Male; Olive Oil; Plant Extracts; Plant Oils; Polyethylene Glycols; Rats; Rats, Wistar; Seeds; Simvastatin; Time Factors; Weight Gain | 2010 |
Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticholesteremic Agents; Brain Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; Fibrinolytic Agents; Male; Rabbits; rho-Associated Kinases; Simvastatin; Stroke; Time Factors; Tissue Plasminogen Activator | 2010 |
[The effect of simvastatin on the expression of high mobility group box-1 protein in atherosclerotic rats].
Topics: Animals; Atherosclerosis; Disease Models, Animal; HMGB1 Protein; Male; Plaque, Atherosclerotic; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Simvastatin | 2010 |
Reduction of endoplasmic reticulum stress--a novel mechanism of action of statins in the protection against atherosclerosis.
Topics: Animals; Antigens, Differentiation; Atherosclerosis; Cell Line; Disease Models, Animal; DNA-Binding Proteins; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Eukaryotic Initiation Factor-2; Fatty Acids; Heat-Shock Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Mice; Mice, Knockout; Phosphorylation; Pravastatin; Receptors, LDL; Regulatory Factor X Transcription Factors; Simvastatin; Stress, Physiological; Transcription Factors | 2010 |
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Epithelial Cells; Epithelium; Lung; Male; Mice; Mice, Inbred BALB C; Mucus; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrosation; Pneumonia; Simvastatin; Stress, Physiological | 2011 |
Lack of neuroprotective effects of simvastatin and minocycline in a model of cervical spinal cord injury.
Topics: Animals; Cervical Vertebrae; Disease Models, Animal; Drug Therapy, Combination; Minocycline; Myelitis; Nerve Regeneration; Neuroprotective Agents; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; Simvastatin; Spinal Cord Injuries; Treatment Failure | 2010 |
Simvastatin effects on portal-systemic collaterals of portal hypertensive rats.
Topics: Animals; Arginine Vasopressin; Collateral Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Portal; Male; Membrane Proteins; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Portal Pressure; Portal System; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Thromboxane B2; Thromboxane-A Synthase; Time Factors; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents | 2010 |
Comparison of the post-embolization effects of tissue-plasminogen activator and simvastatin on neurological outcome in a clinically relevant rat model of acute ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Fibrinolytic Agents; Hypolipidemic Agents; Rats; Simvastatin; Statistics, Nonparametric; Stroke; Tissue Plasminogen Activator; Treatment Outcome | 2010 |
Simvastatin enhances immune responses to Aβ vaccination and attenuates vaccination-induced behavioral alterations.
Topics: Adjuvants, Immunologic; Administration, Inhalation; Alzheimer Vaccines; Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Behavior, Animal; Disease Models, Animal; Female; Interferon-gamma; Mice; Mice, Inbred C57BL; Simvastatin; Th2 Cells | 2010 |
Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling.
Topics: Airway Remodeling; Animals; Disease Models, Animal; Guinea Pigs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Prognosis; Pulmonary Artery; Pulmonary Emphysema; Pulmonary Wedge Pressure; Simvastatin; Smoking; Vasoconstriction | 2011 |
Simvastatin inhibits aortic valve calcification in hypercholesterolemic rabbits.
Topics: Animals; Aortic Valve; Calcinosis; Disease Models, Animal; Heart Valve Diseases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Rabbits; Simvastatin | 2010 |
Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Evoked Potentials, Somatosensory; Female; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recovery of Function; Simvastatin; Spinal Cord Injuries; Up-Regulation | 2011 |
RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice.
Topics: Amides; Animals; Complement C3; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type III; Pain Threshold; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Spinal Cord; Streptozocin; Time Factors | 2011 |
Effects of simvastatin on pulmonary C-fiber sensitivity in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Heme Oxygenase (Decyclizing); Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Nerve Fibers, Unmyelinated; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Simvastatin | 2011 |
Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
Topics: Aerosols; Animals; Arginase; Arginine; Asthma; Blotting, Western; Coloring Agents; Disease Models, Animal; Goblet Cells; Hydroxyproline; Hyperplasia; Immunohistochemistry; Inflammation; Lung; Mice; Nitrates; Nitrites; Ovalbumin; Simvastatin; Transforming Growth Factor beta1 | 2010 |
Differential efficiency of simvastatin and lipoic acid treatments on Bothrops jararaca envenomation-induced acute kidney injury in mice.
Topics: Acute Kidney Injury; Aminopeptidases; Animals; Anticholesteremic Agents; Antioxidants; Bothrops; Crotalid Venoms; Disease Models, Animal; Kidney; Kidney Function Tests; Male; Mice; Oxidative Stress; Simvastatin; Snake Bites; Thioctic Acid; Treatment Outcome | 2011 |
Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA).
Topics: Aged; Animals; beta-Galactosidase; Cartilage, Articular; Cell Proliferation; Cells, Cultured; Cellular Senescence; Chondrocytes; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Mice; Osteoarthritis, Knee; Simvastatin; Time Factors | 2010 |
The effects of simvastatin on angiogenesis: studied by an original model of atherosclerosis and acute myocardial infarction in rabbit.
Topics: Animals; Aorta, Thoracic; Atherosclerosis; Coronary Angiography; Disease Models, Animal; Heart Function Tests; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Lipids; Male; Myocardial Infarction; Neovascularization, Pathologic; Rabbits; Simvastatin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6.
Topics: Animals; Burns; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Interleukin-6; Male; Mice; Sepsis; Simvastatin; Survival Analysis | 2011 |
Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ileitis; Inflammation; Intestine, Small; Mice; Mice, Inbred C57BL; Resveratrol; Simvastatin; Stilbenes; Th1 Cells; Toxoplasma | 2010 |
Acute lipophilicity-dependent effect of intravascular simvastatin in the early phase of focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Electrophysiology; Guinea Pigs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Infusions, Intravenous; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Oxidation-Reduction; Proto-Oncogene Proteins c-akt; Simvastatin; Solubility; Vascular Resistance | 2011 |
Simvastatin improves retinal ganglion cell survival and spatial vision after acute retinal ischemia/reperfusion in mice.
Topics: Acute Disease; Animals; Behavior, Animal; Cell Count; Cell Survival; Contrast Sensitivity; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Simvastatin; Spatial Behavior; Vision, Ocular; Visual Acuity | 2011 |
Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia.
Topics: Animals; Disease Models, Animal; Dyslipidemias; Gene Expression Regulation; Homeostasis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Liver; Male; Metabolomics; Oxidative Stress; Rabbits; Simvastatin; Xanthine Oxidase | 2011 |
Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production.
