simvastatin has been researched along with Depression in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 6 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J; Dong, Y; Feng, C; Li, G; Li, H; Ma, H; Ma, Y; Ren, Y; Wang, Z; Yao, D; Zhou, J; Zhu, Z | 1 |
| Ahmad, F; Ansari, MA; Chaudhry, IB; Chaudhry, N; Hodsoll, J; Husain, MI; Husain, MO; Husain, N; Khan, HA; Khan, N; Khoso, AB; Kiran, T; Meyer, JH; Minhas, F; Mulsant, BH; Naqvi, HA; Nizami, AT; Young, AH | 1 |
| Davoudi, S; Dolatshahi, M; Ghorbanzadeh, B; Naserzadeh, R; Paridar, Y | 1 |
| Chae, WR; Ettrich, B; Friede, T; Gold, SM; Grabe, HJ; Hegerl, U; Hinkelmann, K; Hofmann, T; Janowitz, D; Junghanns, K; Kaczmarczyk, M; Kahl, KG; Klein, JP; Krueger, THC; Leicht, G; Lischewski, S; Märschenz, S; Nowacki, J; Otte, C; Piber, D; Prvulovic, D; Reif, A; Roepke, S; Schmidt, S; Schoettle, D; Strauss, M; Westermair, A | 1 |
| Abdel-Rafei, MK; Moustafa, EM; Rashed, ER; Thabet, NM | 1 |
| Ahmed, S; Eldash, S; Ezzat, H; Maged, N; Menze, ET; Michel, HE; Nadeem, N; Sami, M; Selim, EH; Shawky, S | 1 |
| Liu, QZ; Shang, J; Wang, H; Wang, LL; Zhou, J | 1 |
| Feinstein, A | 1 |
| Cook, RL; Dave, CV; Hartzema, AG; Park, H; Winterstein, AG | 1 |
| Cai, M; Kalavagunta, PK; Liu, Q; Lv, W; Pan, Q; Qin, G; Shang, J; Wang, T; Wu, H; Xia, Z; Zhou, L | 1 |
| An, YQ; Dai, Y; Hu, LF; Lin, GY; Tang, CR; Xu, HQ; Xu, RA; Yu, XB; Zhang, CH; Zhang, HN; Zhou, ZY | 1 |
| Chang, AY; Lin, PY; Lin, TK | 1 |
| Berk, M; Li, X; Redlich, C; Sundquist, J; Sundquist, K; Williams, LJ | 1 |
| Abbasi, SH; Akhondzadeh, S; Beglar, AA; Forghani, S; Mohammadinejad, P; Salehiomran, A; Shahmansouri, N; Zeinoddini, A | 1 |
| ElBatsh, MM | 1 |
| Chang, CH; Chio, CC; Hu, CY; Kuo, JR; Liao, JC; Lim, SW; Shiue, YL; Wang, CC; Wee, HY | 1 |
| Baydemir, C; Erol, K; Kaygisiz, B; Kilic, FS; Ozatik, Y | 1 |
| Hyyppä, MT; Jula, A; Kronholm, E; Leino, A; Virtanen, A | 1 |
| Conklin, SM; Harris, JI; Hibbeln, JR; Manuck, SB; Muldoon, MF; Yao, JK | 1 |
| Boumendil, E; Tubert-Bitter, P | 1 |
5 trial(s) available for simvastatin and Depression
| Article | Year |
|---|---|
Effect of Adjunctive Simvastatin on Depressive Symptoms Among Adults With Treatment-Resistant Depression: A Randomized Clinical Trial.
Topics: Adult; Antidepressive Agents; C-Reactive Protein; Depression; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lipids; Male; Simvastatin | 2023 |
Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial.
Topics: Berlin; Citalopram; Depression; Depressive Disorder, Major; Double-Blind Method; Humans; Multicenter Studies as Topic; Obesity; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome | 2020 |
Simvastatin versus atorvastatin for improving mild to moderate depression in post-coronary artery bypass graft patients: A double-blind, placebo-controlled, randomized trial.
Topics: Adult; Aged; Antidepressive Agents; Atorvastatin; Coronary Artery Bypass; Depression; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Percutaneous Coronary Intervention; Severity of Illness Index; Simvastatin; Treatment Outcome | 2015 |
Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial.
Topics: Adult; Affect; Anticholesteremic Agents; Cross-Over Studies; Dehydroepiandrosterone; Depression; Diet, Mediterranean; Double-Blind Method; Humans; Hypercholesterolemia; Male; Middle Aged; Placebos; Simvastatin; Testosterone | 2003 |
Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers.