Topics: 3' Untranslated Regions; Animals; Anticholesteremic Agents; Cell Line; Cholesterol; Disease Models, Animal; Flow Cytometry; Interleukin-1beta; Macrophages; Male; Mice; MicroRNAs; NF-kappa B; Nuclear Receptor Co-Repressor 1; Polymerase Chain Reaction; Shock, Septic; Simvastatin; Tumor Necrosis Factor-alpha | 2011 |
Simvastatin re-couples dysfunctional endothelial nitric oxide synthase in experimental subarachnoid hemorrhage.
Topics: Animals; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lac Operon; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Multimerization; Simvastatin; Subarachnoid Hemorrhage | 2011 |
Simvastatin improves learning and memory in control but not in olfactory bulbectomized rats.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Simvastatin | 2011 |
Hypolipidaemic and hypoglycaemic effects of total flavonoids from seed residues of Hippophae rhamnoides L. in mice fed a high-fat diet.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Fat Distribution; Cholesterol; Dietary Fats; Disease Models, Animal; Flavonoids; Glucose Intolerance; Hippophae; Hypercholesterolemia; Hypoglycemic Agents; Hypolipidemic Agents; Lipids; Male; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Seeds; Simvastatin; Triglycerides | 2011 |
Validation of human ApoB and ApoAI immunoturbidity assays for non-human primate dyslipidemia and atherosclerosis research.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins B; Atherosclerosis; Biomarkers; Calibration; Disease Models, Animal; Dyslipidemias; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Haplorhini; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoassay; Mass Spectrometry; Nephelometry and Turbidimetry; Predictive Value of Tests; Reproducibility of Results; Simvastatin | 2011 |
Long-term simvastatin attenuates lung injury and oxidative stress in murine acute lung injury models induced by oleic Acid and endotoxin.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Endotoxins; Follow-Up Studies; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Mice; Oleic Acid; Oxidative Stress; Simvastatin; Time Factors | 2011 |
Simvastatin is protective during Staphylococcus aureus pneumonia.
Topics: Animals; Bacterial Load; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Cytokines; Disease Models, Animal; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Peroxidase; Pneumonia, Staphylococcal; Protein C; Simvastatin; Thromboplastin | 2011 |
Simvastatin preserves diastolic function in experimental hypercholesterolemia independently of its lipid lowering effect.
Topics: Animals; Diastole; Disease Models, Animal; Female; Heart Failure; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxyproline; Hypercholesterolemia; Lipids; Microcirculation; Microvessels; Myocardium; Simvastatin; Swine; Tomography, X-Ray Computed; X-Ray Microtomography | 2011 |
Statins alleviate experimental nerve injury-induced neuropathic pain.
Topics: Analysis of Variance; Animals; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorobenzenes; Functional Laterality; Glial Fibrillary Acidic Protein; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Microglia; Neuralgia; Pain Measurement; Pain Threshold; Pyrimidines; Rats; Rats, Sprague-Dawley; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2011 |
Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Fibrosis; Granulocyte Colony-Stimulating Factor; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iron; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocarditis; Simvastatin; Thrombosis; Tirofiban; Tyrosine | 2011 |
The beneficial effects of statin therapy may not apply to all forms of crescentic glomerulonephritis.
Topics: Animals; Atorvastatin; Disease Models, Animal; Glomerulonephritis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Rats; Rats, Inbred WKY; Simvastatin | 2011 |
Beneficial effects of cordycepin on metabolic profiles of liver and plasma from hyperlipidemic hamsters.
Topics: Animals; Cholesterol; Cricetinae; Deoxyadenosines; Disease Models, Animal; Hyperlipidemias; Liver; Male; Metabolome; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Simvastatin; Triglycerides | 2011 |
Reduction of spinal cord ischemia/reperfusion injury with simvastatin in rats.
Topics: Animals; Aorta, Thoracic; Balloon Occlusion; Disease Models, Animal; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Motor Activity; Motor Neurons; Muscle, Skeletal; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Simvastatin; Spinal Cord; Spinal Cord Ischemia; Time Factors | 2011 |
Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.
Topics: Acyl Coenzyme A; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Injections, Intravenous; Losartan; Lovastatin; Male; Rats; Rats, Sprague-Dawley; Rhodamine 123; Simvastatin; Tetrazoles; Time Factors | 2011 |
Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses.
Topics: Animals; Anti-Inflammatory Agents; Anxiety; Apoptosis; Autoradiography; Cell Survival; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Glutamic Acid; Immunohistochemistry; L-Lactate Dehydrogenase; Male; Matrix Metalloproteinase 9; Nerve Degeneration; Oxidopamine; Parkinson Disease; PC12 Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Simvastatin; Substantia Nigra; Tritium; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2011 |
Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats.
Topics: Animals; Apoptosis; Brain; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Estrogens; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Intracranial Aneurysm; Nitric Oxide Synthase Type III; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin | 2011 |
The neuroprotective effect of two statins: simvastatin and pravastatin on a streptozotocin-induced model of Alzheimer's disease in rats.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Pravastatin; Rats; Rats, Wistar; Simvastatin; Streptozocin | 2011 |
Phaleria macrocarpa (Scheff.) Boerl fruit aqueous extract enhances LDL receptor and PCSK9 expression in vivo and in vitro.
Topics: Animals; Anticholesteremic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Hep G2 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Liver; Male; Plant Extracts; Plants, Medicinal; Proprotein Convertase 9; Proprotein Convertases; Rats; Rats, Sprague-Dawley; Receptors, LDL; RNA, Messenger; Serine Endopeptidases; Simvastatin; Solvents; Thymelaeaceae; Time Factors; Up-Regulation; Water; Weight Gain | 2011 |
Simvastatin upregulates Bcl-2 expression and protects retinal neurons from early ischemia/reperfusion injury in the rat retina.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Count; Cell Survival; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Intravitreal Injections; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Simvastatin; Stilbamidines; Up-Regulation | 2011 |
Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3.
Topics: Animals; Anti-Inflammatory Agents; Chondrocytes; Disease Models, Animal; Disease Progression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Male; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Osteoarthritis, Knee; Rats; Rats, Wistar; Simvastatin; Stress, Mechanical | 2011 |
Simvastatin attenuates intestinal fibrosis independent of the anti-inflammatory effect by promoting fibroblast/myofibroblast apoptosis in the regeneration/healing process from TNBS-induced colitis.
Topics: Animals; Apoptosis; Body Weight; Cicatrix, Hypertrophic; Colitis; Disease Models, Animal; Fibroblasts; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Intestines; Male; Mice; Mice, Inbred Strains; Myofibroblasts; Simvastatin; Wound Healing | 2012 |
Cardioprotective effects of low-dose combination therapy with a statin and an angiotensin receptor blocker in a rat myocardial infarction model.
Topics: Angiotensin Receptor Antagonists; Animals; Cardiotonic Agents; Coronary Circulation; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Losartan; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley; Simvastatin | 2012 |
Simvastatin-induced cardiac autonomic control improvement in fructose-fed female rats.
Topics: Animals; Autonomic Nervous System; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Cardiovascular System; Disease Models, Animal; Fasting; Female; Fructose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Metabolic Syndrome; Rats; Rats, Wistar; Simvastatin; Time Factors | 2011 |
Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia.
Topics: Animals; Cricetinae; Disease Models, Animal; Dogs; Dyslipidemias; Fatty Acids; Humans; Lipids; Mice; Primates; Simvastatin; Triglycerides | 2012 |
Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Gentamicins; Hair Cells, Auditory; Hearing Loss, Sensorineural; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Transgenic; Nerve Degeneration; Neuroprotective Agents; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Simvastatin | 2011 |
Effect of Chinese drugs for activating blood circulation and detoxifying on indices of thrombosis, inflammatory reaction, and tissue damage in a rabbit model of toxin-heat and blood stasis syndrome.
Topics: Analysis of Variance; Animals; Atherosclerosis; Blood Circulation; Disease Models, Animal; Drugs, Chinese Herbal; Endothelium, Vascular; Immunohistochemistry; Inflammation; Male; Rabbits; Random Allocation; Sensitivity and Specificity; Simvastatin; Systemic Inflammatory Response Syndrome; Thrombosis | 2013 |
Therapeutic effects of a combinatorial treatment of simvastatin and bone marrow stromal cells on experimental embolic stroke.
Topics: Animals; Behavior, Animal; Biomarkers; Bone Marrow Transplantation; Brain Edema; Cells, Cultured; Combined Modality Therapy; Disease Models, Animal; Fibronectins; Hyaluronan Receptors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Leukocyte Common Antigens; Male; Motor Activity; Rats; Rats, Wistar; Recovery of Function; Simvastatin; Stroke; Stromal Cells; Time Factors | 2012 |
Lipid lowering effect of Cinnamomum zeylanicum in hyperlipidaemic albino rabbits.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cinnamomum zeylanicum; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Hyperlipidemias; Lipids; Phytotherapy; Plant Bark; Plant Extracts; Powders; Rabbits; Simvastatin; Triglycerides | 2012 |
Treatment with simvastatin inhibits the formation of abdominal aortic aneurysms in rabbits.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rabbits; Simvastatin; Time Factors; Tissue Inhibitor of Metalloproteinase-1 | 2012 |
Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach.
Topics: Animals; Brain Damage, Chronic; Brain Injuries; Disease Models, Animal; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Hemorrhages; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Pyrimidines; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Translational Research, Biomedical; Treatment Outcome | 2012 |
Statins inhibit monocyte chemotactic protein 1 expression in endometriosis.
Topics: Adolescent; Adult; Animals; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Endometriosis; Endometrium; Female; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Nude; Middle Aged; RNA, Messenger; Simvastatin; Transplantation, Heterologous | 2012 |
HMG-CoA reductase inhibitors (statins) reduce hypertrophic scar formation in a rabbit ear wounding model.
Topics: Animals; Cicatrix, Hypertrophic; Disease Models, Animal; Ear; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Pravastatin; Rabbits; Simvastatin; Wound Healing | 2012 |
Prostaglandin E1 dose-dependently promotes stability of atherosclerotic plaque in a rabbit model.
Topics: Alprostadil; Angioplasty, Balloon; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Cardiovascular Agents; Chemokine CCL2; Cholesterol, Dietary; Cytokines; Daboia; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Down-Regulation; Fibrosis; Histamine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Lipid Metabolism; Macrophages; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Plaque, Atherosclerotic; Rabbits; RNA, Messenger; Simvastatin; Viper Venoms | 2012 |
Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Animals; Cerebral Amyloid Angiopathy; Disease Models, Animal; Female; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Simvastatin | 2012 |
Simvastatin delivery via inhalation attenuates airway inflammation in a murine model of asthma.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred BALB C; Ovalbumin; RNA, Messenger; Simvastatin | 2012 |
Preparation of injectable auto-forming alginate gel containing simvastatin with amorphous calcium phosphate as a controlled release medium and their therapeutic effect in osteoporosis model rat.
Topics: Alginates; Animals; Buffers; Calcium Phosphates; Catalysis; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Female; Gels; Hypolipidemic Agents; Injections; Osteoporosis; Polymerization; Rats; Rats, Sprague-Dawley; Simvastatin | 2012 |
Simvastatin attenuated cerebrovascular cell proliferation in the development of hypertension through Rho/Rho-kinase pathway.
Topics: Amides; Animals; Basilar Artery; Blood Pressure; Cell Proliferation; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocytes, Smooth Muscle; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin | 2012 |
Short-term statin administration in hypercholesterolaemic rabbits resistant to postconditioning: effects on infarct size, endothelial nitric oxide synthase, and nitro-oxidative stress.
Topics: Animals; Anticholesteremic Agents; Disease Models, Animal; Hypercholesterolemia; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pravastatin; Proto-Oncogene Proteins c-akt; Rabbits; Simvastatin | 2012 |
Effect of pretreatment with simvastatin on spinal cord ischemia-reperfusion injury in rats.
Topics: Animals; Disease Models, Animal; Male; Neuroprotective Agents; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin; Spinal Cord Ischemia; Treatment Outcome | 2013 |
Simvastatin ointment, a new treatment for skin inflammatory conditions.
Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dermatitis, Irritant; Disease Models, Animal; Female; Mice; Ointments; Peroxidase; Proliferating Cell Nuclear Antigen; Simvastatin; Tetradecanoylphorbol Acetate | 2012 |
Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; PPAR alpha; Random Allocation; Simvastatin; Spinal Cord Injuries; Thoracic Vertebrae | 2012 |
Protective role of simvastatin on isolated rabbit atrioventricular node during experimental atrial fibrillation model: role in rate control of ventricular beats.
Topics: Animals; Atrial Fibrillation; Atrioventricular Node; Cardiotonic Agents; Disease Models, Animal; Heart Rate; In Vitro Techniques; Male; Rabbits; Simvastatin | 2012 |
Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia.
Topics: Acute Lung Injury; Administration, Oral; Animals; Anticholesteremic Agents; Cytokines; Disease Models, Animal; Edema; Female; Histocytochemistry; Lung; Mice; Mice, Inbred BALB C; Pneumonia, Pneumococcal; Simvastatin; Streptococcus pneumoniae; Survival Analysis | 2012 |
Short-term therapy with simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Disease Models, Animal; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Myocarditis; Simvastatin; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Role of simvastatin and/or antioxidant vitamins in therapeutic angiogenesis in experimental diabetic hindlimb ischemia: effects on capillary density, angiogenesis markers, and oxidative stress.