Topics: Adult; Affect; Aged; alpha-Linolenic Acid; Anticholesteremic Agents; Cholesterol, LDL; Depression; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Female; Fish Oils; Humans; Hypercholesterolemia; Impulsive Behavior; Male; Middle Aged; Personality; Personality Inventory; Reference Values; Simvastatin; Social Behavior | 2007 |
15 other study(ies) available for simvastatin and Depression
| Article | Year |
|---|---|
Effects of RhoA on depression-like behavior in prenatally stressed offspring rats.
Topics: Animals; Depression; Female; Hippocampus; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Stress, Psychological | 2022 |
Pharmacological evidence for the involvement of the opioid system in the antidepressant-like effect of simvastatin in mice: Without tolerance and withdrawal syndrome.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Depression; Drug Tolerance; Fluoxetine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Locomotion; Mice; Morphine; Naloxone; Narcotic Antagonists; Open Field Test; Receptors, Opioid; Simvastatin; Substance Withdrawal Syndrome; Swimming | 2020 |
Modulation of the Nitric Oxide/BH4 Pathway Protects Against Irradiation-Induced Neuronal Damage.
Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Biopterins; Brain; Brain Injuries; Cranial Irradiation; Depression; Fluoxetine; Gamma Rays; Inflammation; Male; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Rats; Signal Transduction; Sildenafil Citrate; Simvastatin | 2021 |
Simvastatin mitigates depressive-like behavior in ovariectomized rats: Possible role of NLRP3 inflammasome and estrogen receptors' modulation.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammasomes; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein; Ovariectomy; Rats, Sprague-Dawley; Simvastatin; Uterus | 2021 |
Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice.
Topics: Animals; Behavior, Animal; Bezafibrate; Depression; Diet, High-Fat; Glucose Tolerance Test; Hindlimb Suspension; Hippocampus; Male; Mice; Serotonin; Signal Transduction; Simvastatin; Stress, Psychological; Swimming; Tryptophan | 2017 |
Multiple sclerosis: Treatment of cognitive impairment in secondary progressive MS.
Topics: Clinical Trials, Phase II as Topic; Cognitive Dysfunction; Depression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Multiple Sclerosis, Chronic Progressive; Simvastatin | 2017 |
Comparative risk of lipophilic and hydrophilic statins on incident depression: A retrospective cohort study.
Topics: Adult; Aged; Atorvastatin; Depression; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Lovastatin; Male; Middle Aged; Pravastatin; Propensity Score; Retrospective Studies; Risk Factors; Rosuvastatin Calcium; Simvastatin; Suicide, Attempted; United States | 2018 |
Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation.
Topics: Animals; Behavior, Animal; Brain; Depression; Diet, High-Fat; Hippocampus; Hyperlipidemias; Inflammation; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Obesity; Serotonin; Simvastatin | 2019 |
Simvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in mice.
Topics: Animals; Behavior, Animal; Cytokines; Depression; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Mice; Microglia; NF-kappa B; Simvastatin; Stress, Psychological; Tumor Necrosis Factor-alpha | 2019 |
Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rats; Rats, Sprague-Dawley; Simvastatin; Stress, Psychological | 2014 |
Statin use and risk of depression: a Swedish national cohort study.
Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; Cohort Studies; Depression; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Population Surveillance; Pyrroles; Risk Factors; Simvastatin; Sweden | 2014 |
Antidepressant-like effect of simvastatin in diabetic rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Corticosterone; Depression; Diabetes Mellitus, Experimental; Dopamine; Hippocampus; Hypothalamo-Hypophyseal System; Male; Motor Activity; Pituitary-Adrenal System; Rats, Wistar; Serotonin; Simvastatin; Swimming | 2015 |
Simvastatin Therapy in the Acute Stage of Traumatic Brain Injury Attenuates Brain Trauma-Induced Depression-Like Behavior in Rats by Reducing Neuroinflammation in the Hippocampus.
Topics: Acute Disease; Animals; Behavior, Animal; Brain Injuries, Traumatic; Depression; Disease Models, Animal; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Injections, Intraperitoneal; Male; Rats; Rats, Sprague-Dawley; Simvastatin | 2017 |
Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats.
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Depression; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Maze Learning; Motor Activity; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sertraline; Simvastatin | 2012 |
Depression-induced absenteeism in relation to antihyperlipidemic treatment: a study using GAZEL cohort data.
Topics: Absenteeism; Adult; Cohort Studies; Depression; Diet, Fat-Restricted; Female; France; Humans; Hyperlipidemias; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Occupations; Pharmacoepidemiology; Prevalence; Risk Factors; Simvastatin; Surveys and Questionnaires | 1995 |