Topics: Angiogenesis Inducing Agents; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Capillaries; Diabetes Complications; Disease Models, Animal; Heme Oxygenase-1; Hindlimb; Ischemia; Male; Neovascularization, Physiologic; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Simvastatin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vitamin E; Vitamins | 2012 |
Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms.
Topics: Amphetamine; Analysis of Variance; Animals; Atorvastatin; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Glutathione; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Male; Malondialdehyde; Mitochondria; Motor Activity; NADH Dehydrogenase; Nitrites; Oxidopamine; Parkinsonian Disorders; Pyrroles; Rats; Rats, Wistar; Simvastatin; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2012 |
Simvastatin suppresses RANTES-mediated neutrophilia in polyinosinic-polycytidylic acid-induced pneumonia.
Topics: Animals; Anti-Inflammatory Agents; Bronchi; Cell Line, Tumor; Chemokine CCL5; Disease Models, Animal; Doxycycline; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lung; Mice; Mice, Inbred BALB C; Neutrophils; Pneumonia; Poly I-C; RNA, Small Interfering; Simvastatin; STAT3 Transcription Factor | 2013 |
The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals.
Topics: Animals; Antiviral Agents; Blood Group Antigens; Caliciviridae Infections; Cholesterol; Dendritic Cells; Disease Models, Animal; Disease Susceptibility; Enterocytes; Feces; Gene Expression Regulation; Germ-Free Life; Humans; Interferon Regulatory Factor-3; Interferon-alpha; Intestines; Macrophages; NF-kappa B; Norovirus; Phenotype; Receptors, LDL; Simvastatin; Sus scrofa; Toll-Like Receptor 3; Viral Load; Virus Replication; Virus Shedding | 2012 |
Can statins reduce the inflammatory response associated with preterm birth in an animal model?
Topics: Animals; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mice; Pravastatin; Pregnancy; Premature Birth; Simvastatin | 2012 |
Additive effect of tadalafil and simvastatin on monocrotaline-induced pulmonary hypertension rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Arterioles; Carbolines; Disease Models, Animal; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Simvastatin; Tadalafil; Time Factors; Vasodilator Agents | 2012 |
The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins.
Topics: Animals; Atorvastatin; Cell Communication; Disease Models, Animal; Endothelial Cells; Gene Expression; Hepatic Stellate Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Portal; Kruppel-Like Transcription Factors; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Lovastatin; Male; Paracrine Communication; Pyrroles; Rats; Rats, Wistar; Simvastatin; Stress, Mechanical | 2013 |
Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves functional outcome.
Topics: Analysis of Variance; Angiopoietins; Animals; Antibodies; Anticholesteremic Agents; Arteries; Bromodeoxyuridine; Cell Movement; Cells, Cultured; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Lectins; Linear Models; Male; Neovascularization, Pathologic; Neovascularization, Physiologic; Rats; Rats, Wistar; Simvastatin; Stroke; Time Factors | 2012 |
Effect of simvastatin on passive strain-induced skeletal muscle injury in rats.
Topics: Analysis of Variance; Animals; C-Reactive Protein; Creatine Kinase; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscle, Skeletal; Muscular Diseases; Rats; Rats, Wistar; Simvastatin; Stress, Mechanical | 2012 |
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
Topics: Acetylcarnitine; Animals; Body Weight; Carbohydrate Metabolism; Cathepsin L; Cytoprotection; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Enzyme Activation; Enzyme Activators; Female; Forkhead Transcription Factors; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Necrosis; Oxidation-Reduction; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; RNA, Messenger; Simvastatin; SKP Cullin F-Box Protein Ligases; Time Factors | 2012 |
Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and -9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats.
Topics: Animals; Arteriovenous Shunt, Surgical; Biomarkers; Blood Pressure; Blotting, Western; Carotid Arteries; Disease Models, Animal; Down-Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Jugular Veins; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Simvastatin; Treatment Outcome | 2012 |
Effects of simvastatin administration on rodents with lipopolysaccharide-induced liver microvascular dysfunction.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Liver; Liver Circulation; Male; Microcirculation; Rats; Rats, Wistar; Simvastatin; Vascular Resistance | 2013 |
Enhanced neuroprotective effects of co-administration of G-CSF with simvastatin on intracerebral hemorrhage in rats.
Topics: Animals; Apoptosis; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Drug Combinations; Granulocyte Colony-Stimulating Factor; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recovery of Function; Simvastatin | 2012 |
Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CCL20; Cysteine-Rich Protein 61; Disease Models, Animal; Fibroblasts; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin; Sirtuin 1; Synovial Membrane; Tumor Necrosis Factor-alpha | 2013 |
[Impact of simvastatin on microthrombosis in cortical after subarachnoid hemorrhage in rats and its mechanism].
Topics: Animals; Disease Models, Animal; Intracranial Thrombosis; Male; Rats; Rats, Sprague-Dawley; Simvastatin; Subarachnoid Hemorrhage | 2012 |
Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis.
Topics: Adult; Animals; Apoptosis; Cell Proliferation; Cell Survival; Chimera; Disease Models, Animal; Endometriosis; Endometrium; Fatty Acid-Binding Proteins; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Membrane Proteins; Mice; Mice, Nude; Neoplasm Proteins; Primary Cell Culture; Receptors, Retinoic Acid; Simvastatin; Stromal Cells; Tretinoin | 2013 |
Comparison of bare metal and statin-coated coils on rates of intra-aneurysmal tissue organization in a rat model of aneurysm.
Topics: Actins; Animals; Cerebral Angiography; Coated Materials, Biocompatible; Collagen; Disease Models, Animal; Embolization, Therapeutic; Endothelium, Vascular; Equipment Design; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Intracranial Aneurysm; Male; Metals; Myocytes, Smooth Muscle; Rats; Rats, Wistar; Simvastatin | 2013 |
Simvastatin attenuates stroke-induced splenic atrophy and lung susceptibility to spontaneous bacterial infection in mice.
Topics: Animals; Anticholesteremic Agents; Apoptosis; Atrophy; Bacterial Infections; bcl-2-Associated X Protein; Brain Infarction; Disease Models, Animal; Humans; Infarction, Middle Cerebral Artery; Infections; Interferon-gamma; Lung; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-bcl-2; Simvastatin; Spleen; Splenectomy; Stroke | 2013 |
Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering.
Topics: Animals; Anticholesteremic Agents; Body Weight; Capillary Permeability; Cholesterol, HDL; Cholesterol, LDL; Coronary Vessels; Disease Models, Animal; Female; Hemodynamics; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Models, Cardiovascular; Myocardial Ischemia; Random Allocation; Simvastatin; Stroke Volume; Swine; Tomography, X-Ray Computed; Treatment Outcome; Ultrasonography | 2002 |
Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.
Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Disease Models, Animal; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Organ Size; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Treatment Outcome; Tunica Intima | 2002 |
Simvastatin improves fracture healing in mice.
Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Femoral Fractures; Femur; Fracture Healing; Male; Mice; Mice, Inbred BALB C; Simvastatin | 2002 |
Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.
Topics: Animals; Brain; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Middle Cerebral Artery; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Simvastatin; Subarachnoid Hemorrhage; Time Factors; Up-Regulation; Vascular Patency; Vasospasm, Intracranial | 2002 |
A novel anti-inflammatory role for simvastatin in inflammatory arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; CD28 Antigens; CD3 Complex; Cells, Cultured; Coculture Techniques; Collagen; Disease Models, Animal; Epitopes, T-Lymphocyte; Humans; Immune Sera; Immunosuppressive Agents; Injections, Intraperitoneal; Macrophages; Male; Mice; Mice, Inbred CBA; Simvastatin; Th1 Cells | 2003 |
Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage.
Topics: Animals; Brain Chemistry; Brain Damage, Chronic; Brain Injuries; Brain Ischemia; Brain Mapping; Cerebral Arteries; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation | 2003 |
Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Cholesterol, Dietary; Disease Models, Animal; Female; Hypercholesterolemia; Immunohistochemistry; Kidney; Kidney Function Tests; Nitric Oxide Synthase; Probability; Random Allocation; Receptors, LDL; Receptors, Oxidized LDL; Reference Values; Renal Circulation; Sensitivity and Specificity; Simvastatin; Swine; Tyrosine | 2003 |
Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells.
Topics: Bezafibrate; Clofibrate; Clofibric Acid; Disease Models, Animal; Drug Synergism; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Rhabdomyosarcoma, Embryonal; RNA, Messenger; Simvastatin; Time Factors; Transcription Factors; Tumor Cells, Cultured | 2003 |
Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia.
Topics: Administration, Oral; Animals; Atorvastatin; Cholesterol, HDL; Disease Models, Animal; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Mice; Mice, Knockout; Oxazepines; Piperidines; Pyrroles; Rabbits; Receptors, LDL; Simvastatin; Species Specificity; Time Factors; Triglycerides | 2003 |
Simvastatin normalizes autonomic neural control in experimental heart failure.
Topics: Action Potentials; Animals; Arteries; Autonomic Nervous System; Baroreflex; Cholesterol; Cholesterol, HDL; Disease Models, Animal; Heart Failure; Hemodynamics; Kidney; Male; Norepinephrine; Rabbits; Simvastatin; Sympathetic Nervous System | 2003 |
Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation.
Topics: Animals; Apolipoproteins E; Arteriosclerosis; Base Sequence; Chemokine CCL2; Cholesterol; Culture Techniques; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Probability; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Severity of Illness Index; Simvastatin; Thromboplastin | 2003 |
Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does
Topics: Animals; Animals, Newborn; Body Weight; Brain; Brain Chemistry; Cholesterol; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Interleukin-1; Male; Maze Learning; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2003 |
Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion.
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cell Count; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Ischemia; Lung; Lung Diseases; Male; Models, Cardiovascular; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Long-Evans; Reperfusion Injury; Simvastatin; Statistics as Topic; Time Factors; Transcription Factors; Treatment Outcome | 2003 |
Effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in Watanabe heritable hyperlipidemic rabbits and cholesterol-fed rabbits.
Topics: Animals; Animals, Genetically Modified; Bile; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Japan; Lipids; Liver; Male; Pyridines; Rabbits; Simvastatin | 2004 |
A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma.
Topics: Administration, Oral; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cytokines; Disease Models, Animal; Eosinophilia; Epitopes; Female; Injections, Intraperitoneal; Lymph Nodes; Mice; Mice, Inbred BALB C; Ovalbumin; Simvastatin; Th2 Cells | 2004 |
Simvastatin-induced myocardial protection against ischemia-reperfusion injury is mediated by activation of ATP-sensitive K+ channels.
Topics: Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Collateral Circulation; Disease Models, Animal; Drug Therapy, Combination; Glyburide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Models, Cardiovascular; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels; Rats; Rats, Sprague-Dawley; Simvastatin; Statistics as Topic | 2004 |
Simvastatin treatment restores vasoconstriction and the inhibitory effect of LPC on endothelial relaxation via affecting oxidizing metabolism in diabetic rats.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; Hypolipidemic Agents; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Simvastatin; Streptozocin; Triglycerides; Vasodilation | 2004 |
Assessment of the efficacy of different statins in murine collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Atorvastatin; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorobenzenes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Lymph Nodes; Male; Mice; Mice, Inbred DBA; Nuclear Proteins; Pyrimidines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Trans-Activators; Treatment Outcome | 2004 |
Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Atorvastatin; Blood Pressure; Body Weight; Deoxyguanosine; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Infarction, Middle Cerebral Artery; Lipids; Lysine; Oxidative Stress; Pyrroles; Quinolines; Rats; Rats, Inbred SHR; Simvastatin; Survival Analysis | 2005 |
Atheroma stabilizing effects of simvastatin due to depression of macrophages or lipid accumulation in the atheromatous plaques of coronary plaque-prone WHHL rabbits.
Topics: Animals; Aorta; Arteriosclerosis; Disease Models, Animal; Hypolipidemic Agents; In Situ Nick-End Labeling; Lipids; Macrophages; Male; Muscle, Smooth, Vascular; Rabbits; Simvastatin | 2005 |
Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.
Topics: Animals; Atorvastatin; Brain Ischemia; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Embolism; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyrroles; Simvastatin; Stroke; Tissue Plasminogen Activator | 2005 |
The changes in the endothelial expression of cell adhesion molecules and iNOS in the vessel wall after the short-term administration of simvastatin in rabbit model of atherosclerosis.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Carotid Arteries; Cell Adhesion Molecules; Cholesterol; Diet, Atherogenic; Disease Models, Animal; Drug Administration Schedule; Endothelial Cells; Immunohistochemistry; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rabbits; Simvastatin; Time Factors | 2005 |
A comparative study of efficacy of tibolone and simvastatin on atherosclerosis in ovariectomized cholesterol-fed rabbits.
Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Diet, Atherogenic; Disease Models, Animal; DNA Primers; Estrogen Receptor Modulators; Female; Hypercholesterolemia; Norpregnenes; Ovariectomy; Polymerase Chain Reaction; Rabbits; Receptors, Estrogen; Receptors, LDL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin | 2005 |
Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction.
Topics: Animals; Blotting, Western; Body Weight; Collagen Type I; Cytokines; Disease Models, Animal; Echocardiography; Female; Gene Expression; Heart; Hemodynamics; Immunohistochemistry; Lipids; Myocardial Infarction; Myocardium; Organ Size; Polymerase Chain Reaction; Rats; Rats, Wistar; Simvastatin; Ventricular Remodeling | 2005 |
Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Down-Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Medial Forebrain Bundle; Oxidopamine; Parkinsonian Disorders; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Recovery of Function; Simvastatin; Substantia Nigra; Sympatholytics; Treatment Outcome | 2005 |
Drug-eluting biodegradable poly-D/L-lactic acid vascular stents: an experimental pilot study.
Topics: Absorbable Implants; Animals; Arterial Occlusive Diseases; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Coated Materials, Biocompatible; Dexamethasone; Disease Models, Animal; Follow-Up Studies; Glucocorticoids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iliac Artery; Male; Pilot Projects; Polyesters; Prosthesis Design; Simvastatin; Stents; Swine | 2005 |
Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs.
Topics: Administration, Oral; Analysis of Variance; Animals; Biopsy; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Nitric Oxide Synthase; Pulmonary Artery; Pulmonary Emphysema; Rats; Rats, Sprague-Dawley; Risk Factors; Simvastatin; Smoking; Time Factors | 2005 |
Statin monotherapy attenuates renal injury in a salt-sensitive hypertension model of renal disease.
Topics: Albuminuria; Animals; Cell Division; Chemokine CCL2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Enzyme Inhibitors; Extracellular Matrix; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Renal; Lymphocytes; Macrophages; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; RNA, Messenger; Simvastatin; Sodium Chloride; Transforming Growth Factor beta | 2005 |
Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD(P)H oxidase.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Heart Failure; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; NADPH Oxidases; Rabbits; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin; Tachycardia, Ventricular | 2005 |
Enhanced acetylcholine-induced dilation in afferent arterioles in simvastatin-fed rats.
Topics: Acetylcholine; Animals; Arterioles; Diet; Disease Models, Animal; Enzyme Inhibitors; Hydronephrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Microscopy, Video; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Simvastatin; Vasodilation; Vasodilator Agents | 2006 |
MDOC and atorvastatin have potential antiinflammatory effects in vascular endothelium of apoE-/- mouse model of atherosclerosis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Atorvastatin; Cellulose, Oxidized; Diet; Disease Models, Animal; Endothelium, Vascular; Heptanoic Acids; Hyperlipidemias; Intercellular Adhesion Molecule-1; Lipoproteins; Male; Mice; Mice, Knockout; Pyrroles; Simvastatin; Triglycerides; Vascular Cell Adhesion Molecule-1 | 2006 |
Effects of glitazones on blood pressure and vascular structure in mesenteric resistance arteries and basilar artery from genetically hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Basilar Artery; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypertrophy, Left Ventricular; Mesenteric Arteries; Pioglitazone; Rats; Rats, Inbred SHR; Rats, Wistar; Rosiglitazone; Simvastatin; Tetrazoles; Thiazolidinediones; Tunica Media; Valine; Valsartan | 2005 |
Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy.
Topics: 3T3 Cells; Alleles; Amino Acid Substitution; Animals; Cells, Cultured; Crosses, Genetic; Disease Models, Animal; Embryonic Stem Cells; Female; Magnetic Resonance Spectroscopy; Methionine; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; Oxidoreductases Acting on CH-CH Group Donors; Phenotype; Simvastatin; Smith-Lemli-Opitz Syndrome; Threonine | 2006 |
Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells.
Topics: Angiotensin II; Animals; Anticholesteremic Agents; Blood Glucose; Cells, Cultured; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Janus Kinase 2; Male; Mesangial Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Signal Transduction; Simvastatin; STAT1 Transcription Factor; STAT3 Transcription Factor; Terpenes | 2006 |
Activation of NF-kB and ERK1/2 after permanent focal ischemia is abolished by simvastatin treatment.
Topics: Animals; Brain; Brain Ischemia; Chemokine CCL2; Disease Models, Animal; Down-Regulation; Encephalitis; Enzyme Activation; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Interleukin-1; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; NF-kappa B; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation | 2006 |
Post-infarction treatment with simvastatin reduces myocardial no-reflow by opening of the KATP channel.
Topics: Animals; Antigens, CD; Cadherins; Cardiac Output; Cholesterol; Disease Models, Animal; Electrocardiography; Hydroxymethylglutaryl-CoA Reductase Inhibitors; KATP Channels; Myocardial Infarction; Potassium Channels, Inwardly Rectifying; Simvastatin; Swine; Swine, Miniature; Ventricular Function, Left | 2007 |
Simvastatin prolongs survival times in prion infections of the central nervous system.
Topics: Animals; Blotting, Western; Brain; Brain Chemistry; Central Nervous System Infections; Cholesterol; Disease Models, Animal; Mice; Prion Diseases; Simvastatin; Survival Rate | 2006 |
Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Proliferation; Cholesterol; Disease Models, Animal; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Simvastatin; Th2 Cells; Up-Regulation | 2006 |
Effect of combined simvastatin and cyclosporine compared with simvastatin alone on cerebral vasospasm after subarachnoid hemorrhage in a canine model.
Topics: Analysis of Variance; Angiography; Animals; Basilar Artery; Cyclosporine; Disease Models, Animal; Dogs; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Random Allocation; Simvastatin; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial | 2006 |
Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat.
Topics: Animals; Creatinine; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intravenous; Kidney; Male; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Sodium; Urea | 2006 |
Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; CD40 Antigens; CD40 Ligand; Cytokines; Disease Models, Animal; Female; GTP-Binding Proteins; Immunoglobulin E; Leukocyte Count; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Ovalbumin; RNA, Messenger; Simvastatin; Vascular Cell Adhesion Molecule-1 | 2007 |
Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization.
Topics: Angioplasty, Balloon, Coronary; Animals; Apolipoproteins E; Atherosclerosis; Atorvastatin; Biopsy, Needle; Cells, Cultured; Chemokine CCL19; Chemokine CCL21; Chemokines, CC; Coronary Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation; Heptanoic Acids; Humans; Immunohistochemistry; In Vitro Techniques; Leukocytes, Mononuclear; Mice; Mice, Transgenic; Prognosis; Pyrroles; Receptors, CCR7; Receptors, Chemokine; Reference Values; Risk Factors; RNA, Messenger; Sensitivity and Specificity; Simvastatin; Treatment Outcome | 2007 |
Simvastatin enhances learning and memory independent of amyloid load in mice.
Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Brain; Cholesterol; Cytoprotection; Disease Models, Animal; Female; Learning; Learning Disabilities; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Nitric Oxide Synthase Type III; Plaque, Amyloid; Proto-Oncogene Proteins c-akt; Signal Transduction; Simvastatin; Treatment Outcome | 2006 |
Regression of chronic hypoxic pulmonary hypertension by simvastatin.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Male; Protein Serine-Threonine Kinases; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Simvastatin | 2007 |
The role of simvastatin on postoperative peritoneal adhesion formation in an animal model.
Topics: Abdominal Wall; Animals; Cecum; Digestive System Surgical Procedures; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Male; Peritoneal Cavity; Peritoneal Lavage; Postoperative Complications; Rats; Rats, Wistar; Simvastatin; Tissue Adhesions; Tissue Plasminogen Activator | 2007 |
Acute neurovascular unit protection by simvastatin in transient cerebral ischemia.
Topics: Aminoisobutyric Acids; Animals; Anticholesteremic Agents; Autoradiography; Blood-Brain Barrier; Brain Edema; Brain Infarction; Capillary Permeability; Carbon Isotopes; Cholesterol; Disease Models, Animal; Functional Laterality; Ischemic Attack, Transient; Male; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury; Simvastatin | 2006 |
Effects of simvastatin in abdominal sepsis in rats.
Topics: Animals; Anti-Inflammatory Agents; Cecum; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes; Lymphocytes; Neutrophils; Random Allocation; Rats; Rats, Wistar; Sepsis; Simvastatin; Tumor Necrosis Factor-alpha | 2006 |
[Effects of Tongxinluo and Simvastatin on the stabilization of vulnerable atherosclerotic plaques of aorta in aortic atherosclerosis and molecular mechanism thereof: a comparative study with rabbits].
Topics: Animals; Aorta; Atherosclerosis; Blotting, Western; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cyclooxygenase 2; Disease Models, Animal; Drugs, Chinese Herbal; Fas Ligand Protein; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Matrix Metalloproteinase 1; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; Rabbits; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Triglycerides | 2006 |
Effects of Tribuli saponins on ventricular remodeling after myocardial infarction in hyperlipidemic rats.
Topics: Animals; Cardiac Volume; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Myocardial Infarction; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Simvastatin; Stroke Volume; Tribulus; Ultrasonography; Ventricular Remodeling | 2007 |
Inhibition of chemokine receptor CCR2 and CCR5 expression contributes to simvastatin-induced attenuation of cardiac allograft vasculopathy.
Topics: Animals; Chemokine CCL2; Chemokine CCL5; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Graft Rejection; Heart Transplantation; Immunohistochemistry; Male; Random Allocation; Rats; Rats, Inbred F344; Receptors, CCR5; Receptors, Chemokine; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Simvastatin; Transplantation, Homologous | 2007 |
Cholesterol production inhibitor (statin) increased bone healing in surgically created femoral defect in an animal model.
Topics: Animals; Anticholesteremic Agents; Disease Models, Animal; Drug Combinations; Femoral Fractures; Femur; Fracture Healing; Male; Osteogenesis; Rats; Rats, Sprague-Dawley; Simvastatin; Treatment Outcome; Vancomycin | 2007 |
Simvastatin treatment prolongs the survival of scrapie-infected mice.
Topics: Animals; Cholesterol; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Mice; Mice, Inbred C57BL; Motor Activity; Prion Diseases; Simvastatin; Survival Rate | 2007 |
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Brain Edema; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Cognition Disorders; Cytokines; Disease Models, Animal; Encephalitis; Endothelial Cells; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Pyrroles; Recovery of Function; RNA, Messenger; Simvastatin; Treatment Outcome | 2007 |
Simvastatin for rats with thioacetamide-induced liver failure and encephalopathy.
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Disease Models, Animal; Enzyme Inhibitors; Hepatic Encephalopathy; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Failure, Acute; Male; Motor Activity; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Simvastatin; Thioacetamide; Time Factors | 2008 |
The effect of simvastatin on remodelling of the alveolar bone following tooth extraction.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Biocompatible Materials; Bone Density; Bone Remodeling; Disease Models, Animal; Drug Carriers; Drug Implants; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incisor; Lactic Acid; Male; Mandible; Osteogenesis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Random Allocation; Rats; Rats, Wistar; Simvastatin; Time Factors; Tooth Extraction; Tooth Socket | 2008 |
Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension.
Topics: Animals; Brain; Coenzymes; Disease Models, Animal; Down-Regulation; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Liver; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Simvastatin; Time Factors; Ubiquinone | 2007 |
Comparison of the effect of simvastatin, spironolactone and L-arginine on endothelial function of aorta in hereditary hypertriglyceridemic rats.
Topics: Acetylcholine; Animals; Aorta; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Male; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; Rats; Rats, Wistar; Simvastatin; Spironolactone; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model.
Topics: Analysis of Variance; Animals; Basilar Artery; Disease Models, Animal; Evaluation Studies as Topic; Hemorrhage; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Simvastatin; Statistics as Topic; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2008 |
Locally applied Simvastatin improves fracture healing in mice.
Topics: Animals; Compressive Strength; Disease Models, Animal; Dose-Response Relationship, Drug; Femoral Fractures; Femur; Fracture Healing; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infusion Pumps, Implantable; Injections, Subcutaneous; Male; Mice; Mice, Inbred BALB C; Simvastatin; Stress, Mechanical; Weight-Bearing | 2007 |
[Effects of simvastatin on the left ventricular expression of transient outward potassium channel in rabbits with experimental heart failure].
Topics: Animals; Disease Models, Animal; Heart Failure; Heart Ventricles; Potassium Channels; Rabbits; Simvastatin; Ventricular Remodeling | 2007 |
A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo.
Topics: Anabolic Agents; Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Cells, Cultured; Disease Models, Animal; Female; Hydrophobic and Hydrophilic Interactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred BALB C; Osteoclasts; Osteoporosis; Ovariectomy; Pravastatin; Protein Prenylation; Pyridines; Rabbits; rap1 GTP-Binding Proteins; Signal Transduction; Simvastatin; Water | 2007 |
Hyperbaric oxygen treatment augments the efficacy of cilazapril and simvastatin regimens in an experimental nephrotic syndrome model.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Cilazapril; Combined Modality Therapy; Disease Models, Animal; Doxorubicin; Glutathione Peroxidase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperbaric Oxygenation; Kidney; Male; Nephrotic Syndrome; Oxidative Stress; Protein Carbonylation; Proteinuria; Rats; Rats, Sprague-Dawley; Simvastatin; Superoxide Dismutase | 2008 |
Disease modifying effect of statins in dextran sulfate sodium model of mouse colitis.
Topics: Animals; Apolipoprotein A-I; Atorvastatin; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, HDL; Mice; Occult Blood; Pyrroles; Simvastatin; Tumor Necrosis Factor-alpha | 2008 |
Linköping University Medical Dissertation No. 1033. Following the mevalonate pathway to bone heal alley.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density Conservation Agents; Coated Materials, Biocompatible; Diphosphonates; Disease Models, Animal; Femoral Fractures; Fracture Healing; Fractures, Bone; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ibandronic Acid; Injections, Subcutaneous; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Rats; Rats, Sprague-Dawley; Simvastatin | 2007 |
Pretreatment with high-dose statin, but not low-dose statin, ezetimibe, or the combination of low-dose statin and ezetimibe, limits infarct size in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anticholesteremic Agents; Atorvastatin; Azetidines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ezetimibe; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation | 2008 |
Effect of simvastatin in apolipoprotein E deficient mice with surgically induced chronic renal failure.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Calcinosis; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Failure, Chronic; Male; Mice; Oxidative Stress; Simvastatin | 2008 |
Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats.
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Interleukin-1beta; Intracranial Aneurysm; Macrophages; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Simvastatin; Vascular Cell Adhesion Molecule-1; Vasculitis | 2008 |
Reversal of elastase-induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Division; Chemokine CXCL2; Chemokines; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxyproline; Male; Mice; Mice, Inbred C57BL; Neutrophils; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pancreatic Elastase; Proliferating Cell Nuclear Antigen; Pulmonary Alveoli; Pulmonary Emphysema; Recovery of Function; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; Simvastatin; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2008 |
Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes.
Topics: Animals; Anticholesteremic Agents; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Immunohistochemistry; Mice; Nitric Oxide; Platelet Endothelial Cell Adhesion Molecule-1; RNA, Messenger; Simvastatin; Skin; Vascular Endothelial Growth Factor A; Wound Healing | 2008 |
LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin.
Topics: Animals; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Femoral Artery; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Macrophages; Male; Mevalonic Acid; Muscle Cells; Muscle, Smooth, Vascular; Parathyroid Hormone-Related Protein; Polyisoprenyl Phosphates; Rabbits; Receptor, Parathyroid Hormone, Type 1; RNA, Small Interfering; Simvastatin; Tunica Intima; Up-Regulation | 2008 |
Aqueous extract of rhubarb stabilizes vulnerable atherosclerotic plaques due to depression of inflammation and lipid accumulation.
Topics: Animals; Anticholesteremic Agents; Aorta, Abdominal; Aortic Rupture; Atherosclerosis; Cholesterol, HDL; Cholesterol, LDL; Constriction, Pathologic; Disease Models, Animal; Gene Expression; Histamine; Medicine, Chinese Traditional; NF-kappa B; Phytotherapy; Plant Extracts; Rabbits; Rheum; RNA, Messenger; Simvastatin; Toll-Like Receptors; Viper Venoms | 2008 |
[An experimental study on treatment of steroid-associated femoral head necrosis with simvastatin and BMSCs transplantation].
Topics: Animals; Bone Marrow Transplantation; Cells, Cultured; Disease Models, Animal; Femur Head Necrosis; Male; Methylprednisolone; Rabbits; Random Allocation; Simvastatin; Stem Cell Transplantation; Treatment Outcome | 2008 |
Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen.
Topics: Aldehydes; Animals; Anticholesteremic Agents; Antigen-Antibody Complex; Basement Membrane; Cholesterol; Collagen; Disease Models, Animal; Epithelial Cells; Glomerulonephritis; Kidney Glomerulus; Lipid Peroxidation; Lovastatin; Lysine; Male; Malondialdehyde; Probucol; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Simvastatin | 1994 |
Suppressive effect of simvastatin on intramural small coronary arterial lesions in cholesterol-fed rabbits.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Coronary Artery Disease; Coronary Vessels; Depression, Chemical; Diet, Atherogenic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Linear Models; Male; Rabbits; Random Allocation; Simvastatin | 1998 |
[Simvastatin and ischemia-reperfusion damage: its effects on apoptotic myocyte death and on the endothelial expression of nitric-oxide synthetase in an experimental model of the isolated rat heart].
Topics: Acute Disease; Animals; Apoptosis; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium, Vascular; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Rats; Rats, Wistar; Simvastatin | 1999 |
Nitric oxide synthase II (NOS II) gene expression correlates with atherosclerotic intimal thickening. Preventive effects of HMG-CoA reductase inhibitors.
Topics: Animals; Arteriosclerosis; Atorvastatin; Chemokine CCL2; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; DNA; Down-Regulation; Fibrinogen; Gene Expression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Pyrroles; Rabbits; Simvastatin; Tunica Intima | 1999 |
Hypolipidemic effect of NK-104, a potent HMG-CoA reductase inhibitor, in guinea pigs.
Topics: Animals; Apolipoproteins B; Cholesterol; Chromatography, High Pressure Liquid; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins, VLDL; Liver; Male; Quinolines; Receptors, LDL; Simvastatin; Sterols; Triglycerides | 1999 |
Simvastatin improves disturbed endothelial barrier function.
Topics: Animals; Aorta; Arteriosclerosis; Capillary Permeability; Cell Membrane Permeability; Cells, Cultured; Cholesterol; Cholesterol, LDL; Disease Models, Animal; Endothelium, Vascular; Humans; Hypercholesterolemia; Rabbits; Simvastatin | 2000 |
Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Aorta; Apolipoproteins E; Arteriosclerosis; Carrageenan; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hindlimb; Injections, Subcutaneous; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Simvastatin | 2001 |
Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy.
Topics: Animals; Animals, Genetically Modified; Cardiomegaly; Cardiomyopathy, Hypertrophic; Cell Line; Disease Models, Animal; Echocardiography; Echocardiography, Doppler; Endomyocardial Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Myocardium; Myosin Heavy Chains; Phenotype; Rabbits; ras Proteins; Remission Induction; rhoA GTP-Binding Protein; Simvastatin; Ventricular Function, Left | 2001 |
Simvastatin protects against long-lasting behavioral and morphological consequences of neonatal hypoxic/ischemic brain injury.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Choice Behavior; Disease Models, Animal; Hypoxia-Ischemia, Brain; Male; Maze Learning; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Simvastatin | 2001 |
[Different serum lipid adjustment drugs for the treatment of hyperlipidemic fatty liver].
Topics: Animals; Cholesterol; Disease Models, Animal; Fatty Liver; Rats; Simvastatin; Triglycerides | 2001 |
Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E.
Topics: Acetylcholine; Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Mice; Mice, Knockout; Models, Cardiovascular; Muscle Relaxation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Receptors, LDL; RNA, Messenger; Simvastatin; Treatment Outcome; Triglycerides; Vasodilator Agents | 2002 |
Effect of combining ACE inhibitor and statin in severe experimental nephropathy.
Topics: Alanine Transaminase; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartate Aminotransferases; Blood Pressure; Body Weight; CD4-Positive T-Lymphocytes; Chemokine CCL2; Cholesterol; Disease Models, Animal; Drug Therapy, Combination; Eating; Glomerulonephritis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Lisinopril; Male; Proteinuria; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Triglycerides | 2002 |